Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ubiquitin-like domain containing protein, putative

Species:

Leishmania major

UniProt:

E9ACM2_LEIMA

TriTrypDb:

LmjF.03.0770 , LMJLV39_030013100 , LMJSD75_030013200

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	12
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

E9ACM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACM2

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006457	protein folding	2	12
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0007021	tubulin complex assembly	6	2
GO:0007023	post-chaperonin tubulin folding pathway	3	2
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0043014	alpha-tubulin binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.402
CLV_C14_Caspase3-7	317	321	PF00656	0.381
CLV_C14_Caspase3-7	371	375	PF00656	0.382
CLV_C14_Caspase3-7	392	396	PF00656	0.627
CLV_PCSK_SKI1_1	125	129	PF00082	0.425
CLV_PCSK_SKI1_1	155	159	PF00082	0.358
CLV_PCSK_SKI1_1	300	304	PF00082	0.459
CLV_PCSK_SKI1_1	382	386	PF00082	0.521
DEG_APCC_DBOX_1	60	68	PF00400	0.505
DEG_SPOP_SBC_1	147	151	PF00917	0.573
DEG_SPOP_SBC_1	4	8	PF00917	0.592
DEG_SPOP_SBC_1	462	466	PF00917	0.676
DOC_CDC14_PxL_1	120	128	PF14671	0.489
DOC_CDC14_PxL_1	131	139	PF14671	0.516
DOC_CDC14_PxL_1	172	180	PF14671	0.435
DOC_CKS1_1	516	521	PF01111	0.532
DOC_CYCLIN_RxL_1	176	185	PF00134	0.525
DOC_MAPK_gen_1	297	307	PF00069	0.413
DOC_MAPK_gen_1	42	49	PF00069	0.609
DOC_MAPK_gen_1	421	429	PF00069	0.421
DOC_MAPK_gen_1	55	64	PF00069	0.406
DOC_MAPK_MEF2A_6	187	195	PF00069	0.587
DOC_MAPK_MEF2A_6	423	431	PF00069	0.491
DOC_MAPK_MEF2A_6	58	66	PF00069	0.521
DOC_MAPK_MEF2A_6	68	76	PF00069	0.374
DOC_PP2B_LxvP_1	267	270	PF13499	0.506
DOC_PP4_MxPP_1	140	143	PF00568	0.557
DOC_USP7_MATH_1	11	15	PF00917	0.484
DOC_USP7_MATH_1	147	151	PF00917	0.547
DOC_USP7_MATH_1	2	6	PF00917	0.758
DOC_USP7_MATH_1	210	214	PF00917	0.735
DOC_USP7_MATH_1	462	466	PF00917	0.682
DOC_USP7_UBL2_3	421	425	PF12436	0.467
DOC_WW_Pin1_4	466	471	PF00397	0.532
DOC_WW_Pin1_4	5	10	PF00397	0.668
DOC_WW_Pin1_4	515	520	PF00397	0.515
LIG_14-3-3_CanoR_1	125	130	PF00244	0.479
LIG_14-3-3_CanoR_1	300	305	PF00244	0.454
LIG_14-3-3_CanoR_1	333	343	PF00244	0.373
LIG_14-3-3_CanoR_1	503	507	PF00244	0.487
LIG_14-3-3_CanoR_1	61	65	PF00244	0.510
LIG_deltaCOP1_diTrp_1	41	46	PF00928	0.648
LIG_eIF4E_1	379	385	PF01652	0.508
LIG_FHA_1	126	132	PF00498	0.426
LIG_FHA_1	143	149	PF00498	0.544
LIG_FHA_1	227	233	PF00498	0.358
LIG_FHA_1	282	288	PF00498	0.558
LIG_FHA_1	314	320	PF00498	0.439
LIG_FHA_1	329	335	PF00498	0.238
LIG_FHA_1	447	453	PF00498	0.396
LIG_FHA_1	473	479	PF00498	0.515
LIG_FHA_1	61	67	PF00498	0.430
LIG_FHA_1	93	99	PF00498	0.625
LIG_FHA_2	187	193	PF00498	0.530
LIG_FHA_2	340	346	PF00498	0.518
LIG_FHA_2	516	522	PF00498	0.465
LIG_LIR_Gen_1	335	341	PF02991	0.389
LIG_LIR_Gen_1	41	49	PF02991	0.578
LIG_LIR_LC3C_4	63	66	PF02991	0.501
LIG_LIR_Nem_3	161	166	PF02991	0.476
LIG_LIR_Nem_3	221	227	PF02991	0.435
LIG_LIR_Nem_3	238	243	PF02991	0.337
LIG_LIR_Nem_3	335	339	PF02991	0.390
LIG_LIR_Nem_3	41	47	PF02991	0.591
LIG_LIR_Nem_3	526	532	PF02991	0.465
LIG_LYPXL_yS_3	414	417	PF13949	0.386
LIG_MYND_1	135	139	PF01753	0.512
LIG_PTB_Apo_2	157	164	PF02174	0.452
LIG_SH2_CRK	296	300	PF00017	0.413
LIG_SH2_CRK	336	340	PF00017	0.424
LIG_SH2_NCK_1	458	462	PF00017	0.627
LIG_SH2_PTP2	445	448	PF00017	0.537
LIG_SH2_STAP1	336	340	PF00017	0.383
LIG_SH2_STAP1	458	462	PF00017	0.656
LIG_SH2_STAT5	122	125	PF00017	0.493
LIG_SH2_STAT5	258	261	PF00017	0.470
LIG_SH2_STAT5	298	301	PF00017	0.368
LIG_SH2_STAT5	351	354	PF00017	0.354
LIG_SH2_STAT5	379	382	PF00017	0.379
LIG_SH2_STAT5	445	448	PF00017	0.537
LIG_SH2_STAT5	453	456	PF00017	0.513
LIG_SH2_STAT5	539	542	PF00017	0.527
LIG_SH3_1	118	124	PF00018	0.504
LIG_SH3_3	118	124	PF00018	0.504
LIG_SH3_3	136	142	PF00018	0.381
LIG_SH3_3	170	176	PF00018	0.426
LIG_SH3_3	191	197	PF00018	0.615
LIG_SH3_3	219	225	PF00018	0.595
LIG_SH3_3	289	295	PF00018	0.542
LIG_SH3_4	498	505	PF00018	0.536
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.578
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.523
LIG_SUMO_SIM_par_1	446	451	PF11976	0.497
LIG_SUMO_SIM_par_1	510	518	PF11976	0.504
LIG_TYR_ITIM	334	339	PF00017	0.418
LIG_TYR_ITIM	412	417	PF00017	0.419
LIG_TYR_ITIM	527	532	PF00017	0.392
LIG_UBA3_1	304	308	PF00899	0.483
LIG_UBA3_1	416	425	PF00899	0.311
LIG_WRC_WIRS_1	329	334	PF05994	0.332
MOD_CK1_1	106	112	PF00069	0.539
MOD_CK1_1	151	157	PF00069	0.453
MOD_CK1_1	201	207	PF00069	0.717
MOD_CK1_1	3	9	PF00069	0.740
MOD_CK1_1	465	471	PF00069	0.406
MOD_CK1_1	480	486	PF00069	0.238
MOD_CK1_1	505	511	PF00069	0.306
MOD_CK1_1	533	539	PF00069	0.376
MOD_CK1_1	80	86	PF00069	0.658
MOD_CK2_1	109	115	PF00069	0.445
MOD_CK2_1	339	345	PF00069	0.512
MOD_GlcNHglycan	169	172	PF01048	0.284
MOD_GlcNHglycan	200	203	PF01048	0.643
MOD_GlcNHglycan	212	215	PF01048	0.726
MOD_GlcNHglycan	24	27	PF01048	0.608
MOD_GlcNHglycan	400	403	PF01048	0.645
MOD_GlcNHglycan	507	510	PF01048	0.309
MOD_GlcNHglycan	78	82	PF01048	0.699
MOD_GSK3_1	142	149	PF00069	0.563
MOD_GSK3_1	158	165	PF00069	0.395
MOD_GSK3_1	182	189	PF00069	0.491
MOD_GSK3_1	309	316	PF00069	0.455
MOD_GSK3_1	328	335	PF00069	0.182
MOD_GSK3_1	339	346	PF00069	0.392
MOD_GSK3_1	398	405	PF00069	0.656
MOD_GSK3_1	434	441	PF00069	0.630
MOD_GSK3_1	461	468	PF00069	0.647
MOD_GSK3_1	469	476	PF00069	0.300
MOD_GSK3_1	5	12	PF00069	0.711
MOD_N-GLC_1	158	163	PF02516	0.446
MOD_N-GLC_1	309	314	PF02516	0.415
MOD_N-GLC_1	343	348	PF02516	0.366
MOD_N-GLC_1	398	403	PF02516	0.474
MOD_NEK2_1	148	153	PF00069	0.444
MOD_NEK2_1	158	163	PF00069	0.400
MOD_NEK2_1	313	318	PF00069	0.512
MOD_NEK2_1	332	337	PF00069	0.184
MOD_NEK2_1	92	97	PF00069	0.521
MOD_PIKK_1	252	258	PF00454	0.471
MOD_PIKK_1	36	42	PF00454	0.698
MOD_PIKK_1	470	476	PF00454	0.425
MOD_PKA_2	332	338	PF00069	0.353
MOD_PKA_2	363	369	PF00069	0.544
MOD_PKA_2	502	508	PF00069	0.355
MOD_PKA_2	60	66	PF00069	0.511
MOD_Plk_1	106	112	PF00069	0.433
MOD_Plk_1	309	315	PF00069	0.429
MOD_Plk_1	93	99	PF00069	0.512
MOD_Plk_2-3	27	33	PF00069	0.625
MOD_Plk_4	11	17	PF00069	0.453
MOD_Plk_4	269	275	PF00069	0.482
MOD_Plk_4	300	306	PF00069	0.414
MOD_Plk_4	335	341	PF00069	0.455
MOD_Plk_4	448	454	PF00069	0.473
MOD_Plk_4	533	539	PF00069	0.389
MOD_Plk_4	60	66	PF00069	0.511
MOD_Plk_4	93	99	PF00069	0.521
MOD_ProDKin_1	466	472	PF00069	0.415
MOD_ProDKin_1	5	11	PF00069	0.659
MOD_ProDKin_1	515	521	PF00069	0.392
TRG_DiLeu_BaEn_1	115	120	PF01217	0.494
TRG_DiLeu_BaLyEn_6	412	417	PF01217	0.293
TRG_ENDOCYTIC_2	296	299	PF00928	0.366
TRG_ENDOCYTIC_2	336	339	PF00928	0.373
TRG_ENDOCYTIC_2	414	417	PF00928	0.386
TRG_ENDOCYTIC_2	445	448	PF00928	0.537
TRG_ENDOCYTIC_2	529	532	PF00928	0.392
TRG_NES_CRM1_1	174	184	PF08389	0.349
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTC4	Leptomonas seymouri	62%	100%
A0A0S4JLX2	Bodo saltans	40%	100%
A0A1X0P967	Trypanosomatidae	42%	100%
A0A3S5H558	Leishmania donovani	93%	99%
A0A422NHN6	Trypanosoma rangeli	44%	100%
A4H3N8	Leishmania braziliensis	80%	99%
A4HRW5	Leishmania infantum	93%	100%
C9ZKH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AJW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q15813	Homo sapiens	23%	100%
Q32KS0	Bos taurus	23%	100%
Q5RBD9	Pongo abelii	23%	100%
Q5U508	Xenopus laevis	22%	100%
Q8GRL7	Arabidopsis thaliana	25%	100%
V5C274	Trypanosoma cruzi	43%	100%