Inorganic diphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inorganic pyrophosphatase, putative

Species:

Leishmania major

UniProt:

E9ACN6_LEIMA

TriTrypDb:

LmjF.03.0910 , LMJLV39_030014500 , LMJSD75_030014600

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	9

Expansion

Sequence features

E9ACN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACN6

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0044237	cellular metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	11
GO:0003824	catalytic activity	1	11
GO:0004427	inorganic diphosphate phosphatase activity	6	11
GO:0005488	binding	1	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	183	185	PF00082	0.297
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.297
CLV_PCSK_SKI1_1	191	195	PF00082	0.274
DEG_Nend_Nbox_1	1	3	PF02207	0.330
DOC_CKS1_1	112	117	PF01111	0.446
DOC_MAPK_gen_1	39	47	PF00069	0.419
DOC_USP7_MATH_1	22	26	PF00917	0.513
DOC_WW_Pin1_4	111	116	PF00397	0.465
LIG_14-3-3_CanoR_1	70	75	PF00244	0.436
LIG_FHA_1	6	12	PF00498	0.529
LIG_FHA_2	148	154	PF00498	0.548
LIG_FHA_2	166	172	PF00498	0.474
LIG_FHA_2	85	91	PF00498	0.452
LIG_LIR_Apic_2	174	179	PF02991	0.513
LIG_LIR_Apic_2	87	91	PF02991	0.419
LIG_LIR_Gen_1	208	214	PF02991	0.541
LIG_LIR_Nem_3	120	124	PF02991	0.525
LIG_LIR_Nem_3	13	18	PF02991	0.304
LIG_LIR_Nem_3	137	143	PF02991	0.352
LIG_LIR_Nem_3	153	158	PF02991	0.469
LIG_LIR_Nem_3	171	176	PF02991	0.530
LIG_LIR_Nem_3	208	213	PF02991	0.500
LIG_LIR_Nem_3	50	56	PF02991	0.405
LIG_PCNA_yPIPBox_3	160	173	PF02747	0.513
LIG_Pex14_1	172	176	PF04695	0.419
LIG_Pex14_2	79	83	PF04695	0.419
LIG_PTB_Apo_2	217	224	PF02174	0.356
LIG_PTB_Phospho_1	217	223	PF10480	0.360
LIG_SH2_CRK	121	125	PF00017	0.502
LIG_SH2_CRK	155	159	PF00017	0.432
LIG_SH2_CRK	210	214	PF00017	0.381
LIG_SH2_CRK	53	57	PF00017	0.405
LIG_SH2_CRK	81	85	PF00017	0.513
LIG_SH2_STAT5	71	74	PF00017	0.478
LIG_SH3_1	49	55	PF00018	0.465
LIG_SH3_2	52	57	PF14604	0.528
LIG_SH3_3	49	55	PF00018	0.471
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.419
LIG_SUMO_SIM_anti_2	197	204	PF11976	0.439
LIG_SUMO_SIM_par_1	27	32	PF11976	0.280
LIG_SxIP_EBH_1	30	44	PF03271	0.294
LIG_TRAF2_1	48	51	PF00917	0.474
MOD_CDK_SPxK_1	111	117	PF00069	0.446
MOD_CK2_1	147	153	PF00069	0.548
MOD_CK2_1	45	51	PF00069	0.474
MOD_Cter_Amidation	180	183	PF01082	0.250
MOD_GlcNHglycan	100	103	PF01048	0.201
MOD_GlcNHglycan	12	15	PF01048	0.308
MOD_GlcNHglycan	147	150	PF01048	0.310
MOD_GlcNHglycan	24	27	PF01048	0.434
MOD_GSK3_1	143	150	PF00069	0.473
MOD_NEK2_1	165	170	PF00069	0.463
MOD_NEK2_1	29	34	PF00069	0.411
MOD_PIKK_1	205	211	PF00454	0.509
MOD_Plk_4	165	171	PF00069	0.450
MOD_Plk_4	198	204	PF00069	0.437
MOD_Plk_4	7	13	PF00069	0.338
MOD_ProDKin_1	111	117	PF00069	0.465
MOD_SUMO_for_1	43	46	PF00179	0.419
MOD_SUMO_rev_2	134	143	PF00179	0.419
TRG_ENDOCYTIC_2	121	124	PF00928	0.513
TRG_ENDOCYTIC_2	155	158	PF00928	0.424
TRG_ENDOCYTIC_2	210	213	PF00928	0.332
TRG_ENDOCYTIC_2	53	56	PF00928	0.405
TRG_ENDOCYTIC_2	74	77	PF00928	0.419
TRG_ENDOCYTIC_2	81	84	PF00928	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXJ8	Leptomonas seymouri	61%	82%
A0A1X0NCY3	Trypanosomatidae	37%	89%
A0A1X0PAB0	Trypanosomatidae	56%	81%
A0A422N180	Trypanosoma rangeli	56%	83%
A0A451EJT9	Leishmania donovani	95%	100%
A2X8Q3	Oryza sativa subsp. indica	31%	100%
A4H3Q3	Leishmania braziliensis	85%	70%
A4HRX7	Leishmania infantum	94%	100%
C9ZKI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	87%
E9AJX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	86%
O05724	Geobacillus stearothermophilus	27%	100%
O13505	Komagataella pastoris	42%	79%
O23979	Hordeum vulgare subsp. vulgare	31%	100%
O26363	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	28%	100%
O48556	Zea mays	31%	100%
O59570	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
O67501	Aquifex aeolicus (strain VF5)	31%	100%
O77460	Drosophila melanogaster	42%	67%
O82597	Arabidopsis thaliana	30%	100%
O82793	Arabidopsis thaliana	33%	100%
P00817	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	79%
P13998	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	39%	79%
P19117	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	78%
P19514	Bacillus sp. (strain PS3)	29%	100%
P21216	Arabidopsis thaliana	33%	100%
P28239	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	73%
P37980	Bos taurus	42%	78%
P37981	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	26%	100%
P44529	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
P50308	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	30%	100%
P77992	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	29%	100%
P80507	Synechocystis sp. (strain PCC 6803 / Kazusa)	24%	100%
P83777	Candida albicans (strain SC5314 / ATCC MYA-2876)	40%	78%
P87118	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	79%
Q0DYB1	Oryza sativa subsp. japonica	31%	100%
Q15181	Homo sapiens	42%	78%
Q43187	Solanum tuberosum	32%	100%
Q4R543	Macaca fascicularis	42%	78%
Q54PV8	Dictyostelium discoideum	37%	81%
Q5B912	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	42%	79%
Q5JIY3	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	29%	100%
Q5R8T6	Pongo abelii	42%	78%
Q6BWA5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	43%	79%
Q6C1T4	Yarrowia lipolytica (strain CLIB 122 / E 150)	40%	79%
Q6FRB7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	41%	79%
Q6KZB3	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	26%	100%
Q6MVH7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	43%	78%
Q72MG4	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	25%	100%
Q757J8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	79%
Q8DHR2	Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)	25%	100%
Q8EZ21	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	25%	100%
Q8GQS5	Aquifex pyrophilus	31%	100%
Q8SR69	Encephalitozoon cuniculi (strain GB-M1)	37%	82%
Q8TVE2	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	28%	100%
Q8U438	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	28%	100%
Q91VM9	Mus musculus	39%	68%
Q93V56	Arabidopsis thaliana	30%	100%
Q93Y52	Chlamydomonas reinhardtii	42%	81%
Q949J1	Chlamydomonas reinhardtii	30%	100%
Q97W51	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	28%	100%
Q9AC20	Caulobacter vibrioides (strain ATCC 19089 / CB15)	27%	100%
Q9C0T9	Zygosaccharomyces bailii	41%	79%
Q9D819	Mus musculus	42%	78%
Q9H2U2	Homo sapiens	38%	68%
Q9JVG3	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	29%	100%
Q9K0G4	Neisseria meningitidis serogroup B (strain MC58)	29%	100%
Q9KCG7	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	28%	100%
Q9LFF9	Arabidopsis thaliana	32%	100%
Q9LXC9	Arabidopsis thaliana	39%	75%
Q9PHM9	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	26%	100%
Q9PQH6	Ureaplasma parvum serovar 3 (strain ATCC 700970)	29%	100%
Q9UY24	Pyrococcus abyssi (strain GE5 / Orsay)	29%	100%
Q9YBA5	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	30%	100%
V5BSV4	Trypanosoma cruzi	57%	83%