Putative peter pan protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peter pan protein, putative

Species:

Leishmania major

UniProt:

E9ACN5_LEIMA

TriTrypDb:

LmjF.03.0900 , LMJLV39_030014400 , LMJSD75_030014500

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9ACN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACN5

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0065003	protein-containing complex assembly	5	2
GO:0071704	organic substance metabolic process	2	11
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0019843	rRNA binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.413
CLV_NRD_NRD_1	121	123	PF00675	0.213
CLV_NRD_NRD_1	217	219	PF00675	0.241
CLV_NRD_NRD_1	310	312	PF00675	0.490
CLV_NRD_NRD_1	318	320	PF00675	0.458
CLV_NRD_NRD_1	327	329	PF00675	0.440
CLV_NRD_NRD_1	338	340	PF00675	0.312
CLV_NRD_NRD_1	343	345	PF00675	0.453
CLV_PCSK_FUR_1	330	334	PF00082	0.496
CLV_PCSK_KEX2_1	121	123	PF00082	0.213
CLV_PCSK_KEX2_1	217	219	PF00082	0.216
CLV_PCSK_KEX2_1	22	24	PF00082	0.436
CLV_PCSK_KEX2_1	317	319	PF00082	0.488
CLV_PCSK_KEX2_1	329	331	PF00082	0.518
CLV_PCSK_KEX2_1	332	334	PF00082	0.468
CLV_PCSK_KEX2_1	343	345	PF00082	0.458
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.436
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.441
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.457
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.428
CLV_PCSK_PC7_1	328	334	PF00082	0.473
CLV_PCSK_PC7_1	339	345	PF00082	0.421
CLV_PCSK_SKI1_1	161	165	PF00082	0.233
CLV_PCSK_SKI1_1	208	212	PF00082	0.238
CLV_PCSK_SKI1_1	3	7	PF00082	0.596
CLV_PCSK_SKI1_1	318	322	PF00082	0.606
CLV_PCSK_SKI1_1	47	51	PF00082	0.213
CLV_PCSK_SKI1_1	63	67	PF00082	0.213
DEG_APCC_DBOX_1	261	269	PF00400	0.413
DOC_CYCLIN_RxL_1	158	166	PF00134	0.507
DOC_CYCLIN_RxL_1	208	215	PF00134	0.413
DOC_MAPK_DCC_7	128	138	PF00069	0.507
DOC_MAPK_gen_1	119	126	PF00069	0.514
DOC_MAPK_gen_1	22	30	PF00069	0.423
DOC_MAPK_gen_1	255	265	PF00069	0.413
DOC_MAPK_gen_1	295	303	PF00069	0.502
DOC_MAPK_gen_1	63	71	PF00069	0.445
DOC_MAPK_MEF2A_6	161	169	PF00069	0.418
DOC_MAPK_MEF2A_6	32	39	PF00069	0.425
DOC_MAPK_MEF2A_6	96	105	PF00069	0.413
DOC_PP1_RVXF_1	104	111	PF00149	0.413
DOC_PP4_FxxP_1	142	145	PF00568	0.413
DOC_PP4_FxxP_1	83	86	PF00568	0.427
DOC_PP4_FxxP_1	98	101	PF00568	0.468
DOC_USP7_MATH_1	52	56	PF00917	0.413
DOC_USP7_UBL2_3	208	212	PF12436	0.413
DOC_USP7_UBL2_3	22	26	PF12436	0.379
DOC_USP7_UBL2_3	332	336	PF12436	0.512
DOC_USP7_UBL2_3	57	61	PF12436	0.507
DOC_WW_Pin1_4	21	26	PF00397	0.384
LIG_14-3-3_CanoR_1	106	111	PF00244	0.413
LIG_14-3-3_CanoR_1	271	275	PF00244	0.413
LIG_APCC_ABBA_1	110	115	PF00400	0.507
LIG_deltaCOP1_diTrp_1	45	53	PF00928	0.439
LIG_EH_1	353	357	PF12763	0.585
LIG_FHA_1	201	207	PF00498	0.507
LIG_FHA_1	271	277	PF00498	0.413
LIG_FHA_2	141	147	PF00498	0.437
LIG_FHA_2	16	22	PF00498	0.486
LIG_FHA_2	239	245	PF00498	0.413
LIG_FHA_2	295	301	PF00498	0.506
LIG_HP1_1	135	139	PF01393	0.413
LIG_LIR_Gen_1	67	75	PF02991	0.413
LIG_LIR_Nem_3	102	108	PF02991	0.413
LIG_LIR_Nem_3	157	163	PF02991	0.524
LIG_LIR_Nem_3	45	49	PF02991	0.413
LIG_LIR_Nem_3	67	71	PF02991	0.413
LIG_PCNA_yPIPBox_3	56	69	PF02747	0.413
LIG_Pex14_1	46	50	PF04695	0.442
LIG_Pex14_2	160	164	PF04695	0.413
LIG_SH2_GRB2like	198	201	PF00017	0.507
LIG_SH2_NCK_1	185	189	PF00017	0.413
LIG_SH2_SRC	185	188	PF00017	0.413
LIG_SH2_SRC	198	201	PF00017	0.413
LIG_SH2_STAT5	198	201	PF00017	0.415
LIG_SH3_3	46	52	PF00018	0.435
LIG_SUMO_SIM_par_1	122	127	PF11976	0.476
LIG_WRC_WIRS_1	107	112	PF05994	0.413
MOD_CDK_SPK_2	21	26	PF00069	0.384
MOD_CK1_1	87	93	PF00069	0.556
MOD_CK2_1	224	230	PF00069	0.470
MOD_CK2_1	238	244	PF00069	0.413
MOD_CK2_1	274	280	PF00069	0.433
MOD_CK2_1	294	300	PF00069	0.366
MOD_GlcNHglycan	75	78	PF01048	0.335
MOD_GSK3_1	168	175	PF00069	0.494
MOD_GSK3_1	200	207	PF00069	0.488
MOD_GSK3_1	217	224	PF00069	0.352
MOD_GSK3_1	270	277	PF00069	0.493
MOD_GSK3_1	290	297	PF00069	0.409
MOD_GSK3_1	71	78	PF00069	0.416
MOD_GSK3_1	84	91	PF00069	0.413
MOD_LATS_1	59	65	PF00433	0.427
MOD_N-GLC_1	140	145	PF02516	0.227
MOD_N-GLC_1	303	308	PF02516	0.477
MOD_N-GLC_1	61	66	PF02516	0.225
MOD_NEK2_1	108	113	PF00069	0.427
MOD_NEK2_1	156	161	PF00069	0.441
MOD_NEK2_1	274	279	PF00069	0.433
MOD_NEK2_1	75	80	PF00069	0.413
MOD_NEK2_2	101	106	PF00069	0.445
MOD_PIKK_1	84	90	PF00454	0.468
MOD_PKA_1	217	223	PF00069	0.507
MOD_PKA_2	217	223	PF00069	0.510
MOD_PKA_2	270	276	PF00069	0.413
MOD_PKA_2	310	316	PF00069	0.534
MOD_Plk_1	61	67	PF00069	0.414
MOD_Plk_2-3	236	242	PF00069	0.413
MOD_Plk_2-3	294	300	PF00069	0.506
MOD_Plk_4	24	30	PF00069	0.358
MOD_ProDKin_1	21	27	PF00069	0.374
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.427
TRG_ENDOCYTIC_2	185	188	PF00928	0.413
TRG_ER_diArg_1	121	123	PF00400	0.413
TRG_ER_diArg_1	217	219	PF00400	0.507
TRG_ER_diArg_1	308	311	PF00400	0.512
TRG_NLS_Bipartite_1	311	333	PF00514	0.481
TRG_NLS_MonoExtC_3	327	332	PF00514	0.447
TRG_NLS_MonoExtN_4	315	321	PF00514	0.537
TRG_NLS_MonoExtN_4	328	333	PF00514	0.387
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.213
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	40	45	PF00026	0.213

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P540	Leptomonas seymouri	87%	100%
A0A1X0P9W9	Trypanosomatidae	72%	100%
A0A3R7N9Q4	Trypanosoma rangeli	70%	100%
A0A3S5H566	Leishmania donovani	98%	98%
A4H3Q2	Leishmania braziliensis	93%	100%
A4HRX6	Leishmania infantum	96%	98%
C9ZKI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AJX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O14206	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	96%
Q54N44	Dictyostelium discoideum	31%	88%
Q5REM3	Pongo abelii	33%	79%
Q91YU8	Mus musculus	32%	80%
Q9ASU7	Arabidopsis thaliana	30%	100%
Q9NQ55	Homo sapiens	33%	79%
Q9VDE5	Drosophila melanogaster	31%	81%
V5DTY6	Trypanosoma cruzi	70%	100%