Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACM1_LEIMA

TriTrypDb:

LmjF.03.0760 , LMJLV39_030013000 , LMJSD75_030013100

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.706
CLV_C14_Caspase3-7	35	39	PF00656	0.741
CLV_NRD_NRD_1	277	279	PF00675	0.743
CLV_NRD_NRD_1	54	56	PF00675	0.725
CLV_NRD_NRD_1	88	90	PF00675	0.499
CLV_PCSK_KEX2_1	277	279	PF00082	0.742
CLV_PCSK_KEX2_1	54	56	PF00082	0.724
CLV_PCSK_KEX2_1	87	89	PF00082	0.529
CLV_PCSK_SKI1_1	10	14	PF00082	0.694
CLV_PCSK_SKI1_1	248	252	PF00082	0.375
CLV_Separin_Metazoa	267	271	PF03568	0.608
DEG_APCC_DBOX_1	86	94	PF00400	0.483
DEG_Nend_UBRbox_1	1	4	PF02207	0.681
DEG_SPOP_SBC_1	151	155	PF00917	0.699
DEG_SPOP_SBC_1	186	190	PF00917	0.705
DEG_SPOP_SBC_1	43	47	PF00917	0.784
DOC_MAPK_gen_1	87	94	PF00069	0.474
DOC_MAPK_MEF2A_6	209	218	PF00069	0.449
DOC_MAPK_MEF2A_6	87	94	PF00069	0.459
DOC_USP7_MATH_1	12	16	PF00917	0.772
DOC_USP7_MATH_1	151	155	PF00917	0.637
DOC_USP7_MATH_1	162	166	PF00917	0.616
DOC_USP7_MATH_1	173	177	PF00917	0.724
DOC_USP7_MATH_1	186	190	PF00917	0.729
DOC_USP7_MATH_1	42	46	PF00917	0.740
DOC_WW_Pin1_4	165	170	PF00397	0.799
DOC_WW_Pin1_4	20	25	PF00397	0.668
DOC_WW_Pin1_4	45	50	PF00397	0.746
LIG_14-3-3_CanoR_1	114	122	PF00244	0.508
LIG_14-3-3_CanoR_1	54	59	PF00244	0.777
LIG_14-3-3_CanoR_1	7	16	PF00244	0.647
LIG_BRCT_BRCA1_1	115	119	PF00533	0.515
LIG_eIF4E_1	113	119	PF01652	0.557
LIG_EVH1_1	76	80	PF00568	0.756
LIG_FHA_1	11	17	PF00498	0.707
LIG_FHA_1	113	119	PF00498	0.567
LIG_FHA_1	231	237	PF00498	0.617
LIG_FHA_1	258	264	PF00498	0.639
LIG_FHA_2	105	111	PF00498	0.589
LIG_FHA_2	166	172	PF00498	0.763
LIG_Integrin_RGD_1	36	38	PF01839	0.714
LIG_LIR_Gen_1	116	127	PF02991	0.521
LIG_LIR_Nem_3	116	122	PF02991	0.519
LIG_LIR_Nem_3	206	210	PF02991	0.437
LIG_LIR_Nem_3	211	216	PF02991	0.464
LIG_LIR_Nem_3	74	79	PF02991	0.656
LIG_MYND_1	99	103	PF01753	0.607
LIG_NRBOX	264	270	PF00104	0.633
LIG_PDZ_Class_1	311	316	PF00595	0.532
LIG_SH2_STAT5	207	210	PF00017	0.515
LIG_SH2_STAT5	241	244	PF00017	0.540
LIG_SH2_STAT5	295	298	PF00017	0.478
LIG_SH3_2	49	54	PF14604	0.732
LIG_SH3_3	126	132	PF00018	0.440
LIG_SH3_3	142	148	PF00018	0.546
LIG_SH3_3	177	183	PF00018	0.621
LIG_SH3_3	195	201	PF00018	0.600
LIG_SH3_3	46	52	PF00018	0.738
LIG_SH3_3	74	80	PF00018	0.686
LIG_SUMO_SIM_anti_2	176	181	PF11976	0.496
LIG_TRAF2_1	281	284	PF00917	0.718
LIG_UBA3_1	268	275	PF00899	0.477
LIG_WW_3	58	62	PF00397	0.782
MOD_CDK_SPxK_1	20	26	PF00069	0.564
MOD_CK1_1	154	160	PF00069	0.639
MOD_CK1_1	165	171	PF00069	0.565
MOD_CK1_1	187	193	PF00069	0.665
MOD_CK1_1	45	51	PF00069	0.748
MOD_CK1_1	53	59	PF00069	0.735
MOD_CK2_1	250	256	PF00069	0.583
MOD_CK2_1	29	35	PF00069	0.566
MOD_Cter_Amidation	275	278	PF01082	0.738
MOD_GlcNHglycan	115	118	PF01048	0.517
MOD_GlcNHglycan	154	157	PF01048	0.617
MOD_GlcNHglycan	160	163	PF01048	0.669
MOD_GlcNHglycan	313	316	PF01048	0.591
MOD_GlcNHglycan	56	59	PF01048	0.755
MOD_GSK3_1	113	120	PF00069	0.493
MOD_GSK3_1	150	157	PF00069	0.589
MOD_GSK3_1	158	165	PF00069	0.636
MOD_GSK3_1	184	191	PF00069	0.620
MOD_GSK3_1	307	314	PF00069	0.526
MOD_GSK3_1	43	50	PF00069	0.711
MOD_GSK3_1	8	15	PF00069	0.691
MOD_N-GLC_1	18	23	PF02516	0.763
MOD_NEK2_1	150	155	PF00069	0.663
MOD_NEK2_1	230	235	PF00069	0.624
MOD_NEK2_1	250	255	PF00069	0.539
MOD_NEK2_1	307	312	PF00069	0.717
MOD_NEK2_2	5	10	PF00069	0.554
MOD_PIKK_1	154	160	PF00454	0.599
MOD_PK_1	259	265	PF00069	0.647
MOD_PKA_1	54	60	PF00069	0.773
MOD_PKA_2	113	119	PF00069	0.447
MOD_PKA_2	230	236	PF00069	0.618
MOD_PKA_2	53	59	PF00069	0.721
MOD_Plk_1	18	24	PF00069	0.775
MOD_Plk_1	29	35	PF00069	0.649
MOD_ProDKin_1	165	171	PF00069	0.797
MOD_ProDKin_1	20	26	PF00069	0.670
MOD_ProDKin_1	45	51	PF00069	0.746
MOD_SUMO_for_1	281	284	PF00179	0.668
MOD_SUMO_rev_2	280	287	PF00179	0.661
TRG_DiLeu_BaEn_1	264	269	PF01217	0.661
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.592
TRG_ENDOCYTIC_2	207	210	PF00928	0.515
TRG_ENDOCYTIC_2	6	9	PF00928	0.555
TRG_ER_diArg_1	86	89	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN8	Leptomonas seymouri	63%	95%
A0A1X0PA92	Trypanosomatidae	40%	100%
A0A3R7KEM6	Trypanosoma rangeli	42%	100%
A0A3S5H557	Leishmania donovani	91%	100%
A4HRW4	Leishmania infantum	91%	100%
C9ZKG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AJV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
V5BC94	Trypanosoma cruzi	42%	100%