Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACL2_LEIMA

TriTrypDb:

LmjF.03.0670 , LMJLV39_030012000 , LMJSD75_030012100

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.611
CLV_NRD_NRD_1	306	308	PF00675	0.428
CLV_NRD_NRD_1	352	354	PF00675	0.461
CLV_NRD_NRD_1	43	45	PF00675	0.613
CLV_PCSK_KEX2_1	200	202	PF00082	0.611
CLV_PCSK_KEX2_1	306	308	PF00082	0.476
CLV_PCSK_KEX2_1	352	354	PF00082	0.461
CLV_PCSK_KEX2_1	43	45	PF00082	0.638
CLV_PCSK_KEX2_1	494	496	PF00082	0.505
CLV_PCSK_KEX2_1	7	9	PF00082	0.625
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.505
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.557
CLV_PCSK_PC7_1	39	45	PF00082	0.442
CLV_PCSK_SKI1_1	298	302	PF00082	0.480
CLV_PCSK_SKI1_1	352	356	PF00082	0.585
DEG_APCC_DBOX_1	427	435	PF00400	0.291
DEG_Nend_UBRbox_1	1	4	PF02207	0.671
DEG_SCF_FBW7_1	95	100	PF00400	0.584
DOC_CKS1_1	30	35	PF01111	0.426
DOC_MAPK_gen_1	200	206	PF00069	0.673
DOC_MAPK_gen_1	306	315	PF00069	0.372
DOC_MAPK_MEF2A_6	208	215	PF00069	0.681
DOC_MAPK_RevD_3	187	201	PF00069	0.414
DOC_PP2B_LxvP_1	38	41	PF13499	0.518
DOC_USP7_MATH_1	10	14	PF00917	0.513
DOC_USP7_MATH_1	242	246	PF00917	0.660
DOC_USP7_MATH_1	305	309	PF00917	0.468
DOC_USP7_MATH_1	325	329	PF00917	0.488
DOC_WW_Pin1_4	164	169	PF00397	0.623
DOC_WW_Pin1_4	213	218	PF00397	0.506
DOC_WW_Pin1_4	29	34	PF00397	0.399
DOC_WW_Pin1_4	361	366	PF00397	0.586
DOC_WW_Pin1_4	436	441	PF00397	0.590
DOC_WW_Pin1_4	468	473	PF00397	0.547
DOC_WW_Pin1_4	93	98	PF00397	0.761
LIG_14-3-3_CanoR_1	110	118	PF00244	0.466
LIG_14-3-3_CanoR_1	184	191	PF00244	0.547
LIG_14-3-3_CanoR_1	200	206	PF00244	0.620
LIG_14-3-3_CanoR_1	307	315	PF00244	0.409
LIG_14-3-3_CanoR_1	336	344	PF00244	0.539
LIG_14-3-3_CanoR_1	361	365	PF00244	0.540
LIG_14-3-3_CanoR_1	414	421	PF00244	0.580
LIG_14-3-3_CanoR_1	436	440	PF00244	0.493
LIG_AP2alpha_2	79	81	PF02296	0.401
LIG_APCC_ABBAyCdc20_2	227	233	PF00400	0.494
LIG_BRCT_BRCA1_1	550	554	PF00533	0.381
LIG_CtBP_PxDLS_1	212	216	PF00389	0.531
LIG_deltaCOP1_diTrp_1	226	231	PF00928	0.504
LIG_eIF4E_1	219	225	PF01652	0.453
LIG_FHA_1	101	107	PF00498	0.594
LIG_FHA_1	134	140	PF00498	0.514
LIG_FHA_1	184	190	PF00498	0.521
LIG_FHA_1	191	197	PF00498	0.552
LIG_FHA_1	310	316	PF00498	0.354
LIG_FHA_1	35	41	PF00498	0.465
LIG_FHA_1	375	381	PF00498	0.512
LIG_FHA_1	414	420	PF00498	0.637
LIG_FHA_1	424	430	PF00498	0.270
LIG_FHA_1	556	562	PF00498	0.460
LIG_FHA_2	336	342	PF00498	0.460
LIG_FHA_2	507	513	PF00498	0.473
LIG_GBD_Chelix_1	556	564	PF00786	0.476
LIG_LIR_Apic_2	509	514	PF02991	0.500
LIG_LIR_Gen_1	126	132	PF02991	0.706
LIG_LIR_Gen_1	226	236	PF02991	0.529
LIG_LIR_LC3C_4	299	303	PF02991	0.399
LIG_LIR_Nem_3	126	130	PF02991	0.705
LIG_LIR_Nem_3	226	231	PF02991	0.373
LIG_LIR_Nem_3	279	284	PF02991	0.440
LIG_LIR_Nem_3	443	449	PF02991	0.474
LIG_LIR_Nem_3	77	81	PF02991	0.355
LIG_PCNA_yPIPBox_3	170	181	PF02747	0.488
LIG_PDZ_Class_3	564	569	PF00595	0.417
LIG_Pex14_1	74	78	PF04695	0.482
LIG_PTAP_UEV_1	52	57	PF05743	0.483
LIG_Rb_LxCxE_1	541	563	PF01857	0.434
LIG_SH2_CRK	22	26	PF00017	0.484
LIG_SH2_CRK	511	515	PF00017	0.493
LIG_SH2_NCK_1	511	515	PF00017	0.493
LIG_SH2_PTP2	127	130	PF00017	0.516
LIG_SH2_SRC	145	148	PF00017	0.617
LIG_SH2_STAP1	219	223	PF00017	0.502
LIG_SH2_STAT5	127	130	PF00017	0.510
LIG_SH3_3	112	118	PF00018	0.452
LIG_SH3_3	153	159	PF00018	0.672
LIG_SH3_3	236	242	PF00018	0.514
LIG_SH3_3	299	305	PF00018	0.433
LIG_SH3_3	394	400	PF00018	0.478
LIG_SH3_3	50	56	PF00018	0.556
LIG_SH3_3	92	98	PF00018	0.712
LIG_Sin3_3	234	241	PF02671	0.440
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.432
LIG_SUMO_SIM_par_1	211	216	PF11976	0.713
LIG_SUMO_SIM_par_1	447	453	PF11976	0.490
LIG_SUMO_SIM_par_1	456	461	PF11976	0.394
LIG_TYR_ITIM	20	25	PF00017	0.497
LIG_WRC_WIRS_1	399	404	PF05994	0.337
MOD_CDC14_SPxK_1	167	170	PF00782	0.613
MOD_CDK_SPxK_1	164	170	PF00069	0.628
MOD_CDK_SPxK_1	470	476	PF00069	0.555
MOD_CK1_1	245	251	PF00069	0.581
MOD_CK1_1	308	314	PF00069	0.375
MOD_CK1_1	327	333	PF00069	0.631
MOD_CK1_1	51	57	PF00069	0.613
MOD_CK1_1	563	569	PF00069	0.564
MOD_CK2_1	335	341	PF00069	0.508
MOD_DYRK1A_RPxSP_1	436	440	PF00069	0.493
MOD_GlcNHglycan	111	114	PF01048	0.514
MOD_GlcNHglycan	221	224	PF01048	0.603
MOD_GlcNHglycan	244	247	PF01048	0.613
MOD_GlcNHglycan	307	310	PF01048	0.387
MOD_GlcNHglycan	318	321	PF01048	0.347
MOD_GlcNHglycan	327	330	PF01048	0.584
MOD_GlcNHglycan	468	471	PF01048	0.585
MOD_GlcNHglycan	53	56	PF01048	0.574
MOD_GlcNHglycan	67	70	PF01048	0.545
MOD_GlcNHglycan	86	90	PF01048	0.594
MOD_GSK3_1	105	112	PF00069	0.601
MOD_GSK3_1	192	199	PF00069	0.591
MOD_GSK3_1	237	244	PF00069	0.477
MOD_GSK3_1	245	252	PF00069	0.501
MOD_GSK3_1	289	296	PF00069	0.464
MOD_GSK3_1	305	312	PF00069	0.359
MOD_GSK3_1	323	330	PF00069	0.576
MOD_GSK3_1	356	363	PF00069	0.516
MOD_GSK3_1	436	443	PF00069	0.581
MOD_GSK3_1	466	473	PF00069	0.505
MOD_GSK3_1	47	54	PF00069	0.686
MOD_GSK3_1	61	68	PF00069	0.502
MOD_GSK3_1	85	92	PF00069	0.603
MOD_GSK3_1	93	100	PF00069	0.641
MOD_N-GLC_1	538	543	PF02516	0.399
MOD_N-GLC_1	65	70	PF02516	0.447
MOD_NEK2_1	106	111	PF00069	0.435
MOD_NEK2_1	196	201	PF00069	0.540
MOD_NEK2_1	249	254	PF00069	0.541
MOD_NEK2_1	323	328	PF00069	0.469
MOD_NEK2_1	34	39	PF00069	0.545
MOD_NEK2_1	368	373	PF00069	0.447
MOD_NEK2_1	423	428	PF00069	0.571
MOD_NEK2_1	506	511	PF00069	0.436
MOD_NEK2_1	560	565	PF00069	0.452
MOD_NEK2_1	61	66	PF00069	0.452
MOD_PIKK_1	130	136	PF00454	0.436
MOD_PIKK_1	249	255	PF00454	0.604
MOD_PIKK_1	441	447	PF00454	0.575
MOD_PIKK_1	555	561	PF00454	0.470
MOD_PKA_2	109	115	PF00069	0.450
MOD_PKA_2	183	189	PF00069	0.535
MOD_PKA_2	199	205	PF00069	0.603
MOD_PKA_2	305	311	PF00069	0.385
MOD_PKA_2	335	341	PF00069	0.543
MOD_PKA_2	360	366	PF00069	0.538
MOD_PKA_2	413	419	PF00069	0.574
MOD_PKA_2	435	441	PF00069	0.478
MOD_Plk_1	65	71	PF00069	0.445
MOD_Plk_4	192	198	PF00069	0.643
MOD_Plk_4	363	369	PF00069	0.470
MOD_Plk_4	398	404	PF00069	0.515
MOD_Plk_4	560	566	PF00069	0.419
MOD_ProDKin_1	164	170	PF00069	0.623
MOD_ProDKin_1	213	219	PF00069	0.507
MOD_ProDKin_1	29	35	PF00069	0.400
MOD_ProDKin_1	361	367	PF00069	0.576
MOD_ProDKin_1	436	442	PF00069	0.594
MOD_ProDKin_1	468	474	PF00069	0.547
MOD_ProDKin_1	93	99	PF00069	0.762
TRG_DiLeu_BaEn_2	397	403	PF01217	0.477
TRG_DiLeu_BaEn_2	76	82	PF01217	0.438
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.540
TRG_ENDOCYTIC_2	127	130	PF00928	0.571
TRG_ENDOCYTIC_2	22	25	PF00928	0.486
TRG_ENDOCYTIC_2	281	284	PF00928	0.428
TRG_ENDOCYTIC_2	78	81	PF00928	0.360
TRG_ER_diArg_1	305	307	PF00400	0.494
TRG_ER_diArg_1	351	353	PF00400	0.560
TRG_ER_diArg_1	42	44	PF00400	0.600
TRG_ER_diArg_1	427	430	PF00400	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSY5	Leptomonas seymouri	54%	98%
A0A1X0P955	Trypanosomatidae	30%	100%
A0A3S5H552	Leishmania donovani	95%	100%
A0A422NMI0	Trypanosoma rangeli	30%	100%
A4H3M8	Leishmania braziliensis	85%	100%
D0A270	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AG56	Leishmania infantum	95%	100%
E9AJV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BXE2	Trypanosoma cruzi	32%	100%