Uroporphyrinogen-III synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uroporphyrinogen-III synthase HemD, putative

Species:

Leishmania major

UniProt:

E9ACL3_LEIMA

TriTrypDb:

LmjF.03.0680

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACL3

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006778	porphyrin-containing compound metabolic process	5	6
GO:0006779	porphyrin-containing compound biosynthetic process	6	6
GO:0006782	protoporphyrinogen IX biosynthetic process	7	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009987	cellular process	1	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019438	aromatic compound biosynthetic process	4	6
GO:0033013	tetrapyrrole metabolic process	4	6
GO:0033014	tetrapyrrole biosynthetic process	5	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044271	cellular nitrogen compound biosynthetic process	4	6
GO:0046483	heterocycle metabolic process	3	6
GO:0046501	protoporphyrinogen IX metabolic process	6	6
GO:0071704	organic substance metabolic process	2	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004852	uroporphyrinogen-III synthase activity	5	6
GO:0016829	lyase activity	2	6
GO:0016835	carbon-oxygen lyase activity	3	6
GO:0016836	hydro-lyase activity	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.417
CLV_NRD_NRD_1	233	235	PF00675	0.413
CLV_PCSK_KEX2_1	100	102	PF00082	0.491
CLV_PCSK_KEX2_1	16	18	PF00082	0.495
CLV_PCSK_KEX2_1	233	235	PF00082	0.452
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.526
CLV_PCSK_SKI1_1	100	104	PF00082	0.491
CLV_PCSK_SKI1_1	111	115	PF00082	0.316
CLV_PCSK_SKI1_1	47	51	PF00082	0.530
DOC_CKS1_1	38	43	PF01111	0.491
DOC_MAPK_gen_1	100	108	PF00069	0.415
DOC_MAPK_HePTP_8	22	34	PF00069	0.413
DOC_MAPK_MEF2A_6	25	34	PF00069	0.413
DOC_PP1_RVXF_1	216	223	PF00149	0.413
DOC_PP4_FxxP_1	169	172	PF00568	0.518
DOC_USP7_MATH_1	221	225	PF00917	0.485
DOC_USP7_MATH_1	61	65	PF00917	0.512
DOC_USP7_MATH_1	67	71	PF00917	0.436
DOC_USP7_UBL2_3	107	111	PF12436	0.413
DOC_USP7_UBL2_3	257	261	PF12436	0.413
DOC_WW_Pin1_4	137	142	PF00397	0.491
DOC_WW_Pin1_4	232	237	PF00397	0.505
DOC_WW_Pin1_4	37	42	PF00397	0.491
LIG_14-3-3_CanoR_1	100	109	PF00244	0.448
LIG_14-3-3_CanoR_1	129	136	PF00244	0.285
LIG_14-3-3_CanoR_1	198	205	PF00244	0.452
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_BRCT_BRCA1_1	14	18	PF00533	0.491
LIG_Clathr_ClatBox_1	239	243	PF01394	0.413
LIG_FHA_1	101	107	PF00498	0.394
LIG_FHA_1	156	162	PF00498	0.491
LIG_FHA_1	195	201	PF00498	0.491
LIG_FHA_2	168	174	PF00498	0.258
LIG_FHA_2	7	13	PF00498	0.497
LIG_HCF-1_HBM_1	76	79	PF13415	0.413
LIG_LIR_Apic_2	167	172	PF02991	0.439
LIG_LIR_Gen_1	122	130	PF02991	0.258
LIG_LIR_Gen_1	58	67	PF02991	0.483
LIG_LIR_Nem_3	122	128	PF02991	0.258
LIG_LIR_Nem_3	268	272	PF02991	0.491
LIG_LIR_Nem_3	58	62	PF02991	0.483
LIG_SH2_STAP1	14	18	PF00017	0.491
LIG_SH2_STAT5	123	126	PF00017	0.530
LIG_SH2_STAT5	250	253	PF00017	0.495
LIG_SH2_STAT5	59	62	PF00017	0.491
LIG_SH3_3	133	139	PF00018	0.510
LIG_SH3_3	158	164	PF00018	0.516
LIG_SUMO_SIM_anti_2	158	163	PF11976	0.491
LIG_SUMO_SIM_anti_2	227	232	PF11976	0.487
LIG_SxIP_EBH_1	25	34	PF03271	0.413
LIG_WRC_WIRS_1	269	274	PF05994	0.491
MOD_CK2_1	221	227	PF00069	0.491
MOD_CK2_1	6	12	PF00069	0.482
MOD_CK2_1	82	88	PF00069	0.375
MOD_GlcNHglycan	150	153	PF01048	0.512
MOD_GlcNHglycan	205	208	PF01048	0.386
MOD_GlcNHglycan	223	226	PF01048	0.334
MOD_GlcNHglycan	71	74	PF01048	0.524
MOD_GlcNHglycan	91	94	PF01048	0.199
MOD_GSK3_1	194	201	PF00069	0.491
MOD_GSK3_1	203	210	PF00069	0.487
MOD_N-GLC_1	213	218	PF02516	0.413
MOD_NEK2_1	148	153	PF00069	0.491
MOD_PK_1	213	219	PF00069	0.375
MOD_PKA_1	100	106	PF00069	0.491
MOD_PKA_2	100	106	PF00069	0.444
MOD_PKA_2	130	136	PF00069	0.289
MOD_PKB_1	127	135	PF00069	0.258
MOD_Plk_2-3	167	173	PF00069	0.258
MOD_Plk_2-3	268	274	PF00069	0.491
MOD_ProDKin_1	137	143	PF00069	0.491
MOD_ProDKin_1	232	238	PF00069	0.505
MOD_ProDKin_1	37	43	PF00069	0.491
TRG_DiLeu_BaEn_1	227	232	PF01217	0.491
TRG_DiLeu_BaEn_1	23	28	PF01217	0.528
TRG_ENDOCYTIC_2	59	62	PF00928	0.491
TRG_ER_diArg_1	127	130	PF00400	0.452
TRG_ER_diArg_1	232	234	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H553	Leishmania donovani	96%	100%
A4H3M9	Leishmania braziliensis	82%	100%
A4HRV6	Leishmania infantum	96%	100%
E9AJV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%