FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania major

UniProt:

E9ACN4_LEIMA

TriTrypDb:

LmjF.03.0890 , LMJLV39_030014300 , LMJSD75_030014400

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACN4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.623
CLV_C14_Caspase3-7	660	664	PF00656	0.648
CLV_C14_Caspase3-7	96	100	PF00656	0.611
CLV_MEL_PAP_1	273	279	PF00089	0.625
CLV_NRD_NRD_1	138	140	PF00675	0.764
CLV_NRD_NRD_1	151	153	PF00675	0.503
CLV_NRD_NRD_1	412	414	PF00675	0.591
CLV_NRD_NRD_1	621	623	PF00675	0.724
CLV_PCSK_KEX2_1	138	140	PF00082	0.764
CLV_PCSK_KEX2_1	151	153	PF00082	0.503
CLV_PCSK_KEX2_1	275	277	PF00082	0.591
CLV_PCSK_KEX2_1	620	622	PF00082	0.725
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.659
CLV_PCSK_PC7_1	616	622	PF00082	0.711
CLV_PCSK_SKI1_1	151	155	PF00082	0.592
CLV_PCSK_SKI1_1	359	363	PF00082	0.369
CLV_PCSK_SKI1_1	393	397	PF00082	0.289
CLV_PCSK_SKI1_1	409	413	PF00082	0.432
CLV_PCSK_SKI1_1	572	576	PF00082	0.300
CLV_PCSK_SKI1_1	659	663	PF00082	0.654
CLV_PCSK_SKI1_1	729	733	PF00082	0.527
DEG_APCC_DBOX_1	408	416	PF00400	0.485
DEG_Nend_Nbox_1	1	3	PF02207	0.474
DEG_SPOP_SBC_1	324	328	PF00917	0.360
DOC_CYCLIN_yCln2_LP_2	173	176	PF00134	0.567
DOC_MAPK_DCC_7	572	582	PF00069	0.300
DOC_MAPK_gen_1	107	116	PF00069	0.587
DOC_MAPK_gen_1	309	317	PF00069	0.322
DOC_MAPK_gen_1	572	582	PF00069	0.303
DOC_MAPK_MEF2A_6	107	116	PF00069	0.587
DOC_MAPK_MEF2A_6	309	317	PF00069	0.331
DOC_MAPK_MEF2A_6	40	48	PF00069	0.462
DOC_MAPK_MEF2A_6	575	584	PF00069	0.300
DOC_PP1_RVXF_1	149	156	PF00149	0.630
DOC_PP1_RVXF_1	278	285	PF00149	0.547
DOC_PP1_SILK_1	729	734	PF00149	0.590
DOC_PP2B_LxvP_1	172	175	PF13499	0.632
DOC_PP2B_LxvP_1	574	577	PF13499	0.300
DOC_PP2B_LxvP_1	599	602	PF13499	0.374
DOC_PP2B_LxvP_1	723	726	PF13499	0.500
DOC_PP4_MxPP_1	611	614	PF00568	0.625
DOC_USP7_MATH_1	117	121	PF00917	0.634
DOC_USP7_MATH_1	125	129	PF00917	0.612
DOC_USP7_MATH_1	167	171	PF00917	0.624
DOC_USP7_MATH_1	200	204	PF00917	0.612
DOC_USP7_MATH_1	342	346	PF00917	0.307
DOC_USP7_MATH_1	425	429	PF00917	0.662
DOC_USP7_MATH_1	438	442	PF00917	0.601
DOC_USP7_MATH_1	516	520	PF00917	0.771
DOC_USP7_MATH_1	641	645	PF00917	0.662
DOC_USP7_MATH_1	67	71	PF00917	0.650
DOC_USP7_MATH_1	74	78	PF00917	0.515
DOC_USP7_UBL2_3	565	569	PF12436	0.360
LIG_14-3-3_CanoR_1	110	115	PF00244	0.582
LIG_14-3-3_CanoR_1	267	273	PF00244	0.633
LIG_14-3-3_CanoR_1	276	284	PF00244	0.622
LIG_14-3-3_CanoR_1	359	369	PF00244	0.361
LIG_14-3-3_CanoR_1	434	438	PF00244	0.706
LIG_14-3-3_CanoR_1	472	479	PF00244	0.655
LIG_14-3-3_CanoR_1	659	668	PF00244	0.673
LIG_14-3-3_CanoR_1	79	87	PF00244	0.682
LIG_Actin_WH2_2	718	735	PF00022	0.505
LIG_BIR_III_4	651	655	PF00653	0.677
LIG_Clathr_ClatBox_1	581	585	PF01394	0.360
LIG_deltaCOP1_diTrp_1	211	218	PF00928	0.674
LIG_deltaCOP1_diTrp_1	31	36	PF00928	0.483
LIG_FHA_1	532	538	PF00498	0.607
LIG_FHA_1	55	61	PF00498	0.666
LIG_FHA_2	334	340	PF00498	0.300
LIG_FHA_2	486	492	PF00498	0.690
LIG_FHA_2	539	545	PF00498	0.742
LIG_FHA_2	658	664	PF00498	0.663
LIG_FHA_2	702	708	PF00498	0.739
LIG_FHA_2	71	77	PF00498	0.503
LIG_GBD_Chelix_1	313	321	PF00786	0.360
LIG_IRF3_LxIS_1	641	648	PF10401	0.541
LIG_LIR_Gen_1	30	39	PF02991	0.586
LIG_LIR_Gen_1	336	344	PF02991	0.306
LIG_LIR_Gen_1	354	365	PF02991	0.391
LIG_LIR_LC3C_4	720	725	PF02991	0.479
LIG_LIR_Nem_3	271	277	PF02991	0.594
LIG_LIR_Nem_3	30	36	PF02991	0.595
LIG_LIR_Nem_3	336	340	PF02991	0.314
LIG_LIR_Nem_3	354	360	PF02991	0.440
LIG_NRBOX	711	717	PF00104	0.574
LIG_NRBOX	718	724	PF00104	0.474
LIG_PAM2_1	360	372	PF00658	0.360
LIG_Pex14_1	214	218	PF04695	0.674
LIG_Pex14_1	353	357	PF04695	0.360
LIG_Pex14_2	49	53	PF04695	0.341
LIG_SH2_CRK	274	278	PF00017	0.626
LIG_SH2_CRK	357	361	PF00017	0.360
LIG_SH2_CRK	89	93	PF00017	0.743
LIG_SH2_SRC	604	607	PF00017	0.518
LIG_SH2_STAP1	357	361	PF00017	0.360
LIG_SH2_STAP1	381	385	PF00017	0.300
LIG_SH2_STAP1	8	12	PF00017	0.441
LIG_SH2_STAT3	399	402	PF00017	0.360
LIG_SH2_STAT5	20	23	PF00017	0.459
LIG_SH2_STAT5	604	607	PF00017	0.518
LIG_SH3_3	13	19	PF00018	0.554
LIG_SH3_3	173	179	PF00018	0.653
LIG_SH3_3	190	196	PF00018	0.560
LIG_SH3_3	209	215	PF00018	0.499
LIG_SH3_3	597	603	PF00018	0.307
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.460
LIG_SUMO_SIM_anti_2	579	585	PF11976	0.300
LIG_SUMO_SIM_anti_2	720	727	PF11976	0.488
LIG_SUMO_SIM_par_1	311	316	PF11976	0.328
LIG_SUMO_SIM_par_1	579	585	PF11976	0.324
LIG_SUMO_SIM_par_1	706	717	PF11976	0.649
LIG_SUMO_SIM_par_1	720	727	PF11976	0.462
LIG_TYR_ITIM	272	277	PF00017	0.631
LIG_UBA3_1	1	7	PF00899	0.459
MOD_CK1_1	24	30	PF00069	0.493
MOD_CK1_1	244	250	PF00069	0.734
MOD_CK1_1	325	331	PF00069	0.360
MOD_CK1_1	463	469	PF00069	0.745
MOD_CK1_1	475	481	PF00069	0.643
MOD_CK1_1	484	490	PF00069	0.608
MOD_CK1_1	523	529	PF00069	0.732
MOD_CK1_1	54	60	PF00069	0.552
MOD_CK1_1	689	695	PF00069	0.768
MOD_CK1_1	70	76	PF00069	0.478
MOD_CK2_1	117	123	PF00069	0.621
MOD_CK2_1	333	339	PF00069	0.300
MOD_CK2_1	342	348	PF00069	0.300
MOD_CK2_1	60	66	PF00069	0.544
MOD_CK2_1	70	76	PF00069	0.545
MOD_CK2_1	714	720	PF00069	0.555
MOD_CK2_1	90	96	PF00069	0.610
MOD_Cter_Amidation	155	158	PF01082	0.625
MOD_GlcNHglycan	127	130	PF01048	0.652
MOD_GlcNHglycan	165	168	PF01048	0.626
MOD_GlcNHglycan	223	226	PF01048	0.612
MOD_GlcNHglycan	247	250	PF01048	0.651
MOD_GlcNHglycan	344	347	PF01048	0.300
MOD_GlcNHglycan	375	378	PF01048	0.334
MOD_GlcNHglycan	427	430	PF01048	0.685
MOD_GlcNHglycan	445	449	PF01048	0.703
MOD_GlcNHglycan	451	454	PF01048	0.768
MOD_GlcNHglycan	465	468	PF01048	0.688
MOD_GlcNHglycan	474	477	PF01048	0.650
MOD_GlcNHglycan	483	486	PF01048	0.614
MOD_GlcNHglycan	496	499	PF01048	0.792
MOD_GlcNHglycan	522	525	PF01048	0.700
MOD_GlcNHglycan	62	65	PF01048	0.549
MOD_GlcNHglycan	631	634	PF01048	0.820
MOD_GlcNHglycan	669	673	PF01048	0.551
MOD_GlcNHglycan	69	72	PF01048	0.548
MOD_GlcNHglycan	690	695	PF01048	0.551
MOD_GlcNHglycan	80	83	PF01048	0.665
MOD_GSK3_1	119	126	PF00069	0.647
MOD_GSK3_1	163	170	PF00069	0.671
MOD_GSK3_1	20	27	PF00069	0.473
MOD_GSK3_1	200	207	PF00069	0.619
MOD_GSK3_1	221	228	PF00069	0.598
MOD_GSK3_1	236	243	PF00069	0.551
MOD_GSK3_1	301	308	PF00069	0.544
MOD_GSK3_1	471	478	PF00069	0.606
MOD_GSK3_1	481	488	PF00069	0.774
MOD_GSK3_1	516	523	PF00069	0.756
MOD_GSK3_1	54	61	PF00069	0.585
MOD_GSK3_1	584	591	PF00069	0.376
MOD_GSK3_1	641	648	PF00069	0.737
MOD_GSK3_1	659	666	PF00069	0.640
MOD_GSK3_1	682	689	PF00069	0.798
MOD_GSK3_1	70	77	PF00069	0.507
MOD_GSK3_1	78	85	PF00069	0.641
MOD_N-GLC_1	241	246	PF02516	0.705
MOD_N-GLC_1	494	499	PF02516	0.781
MOD_NEK2_1	180	185	PF00069	0.599
MOD_NEK2_1	218	223	PF00069	0.675
MOD_NEK2_1	282	287	PF00069	0.553
MOD_NEK2_1	293	298	PF00069	0.522
MOD_NEK2_1	317	322	PF00069	0.300
MOD_NEK2_1	360	365	PF00069	0.302
MOD_NEK2_1	373	378	PF00069	0.294
MOD_NEK2_1	39	44	PF00069	0.479
MOD_NEK2_1	520	525	PF00069	0.676
MOD_NEK2_1	533	538	PF00069	0.548
MOD_NEK2_1	60	65	PF00069	0.546
MOD_NEK2_2	641	646	PF00069	0.637
MOD_PIKK_1	82	88	PF00454	0.512
MOD_PK_1	110	116	PF00069	0.584
MOD_PKA_1	275	281	PF00069	0.595
MOD_PKA_1	621	627	PF00069	0.718
MOD_PKA_2	219	225	PF00069	0.615
MOD_PKA_2	275	281	PF00069	0.580
MOD_PKA_2	433	439	PF00069	0.665
MOD_PKA_2	471	477	PF00069	0.591
MOD_PKA_2	481	487	PF00069	0.692
MOD_PKA_2	615	621	PF00069	0.706
MOD_PKA_2	78	84	PF00069	0.677
MOD_PKB_1	265	273	PF00069	0.668
MOD_Plk_1	317	323	PF00069	0.300
MOD_Plk_1	588	594	PF00069	0.302
MOD_Plk_2-3	236	242	PF00069	0.681
MOD_Plk_2-3	99	105	PF00069	0.653
MOD_Plk_4	188	194	PF00069	0.545
MOD_Plk_4	229	235	PF00069	0.647
MOD_Plk_4	268	274	PF00069	0.571
MOD_Plk_4	32	38	PF00069	0.491
MOD_Plk_4	381	387	PF00069	0.300
MOD_Plk_4	39	45	PF00069	0.388
MOD_Plk_4	516	522	PF00069	0.602
MOD_Plk_4	533	539	PF00069	0.530
MOD_Plk_4	588	594	PF00069	0.302
MOD_Plk_4	714	720	PF00069	0.579
MOD_SUMO_rev_2	513	519	PF00179	0.665
MOD_SUMO_rev_2	99	109	PF00179	0.620
TRG_DiLeu_BaEn_1	588	593	PF01217	0.360
TRG_DiLeu_BaEn_1	708	713	PF01217	0.596
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.643
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.633
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.285
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.376
TRG_ENDOCYTIC_2	274	277	PF00928	0.633
TRG_ENDOCYTIC_2	357	360	PF00928	0.360
TRG_ENDOCYTIC_2	89	92	PF00928	0.769
TRG_ER_diArg_1	151	153	PF00400	0.559
TRG_ER_diArg_1	168	171	PF00400	0.553
TRG_ER_diArg_1	254	257	PF00400	0.656
TRG_ER_diArg_1	620	622	PF00400	0.725
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT8	Leptomonas seymouri	54%	100%
A0A3S5H565	Leishmania donovani	94%	100%
A4H3Q1	Leishmania braziliensis	76%	100%
A4HRX5	Leishmania infantum	93%	100%
E9AJX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BXB7	Trypanosoma cruzi	37%	100%