Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACM4_LEIMA

TriTrypDb:

LmjF.03.0790 , LMJLV39_030013300 , LMJSD75_030013400

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.578
CLV_C14_Caspase3-7	289	293	PF00656	0.700
CLV_NRD_NRD_1	22	24	PF00675	0.630
CLV_NRD_NRD_1	241	243	PF00675	0.518
CLV_NRD_NRD_1	250	252	PF00675	0.559
CLV_PCSK_FUR_1	20	24	PF00082	0.633
CLV_PCSK_KEX2_1	20	22	PF00082	0.601
CLV_PCSK_KEX2_1	241	243	PF00082	0.518
CLV_PCSK_KEX2_1	249	251	PF00082	0.570
CLV_PCSK_SKI1_1	382	386	PF00082	0.577
DEG_Nend_UBRbox_3	1	3	PF02207	0.711
DOC_CKS1_1	330	335	PF01111	0.730
DOC_CYCLIN_RxL_1	379	389	PF00134	0.665
DOC_CYCLIN_yClb3_PxF_3	261	267	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.689
DOC_PP2B_LxvP_1	252	255	PF13499	0.655
DOC_PP2B_LxvP_1	259	262	PF13499	0.670
DOC_USP7_MATH_1	103	107	PF00917	0.520
DOC_USP7_MATH_1	112	116	PF00917	0.578
DOC_USP7_MATH_1	133	137	PF00917	0.592
DOC_USP7_MATH_1	187	191	PF00917	0.712
DOC_USP7_MATH_1	307	311	PF00917	0.839
DOC_USP7_MATH_1	360	364	PF00917	0.745
DOC_USP7_MATH_1	380	384	PF00917	0.639
DOC_USP7_MATH_1	65	69	PF00917	0.646
DOC_USP7_MATH_1	95	99	PF00917	0.704
DOC_WW_Pin1_4	110	115	PF00397	0.628
DOC_WW_Pin1_4	143	148	PF00397	0.702
DOC_WW_Pin1_4	153	158	PF00397	0.696
DOC_WW_Pin1_4	261	266	PF00397	0.712
DOC_WW_Pin1_4	329	334	PF00397	0.740
DOC_WW_Pin1_4	336	341	PF00397	0.650
DOC_WW_Pin1_4	364	369	PF00397	0.670
DOC_WW_Pin1_4	5	10	PF00397	0.639
LIG_14-3-3_CanoR_1	151	160	PF00244	0.656
LIG_14-3-3_CanoR_1	382	391	PF00244	0.626
LIG_14-3-3_CanoR_1	72	77	PF00244	0.720
LIG_BIR_III_4	318	322	PF00653	0.816
LIG_BRCT_BRCA1_1	263	267	PF00533	0.549
LIG_CSL_BTD_1	252	255	PF09270	0.553
LIG_FHA_1	105	111	PF00498	0.544
LIG_FHA_1	330	336	PF00498	0.805
LIG_FHA_2	154	160	PF00498	0.590
LIG_FHA_2	313	319	PF00498	0.772
LIG_FHA_2	9	15	PF00498	0.583
LIG_LIR_Apic_2	257	263	PF02991	0.548
LIG_LIR_Gen_1	164	171	PF02991	0.791
LIG_LIR_Gen_1	198	209	PF02991	0.522
LIG_LIR_Gen_1	223	231	PF02991	0.537
LIG_LIR_LC3C_4	116	121	PF02991	0.676
LIG_LIR_Nem_3	14	19	PF02991	0.612
LIG_LIR_Nem_3	164	170	PF02991	0.789
LIG_LIR_Nem_3	198	204	PF02991	0.528
LIG_LIR_Nem_3	223	228	PF02991	0.541
LIG_LIR_Nem_3	403	408	PF02991	0.514
LIG_NRBOX	118	124	PF00104	0.677
LIG_PCNA_yPIPBox_3	12	26	PF02747	0.608
LIG_PTAP_UEV_1	60	65	PF05743	0.553
LIG_SH2_CRK	16	20	PF00017	0.592
LIG_SH2_CRK	167	171	PF00017	0.796
LIG_SH2_CRK	201	205	PF00017	0.544
LIG_SH2_STAP1	201	205	PF00017	0.522
LIG_SH2_STAT3	371	374	PF00017	0.750
LIG_SH2_STAT5	131	134	PF00017	0.557
LIG_SH3_1	260	266	PF00018	0.635
LIG_SH3_3	157	163	PF00018	0.598
LIG_SH3_3	259	265	PF00018	0.754
LIG_SH3_3	392	398	PF00018	0.515
LIG_SH3_3	58	64	PF00018	0.633
LIG_SUMO_SIM_par_1	118	125	PF11976	0.567
LIG_SUMO_SIM_par_1	332	337	PF11976	0.691
LIG_TRFH_1	34	38	PF08558	0.691
MOD_CDK_SPK_2	153	158	PF00069	0.696
MOD_CK1_1	106	112	PF00069	0.552
MOD_CK1_1	113	119	PF00069	0.526
MOD_CK1_1	275	281	PF00069	0.789
MOD_CK1_1	367	373	PF00069	0.640
MOD_CK1_1	383	389	PF00069	0.380
MOD_CK1_1	5	11	PF00069	0.631
MOD_CK1_1	68	74	PF00069	0.711
MOD_CK1_1	75	81	PF00069	0.796
MOD_CK1_1	98	104	PF00069	0.663
MOD_CK2_1	383	389	PF00069	0.626
MOD_CK2_1	8	14	PF00069	0.616
MOD_GlcNHglycan	141	144	PF01048	0.635
MOD_GlcNHglycan	183	186	PF01048	0.667
MOD_GlcNHglycan	277	280	PF01048	0.770
MOD_GlcNHglycan	309	312	PF01048	0.765
MOD_GlcNHglycan	61	64	PF01048	0.630
MOD_GlcNHglycan	65	68	PF01048	0.632
MOD_GlcNHglycan	85	88	PF01048	0.674
MOD_GlcNHglycan	97	100	PF01048	0.554
MOD_GSK3_1	106	113	PF00069	0.594
MOD_GSK3_1	139	146	PF00069	0.670
MOD_GSK3_1	170	177	PF00069	0.731
MOD_GSK3_1	183	190	PF00069	0.656
MOD_GSK3_1	266	273	PF00069	0.798
MOD_GSK3_1	325	332	PF00069	0.818
MOD_GSK3_1	360	367	PF00069	0.699
MOD_GSK3_1	59	66	PF00069	0.650
MOD_GSK3_1	68	75	PF00069	0.686
MOD_N-GLC_1	133	138	PF02516	0.704
MOD_N-GLC_1	275	280	PF02516	0.789
MOD_N-GLC_1	325	330	PF02516	0.821
MOD_NEK2_1	139	144	PF00069	0.687
MOD_NEK2_1	196	201	PF00069	0.618
MOD_NEK2_1	267	272	PF00069	0.702
MOD_NEK2_1	40	45	PF00069	0.658
MOD_PIKK_1	299	305	PF00454	0.772
MOD_PK_1	72	78	PF00069	0.722
MOD_PKA_2	299	305	PF00069	0.823
MOD_PKA_2	307	313	PF00069	0.727
MOD_Plk_1	124	130	PF00069	0.549
MOD_Plk_1	133	139	PF00069	0.602
MOD_Plk_1	325	331	PF00069	0.742
MOD_Plk_4	106	112	PF00069	0.592
MOD_Plk_4	124	130	PF00069	0.619
MOD_Plk_4	134	140	PF00069	0.617
MOD_Plk_4	162	168	PF00069	0.675
MOD_Plk_4	187	193	PF00069	0.583
MOD_Plk_4	72	78	PF00069	0.757
MOD_ProDKin_1	110	116	PF00069	0.619
MOD_ProDKin_1	143	149	PF00069	0.701
MOD_ProDKin_1	153	159	PF00069	0.696
MOD_ProDKin_1	261	267	PF00069	0.717
MOD_ProDKin_1	329	335	PF00069	0.739
MOD_ProDKin_1	336	342	PF00069	0.652
MOD_ProDKin_1	364	370	PF00069	0.664
MOD_ProDKin_1	5	11	PF00069	0.631
MOD_SUMO_for_1	281	284	PF00179	0.818
TRG_DiLeu_BaEn_1	14	19	PF01217	0.630
TRG_DiLeu_BaEn_1	389	394	PF01217	0.609
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.706
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.514
TRG_ENDOCYTIC_2	16	19	PF00928	0.593
TRG_ENDOCYTIC_2	167	170	PF00928	0.794
TRG_ENDOCYTIC_2	201	204	PF00928	0.501
TRG_ENDOCYTIC_2	405	408	PF00928	0.523
TRG_ER_diArg_1	150	153	PF00400	0.677
TRG_ER_diArg_1	19	22	PF00400	0.633
TRG_ER_diArg_1	240	242	PF00400	0.519
TRG_ER_diArg_1	248	251	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	382	387	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J3	Leptomonas seymouri	47%	95%
A0A3S5H559	Leishmania donovani	94%	100%
A4H3P0	Leishmania braziliensis	73%	97%
A4HRW7	Leishmania infantum	94%	100%
E9AJW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%