CDT1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACL8_LEIMA

TriTrypDb:

LmjF.03.0730 , LMJLV39_030012700 , LMJSD75_030012800

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.678
CLV_NRD_NRD_1	216	218	PF00675	0.506
CLV_NRD_NRD_1	299	301	PF00675	0.652
CLV_NRD_NRD_1	364	366	PF00675	0.636
CLV_NRD_NRD_1	93	95	PF00675	0.600
CLV_PCSK_FUR_1	297	301	PF00082	0.657
CLV_PCSK_KEX2_1	155	157	PF00082	0.703
CLV_PCSK_KEX2_1	25	27	PF00082	0.673
CLV_PCSK_KEX2_1	299	301	PF00082	0.652
CLV_PCSK_KEX2_1	364	366	PF00082	0.580
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.688
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.728
CLV_PCSK_SKI1_1	155	159	PF00082	0.671
CLV_PCSK_SKI1_1	286	290	PF00082	0.719
CLV_PCSK_SKI1_1	29	33	PF00082	0.675
CLV_PCSK_SKI1_1	389	393	PF00082	0.632
CLV_Separin_Metazoa	125	129	PF03568	0.592
DEG_APCC_DBOX_1	153	161	PF00400	0.733
DEG_APCC_DBOX_1	216	224	PF00400	0.627
DOC_CKS1_1	392	397	PF01111	0.750
DOC_MAPK_gen_1	217	225	PF00069	0.647
DOC_MAPK_MEF2A_6	200	209	PF00069	0.516
DOC_MAPK_NFAT4_5	206	214	PF00069	0.459
DOC_MAPK_RevD_3	203	218	PF00069	0.537
DOC_PP2B_LxvP_1	136	139	PF13499	0.781
DOC_PP4_FxxP_1	370	373	PF00568	0.644
DOC_USP7_MATH_1	149	153	PF00917	0.764
DOC_USP7_MATH_1	174	178	PF00917	0.693
DOC_USP7_MATH_1	179	183	PF00917	0.709
DOC_USP7_MATH_1	18	22	PF00917	0.580
DOC_USP7_MATH_1	191	195	PF00917	0.567
DOC_USP7_MATH_1	224	228	PF00917	0.595
DOC_USP7_MATH_1	342	346	PF00917	0.717
DOC_USP7_MATH_1	351	355	PF00917	0.634
DOC_USP7_MATH_1	4	8	PF00917	0.668
DOC_USP7_MATH_1	49	53	PF00917	0.635
DOC_USP7_MATH_1	67	71	PF00917	0.540
DOC_USP7_UBL2_3	151	155	PF12436	0.697
DOC_USP7_UBL2_3	37	41	PF12436	0.794
DOC_USP7_UBL2_3	91	95	PF12436	0.589
DOC_WW_Pin1_4	145	150	PF00397	0.615
DOC_WW_Pin1_4	287	292	PF00397	0.636
DOC_WW_Pin1_4	347	352	PF00397	0.734
DOC_WW_Pin1_4	391	396	PF00397	0.742
DOC_WW_Pin1_4	45	50	PF00397	0.763
DOC_WW_Pin1_4	63	68	PF00397	0.618
LIG_14-3-3_CanoR_1	200	207	PF00244	0.607
LIG_14-3-3_CanoR_1	217	221	PF00244	0.454
LIG_14-3-3_CanoR_1	248	255	PF00244	0.508
LIG_14-3-3_CanoR_1	286	291	PF00244	0.710
LIG_14-3-3_CanoR_1	29	34	PF00244	0.713
LIG_Actin_WH2_1	206	223	PF00022	0.549
LIG_Actin_WH2_2	207	223	PF00022	0.548
LIG_APCC_ABBA_1	53	58	PF00400	0.593
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BIR_III_1	1	5	PF00653	0.684
LIG_BIR_III_2	166	170	PF00653	0.622
LIG_BIR_III_2	346	350	PF00653	0.627
LIG_BIR_III_3	1	5	PF00653	0.684
LIG_BRCT_BRCA1_1	109	113	PF00533	0.573
LIG_BRCT_BRCA1_1	49	53	PF00533	0.593
LIG_deltaCOP1_diTrp_1	166	171	PF00928	0.668
LIG_FHA_1	220	226	PF00498	0.670
LIG_FHA_1	272	278	PF00498	0.586
LIG_FHA_2	182	188	PF00498	0.550
LIG_LIR_Apic_2	170	174	PF02991	0.713
LIG_LIR_Apic_2	367	373	PF02991	0.643
LIG_LIR_Gen_1	234	245	PF02991	0.576
LIG_LIR_Gen_1	50	60	PF02991	0.593
LIG_LIR_Nem_3	234	240	PF02991	0.560
LIG_LIR_Nem_3	50	56	PF02991	0.594
LIG_SH2_CRK	237	241	PF00017	0.564
LIG_SH2_PTP2	374	377	PF00017	0.716
LIG_SH2_SRC	107	110	PF00017	0.546
LIG_SH2_STAT3	235	238	PF00017	0.558
LIG_SH2_STAT5	235	238	PF00017	0.626
LIG_SH2_STAT5	374	377	PF00017	0.619
LIG_SH3_3	237	243	PF00018	0.563
LIG_SH3_3	28	34	PF00018	0.579
LIG_SH3_3	372	378	PF00018	0.694
LIG_TRAF2_1	306	309	PF00917	0.615
MOD_CDC14_SPxK_1	350	353	PF00782	0.615
MOD_CDK_SPxK_1	145	151	PF00069	0.621
MOD_CDK_SPxK_1	347	353	PF00069	0.621
MOD_CDK_SPxK_1	391	397	PF00069	0.707
MOD_CK1_1	116	122	PF00069	0.657
MOD_CK1_1	194	200	PF00069	0.535
MOD_CK1_1	216	222	PF00069	0.535
MOD_CK1_1	6	12	PF00069	0.671
MOD_CK1_1	80	86	PF00069	0.563
MOD_CK2_1	115	121	PF00069	0.589
MOD_CK2_1	181	187	PF00069	0.659
MOD_CMANNOS	168	171	PF00535	0.663
MOD_Cter_Amidation	23	26	PF01082	0.692
MOD_Cter_Amidation	92	95	PF01082	0.389
MOD_GlcNHglycan	130	133	PF01048	0.625
MOD_GlcNHglycan	20	23	PF01048	0.596
MOD_GlcNHglycan	201	204	PF01048	0.527
MOD_GlcNHglycan	243	246	PF01048	0.665
MOD_GlcNHglycan	324	327	PF01048	0.685
MOD_GlcNHglycan	334	337	PF01048	0.483
MOD_GlcNHglycan	6	9	PF01048	0.630
MOD_GSK3_1	14	21	PF00069	0.719
MOD_GSK3_1	145	152	PF00069	0.626
MOD_GSK3_1	243	250	PF00069	0.644
MOD_GSK3_1	25	32	PF00069	0.612
MOD_GSK3_1	257	264	PF00069	0.641
MOD_GSK3_1	267	274	PF00069	0.607
MOD_GSK3_1	322	329	PF00069	0.666
MOD_GSK3_1	347	354	PF00069	0.683
MOD_GSK3_1	45	52	PF00069	0.612
MOD_GSK3_1	63	70	PF00069	0.608
MOD_GSK3_1	77	84	PF00069	0.418
MOD_N-GLC_1	174	179	PF02516	0.518
MOD_N-GLC_1	18	23	PF02516	0.684
MOD_N-GLC_1	320	325	PF02516	0.651
MOD_NEK2_1	113	118	PF00069	0.622
MOD_NEK2_1	14	19	PF00069	0.718
MOD_NEK2_1	355	360	PF00069	0.640
MOD_PIKK_1	243	249	PF00454	0.722
MOD_PIKK_1	326	332	PF00454	0.686
MOD_PKA_1	155	161	PF00069	0.654
MOD_PKA_1	25	31	PF00069	0.768
MOD_PKA_2	155	161	PF00069	0.664
MOD_PKA_2	199	205	PF00069	0.631
MOD_PKA_2	216	222	PF00069	0.460
MOD_PKA_2	247	253	PF00069	0.664
MOD_PKA_2	25	31	PF00069	0.768
MOD_Plk_1	272	278	PF00069	0.535
MOD_Plk_1	320	326	PF00069	0.656
MOD_Plk_1	67	73	PF00069	0.608
MOD_Plk_4	272	278	PF00069	0.554
MOD_Plk_4	67	73	PF00069	0.525
MOD_Plk_4	77	83	PF00069	0.475
MOD_Plk_4	9	15	PF00069	0.750
MOD_ProDKin_1	145	151	PF00069	0.616
MOD_ProDKin_1	287	293	PF00069	0.634
MOD_ProDKin_1	347	353	PF00069	0.735
MOD_ProDKin_1	391	397	PF00069	0.746
MOD_ProDKin_1	45	51	PF00069	0.754
MOD_ProDKin_1	63	69	PF00069	0.615
MOD_SUMO_rev_2	152	157	PF00179	0.670
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.676
TRG_ENDOCYTIC_2	237	240	PF00928	0.560
TRG_ENDOCYTIC_2	285	288	PF00928	0.688
TRG_ENDOCYTIC_2	363	366	PF00928	0.624
TRG_ENDOCYTIC_2	374	377	PF00928	0.683
TRG_ER_diArg_1	154	157	PF00400	0.732
TRG_ER_diArg_1	225	228	PF00400	0.592
TRG_ER_diArg_1	296	299	PF00400	0.649
TRG_ER_diArg_1	363	365	PF00400	0.592
TRG_NES_CRM1_1	257	271	PF08389	0.626
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW0	Leptomonas seymouri	40%	84%
A0A3R7KL86	Trypanosoma rangeli	23%	100%
A0A451EJS2	Leishmania donovani	91%	99%
A4H3N4	Leishmania braziliensis	61%	73%
A4HRW1	Leishmania infantum	91%	99%
E9AJV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%