Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACM6_LEIMA

TriTrypDb:

LmjF.03.0810 , LMJLV39_030013500 , LMJSD75_030013600

Length:

1078

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ACM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.709
CLV_C14_Caspase3-7	214	218	PF00656	0.690
CLV_C14_Caspase3-7	557	561	PF00656	0.600
CLV_NRD_NRD_1	131	133	PF00675	0.539
CLV_NRD_NRD_1	288	290	PF00675	0.547
CLV_NRD_NRD_1	357	359	PF00675	0.474
CLV_NRD_NRD_1	360	362	PF00675	0.469
CLV_NRD_NRD_1	374	376	PF00675	0.429
CLV_NRD_NRD_1	413	415	PF00675	0.481
CLV_NRD_NRD_1	44	46	PF00675	0.513
CLV_NRD_NRD_1	609	611	PF00675	0.514
CLV_NRD_NRD_1	84	86	PF00675	0.558
CLV_NRD_NRD_1	857	859	PF00675	0.485
CLV_NRD_NRD_1	880	882	PF00675	0.518
CLV_PCSK_FUR_1	129	133	PF00082	0.495
CLV_PCSK_FUR_1	358	362	PF00082	0.483
CLV_PCSK_KEX2_1	129	131	PF00082	0.554
CLV_PCSK_KEX2_1	357	359	PF00082	0.474
CLV_PCSK_KEX2_1	360	362	PF00082	0.469
CLV_PCSK_KEX2_1	374	376	PF00082	0.429
CLV_PCSK_KEX2_1	413	415	PF00082	0.485
CLV_PCSK_KEX2_1	566	568	PF00082	0.477
CLV_PCSK_KEX2_1	573	575	PF00082	0.517
CLV_PCSK_KEX2_1	609	611	PF00082	0.514
CLV_PCSK_KEX2_1	857	859	PF00082	0.485
CLV_PCSK_KEX2_1	86	88	PF00082	0.539
CLV_PCSK_KEX2_1	880	882	PF00082	0.518
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.484
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.517
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.512
CLV_PCSK_PC7_1	353	359	PF00082	0.469
CLV_PCSK_PC7_1	82	88	PF00082	0.509
CLV_PCSK_SKI1_1	1064	1068	PF00082	0.249
CLV_PCSK_SKI1_1	170	174	PF00082	0.528
CLV_PCSK_SKI1_1	205	209	PF00082	0.486
CLV_PCSK_SKI1_1	414	418	PF00082	0.456
CLV_PCSK_SKI1_1	46	50	PF00082	0.459
CLV_PCSK_SKI1_1	57	61	PF00082	0.579
CLV_PCSK_SKI1_1	631	635	PF00082	0.533
CLV_PCSK_SKI1_1	691	695	PF00082	0.643
CLV_PCSK_SKI1_1	87	91	PF00082	0.538
DEG_APCC_DBOX_1	1063	1071	PF00400	0.262
DEG_APCC_DBOX_1	413	421	PF00400	0.668
DEG_APCC_DBOX_1	696	704	PF00400	0.731
DEG_Nend_Nbox_1	1	3	PF02207	0.760
DEG_SPOP_SBC_1	237	241	PF00917	0.739
DEG_SPOP_SBC_1	619	623	PF00917	0.737
DOC_ANK_TNKS_1	573	580	PF00023	0.679
DOC_CKS1_1	206	211	PF01111	0.738
DOC_MAPK_gen_1	822	831	PF00069	0.656
DOC_MAPK_MEF2A_6	421	430	PF00069	0.667
DOC_MAPK_MEF2A_6	822	831	PF00069	0.725
DOC_MAPK_MEF2A_6	948	956	PF00069	0.542
DOC_PP2B_LxvP_1	824	827	PF13499	0.730
DOC_PP4_FxxP_1	449	452	PF00568	0.496
DOC_USP7_MATH_1	1015	1019	PF00917	0.535
DOC_USP7_MATH_1	1029	1033	PF00917	0.489
DOC_USP7_MATH_1	122	126	PF00917	0.715
DOC_USP7_MATH_1	136	140	PF00917	0.720
DOC_USP7_MATH_1	161	165	PF00917	0.688
DOC_USP7_MATH_1	273	277	PF00917	0.825
DOC_USP7_MATH_1	391	395	PF00917	0.708
DOC_USP7_MATH_1	435	439	PF00917	0.399
DOC_USP7_MATH_1	478	482	PF00917	0.530
DOC_USP7_MATH_1	53	57	PF00917	0.762
DOC_USP7_MATH_1	595	599	PF00917	0.711
DOC_USP7_MATH_1	619	623	PF00917	0.812
DOC_USP7_MATH_1	673	677	PF00917	0.806
DOC_USP7_MATH_1	987	991	PF00917	0.528
DOC_WW_Pin1_4	1008	1013	PF00397	0.505
DOC_WW_Pin1_4	111	116	PF00397	0.677
DOC_WW_Pin1_4	192	197	PF00397	0.704
DOC_WW_Pin1_4	205	210	PF00397	0.710
DOC_WW_Pin1_4	281	286	PF00397	0.726
DOC_WW_Pin1_4	480	485	PF00397	0.494
DOC_WW_Pin1_4	640	645	PF00397	0.768
DOC_WW_Pin1_4	753	758	PF00397	0.759
DOC_WW_Pin1_4	922	927	PF00397	0.678
DOC_WW_Pin1_4	96	101	PF00397	0.758
LIG_14-3-3_CanoR_1	289	298	PF00244	0.758
LIG_14-3-3_CanoR_1	414	423	PF00244	0.660
LIG_14-3-3_CanoR_1	647	653	PF00244	0.703
LIG_14-3-3_CanoR_1	691	700	PF00244	0.816
LIG_14-3-3_CanoR_1	772	779	PF00244	0.737
LIG_14-3-3_CanoR_1	93	97	PF00244	0.723
LIG_14-3-3_CanoR_1	992	1001	PF00244	0.527
LIG_APCC_ABBA_1	802	807	PF00400	0.653
LIG_BIR_III_2	903	907	PF00653	0.715
LIG_BIR_III_4	786	790	PF00653	0.680
LIG_BRCT_BRCA1_1	631	635	PF00533	0.750
LIG_BRCT_BRCA1_1	94	98	PF00533	0.726
LIG_CSL_BTD_1	1	4	PF09270	0.705
LIG_CtBP_PxDLS_1	152	156	PF00389	0.710
LIG_deltaCOP1_diTrp_1	543	553	PF00928	0.659
LIG_deltaCOP1_diTrp_1	972	982	PF00928	0.458
LIG_eIF4E_1	1052	1058	PF01652	0.298
LIG_eIF4E_1	504	510	PF01652	0.476
LIG_eIF4E_1	517	523	PF01652	0.249
LIG_FHA_1	15	21	PF00498	0.758
LIG_FHA_1	206	212	PF00498	0.758
LIG_FHA_1	237	243	PF00498	0.776
LIG_FHA_1	382	388	PF00498	0.733
LIG_FHA_1	583	589	PF00498	0.679
LIG_FHA_1	635	641	PF00498	0.850
LIG_FHA_1	67	73	PF00498	0.643
LIG_FHA_1	682	688	PF00498	0.726
LIG_FHA_1	929	935	PF00498	0.691
LIG_FHA_1	968	974	PF00498	0.450
LIG_FHA_2	27	33	PF00498	0.740
LIG_FHA_2	300	306	PF00498	0.669
LIG_FHA_2	38	44	PF00498	0.697
LIG_FHA_2	481	487	PF00498	0.504
LIG_FHA_2	63	69	PF00498	0.736
LIG_FHA_2	738	744	PF00498	0.712
LIG_FHA_2	957	963	PF00498	0.399
LIG_Integrin_RGD_1	881	883	PF01839	0.493
LIG_LIR_Apic_2	446	452	PF02991	0.610
LIG_LIR_Apic_2	743	749	PF02991	0.681
LIG_LIR_Gen_1	849	860	PF02991	0.695
LIG_LIR_Nem_3	220	226	PF02991	0.690
LIG_LIR_Nem_3	35	41	PF02991	0.674
LIG_LIR_Nem_3	401	407	PF02991	0.630
LIG_LIR_Nem_3	501	507	PF02991	0.503
LIG_LIR_Nem_3	512	517	PF02991	0.429
LIG_LIR_Nem_3	548	554	PF02991	0.590
LIG_LIR_Nem_3	721	725	PF02991	0.730
LIG_LIR_Nem_3	735	741	PF02991	0.668
LIG_LIR_Nem_3	765	770	PF02991	0.748
LIG_LIR_Nem_3	849	855	PF02991	0.716
LIG_LIR_Nem_3	903	908	PF02991	0.663
LIG_MYND_3	497	501	PF01753	0.456
LIG_NRBOX	438	444	PF00104	0.399
LIG_NRBOX	524	530	PF00104	0.399
LIG_OCRL_FandH_1	937	949	PF00620	0.631
LIG_PCNA_yPIPBox_3	845	858	PF02747	0.618
LIG_PDZ_Class_1	1073	1078	PF00595	0.534
LIG_Pex14_2	1068	1072	PF04695	0.262
LIG_Pex14_2	510	514	PF04695	0.443
LIG_Rb_pABgroove_1	846	854	PF01858	0.625
LIG_REV1ctd_RIR_1	81	91	PF16727	0.709
LIG_RPA_C_Fungi	890	902	PF08784	0.554
LIG_SH2_CRK	38	42	PF00017	0.619
LIG_SH2_CRK	746	750	PF00017	0.594
LIG_SH2_CRK	767	771	PF00017	0.686
LIG_SH2_NCK_1	407	411	PF00017	0.585
LIG_SH2_NCK_1	534	538	PF00017	0.362
LIG_SH2_NCK_1	746	750	PF00017	0.556
LIG_SH2_SRC	534	537	PF00017	0.362
LIG_SH2_STAP1	341	345	PF00017	0.545
LIG_SH2_STAT3	320	323	PF00017	0.590
LIG_SH2_STAT3	796	799	PF00017	0.635
LIG_SH2_STAT5	1052	1055	PF00017	0.337
LIG_SH2_STAT5	159	162	PF00017	0.657
LIG_SH2_STAT5	320	323	PF00017	0.646
LIG_SH2_STAT5	453	456	PF00017	0.631
LIG_SH2_STAT5	746	749	PF00017	0.559
LIG_SH2_STAT5	908	911	PF00017	0.675
LIG_SH3_3	112	118	PF00018	0.555
LIG_SH3_3	203	209	PF00018	0.674
LIG_SH3_3	224	230	PF00018	0.723
LIG_SH3_3	318	324	PF00018	0.596
LIG_SH3_3	444	450	PF00018	0.596
LIG_SH3_3	754	760	PF00018	0.652
LIG_SH3_3	930	936	PF00018	0.600
LIG_SH3_3	94	100	PF00018	0.698
LIG_SH3_3	941	947	PF00018	0.443
LIG_SH3_3	996	1002	PF00018	0.654
LIG_Sin3_3	468	475	PF02671	0.551
LIG_SUMO_SIM_anti_2	438	444	PF11976	0.399
LIG_SUMO_SIM_anti_2	469	475	PF11976	0.552
LIG_SUMO_SIM_anti_2	962	968	PF11976	0.374
LIG_SUMO_SIM_anti_2	970	975	PF11976	0.527
LIG_SUMO_SIM_par_1	441	446	PF11976	0.399
LIG_SUMO_SIM_par_1	526	532	PF11976	0.399
LIG_SUMO_SIM_par_1	956	962	PF11976	0.337
LIG_TRFH_1	746	750	PF08558	0.556
LIG_Vh1_VBS_1	1056	1074	PF01044	0.374
MOD_CDK_SPK_2	753	758	PF00069	0.681
MOD_CDK_SPxxK_3	640	647	PF00069	0.569
MOD_CK1_1	111	117	PF00069	0.601
MOD_CK1_1	125	131	PF00069	0.553
MOD_CK1_1	137	143	PF00069	0.555
MOD_CK1_1	183	189	PF00069	0.657
MOD_CK1_1	23	29	PF00069	0.760
MOD_CK1_1	231	237	PF00069	0.709
MOD_CK1_1	276	282	PF00069	0.764
MOD_CK1_1	31	37	PF00069	0.707
MOD_CK1_1	438	444	PF00069	0.287
MOD_CK1_1	466	472	PF00069	0.592
MOD_CK1_1	591	597	PF00069	0.686
MOD_CK1_1	62	68	PF00069	0.654
MOD_CK1_1	621	627	PF00069	0.651
MOD_CK1_1	782	788	PF00069	0.707
MOD_CK1_1	922	928	PF00069	0.626
MOD_CK1_1	990	996	PF00069	0.577
MOD_CK2_1	213	219	PF00069	0.618
MOD_CK2_1	299	305	PF00069	0.580
MOD_CK2_1	537	543	PF00069	0.597
MOD_CK2_1	64	70	PF00069	0.635
MOD_CK2_1	737	743	PF00069	0.652
MOD_CK2_1	833	839	PF00069	0.644
MOD_CK2_1	956	962	PF00069	0.399
MOD_Cter_Amidation	571	574	PF01082	0.655
MOD_DYRK1A_RPxSP_1	205	209	PF00069	0.675
MOD_GlcNHglycan	1013	1016	PF01048	0.500
MOD_GlcNHglycan	1017	1020	PF01048	0.636
MOD_GlcNHglycan	1047	1052	PF01048	0.568
MOD_GlcNHglycan	110	113	PF01048	0.732
MOD_GlcNHglycan	124	127	PF01048	0.602
MOD_GlcNHglycan	163	166	PF01048	0.600
MOD_GlcNHglycan	182	185	PF01048	0.696
MOD_GlcNHglycan	233	236	PF01048	0.707
MOD_GlcNHglycan	278	281	PF01048	0.771
MOD_GlcNHglycan	370	373	PF01048	0.629
MOD_GlcNHglycan	389	392	PF01048	0.480
MOD_GlcNHglycan	393	396	PF01048	0.567
MOD_GlcNHglycan	4	7	PF01048	0.660
MOD_GlcNHglycan	400	403	PF01048	0.485
MOD_GlcNHglycan	465	468	PF01048	0.697
MOD_GlcNHglycan	480	483	PF01048	0.466
MOD_GlcNHglycan	597	600	PF01048	0.653
MOD_GlcNHglycan	631	634	PF01048	0.661
MOD_GlcNHglycan	680	684	PF01048	0.644
MOD_GlcNHglycan	715	718	PF01048	0.630
MOD_GlcNHglycan	781	784	PF01048	0.708
MOD_GlcNHglycan	842	845	PF01048	0.650
MOD_GlcNHglycan	888	891	PF01048	0.674
MOD_GlcNHglycan	983	986	PF01048	0.625
MOD_GlcNHglycan	995	998	PF01048	0.521
MOD_GSK3_1	1011	1018	PF00069	0.647
MOD_GSK3_1	132	139	PF00069	0.701
MOD_GSK3_1	176	183	PF00069	0.708
MOD_GSK3_1	20	27	PF00069	0.678
MOD_GSK3_1	299	306	PF00069	0.712
MOD_GSK3_1	387	394	PF00069	0.599
MOD_GSK3_1	480	487	PF00069	0.611
MOD_GSK3_1	53	60	PF00069	0.686
MOD_GSK3_1	584	591	PF00069	0.712
MOD_GSK3_1	605	612	PF00069	0.562
MOD_GSK3_1	62	69	PF00069	0.571
MOD_GSK3_1	636	643	PF00069	0.764
MOD_GSK3_1	687	694	PF00069	0.694
MOD_GSK3_1	709	716	PF00069	0.617
MOD_GSK3_1	728	735	PF00069	0.483
MOD_GSK3_1	749	756	PF00069	0.704
MOD_GSK3_1	834	841	PF00069	0.613
MOD_GSK3_1	882	889	PF00069	0.650
MOD_GSK3_1	92	99	PF00069	0.693
MOD_GSK3_1	987	994	PF00069	0.661
MOD_N-GLC_1	1008	1013	PF02516	0.664
MOD_N-GLC_1	391	396	PF02516	0.590
MOD_N-GLC_1	478	483	PF02516	0.589
MOD_NEK2_1	1073	1078	PF00069	0.534
MOD_NEK2_1	20	25	PF00069	0.675
MOD_NEK2_1	398	403	PF00069	0.516
MOD_NEK2_1	416	421	PF00069	0.481
MOD_NEK2_1	443	448	PF00069	0.399
MOD_NEK2_1	509	514	PF00069	0.554
MOD_NEK2_1	529	534	PF00069	0.214
MOD_NEK2_1	59	64	PF00069	0.693
MOD_NEK2_1	605	610	PF00069	0.566
MOD_NEK2_1	620	625	PF00069	0.540
MOD_NEK2_1	634	639	PF00069	0.680
MOD_NEK2_1	648	653	PF00069	0.609
MOD_NEK2_1	679	684	PF00069	0.667
MOD_NEK2_1	687	692	PF00069	0.638
MOD_NEK2_1	709	714	PF00069	0.647
MOD_NEK2_1	718	723	PF00069	0.559
MOD_NEK2_1	838	843	PF00069	0.615
MOD_NEK2_1	920	925	PF00069	0.674
MOD_NEK2_1	956	961	PF00069	0.399
MOD_NEK2_2	636	641	PF00069	0.680
MOD_NEK2_2	882	887	PF00069	0.604
MOD_PIKK_1	545	551	PF00454	0.464
MOD_PIKK_1	987	993	PF00454	0.663
MOD_PKA_1	289	295	PF00069	0.683
MOD_PKA_1	609	615	PF00069	0.599
MOD_PKA_2	1015	1021	PF00069	0.672
MOD_PKA_2	108	114	PF00069	0.576
MOD_PKA_2	174	180	PF00069	0.692
MOD_PKA_2	186	192	PF00069	0.635
MOD_PKA_2	228	234	PF00069	0.710
MOD_PKA_2	368	374	PF00069	0.601
MOD_PKA_2	609	615	PF00069	0.662
MOD_PKA_2	62	68	PF00069	0.648
MOD_PKA_2	646	652	PF00069	0.622
MOD_PKA_2	771	777	PF00069	0.669
MOD_PKA_2	92	98	PF00069	0.654
MOD_PKA_2	991	997	PF00069	0.659
MOD_PKB_1	130	138	PF00069	0.689
MOD_PKB_1	697	705	PF00069	0.703
MOD_Plk_1	882	888	PF00069	0.609
MOD_Plk_1	967	973	PF00069	0.588
MOD_Plk_2-3	213	219	PF00069	0.586
MOD_Plk_2-3	37	43	PF00069	0.551
MOD_Plk_2-3	737	743	PF00069	0.552
MOD_Plk_2-3	967	973	PF00069	0.588
MOD_Plk_4	15	21	PF00069	0.701
MOD_Plk_4	435	441	PF00069	0.399
MOD_Plk_4	517	523	PF00069	0.399
MOD_Plk_4	621	627	PF00069	0.651
MOD_Plk_4	749	755	PF00069	0.710
MOD_Plk_4	92	98	PF00069	0.692
MOD_Plk_4	956	962	PF00069	0.362
MOD_ProDKin_1	1008	1014	PF00069	0.628
MOD_ProDKin_1	111	117	PF00069	0.589
MOD_ProDKin_1	192	198	PF00069	0.623
MOD_ProDKin_1	205	211	PF00069	0.636
MOD_ProDKin_1	281	287	PF00069	0.655
MOD_ProDKin_1	480	486	PF00069	0.612
MOD_ProDKin_1	640	646	PF00069	0.717
MOD_ProDKin_1	753	759	PF00069	0.702
MOD_ProDKin_1	922	928	PF00069	0.588
MOD_ProDKin_1	96	102	PF00069	0.702
TRG_ENDOCYTIC_2	38	41	PF00928	0.582
TRG_ENDOCYTIC_2	504	507	PF00928	0.595
TRG_ENDOCYTIC_2	767	770	PF00928	0.726
TRG_ER_diArg_1	129	132	PF00400	0.688
TRG_ER_diArg_1	357	360	PF00400	0.699
TRG_ER_diArg_1	412	414	PF00400	0.579
TRG_ER_diArg_1	574	577	PF00400	0.665
TRG_ER_diArg_1	609	611	PF00400	0.601
TRG_ER_diArg_1	697	700	PF00400	0.666
TRG_ER_diArg_1	84	87	PF00400	0.666
TRG_NLS_MonoCore_2	572	577	PF00514	0.659
TRG_NLS_MonoExtC_3	572	577	PF00514	0.659
TRG_NLS_MonoExtN_4	82	89	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H561	Leishmania donovani	86%	99%
A4H3P3	Leishmania braziliensis	52%	93%
A4HRW9	Leishmania infantum	86%	99%
E9AJW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%