Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACM8_LEIMA

TriTrypDb:

LmjF.03.0830 , LMJLV39_030013700 , LMJSD75_030013800

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.409
CLV_NRD_NRD_1	149	151	PF00675	0.452
CLV_NRD_NRD_1	173	175	PF00675	0.409
CLV_NRD_NRD_1	87	89	PF00675	0.389
CLV_PCSK_KEX2_1	149	151	PF00082	0.575
CLV_PCSK_KEX2_1	173	175	PF00082	0.482
CLV_PCSK_KEX2_1	301	303	PF00082	0.512
CLV_PCSK_KEX2_1	87	89	PF00082	0.389
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.457
CLV_PCSK_SKI1_1	103	107	PF00082	0.354
CLV_PCSK_SKI1_1	124	128	PF00082	0.363
CLV_PCSK_SKI1_1	135	139	PF00082	0.372
CLV_PCSK_SKI1_1	173	177	PF00082	0.405
CLV_PCSK_SKI1_1	252	256	PF00082	0.368
CLV_PCSK_SKI1_1	259	263	PF00082	0.309
CLV_PCSK_SKI1_1	398	402	PF00082	0.525
CLV_PCSK_SKI1_1	54	58	PF00082	0.372
CLV_PCSK_SKI1_1	76	80	PF00082	0.369
CLV_PCSK_SKI1_1	87	91	PF00082	0.414
DEG_APCC_DBOX_1	134	142	PF00400	0.518
DEG_APCC_DBOX_1	53	61	PF00400	0.370
DEG_APCC_DBOX_1	86	94	PF00400	0.426
DEG_Kelch_Keap1_1	232	237	PF01344	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DEG_SPOP_SBC_1	24	28	PF00917	0.566
DOC_CDC14_PxL_1	98	106	PF14671	0.380
DOC_CYCLIN_RxL_1	100	108	PF00134	0.357
DOC_CYCLIN_RxL_1	133	142	PF00134	0.436
DOC_CYCLIN_RxL_1	168	179	PF00134	0.414
DOC_CYCLIN_RxL_1	249	260	PF00134	0.467
DOC_MAPK_gen_1	135	143	PF00069	0.538
DOC_MAPK_MEF2A_6	331	338	PF00069	0.501
DOC_USP7_MATH_1	182	186	PF00917	0.449
DOC_USP7_MATH_1	24	28	PF00917	0.689
DOC_USP7_MATH_1	44	48	PF00917	0.547
DOC_USP7_MATH_1	97	101	PF00917	0.473
DOC_WW_Pin1_4	193	198	PF00397	0.415
DOC_WW_Pin1_4	25	30	PF00397	0.693
DOC_WW_Pin1_4	285	290	PF00397	0.463
DOC_WW_Pin1_4	40	45	PF00397	0.642
LIG_14-3-3_CanoR_1	181	191	PF00244	0.430
LIG_14-3-3_CanoR_1	290	295	PF00244	0.333
LIG_14-3-3_CanoR_1	366	372	PF00244	0.537
LIG_14-3-3_CanoR_1	6	12	PF00244	0.534
LIG_14-3-3_CanoR_1	64	73	PF00244	0.436
LIG_APCC_ABBA_1	137	142	PF00400	0.425
LIG_APCC_ABBA_1	355	360	PF00400	0.468
LIG_APCC_ABBAyCdc20_2	136	142	PF00400	0.423
LIG_BIR_III_4	260	264	PF00653	0.336
LIG_Clathr_ClatBox_1	138	142	PF01394	0.466
LIG_Clathr_ClatBox_1	254	258	PF01394	0.445
LIG_FAT_LD_1	247	255	PF03623	0.413
LIG_FHA_1	343	349	PF00498	0.398
LIG_FHA_2	392	398	PF00498	0.471
LIG_GBD_Chelix_1	246	254	PF00786	0.423
LIG_Integrin_RGD_1	270	272	PF01839	0.479
LIG_LIR_Gen_1	108	118	PF02991	0.382
LIG_LIR_Gen_1	162	172	PF02991	0.514
LIG_LIR_Gen_1	185	193	PF02991	0.474
LIG_LIR_Gen_1	291	300	PF02991	0.438
LIG_LIR_Nem_3	162	167	PF02991	0.481
LIG_LIR_Nem_3	185	190	PF02991	0.542
LIG_LIR_Nem_3	260	265	PF02991	0.362
LIG_LIR_Nem_3	394	399	PF02991	0.547
LIG_PCNA_PIPBox_1	120	129	PF02747	0.392
LIG_Pex14_1	396	400	PF04695	0.456
LIG_PTB_Apo_2	389	396	PF02174	0.459
LIG_SH2_CRK	187	191	PF00017	0.396
LIG_SH2_SRC	198	201	PF00017	0.378
LIG_SH2_SRC	359	362	PF00017	0.481
LIG_SH2_STAP1	187	191	PF00017	0.374
LIG_SH2_STAT5	198	201	PF00017	0.482
LIG_SH2_STAT5	306	309	PF00017	0.390
LIG_SH2_STAT5	399	402	PF00017	0.563
LIG_SH2_STAT5	74	77	PF00017	0.452
LIG_SH3_1	331	337	PF00018	0.516
LIG_SH3_3	194	200	PF00018	0.528
LIG_SH3_3	331	337	PF00018	0.538
LIG_SH3_3	38	44	PF00018	0.610
LIG_SH3_3	93	99	PF00018	0.352
LIG_SUMO_SIM_anti_2	253	258	PF11976	0.446
LIG_SUMO_SIM_par_1	253	258	PF11976	0.382
LIG_UBA3_1	137	145	PF00899	0.456
LIG_UBA3_1	7	15	PF00899	0.458
MOD_CDK_SPK_2	285	290	PF00069	0.427
MOD_CK1_1	27	33	PF00069	0.682
MOD_CK2_1	367	373	PF00069	0.487
MOD_CK2_1	391	397	PF00069	0.448
MOD_GlcNHglycan	145	148	PF01048	0.683
MOD_GlcNHglycan	67	70	PF01048	0.515
MOD_GSK3_1	204	211	PF00069	0.447
MOD_GSK3_1	23	30	PF00069	0.606
MOD_GSK3_1	338	345	PF00069	0.417
MOD_GSK3_1	40	47	PF00069	0.578
MOD_GSK3_1	65	72	PF00069	0.570
MOD_N-GLC_1	391	396	PF02516	0.565
MOD_N-GLC_2	305	307	PF02516	0.475
MOD_NEK2_1	141	146	PF00069	0.508
MOD_NEK2_1	191	196	PF00069	0.438
MOD_NEK2_1	276	281	PF00069	0.514
MOD_NEK2_1	338	343	PF00069	0.410
MOD_NEK2_1	388	393	PF00069	0.611
MOD_NEK2_1	7	12	PF00069	0.548
MOD_PIKK_1	10	16	PF00454	0.470
MOD_PK_1	290	296	PF00069	0.479
MOD_Plk_1	391	397	PF00069	0.509
MOD_Plk_1	52	58	PF00069	0.480
MOD_Plk_4	338	344	PF00069	0.454
MOD_Plk_4	69	75	PF00069	0.421
MOD_Plk_4	7	13	PF00069	0.385
MOD_ProDKin_1	193	199	PF00069	0.415
MOD_ProDKin_1	25	31	PF00069	0.696
MOD_ProDKin_1	285	291	PF00069	0.461
MOD_ProDKin_1	40	46	PF00069	0.642
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.292
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.349
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.459
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.494
TRG_ENDOCYTIC_2	187	190	PF00928	0.351
TRG_ER_diArg_1	149	151	PF00400	0.558
TRG_ER_diArg_1	172	174	PF00400	0.414
TRG_ER_diArg_1	4	7	PF00400	0.554
TRG_ER_diArg_1	86	88	PF00400	0.390
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	174	179	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P542	Leptomonas seymouri	66%	100%
A0A0S4IVU1	Bodo saltans	38%	100%
A0A1X0P922	Trypanosomatidae	48%	100%
A0A451EJT2	Leishmania donovani	94%	100%
A4H3P5	Leishmania braziliensis	84%	100%
C9ZKH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E8NHC8	Leishmania infantum	94%	100%
E9AJW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DTZ7	Trypanosoma cruzi	48%	100%