Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACL7_LEIMA

TriTrypDb:

LmjF.03.0720 , LMJLV39_030012600 , LMJSD75_030012700

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACL7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.552
CLV_C14_Caspase3-7	180	184	PF00656	0.480
CLV_C14_Caspase3-7	257	261	PF00656	0.683
CLV_C14_Caspase3-7	29	33	PF00656	0.659
CLV_C14_Caspase3-7	623	627	PF00656	0.492
CLV_NRD_NRD_1	10	12	PF00675	0.629
CLV_NRD_NRD_1	280	282	PF00675	0.653
CLV_NRD_NRD_1	389	391	PF00675	0.454
CLV_NRD_NRD_1	40	42	PF00675	0.720
CLV_NRD_NRD_1	414	416	PF00675	0.505
CLV_NRD_NRD_1	511	513	PF00675	0.809
CLV_NRD_NRD_1	667	669	PF00675	0.732
CLV_NRD_NRD_1	700	702	PF00675	0.540
CLV_NRD_NRD_1	732	734	PF00675	0.482
CLV_NRD_NRD_1	831	833	PF00675	0.767
CLV_NRD_NRD_1	848	850	PF00675	0.693
CLV_PCSK_FUR_1	35	39	PF00082	0.724
CLV_PCSK_FUR_1	698	702	PF00082	0.520
CLV_PCSK_KEX2_1	10	12	PF00082	0.629
CLV_PCSK_KEX2_1	279	281	PF00082	0.652
CLV_PCSK_KEX2_1	37	39	PF00082	0.728
CLV_PCSK_KEX2_1	389	391	PF00082	0.454
CLV_PCSK_KEX2_1	40	42	PF00082	0.671
CLV_PCSK_KEX2_1	413	415	PF00082	0.457
CLV_PCSK_KEX2_1	45	47	PF00082	0.605
CLV_PCSK_KEX2_1	511	513	PF00082	0.809
CLV_PCSK_KEX2_1	667	669	PF00082	0.677
CLV_PCSK_KEX2_1	700	702	PF00082	0.559
CLV_PCSK_KEX2_1	732	734	PF00082	0.482
CLV_PCSK_KEX2_1	76	78	PF00082	0.546
CLV_PCSK_KEX2_1	795	797	PF00082	0.510
CLV_PCSK_KEX2_1	830	832	PF00082	0.756
CLV_PCSK_KEX2_1	848	850	PF00082	0.676
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.728
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.605
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.546
CLV_PCSK_PC1ET2_1	795	797	PF00082	0.556
CLV_PCSK_PC7_1	35	41	PF00082	0.647
CLV_PCSK_PC7_1	791	797	PF00082	0.544
CLV_PCSK_SKI1_1	127	131	PF00082	0.594
CLV_PCSK_SKI1_1	141	145	PF00082	0.599
CLV_PCSK_SKI1_1	280	284	PF00082	0.643
CLV_PCSK_SKI1_1	415	419	PF00082	0.619
CLV_PCSK_SKI1_1	608	612	PF00082	0.539
CLV_PCSK_SKI1_1	620	624	PF00082	0.528
CLV_PCSK_SKI1_1	639	643	PF00082	0.513
CLV_PCSK_SKI1_1	66	70	PF00082	0.580
CLV_PCSK_SKI1_1	848	852	PF00082	0.665
CLV_Separin_Metazoa	7	11	PF03568	0.722
DEG_APCC_DBOX_1	140	148	PF00400	0.610
DEG_APCC_DBOX_1	607	615	PF00400	0.569
DEG_APCC_DBOX_1	638	646	PF00400	0.550
DEG_APCC_DBOX_1	76	84	PF00400	0.655
DEG_ODPH_VHL_1	632	644	PF01847	0.438
DEG_SCF_FBW7_1	14	19	PF00400	0.704
DEG_SPOP_SBC_1	705	709	PF00917	0.503
DEG_SPOP_SBC_1	835	839	PF00917	0.724
DOC_CYCLIN_RxL_1	138	148	PF00134	0.572
DOC_CYCLIN_RxL_1	636	646	PF00134	0.470
DOC_MAPK_gen_1	389	399	PF00069	0.592
DOC_MAPK_gen_1	605	615	PF00069	0.568
DOC_MAPK_gen_1	76	82	PF00069	0.565
DOC_MAPK_MEF2A_6	608	615	PF00069	0.549
DOC_MAPK_NFAT4_5	608	616	PF00069	0.575
DOC_MAPK_RevD_3	398	414	PF00069	0.517
DOC_MAPK_RevD_3	783	796	PF00069	0.527
DOC_PP1_RVXF_1	351	357	PF00149	0.412
DOC_PP2B_LxvP_1	365	368	PF13499	0.567
DOC_USP7_MATH_1	156	160	PF00917	0.397
DOC_USP7_MATH_1	16	20	PF00917	0.711
DOC_USP7_MATH_1	323	327	PF00917	0.718
DOC_USP7_MATH_1	330	334	PF00917	0.600
DOC_USP7_MATH_1	47	51	PF00917	0.611
DOC_USP7_MATH_1	522	526	PF00917	0.638
DOC_USP7_MATH_1	548	552	PF00917	0.775
DOC_USP7_MATH_1	592	596	PF00917	0.702
DOC_USP7_MATH_1	706	710	PF00917	0.512
DOC_USP7_MATH_1	755	759	PF00917	0.649
DOC_USP7_MATH_1	814	818	PF00917	0.647
DOC_USP7_MATH_1	835	839	PF00917	0.798
DOC_USP7_MATH_1	97	101	PF00917	0.676
DOC_WW_Pin1_4	10	15	PF00397	0.751
DOC_WW_Pin1_4	130	135	PF00397	0.640
DOC_WW_Pin1_4	196	201	PF00397	0.708
DOC_WW_Pin1_4	524	529	PF00397	0.730
DOC_WW_Pin1_4	531	536	PF00397	0.792
DOC_WW_Pin1_4	839	844	PF00397	0.781
DOC_WW_Pin1_4	87	92	PF00397	0.708
LIG_14-3-3_CanoR_1	109	116	PF00244	0.808
LIG_14-3-3_CanoR_1	230	234	PF00244	0.562
LIG_14-3-3_CanoR_1	338	347	PF00244	0.545
LIG_14-3-3_CanoR_1	511	517	PF00244	0.766
LIG_14-3-3_CanoR_1	602	608	PF00244	0.565
LIG_14-3-3_CanoR_1	620	626	PF00244	0.557
LIG_14-3-3_CanoR_1	639	645	PF00244	0.506
LIG_14-3-3_CanoR_1	66	75	PF00244	0.563
LIG_14-3-3_CanoR_1	818	826	PF00244	0.661
LIG_14-3-3_CanoR_1	848	855	PF00244	0.642
LIG_14-3-3_CanoR_1	857	865	PF00244	0.439
LIG_Actin_WH2_2	214	232	PF00022	0.552
LIG_APCC_ABBA_1	185	190	PF00400	0.572
LIG_BIR_III_2	504	508	PF00653	0.566
LIG_BIR_III_4	260	264	PF00653	0.678
LIG_BRCT_BRCA1_1	214	218	PF00533	0.545
LIG_BRCT_BRCA1_1	342	346	PF00533	0.495
LIG_BRCT_BRCA1_1	553	557	PF00533	0.660
LIG_CaM_NSCaTE_8	357	364	PF13499	0.525
LIG_Clathr_ClatBox_1	171	175	PF01394	0.605
LIG_FHA_1	155	161	PF00498	0.558
LIG_FHA_1	16	22	PF00498	0.760
LIG_FHA_1	254	260	PF00498	0.694
LIG_FHA_1	273	279	PF00498	0.521
LIG_FHA_1	322	328	PF00498	0.672
LIG_FHA_1	340	346	PF00498	0.380
LIG_FHA_1	368	374	PF00498	0.526
LIG_FHA_1	407	413	PF00498	0.494
LIG_FHA_1	444	450	PF00498	0.659
LIG_FHA_1	525	531	PF00498	0.753
LIG_FHA_1	575	581	PF00498	0.448
LIG_FHA_1	646	652	PF00498	0.589
LIG_FHA_1	655	661	PF00498	0.627
LIG_FHA_1	67	73	PF00498	0.532
LIG_FHA_1	672	678	PF00498	0.586
LIG_FHA_1	856	862	PF00498	0.494
LIG_FHA_1	864	870	PF00498	0.465
LIG_FHA_2	178	184	PF00498	0.426
LIG_FHA_2	208	214	PF00498	0.557
LIG_FHA_2	554	560	PF00498	0.666
LIG_FHA_2	592	598	PF00498	0.716
LIG_FHA_2	604	610	PF00498	0.401
LIG_FHA_2	621	627	PF00498	0.579
LIG_FHA_2	641	647	PF00498	0.216
LIG_FHA_2	788	794	PF00498	0.488
LIG_GBD_Chelix_1	181	189	PF00786	0.520
LIG_GBD_Chelix_1	299	307	PF00786	0.530
LIG_Integrin_isoDGR_2	292	294	PF01839	0.625
LIG_Integrin_RGD_1	457	459	PF01839	0.580
LIG_LIR_Gen_1	212	222	PF02991	0.422
LIG_LIR_Gen_1	342	351	PF02991	0.443
LIG_LIR_Gen_1	554	564	PF02991	0.485
LIG_LIR_Gen_1	687	697	PF02991	0.483
LIG_LIR_LC3C_4	378	383	PF02991	0.578
LIG_LIR_Nem_3	212	217	PF02991	0.435
LIG_LIR_Nem_3	342	347	PF02991	0.450
LIG_LIR_Nem_3	554	560	PF02991	0.514
LIG_LIR_Nem_3	687	693	PF02991	0.393
LIG_LIR_Nem_3	859	865	PF02991	0.443
LIG_NRBOX	138	144	PF00104	0.521
LIG_NRBOX	406	412	PF00104	0.439
LIG_NRBOX	640	646	PF00104	0.467
LIG_PCNA_yPIPBox_3	404	415	PF02747	0.560
LIG_RPA_C_Fungi	35	47	PF08784	0.492
LIG_RPA_C_Fungi	409	421	PF08784	0.589
LIG_RPA_C_Fungi	813	825	PF08784	0.647
LIG_SH2_CRK	214	218	PF00017	0.438
LIG_SH2_CRK	722	726	PF00017	0.594
LIG_SH2_GRB2like	671	674	PF00017	0.500
LIG_SH2_NCK_1	819	823	PF00017	0.661
LIG_SH2_STAP1	214	218	PF00017	0.438
LIG_SH2_STAP1	671	675	PF00017	0.698
LIG_SH2_STAP1	690	694	PF00017	0.275
LIG_SH2_STAP1	819	823	PF00017	0.688
LIG_SH2_STAP1	865	869	PF00017	0.520
LIG_SH2_STAT3	233	236	PF00017	0.649
LIG_SH2_STAT5	233	236	PF00017	0.649
LIG_SH2_STAT5	372	375	PF00017	0.493
LIG_SH2_STAT5	671	674	PF00017	0.770
LIG_SH2_STAT5	865	868	PF00017	0.568
LIG_SH3_1	700	706	PF00018	0.636
LIG_SH3_3	537	543	PF00018	0.701
LIG_SH3_3	577	583	PF00018	0.616
LIG_SH3_3	674	680	PF00018	0.690
LIG_SH3_3	699	705	PF00018	0.611
LIG_SH3_4	114	121	PF00018	0.722
LIG_SUMO_SIM_anti_2	304	309	PF11976	0.528
LIG_SUMO_SIM_anti_2	378	385	PF11976	0.582
LIG_SUMO_SIM_anti_2	396	401	PF11976	0.403
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.473
LIG_SUMO_SIM_par_1	640	646	PF11976	0.466
LIG_SUMO_SIM_par_1	682	687	PF11976	0.383
LIG_TRAF2_1	210	213	PF00917	0.589
LIG_TRAF2_1	238	241	PF00917	0.653
LIG_TYR_ITIM	688	693	PF00017	0.393
LIG_TYR_ITIM	720	725	PF00017	0.533
LIG_UBA3_1	171	179	PF00899	0.480
LIG_Vh1_VBS_1	67	85	PF01044	0.553
LIG_WW_3	582	586	PF00397	0.649
LIG_WW_3	701	705	PF00397	0.638
MOD_CK1_1	202	208	PF00069	0.612
MOD_CK1_1	406	412	PF00069	0.532
MOD_CK1_1	500	506	PF00069	0.683
MOD_CK1_1	551	557	PF00069	0.731
MOD_CK1_1	834	840	PF00069	0.800
MOD_CK2_1	207	213	PF00069	0.579
MOD_CK2_1	245	251	PF00069	0.809
MOD_CK2_1	591	597	PF00069	0.725
MOD_CK2_1	603	609	PF00069	0.384
MOD_CK2_1	640	646	PF00069	0.484
MOD_CK2_1	787	793	PF00069	0.495
MOD_Cter_Amidation	387	390	PF01082	0.441
MOD_Cter_Amidation	846	849	PF01082	0.623
MOD_GlcNHglycan	18	21	PF01048	0.741
MOD_GlcNHglycan	193	196	PF01048	0.622
MOD_GlcNHglycan	247	250	PF01048	0.792
MOD_GlcNHglycan	272	275	PF01048	0.674
MOD_GlcNHglycan	331	335	PF01048	0.621
MOD_GlcNHglycan	378	381	PF01048	0.525
MOD_GlcNHglycan	393	396	PF01048	0.589
MOD_GlcNHglycan	446	449	PF01048	0.589
MOD_GlcNHglycan	499	502	PF01048	0.659
MOD_GlcNHglycan	55	58	PF01048	0.732
MOD_GlcNHglycan	550	553	PF01048	0.741
MOD_GlcNHglycan	594	597	PF01048	0.686
MOD_GlcNHglycan	727	730	PF01048	0.577
MOD_GlcNHglycan	820	823	PF01048	0.635
MOD_GlcNHglycan	826	829	PF01048	0.685
MOD_GlcNHglycan	833	836	PF01048	0.757
MOD_GlcNHglycan	94	97	PF01048	0.746
MOD_GSK3_1	10	17	PF00069	0.671
MOD_GSK3_1	145	152	PF00069	0.414
MOD_GSK3_1	177	184	PF00069	0.512
MOD_GSK3_1	345	352	PF00069	0.505
MOD_GSK3_1	444	451	PF00069	0.585
MOD_GSK3_1	459	466	PF00069	0.833
MOD_GSK3_1	467	474	PF00069	0.824
MOD_GSK3_1	496	503	PF00069	0.720
MOD_GSK3_1	506	513	PF00069	0.666
MOD_GSK3_1	520	527	PF00069	0.569
MOD_GSK3_1	53	60	PF00069	0.700
MOD_GSK3_1	616	623	PF00069	0.545
MOD_GSK3_1	66	73	PF00069	0.506
MOD_GSK3_1	669	676	PF00069	0.774
MOD_GSK3_1	704	711	PF00069	0.679
MOD_GSK3_1	814	821	PF00069	0.640
MOD_GSK3_1	831	838	PF00069	0.744
MOD_GSK3_1	863	870	PF00069	0.474
MOD_GSK3_1	87	94	PF00069	0.719
MOD_N-GLC_1	339	344	PF02516	0.594
MOD_N-GLC_1	391	396	PF02516	0.596
MOD_N-GLC_1	92	97	PF02516	0.681
MOD_NEK2_1	154	159	PF00069	0.580
MOD_NEK2_1	181	186	PF00069	0.555
MOD_NEK2_1	217	222	PF00069	0.471
MOD_NEK2_1	229	234	PF00069	0.411
MOD_NEK2_1	303	308	PF00069	0.435
MOD_NEK2_1	339	344	PF00069	0.501
MOD_NEK2_1	345	350	PF00069	0.419
MOD_NEK2_1	403	408	PF00069	0.392
MOD_NEK2_1	497	502	PF00069	0.687
MOD_NEK2_1	603	608	PF00069	0.496
MOD_NEK2_1	615	620	PF00069	0.454
MOD_NEK2_1	645	650	PF00069	0.542
MOD_NEK2_1	747	752	PF00069	0.600
MOD_NEK2_1	787	792	PF00069	0.608
MOD_PIKK_1	448	454	PF00454	0.741
MOD_PIKK_1	706	712	PF00454	0.707
MOD_PKA_1	831	837	PF00069	0.706
MOD_PKA_1	848	854	PF00069	0.517
MOD_PKA_2	108	114	PF00069	0.739
MOD_PKA_2	137	143	PF00069	0.488
MOD_PKA_2	229	235	PF00069	0.607
MOD_PKA_2	510	516	PF00069	0.809
MOD_PKA_2	824	830	PF00069	0.704
MOD_PKA_2	831	837	PF00069	0.787
MOD_PKA_2	848	854	PF00069	0.522
MOD_PKA_2	856	862	PF00069	0.482
MOD_Plk_1	149	155	PF00069	0.553
MOD_Plk_1	212	218	PF00069	0.505
MOD_Plk_1	339	345	PF00069	0.592
MOD_Plk_2-3	254	260	PF00069	0.733
MOD_Plk_4	177	183	PF00069	0.516
MOD_Plk_4	212	218	PF00069	0.460
MOD_Plk_4	229	235	PF00069	0.598
MOD_Plk_4	254	260	PF00069	0.694
MOD_Plk_4	303	309	PF00069	0.514
MOD_Plk_4	340	346	PF00069	0.446
MOD_Plk_4	403	409	PF00069	0.394
MOD_Plk_4	553	559	PF00069	0.550
MOD_Plk_4	57	63	PF00069	0.658
MOD_Plk_4	640	646	PF00069	0.554
MOD_Plk_4	70	76	PF00069	0.498
MOD_ProDKin_1	10	16	PF00069	0.756
MOD_ProDKin_1	130	136	PF00069	0.631
MOD_ProDKin_1	196	202	PF00069	0.710
MOD_ProDKin_1	524	530	PF00069	0.734
MOD_ProDKin_1	531	537	PF00069	0.794
MOD_ProDKin_1	839	845	PF00069	0.779
MOD_ProDKin_1	87	93	PF00069	0.711
MOD_SUMO_for_1	794	797	PF00179	0.398
MOD_SUMO_rev_2	84	90	PF00179	0.695
TRG_DiLeu_BaEn_1	212	217	PF01217	0.510
TRG_DiLeu_BaEn_1	609	614	PF01217	0.569
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.603
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.508
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.513
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.550
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.538
TRG_DiLeu_BaLyEn_6	868	873	PF01217	0.534
TRG_ENDOCYTIC_2	214	217	PF00928	0.442
TRG_ENDOCYTIC_2	690	693	PF00928	0.470
TRG_ENDOCYTIC_2	722	725	PF00928	0.599
TRG_ER_diArg_1	278	281	PF00400	0.680
TRG_ER_diArg_1	38	41	PF00400	0.729
TRG_ER_diArg_1	412	415	PF00400	0.502
TRG_ER_diArg_1	599	602	PF00400	0.619
TRG_ER_diArg_1	666	668	PF00400	0.670
TRG_ER_diArg_1	697	700	PF00400	0.547
TRG_ER_diArg_1	731	733	PF00400	0.526
TRG_ER_diArg_1	764	767	PF00400	0.651
TRG_ER_diArg_1	830	832	PF00400	0.751
TRG_ER_diArg_1	9	11	PF00400	0.614
TRG_NLS_MonoCore_2	36	41	PF00514	0.648
TRG_NLS_MonoExtC_3	36	41	PF00514	0.725
TRG_NLS_MonoExtN_4	35	41	PF00514	0.725
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG87	Leptomonas seymouri	33%	80%
A0A3S5H555	Leishmania donovani	90%	99%
A0A422MU26	Trypanosoma rangeli	25%	100%
A4H3N3	Leishmania braziliensis	64%	82%
A4HRW0	Leishmania infantum	90%	79%
C9ZKG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AJV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	96%
V5BXD7	Trypanosoma cruzi	24%	100%