C6H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACM9_LEIMA

TriTrypDb:

LmjF.03.0840 , LMJLV39_030013800 , LMJSD75_030013900

Length:

974

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.649
CLV_C14_Caspase3-7	520	524	PF00656	0.678
CLV_C14_Caspase3-7	618	622	PF00656	0.562
CLV_C14_Caspase3-7	640	644	PF00656	0.596
CLV_NRD_NRD_1	268	270	PF00675	0.410
CLV_NRD_NRD_1	531	533	PF00675	0.733
CLV_NRD_NRD_1	673	675	PF00675	0.512
CLV_NRD_NRD_1	714	716	PF00675	0.787
CLV_NRD_NRD_1	84	86	PF00675	0.691
CLV_NRD_NRD_1	860	862	PF00675	0.472
CLV_NRD_NRD_1	891	893	PF00675	0.592
CLV_NRD_NRD_1	920	922	PF00675	0.522
CLV_NRD_NRD_1	956	958	PF00675	0.633
CLV_PCSK_FUR_1	921	925	PF00082	0.636
CLV_PCSK_KEX2_1	268	270	PF00082	0.410
CLV_PCSK_KEX2_1	530	532	PF00082	0.700
CLV_PCSK_KEX2_1	66	68	PF00082	0.788
CLV_PCSK_KEX2_1	673	675	PF00082	0.489
CLV_PCSK_KEX2_1	860	862	PF00082	0.472
CLV_PCSK_KEX2_1	91	93	PF00082	0.694
CLV_PCSK_KEX2_1	923	925	PF00082	0.636
CLV_PCSK_KEX2_1	952	954	PF00082	0.652
CLV_PCSK_KEX2_1	956	958	PF00082	0.660
CLV_PCSK_KEX2_1	967	969	PF00082	0.572
CLV_PCSK_KEX2_1	971	973	PF00082	0.517
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.739
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.734
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.694
CLV_PCSK_PC1ET2_1	923	925	PF00082	0.636
CLV_PCSK_PC1ET2_1	952	954	PF00082	0.640
CLV_PCSK_PC1ET2_1	967	969	PF00082	0.602
CLV_PCSK_PC1ET2_1	971	973	PF00082	0.572
CLV_PCSK_PC7_1	919	925	PF00082	0.642
CLV_PCSK_SKI1_1	262	266	PF00082	0.580
CLV_PCSK_SKI1_1	327	331	PF00082	0.482
CLV_PCSK_SKI1_1	36	40	PF00082	0.255
CLV_PCSK_SKI1_1	479	483	PF00082	0.555
CLV_PCSK_SKI1_1	63	67	PF00082	0.668
CLV_PCSK_SKI1_1	715	719	PF00082	0.770
CLV_PCSK_SKI1_1	897	901	PF00082	0.584
CLV_PCSK_SKI1_1	924	928	PF00082	0.547
CLV_PCSK_SKI1_1	956	960	PF00082	0.628
CLV_PCSK_SKI1_1	968	972	PF00082	0.645
DEG_SIAH_1	147	155	PF03145	0.674
DEG_SPOP_SBC_1	284	288	PF00917	0.631
DEG_SPOP_SBC_1	379	383	PF00917	0.732
DOC_CDC14_PxL_1	577	585	PF14671	0.490
DOC_CKS1_1	138	143	PF01111	0.694
DOC_CYCLIN_yClb5_NLxxxL_5	835	844	PF00134	0.340
DOC_MAPK_gen_1	673	681	PF00069	0.479
DOC_MAPK_MEF2A_6	831	840	PF00069	0.463
DOC_MAPK_MEF2A_6	865	873	PF00069	0.646
DOC_PP1_RVXF_1	325	332	PF00149	0.499
DOC_PP1_RVXF_1	469	476	PF00149	0.466
DOC_PP1_RVXF_1	671	678	PF00149	0.568
DOC_PP1_RVXF_1	868	874	PF00149	0.707
DOC_PP2B_LxvP_1	145	148	PF13499	0.682
DOC_PP2B_LxvP_1	704	707	PF13499	0.708
DOC_PP4_FxxP_1	23	26	PF00568	0.460
DOC_PP4_FxxP_1	331	334	PF00568	0.621
DOC_PP4_FxxP_1	475	478	PF00568	0.517
DOC_USP7_MATH_1	160	164	PF00917	0.655
DOC_USP7_MATH_1	191	195	PF00917	0.694
DOC_USP7_MATH_1	232	236	PF00917	0.720
DOC_USP7_MATH_1	258	262	PF00917	0.573
DOC_USP7_MATH_1	284	288	PF00917	0.649
DOC_USP7_MATH_1	304	308	PF00917	0.440
DOC_USP7_MATH_1	379	383	PF00917	0.678
DOC_USP7_MATH_1	401	405	PF00917	0.638
DOC_USP7_MATH_1	513	517	PF00917	0.651
DOC_USP7_MATH_1	525	529	PF00917	0.684
DOC_USP7_MATH_1	557	561	PF00917	0.696
DOC_USP7_MATH_1	615	619	PF00917	0.505
DOC_USP7_MATH_1	707	711	PF00917	0.769
DOC_USP7_MATH_1	752	756	PF00917	0.696
DOC_USP7_MATH_1	764	768	PF00917	0.529
DOC_USP7_UBL2_3	47	51	PF12436	0.542
DOC_USP7_UBL2_3	907	911	PF12436	0.698
DOC_USP7_UBL2_3	923	927	PF12436	0.420
DOC_USP7_UBL2_3	959	963	PF12436	0.698
DOC_USP7_UBL2_3	967	971	PF12436	0.620
DOC_WW_Pin1_4	137	142	PF00397	0.623
DOC_WW_Pin1_4	256	261	PF00397	0.642
DOC_WW_Pin1_4	380	385	PF00397	0.717
DOC_WW_Pin1_4	552	557	PF00397	0.756
DOC_WW_Pin1_4	594	599	PF00397	0.504
DOC_WW_Pin1_4	722	727	PF00397	0.705
LIG_14-3-3_CanoR_1	262	272	PF00244	0.485
LIG_14-3-3_CanoR_1	53	57	PF00244	0.510
LIG_BIR_III_4	659	663	PF00653	0.594
LIG_BRCT_BRCA1_1	260	264	PF00533	0.620
LIG_BRCT_BRCA1_1	471	475	PF00533	0.441
LIG_CaM_NSCaTE_8	173	180	PF13499	0.529
LIG_CSL_BTD_1	121	124	PF09270	0.606
LIG_deltaCOP1_diTrp_1	775	781	PF00928	0.561
LIG_EVH1_1	122	126	PF00568	0.697
LIG_FHA_1	138	144	PF00498	0.624
LIG_FHA_1	272	278	PF00498	0.418
LIG_FHA_1	324	330	PF00498	0.546
LIG_FHA_1	533	539	PF00498	0.648
LIG_FHA_1	553	559	PF00498	0.771
LIG_FHA_1	637	643	PF00498	0.568
LIG_FHA_1	743	749	PF00498	0.651
LIG_FHA_1	778	784	PF00498	0.514
LIG_FHA_1	864	870	PF00498	0.585
LIG_FHA_1	911	917	PF00498	0.558
LIG_FHA_2	101	107	PF00498	0.782
LIG_FHA_2	309	315	PF00498	0.573
LIG_FHA_2	336	342	PF00498	0.700
LIG_FHA_2	355	361	PF00498	0.619
LIG_FHA_2	638	644	PF00498	0.535
LIG_LIR_Apic_2	20	26	PF02991	0.463
LIG_LIR_Apic_2	472	478	PF02991	0.499
LIG_LIR_Gen_1	353	362	PF02991	0.682
LIG_LIR_Nem_3	353	359	PF02991	0.700
LIG_LIR_Nem_3	439	445	PF02991	0.454
LIG_LIR_Nem_3	768	774	PF02991	0.585
LIG_LIR_Nem_3	775	781	PF02991	0.438
LIG_LIR_Nem_3	830	835	PF02991	0.570
LIG_LIR_Nem_3	849	854	PF02991	0.413
LIG_MLH1_MIPbox_1	260	264	PF16413	0.620
LIG_PCNA_PIPBox_1	586	595	PF02747	0.451
LIG_PCNA_yPIPBox_3	789	803	PF02747	0.601
LIG_Pex14_2	45	49	PF04695	0.479
LIG_Pex14_2	604	608	PF04695	0.441
LIG_Pex14_2	828	832	PF04695	0.420
LIG_Rb_pABgroove_1	652	660	PF01858	0.360
LIG_RPA_C_Fungi	622	634	PF08784	0.543
LIG_SH2_CRK	611	615	PF00017	0.551
LIG_SH2_CRK	658	662	PF00017	0.429
LIG_SH2_CRK	664	668	PF00017	0.495
LIG_SH2_GRB2like	573	576	PF00017	0.624
LIG_SH2_NCK_1	658	662	PF00017	0.429
LIG_SH2_PTP2	182	185	PF00017	0.521
LIG_SH2_PTP2	650	653	PF00017	0.434
LIG_SH2_SRC	544	547	PF00017	0.774
LIG_SH2_SRC	613	616	PF00017	0.502
LIG_SH2_STAP1	573	577	PF00017	0.630
LIG_SH2_STAT3	430	433	PF00017	0.531
LIG_SH2_STAT5	182	185	PF00017	0.547
LIG_SH2_STAT5	263	266	PF00017	0.548
LIG_SH2_STAT5	354	357	PF00017	0.697
LIG_SH2_STAT5	443	446	PF00017	0.516
LIG_SH2_STAT5	463	466	PF00017	0.189
LIG_SH2_STAT5	577	580	PF00017	0.555
LIG_SH2_STAT5	613	616	PF00017	0.498
LIG_SH2_STAT5	650	653	PF00017	0.359
LIG_SH2_STAT5	691	694	PF00017	0.516
LIG_SH2_STAT5	814	817	PF00017	0.460
LIG_SH2_STAT5	950	953	PF00017	0.579
LIG_SH3_3	118	124	PF00018	0.594
LIG_SH3_3	138	144	PF00018	0.462
LIG_SH3_3	148	154	PF00018	0.542
LIG_SH3_3	307	313	PF00018	0.473
LIG_SH3_3	331	337	PF00018	0.733
LIG_SH3_3	540	546	PF00018	0.759
LIG_SH3_3	559	565	PF00018	0.479
LIG_SH3_3	804	810	PF00018	0.464
LIG_SH3_3	911	917	PF00018	0.674
LIG_SUMO_SIM_anti_2	357	365	PF11976	0.717
LIG_SUMO_SIM_par_1	307	314	PF11976	0.565
LIG_TRAF2_1	516	519	PF00917	0.619
LIG_TRAF2_1	566	569	PF00917	0.698
LIG_TRAF2_1	798	801	PF00917	0.452
LIG_TYR_ITIM	648	653	PF00017	0.504
LIG_TYR_ITIM	656	661	PF00017	0.499
LIG_WRC_WIRS_1	601	606	PF05994	0.504
LIG_WW_2	123	126	PF00397	0.741
MOD_CDC14_SPxK_1	259	262	PF00782	0.541
MOD_CDK_SPxK_1	256	262	PF00069	0.630
MOD_CK1_1	16	22	PF00069	0.421
MOD_CK1_1	244	250	PF00069	0.748
MOD_CK1_1	287	293	PF00069	0.683
MOD_CK1_1	382	388	PF00069	0.692
MOD_CK1_1	517	523	PF00069	0.659
MOD_CK1_1	547	553	PF00069	0.761
MOD_CK1_1	560	566	PF00069	0.565
MOD_CK1_1	737	743	PF00069	0.759
MOD_CK2_1	354	360	PF00069	0.706
MOD_CK2_1	513	519	PF00069	0.676
MOD_CK2_1	563	569	PF00069	0.570
MOD_CK2_1	740	746	PF00069	0.636
MOD_Cter_Amidation	83	86	PF01082	0.726
MOD_Cter_Amidation	89	92	PF01082	0.748
MOD_Cter_Amidation	961	964	PF01082	0.644
MOD_DYRK1A_RPxSP_1	722	726	PF00069	0.538
MOD_GlcNHglycan	100	103	PF01048	0.814
MOD_GlcNHglycan	106	110	PF01048	0.785
MOD_GlcNHglycan	162	165	PF01048	0.655
MOD_GlcNHglycan	173	176	PF01048	0.396
MOD_GlcNHglycan	193	196	PF01048	0.579
MOD_GlcNHglycan	206	209	PF01048	0.380
MOD_GlcNHglycan	274	277	PF01048	0.508
MOD_GlcNHglycan	280	283	PF01048	0.558
MOD_GlcNHglycan	292	295	PF01048	0.406
MOD_GlcNHglycan	376	379	PF01048	0.642
MOD_GlcNHglycan	390	393	PF01048	0.572
MOD_GlcNHglycan	519	522	PF01048	0.720
MOD_GlcNHglycan	559	562	PF01048	0.698
MOD_GlcNHglycan	565	568	PF01048	0.595
MOD_GlcNHglycan	58	61	PF01048	0.635
MOD_GlcNHglycan	627	630	PF01048	0.560
MOD_GlcNHglycan	643	646	PF01048	0.445
MOD_GlcNHglycan	767	770	PF01048	0.711
MOD_GlcNHglycan	907	910	PF01048	0.612
MOD_GlcNHglycan	942	946	PF01048	0.595
MOD_GSK3_1	13	20	PF00069	0.443
MOD_GSK3_1	226	233	PF00069	0.571
MOD_GSK3_1	238	245	PF00069	0.722
MOD_GSK3_1	249	256	PF00069	0.551
MOD_GSK3_1	258	265	PF00069	0.400
MOD_GSK3_1	283	290	PF00069	0.659
MOD_GSK3_1	294	301	PF00069	0.481
MOD_GSK3_1	304	311	PF00069	0.405
MOD_GSK3_1	350	357	PF00069	0.687
MOD_GSK3_1	374	381	PF00069	0.656
MOD_GSK3_1	513	520	PF00069	0.676
MOD_GSK3_1	52	59	PF00069	0.369
MOD_GSK3_1	544	551	PF00069	0.733
MOD_GSK3_1	637	644	PF00069	0.514
MOD_GSK3_1	734	741	PF00069	0.753
MOD_GSK3_1	777	784	PF00069	0.528
MOD_GSK3_1	859	866	PF00069	0.516
MOD_GSK3_1	881	888	PF00069	0.746
MOD_GSK3_1	901	908	PF00069	0.650
MOD_GSK3_1	937	944	PF00069	0.691
MOD_GSK3_1	98	105	PF00069	0.782
MOD_N-GLC_1	160	165	PF02516	0.529
MOD_N-GLC_1	242	247	PF02516	0.685
MOD_N-GLC_1	479	484	PF02516	0.618
MOD_N-GLC_1	513	518	PF02516	0.677
MOD_N-GLC_1	525	530	PF02516	0.516
MOD_NEK2_1	1	6	PF00069	0.663
MOD_NEK2_1	283	288	PF00069	0.653
MOD_NEK2_1	298	303	PF00069	0.477
MOD_NEK2_1	308	313	PF00069	0.396
MOD_NEK2_1	441	446	PF00069	0.428
MOD_NEK2_1	548	553	PF00069	0.737
MOD_NEK2_1	56	61	PF00069	0.606
MOD_NEK2_1	585	590	PF00069	0.362
MOD_NEK2_2	469	474	PF00069	0.536
MOD_PIKK_1	14	20	PF00454	0.383
MOD_PIKK_1	38	44	PF00454	0.404
MOD_PIKK_1	514	520	PF00454	0.670
MOD_PIKK_1	738	744	PF00454	0.759
MOD_PKA_2	241	247	PF00069	0.534
MOD_PKA_2	278	284	PF00069	0.605
MOD_PKA_2	52	58	PF00069	0.349
MOD_PKA_2	636	642	PF00069	0.605
MOD_PKA_2	737	743	PF00069	0.739
MOD_PKA_2	859	865	PF00069	0.482
MOD_PKB_1	635	643	PF00069	0.472
MOD_Plk_1	233	239	PF00069	0.642
MOD_Plk_1	469	475	PF00069	0.548
MOD_Plk_1	479	485	PF00069	0.498
MOD_Plk_1	677	683	PF00069	0.569
MOD_Plk_2-3	684	690	PF00069	0.535
MOD_Plk_4	294	300	PF00069	0.518
MOD_Plk_4	304	310	PF00069	0.435
MOD_Plk_4	450	456	PF00069	0.483
MOD_ProDKin_1	137	143	PF00069	0.618
MOD_ProDKin_1	256	262	PF00069	0.643
MOD_ProDKin_1	380	386	PF00069	0.718
MOD_ProDKin_1	552	558	PF00069	0.756
MOD_ProDKin_1	594	600	PF00069	0.496
MOD_ProDKin_1	722	728	PF00069	0.707
MOD_SUMO_rev_2	59	68	PF00179	0.666
TRG_DiLeu_BaLyEn_6	493	498	PF01217	0.533
TRG_ENDOCYTIC_2	182	185	PF00928	0.599
TRG_ENDOCYTIC_2	356	359	PF00928	0.688
TRG_ENDOCYTIC_2	442	445	PF00928	0.516
TRG_ENDOCYTIC_2	577	580	PF00928	0.502
TRG_ENDOCYTIC_2	611	614	PF00928	0.561
TRG_ENDOCYTIC_2	650	653	PF00928	0.366
TRG_ENDOCYTIC_2	658	661	PF00928	0.444
TRG_ENDOCYTIC_2	771	774	PF00928	0.672
TRG_ENDOCYTIC_2	938	941	PF00928	0.582
TRG_ER_diArg_1	268	270	PF00400	0.411
TRG_ER_diArg_1	531	533	PF00400	0.745
TRG_ER_diArg_1	634	637	PF00400	0.493
TRG_ER_diArg_1	673	675	PF00400	0.585
TRG_ER_diArg_1	869	872	PF00400	0.643
TRG_ER_diArg_1	955	957	PF00400	0.742
TRG_NLS_MonoCore_2	528	533	PF00514	0.784
TRG_NLS_MonoCore_2	920	925	PF00514	0.635
TRG_NLS_MonoExtC_3	714	719	PF00514	0.672
TRG_NLS_MonoExtN_4	527	534	PF00514	0.783
TRG_NLS_MonoExtN_4	713	719	PF00514	0.766
TRG_NLS_MonoExtN_4	83	89	PF00514	0.728
TRG_NLS_MonoExtN_4	919	926	PF00514	0.528
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	673	678	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	924	928	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW4	Leptomonas seymouri	58%	100%
A0A1X0P9W0	Trypanosomatidae	40%	100%
A0A422NHM2	Trypanosoma rangeli	41%	100%
A0A451EJT3	Leishmania donovani	93%	100%
A4H3P6	Leishmania braziliensis	79%	100%
C9ZKH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E8NHC7	Leishmania infantum	94%	100%
E9AJW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BC86	Trypanosoma cruzi	41%	100%