tRNA_edit domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminoacyl-tRNA editing domain containing protein, putative

Species:

Leishmania major

UniProt:

E9ACL6_LEIMA

TriTrypDb:

LmjF.03.0710 , LMJLV39_030012500 , LMJSD75_030012600

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACL6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	9
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0052689	carboxylic ester hydrolase activity	4	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140101	catalytic activity, acting on a tRNA	4	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	166	168	PF00082	0.254
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.274
CLV_PCSK_SKI1_1	130	134	PF00082	0.318
DEG_Nend_UBRbox_2	1	3	PF02207	0.450
DOC_MAPK_MEF2A_6	158	165	PF00069	0.463
DOC_MAPK_RevD_3	105	120	PF00069	0.509
DOC_PP1_RVXF_1	44	51	PF00149	0.353
DOC_USP7_MATH_1	114	118	PF00917	0.509
DOC_USP7_MATH_1	222	226	PF00917	0.655
DOC_USP7_MATH_1	24	28	PF00917	0.456
DOC_USP7_MATH_1	245	249	PF00917	0.596
DOC_USP7_UBL2_3	115	119	PF12436	0.472
DOC_USP7_UBL2_3	120	124	PF12436	0.438
DOC_USP7_UBL2_3	54	58	PF12436	0.598
DOC_USP7_UBL2_3	62	66	PF12436	0.590
DOC_WW_Pin1_4	87	92	PF00397	0.726
LIG_14-3-3_CanoR_1	19	24	PF00244	0.338
LIG_APCC_ABBA_1	151	156	PF00400	0.465
LIG_APCC_ABBA_1	157	162	PF00400	0.447
LIG_BRCT_BRCA1_1	46	50	PF00533	0.357
LIG_deltaCOP1_diTrp_1	198	206	PF00928	0.371
LIG_FHA_1	101	107	PF00498	0.461
LIG_FHA_1	15	21	PF00498	0.459
LIG_FHA_1	225	231	PF00498	0.533
LIG_FHA_1	27	33	PF00498	0.400
LIG_FHA_2	183	189	PF00498	0.509
LIG_FHA_2	20	26	PF00498	0.405
LIG_FHA_2	96	102	PF00498	0.619
LIG_GBD_Chelix_1	44	52	PF00786	0.367
LIG_LIR_Gen_1	198	204	PF02991	0.364
LIG_LIR_Nem_3	138	143	PF02991	0.509
LIG_LIR_Nem_3	198	202	PF02991	0.391
LIG_NRBOX	47	53	PF00104	0.408
LIG_SH2_PTP2	170	173	PF00017	0.509
LIG_SH2_SRC	160	163	PF00017	0.521
LIG_SH2_SRC	170	173	PF00017	0.521
LIG_SH2_STAP1	192	196	PF00017	0.477
LIG_SH2_STAT5	140	143	PF00017	0.509
LIG_SH2_STAT5	160	163	PF00017	0.521
LIG_SH2_STAT5	170	173	PF00017	0.521
LIG_SH3_4	54	61	PF00018	0.532
LIG_SUMO_SIM_anti_2	101	109	PF11976	0.405
LIG_WRC_WIRS_1	20	25	PF05994	0.339
MOD_CK1_1	26	32	PF00069	0.418
MOD_CK1_1	90	96	PF00069	0.705
MOD_CK2_1	182	188	PF00069	0.499
MOD_CK2_1	19	25	PF00069	0.407
MOD_CK2_1	54	60	PF00069	0.577
MOD_GlcNHglycan	247	250	PF01048	0.599
MOD_GlcNHglycan	25	29	PF01048	0.394
MOD_GlcNHglycan	77	81	PF01048	0.734
MOD_GlcNHglycan	87	90	PF01048	0.669
MOD_GSK3_1	19	26	PF00069	0.458
MOD_GSK3_1	218	225	PF00069	0.561
MOD_GSK3_1	245	252	PF00069	0.580
MOD_NEK2_1	161	166	PF00069	0.461
MOD_NEK2_1	23	28	PF00069	0.469
MOD_PIKK_1	70	76	PF00454	0.524
MOD_PIKK_1	90	96	PF00454	0.533
MOD_PKA_2	85	91	PF00069	0.638
MOD_Plk_1	161	167	PF00069	0.454
MOD_Plk_4	46	52	PF00069	0.392
MOD_ProDKin_1	87	93	PF00069	0.725
MOD_SUMO_for_1	132	135	PF00179	0.471
MOD_SUMO_rev_2	57	63	PF00179	0.582
TRG_ENDOCYTIC_2	140	143	PF00928	0.509
TRG_ENDOCYTIC_2	160	163	PF00928	0.521
TRG_NLS_MonoCore_2	52	57	PF00514	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U1	Leptomonas seymouri	62%	100%
A0A1X0P8W1	Trypanosomatidae	44%	100%
A0A3R7N573	Trypanosoma rangeli	38%	100%
A0A3S5H554	Leishmania donovani	82%	100%
A4H3N2	Leishmania braziliensis	71%	100%
A4HRV9	Leishmania infantum	83%	100%
E9AJV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%