Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TatD related DNase, putative

Species:

Leishmania major

UniProt:

E9ACM0_LEIMA

TriTrypDb:

LmjF.03.0750 , LMJLV39_030012900 , LMJSD75_030013000

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACM0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0004529	DNA exonuclease activity	5	2
GO:0004536	DNA nuclease activity	4	2
GO:0008296	3'-5'-DNA exonuclease activity	7	2
GO:0008297	single-stranded DNA exodeoxyribonuclease activity	7	2
GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	8	2
GO:0008408	3'-5' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.542
CLV_C14_Caspase3-7	412	416	PF00656	0.362
CLV_C14_Caspase3-7	519	523	PF00656	0.700
CLV_C14_Caspase3-7	639	643	PF00656	0.673
CLV_NRD_NRD_1	109	111	PF00675	0.301
CLV_NRD_NRD_1	121	123	PF00675	0.301
CLV_NRD_NRD_1	18	20	PF00675	0.693
CLV_NRD_NRD_1	529	531	PF00675	0.521
CLV_NRD_NRD_1	591	593	PF00675	0.558
CLV_NRD_NRD_1	706	708	PF00675	0.699
CLV_PCSK_FUR_1	589	593	PF00082	0.677
CLV_PCSK_KEX2_1	121	123	PF00082	0.360
CLV_PCSK_KEX2_1	18	20	PF00082	0.717
CLV_PCSK_KEX2_1	529	531	PF00082	0.521
CLV_PCSK_KEX2_1	549	551	PF00082	0.598
CLV_PCSK_KEX2_1	588	590	PF00082	0.517
CLV_PCSK_KEX2_1	591	593	PF00082	0.550
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.598
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.527
CLV_PCSK_SKI1_1	10	14	PF00082	0.666
CLV_PCSK_SKI1_1	261	265	PF00082	0.398
CLV_PCSK_SKI1_1	295	299	PF00082	0.342
CLV_PCSK_SKI1_1	32	36	PF00082	0.680
CLV_PCSK_SKI1_1	596	600	PF00082	0.602
CLV_PCSK_SKI1_1	672	676	PF00082	0.483
DEG_SPOP_SBC_1	191	195	PF00917	0.459
DEG_SPOP_SBC_1	407	411	PF00917	0.452
DEG_SPOP_SBC_1	648	652	PF00917	0.751
DOC_CKS1_1	38	43	PF01111	0.621
DOC_CKS1_1	431	436	PF01111	0.501
DOC_CYCLIN_yCln2_LP_2	393	396	PF00134	0.560
DOC_MAPK_MEF2A_6	268	277	PF00069	0.525
DOC_PP1_RVXF_1	172	179	PF00149	0.560
DOC_PP2B_LxvP_1	393	396	PF13499	0.560
DOC_USP7_MATH_1	24	28	PF00917	0.606
DOC_USP7_MATH_1	305	309	PF00917	0.459
DOC_USP7_MATH_1	316	320	PF00917	0.596
DOC_USP7_MATH_1	616	620	PF00917	0.792
DOC_USP7_MATH_1	62	66	PF00917	0.553
DOC_USP7_MATH_1	648	652	PF00917	0.770
DOC_USP7_MATH_1	654	658	PF00917	0.633
DOC_USP7_UBL2_3	32	36	PF12436	0.676
DOC_USP7_UBL2_3	595	599	PF12436	0.605
DOC_WW_Pin1_4	37	42	PF00397	0.609
DOC_WW_Pin1_4	43	48	PF00397	0.520
DOC_WW_Pin1_4	430	435	PF00397	0.506
DOC_WW_Pin1_4	644	649	PF00397	0.723
DOC_WW_Pin1_4	734	739	PF00397	0.621
DOC_WW_Pin1_4	95	100	PF00397	0.531
LIG_14-3-3_CanoR_1	141	145	PF00244	0.609
LIG_eIF4E_1	257	263	PF01652	0.560
LIG_FHA_1	288	294	PF00498	0.598
LIG_FHA_2	456	462	PF00498	0.560
LIG_FHA_2	478	484	PF00498	0.548
LIG_FHA_2	517	523	PF00498	0.573
LIG_FHA_2	637	643	PF00498	0.763
LIG_FHA_2	67	73	PF00498	0.640
LIG_FHA_2	76	82	PF00498	0.544
LIG_GBD_Chelix_1	455	463	PF00786	0.339
LIG_LIR_Apic_2	37	41	PF02991	0.646
LIG_LIR_Gen_1	458	468	PF02991	0.527
LIG_LIR_Gen_1	604	614	PF02991	0.633
LIG_LIR_Nem_3	604	609	PF02991	0.624
LIG_LYPXL_SIV_4	99	107	PF13949	0.415
LIG_NRBOX	299	305	PF00104	0.598
LIG_NRBOX	419	425	PF00104	0.501
LIG_NRBOX	551	557	PF00104	0.548
LIG_Pex14_2	263	267	PF04695	0.573
LIG_PTB_Apo_2	608	615	PF02174	0.642
LIG_Rb_pABgroove_1	454	462	PF01858	0.570
LIG_SH2_CRK	206	210	PF00017	0.501
LIG_SH2_CRK	38	42	PF00017	0.656
LIG_SH2_CRK	452	456	PF00017	0.525
LIG_SH2_NCK_1	38	42	PF00017	0.656
LIG_SH2_SRC	100	103	PF00017	0.415
LIG_SH2_SRC	452	455	PF00017	0.548
LIG_SH2_STAP1	452	456	PF00017	0.598
LIG_SH2_STAT3	454	457	PF00017	0.598
LIG_SH2_STAT5	100	103	PF00017	0.415
LIG_SH2_STAT5	357	360	PF00017	0.485
LIG_SH2_STAT5	38	41	PF00017	0.648
LIG_SH2_STAT5	441	444	PF00017	0.527
LIG_SH2_STAT5	454	457	PF00017	0.471
LIG_SH2_STAT5	492	495	PF00017	0.511
LIG_SH2_STAT5	749	752	PF00017	0.766
LIG_SH3_1	44	50	PF00018	0.466
LIG_SH3_1	464	470	PF00018	0.431
LIG_SH3_3	270	276	PF00018	0.554
LIG_SH3_3	44	50	PF00018	0.466
LIG_SH3_3	443	449	PF00018	0.525
LIG_SH3_3	463	469	PF00018	0.362
LIG_TRAF2_1	123	126	PF00917	0.525
LIG_TRAF2_1	619	622	PF00917	0.797
LIG_TYR_ITIM	204	209	PF00017	0.548
LIG_WW_3	394	398	PF00397	0.554
MOD_CDK_SPxxK_3	37	44	PF00069	0.618
MOD_CK1_1	166	172	PF00069	0.500
MOD_CK1_1	195	201	PF00069	0.465
MOD_CK1_1	383	389	PF00069	0.566
MOD_CK1_1	406	412	PF00069	0.544
MOD_CK1_1	604	610	PF00069	0.626
MOD_CK1_1	649	655	PF00069	0.788
MOD_CK1_1	739	745	PF00069	0.794
MOD_CK1_1	77	83	PF00069	0.538
MOD_CK2_1	285	291	PF00069	0.598
MOD_CK2_1	370	376	PF00069	0.569
MOD_CK2_1	512	518	PF00069	0.494
MOD_CK2_1	587	593	PF00069	0.672
MOD_CK2_1	616	622	PF00069	0.744
MOD_CK2_1	66	72	PF00069	0.685
MOD_CK2_1	77	83	PF00069	0.559
MOD_GlcNHglycan	166	169	PF01048	0.355
MOD_GlcNHglycan	307	310	PF01048	0.345
MOD_GlcNHglycan	318	321	PF01048	0.383
MOD_GlcNHglycan	32	35	PF01048	0.640
MOD_GlcNHglycan	382	385	PF01048	0.362
MOD_GlcNHglycan	405	408	PF01048	0.369
MOD_GlcNHglycan	411	414	PF01048	0.201
MOD_GlcNHglycan	483	487	PF01048	0.396
MOD_GlcNHglycan	512	515	PF01048	0.588
MOD_GlcNHglycan	64	67	PF01048	0.503
MOD_GlcNHglycan	651	654	PF01048	0.729
MOD_GlcNHglycan	656	659	PF01048	0.701
MOD_GlcNHglycan	711	714	PF01048	0.785
MOD_GSK3_1	13	20	PF00069	0.647
MOD_GSK3_1	190	197	PF00069	0.594
MOD_GSK3_1	285	292	PF00069	0.560
MOD_GSK3_1	36	43	PF00069	0.598
MOD_GSK3_1	399	406	PF00069	0.538
MOD_GSK3_1	512	519	PF00069	0.589
MOD_GSK3_1	62	69	PF00069	0.492
MOD_GSK3_1	644	651	PF00069	0.735
MOD_GSK3_1	652	659	PF00069	0.665
MOD_GSK3_1	71	78	PF00069	0.667
MOD_N-GLC_1	247	252	PF02516	0.360
MOD_N-GLC_1	30	35	PF02516	0.739
MOD_N-GLC_1	601	606	PF02516	0.615
MOD_N-GLC_1	734	739	PF02516	0.699
MOD_N-GLC_2	147	149	PF02516	0.231
MOD_NEK2_1	145	150	PF00069	0.558
MOD_NEK2_1	17	22	PF00069	0.636
MOD_NEK2_1	289	294	PF00069	0.560
MOD_NEK2_1	304	309	PF00069	0.560
MOD_NEK2_1	330	335	PF00069	0.525
MOD_NEK2_1	424	429	PF00069	0.525
MOD_NEK2_1	703	708	PF00069	0.737
MOD_NEK2_1	71	76	PF00069	0.686
MOD_PIKK_1	418	424	PF00454	0.501
MOD_PIKK_1	531	537	PF00454	0.611
MOD_PKA_2	140	146	PF00069	0.609
MOD_PKA_2	156	162	PF00069	0.409
MOD_PKA_2	164	170	PF00069	0.470
MOD_PKA_2	17	23	PF00069	0.644
MOD_PKA_2	616	622	PF00069	0.795
MOD_PKA_2	747	753	PF00069	0.697
MOD_PKB_1	644	652	PF00069	0.699
MOD_Plk_1	477	483	PF00069	0.584
MOD_Plk_1	604	610	PF00069	0.626
MOD_Plk_2-3	285	291	PF00069	0.560
MOD_Plk_4	140	146	PF00069	0.594
MOD_Plk_4	199	205	PF00069	0.481
MOD_Plk_4	455	461	PF00069	0.557
MOD_ProDKin_1	37	43	PF00069	0.612
MOD_ProDKin_1	430	436	PF00069	0.506
MOD_ProDKin_1	45	51	PF00069	0.487
MOD_ProDKin_1	644	650	PF00069	0.725
MOD_ProDKin_1	734	740	PF00069	0.622
MOD_ProDKin_1	95	101	PF00069	0.522
MOD_SUMO_for_1	368	371	PF00179	0.542
MOD_SUMO_rev_2	125	130	PF00179	0.598
MOD_SUMO_rev_2	5	15	PF00179	0.662
MOD_SUMO_rev_2	712	718	PF00179	0.693
TRG_DiLeu_BaEn_1	140	145	PF01217	0.598
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.640
TRG_ENDOCYTIC_2	206	209	PF00928	0.501
TRG_ENDOCYTIC_2	452	455	PF00928	0.501
TRG_ENDOCYTIC_2	460	463	PF00928	0.501
TRG_ER_diArg_1	120	122	PF00400	0.560
TRG_ER_diArg_1	17	19	PF00400	0.731
TRG_ER_diArg_1	529	531	PF00400	0.547
TRG_ER_diArg_1	589	592	PF00400	0.560
TRG_ER_FFAT_2	33	43	PF00635	0.640
TRG_NLS_MonoExtC_3	587	592	PF00514	0.464
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E3	Leptomonas seymouri	56%	94%
A0A1X0P9U8	Trypanosomatidae	32%	94%
A0A451EJS4	Leishmania donovani	86%	100%
A4H3N6	Leishmania braziliensis	68%	96%
A4HRW3	Leishmania infantum	86%	100%
C9ZKG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AJV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%