Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACL1_LEIMA

TriTrypDb:

LmjF.03.0660 , LMJLV39_030011900 , LMJSD75_030012000

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ACL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.709
CLV_C14_Caspase3-7	494	498	PF00656	0.658
CLV_C14_Caspase3-7	517	521	PF00656	0.752
CLV_C14_Caspase3-7	639	643	PF00656	0.358
CLV_C14_Caspase3-7	725	729	PF00656	0.488
CLV_NRD_NRD_1	100	102	PF00675	0.506
CLV_NRD_NRD_1	256	258	PF00675	0.430
CLV_NRD_NRD_1	321	323	PF00675	0.384
CLV_NRD_NRD_1	5	7	PF00675	0.443
CLV_PCSK_KEX2_1	100	102	PF00082	0.505
CLV_PCSK_KEX2_1	256	258	PF00082	0.430
CLV_PCSK_KEX2_1	321	323	PF00082	0.384
CLV_PCSK_SKI1_1	112	116	PF00082	0.483
CLV_PCSK_SKI1_1	314	318	PF00082	0.474
CLV_PCSK_SKI1_1	397	401	PF00082	0.370
CLV_PCSK_SKI1_1	481	485	PF00082	0.518
CLV_PCSK_SKI1_1	574	578	PF00082	0.405
CLV_PCSK_SKI1_1	635	639	PF00082	0.587
DEG_APCC_DBOX_1	182	190	PF00400	0.579
DEG_SCF_FBW7_1	418	423	PF00400	0.687
DEG_SCF_FBW7_1	527	534	PF00400	0.670
DEG_SCF_FBW7_2	134	141	PF00400	0.687
DOC_CYCLIN_RxL_1	109	119	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	678	684	PF00134	0.525
DOC_MAPK_gen_1	183	191	PF00069	0.559
DOC_MAPK_gen_1	256	262	PF00069	0.626
DOC_MAPK_gen_1	321	328	PF00069	0.586
DOC_MAPK_gen_1	6	14	PF00069	0.752
DOC_MAPK_HePTP_8	4	16	PF00069	0.753
DOC_MAPK_MEF2A_6	357	364	PF00069	0.346
DOC_MAPK_MEF2A_6	7	16	PF00069	0.755
DOC_PP2B_LxvP_1	365	368	PF13499	0.525
DOC_PP4_FxxP_1	121	124	PF00568	0.685
DOC_PP4_FxxP_1	234	237	PF00568	0.405
DOC_USP7_MATH_1	105	109	PF00917	0.688
DOC_USP7_MATH_1	280	284	PF00917	0.525
DOC_USP7_MATH_1	41	45	PF00917	0.806
DOC_USP7_MATH_1	420	424	PF00917	0.732
DOC_USP7_MATH_1	513	517	PF00917	0.766
DOC_USP7_MATH_1	538	542	PF00917	0.800
DOC_USP7_MATH_1	57	61	PF00917	0.737
DOC_USP7_MATH_1	670	674	PF00917	0.405
DOC_WW_Pin1_4	120	125	PF00397	0.697
DOC_WW_Pin1_4	134	139	PF00397	0.659
DOC_WW_Pin1_4	224	229	PF00397	0.436
DOC_WW_Pin1_4	416	421	PF00397	0.748
DOC_WW_Pin1_4	436	441	PF00397	0.594
DOC_WW_Pin1_4	527	532	PF00397	0.760
DOC_WW_Pin1_4	677	682	PF00397	0.405
DOC_WW_Pin1_4	698	703	PF00397	0.515
LIG_14-3-3_CanoR_1	100	109	PF00244	0.669
LIG_14-3-3_CanoR_1	117	122	PF00244	0.737
LIG_14-3-3_CanoR_1	126	131	PF00244	0.713
LIG_14-3-3_CanoR_1	148	152	PF00244	0.630
LIG_14-3-3_CanoR_1	170	175	PF00244	0.580
LIG_14-3-3_CanoR_1	574	580	PF00244	0.599
LIG_14-3-3_CanoR_1	746	755	PF00244	0.692
LIG_Actin_WH2_2	548	564	PF00022	0.711
LIG_AP2alpha_1	277	281	PF02296	0.356
LIG_BIR_II_1	1	5	PF00653	0.746
LIG_BIR_III_2	612	616	PF00653	0.481
LIG_BIR_III_4	502	506	PF00653	0.741
LIG_BRCT_BRCA1_1	258	262	PF00533	0.585
LIG_BRCT_BRCA1_1	365	369	PF00533	0.405
LIG_BRCT_BRCA1_1	422	426	PF00533	0.731
LIG_deltaCOP1_diTrp_1	355	364	PF00928	0.346
LIG_deltaCOP1_diTrp_1	700	708	PF00928	0.306
LIG_eIF4E_1	455	461	PF01652	0.708
LIG_FHA_1	169	175	PF00498	0.578
LIG_FHA_1	190	196	PF00498	0.516
LIG_FHA_1	291	297	PF00498	0.484
LIG_FHA_1	538	544	PF00498	0.716
LIG_FHA_1	603	609	PF00498	0.405
LIG_FHA_1	76	82	PF00498	0.729
LIG_FHA_2	17	23	PF00498	0.749
LIG_FHA_2	398	404	PF00498	0.624
LIG_FHA_2	637	643	PF00498	0.389
LIG_FHA_2	725	731	PF00498	0.643
LIG_LIR_Apic_2	119	124	PF02991	0.686
LIG_LIR_Apic_2	232	237	PF02991	0.346
LIG_LIR_Apic_2	557	563	PF02991	0.710
LIG_LIR_Gen_1	320	331	PF02991	0.550
LIG_LIR_Gen_1	378	388	PF02991	0.565
LIG_LIR_Nem_3	320	326	PF02991	0.603
LIG_LIR_Nem_3	343	348	PF02991	0.519
LIG_LIR_Nem_3	355	361	PF02991	0.346
LIG_LIR_Nem_3	366	372	PF02991	0.292
LIG_LIR_Nem_3	378	383	PF02991	0.467
LIG_NRBOX	243	249	PF00104	0.405
LIG_PCNA_PIPBox_1	211	220	PF02747	0.444
LIG_Pex14_1	218	222	PF04695	0.466
LIG_Pex14_1	284	288	PF04695	0.435
LIG_Pex14_1	359	363	PF04695	0.525
LIG_Pex14_1	376	380	PF04695	0.447
LIG_Pex14_2	241	245	PF04695	0.525
LIG_Pex14_2	277	281	PF04695	0.386
LIG_Pex14_2	311	315	PF04695	0.405
LIG_Pex14_2	644	648	PF04695	0.405
LIG_Pex14_2	708	712	PF04695	0.260
LIG_REV1ctd_RIR_1	424	432	PF16727	0.680
LIG_SH2_CRK	252	256	PF00017	0.395
LIG_SH2_CRK	323	327	PF00017	0.546
LIG_SH2_CRK	345	349	PF00017	0.479
LIG_SH2_CRK	380	384	PF00017	0.554
LIG_SH2_CRK	646	650	PF00017	0.525
LIG_SH2_GRB2like	323	326	PF00017	0.655
LIG_SH2_GRB2like	663	666	PF00017	0.553
LIG_SH2_GRB2like	704	707	PF00017	0.329
LIG_SH2_NCK_1	323	327	PF00017	0.546
LIG_SH2_SRC	323	326	PF00017	0.655
LIG_SH2_SRC	663	666	PF00017	0.432
LIG_SH2_STAP1	231	235	PF00017	0.432
LIG_SH2_STAP1	288	292	PF00017	0.379
LIG_SH2_STAP1	308	312	PF00017	0.320
LIG_SH2_STAP1	323	327	PF00017	0.457
LIG_SH2_STAP1	667	671	PF00017	0.632
LIG_SH2_STAP1	736	740	PF00017	0.582
LIG_SH2_STAT5	231	234	PF00017	0.428
LIG_SH2_STAT5	252	255	PF00017	0.465
LIG_SH2_STAT5	292	295	PF00017	0.390
LIG_SH2_STAT5	327	330	PF00017	0.525
LIG_SH2_STAT5	384	387	PF00017	0.656
LIG_SH2_STAT5	560	563	PF00017	0.713
LIG_SH2_STAT5	646	649	PF00017	0.525
LIG_SH2_STAT5	650	653	PF00017	0.460
LIG_SH2_STAT5	658	661	PF00017	0.330
LIG_SH2_STAT5	663	666	PF00017	0.276
LIG_SH2_STAT5	720	723	PF00017	0.410
LIG_SH3_2	569	574	PF14604	0.611
LIG_SH3_3	171	177	PF00018	0.639
LIG_SH3_3	431	437	PF00018	0.685
LIG_SH3_3	532	538	PF00018	0.768
LIG_SH3_3	566	572	PF00018	0.718
LIG_SH3_3	685	691	PF00018	0.405
LIG_SUMO_SIM_anti_2	683	689	PF11976	0.525
LIG_SUMO_SIM_par_1	686	692	PF11976	0.405
LIG_TRAF2_1	34	37	PF00917	0.743
LIG_TRAF2_1	400	403	PF00917	0.574
LIG_WW_2	569	572	PF00397	0.677
MOD_CDC14_SPxK_1	123	126	PF00782	0.621
MOD_CDK_SPxK_1	120	126	PF00069	0.620
MOD_CK1_1	120	126	PF00069	0.723
MOD_CK1_1	166	172	PF00069	0.672
MOD_CK1_1	221	227	PF00069	0.445
MOD_CK1_1	291	297	PF00069	0.397
MOD_CK1_1	44	50	PF00069	0.841
MOD_CK1_1	516	522	PF00069	0.743
MOD_CK1_1	673	679	PF00069	0.525
MOD_CK1_1	680	686	PF00069	0.411
MOD_CK1_1	75	81	PF00069	0.794
MOD_CK2_1	31	37	PF00069	0.727
MOD_CK2_1	397	403	PF00069	0.596
MOD_CK2_1	406	412	PF00069	0.632
MOD_CK2_1	459	465	PF00069	0.622
MOD_CK2_1	531	537	PF00069	0.731
MOD_CK2_1	550	556	PF00069	0.603
MOD_CK2_1	724	730	PF00069	0.642
MOD_CK2_1	745	751	PF00069	0.719
MOD_GlcNHglycan	408	411	PF01048	0.503
MOD_GlcNHglycan	461	464	PF01048	0.457
MOD_GlcNHglycan	523	526	PF01048	0.514
MOD_GlcNHglycan	551	555	PF01048	0.518
MOD_GlcNHglycan	59	62	PF01048	0.519
MOD_GlcNHglycan	623	626	PF01048	0.592
MOD_GlcNHglycan	667	670	PF01048	0.426
MOD_GlcNHglycan	96	99	PF01048	0.425
MOD_GSK3_1	116	123	PF00069	0.723
MOD_GSK3_1	140	147	PF00069	0.649
MOD_GSK3_1	159	166	PF00069	0.622
MOD_GSK3_1	280	287	PF00069	0.405
MOD_GSK3_1	41	48	PF00069	0.836
MOD_GSK3_1	412	419	PF00069	0.719
MOD_GSK3_1	487	494	PF00069	0.701
MOD_GSK3_1	515	522	PF00069	0.725
MOD_GSK3_1	527	534	PF00069	0.699
MOD_GSK3_1	617	624	PF00069	0.400
MOD_GSK3_1	673	680	PF00069	0.507
MOD_N-GLC_1	229	234	PF02516	0.566
MOD_N-GLC_1	75	80	PF02516	0.560
MOD_N-GLC_2	303	305	PF02516	0.405
MOD_NEK2_1	125	130	PF00069	0.705
MOD_NEK2_1	163	168	PF00069	0.683
MOD_NEK2_1	189	194	PF00069	0.534
MOD_NEK2_1	317	322	PF00069	0.597
MOD_NEK2_1	332	337	PF00069	0.359
MOD_NEK2_1	340	345	PF00069	0.407
MOD_NEK2_1	363	368	PF00069	0.525
MOD_NEK2_1	487	492	PF00069	0.678
MOD_NEK2_1	602	607	PF00069	0.435
MOD_NEK2_1	648	653	PF00069	0.519
MOD_NEK2_1	654	659	PF00069	0.433
MOD_NEK2_2	327	332	PF00069	0.447
MOD_NEK2_2	572	577	PF00069	0.677
MOD_NEK2_2	636	641	PF00069	0.399
MOD_PIKK_1	189	195	PF00454	0.492
MOD_PIKK_1	23	29	PF00454	0.677
MOD_PIKK_1	673	679	PF00454	0.525
MOD_PK_1	126	132	PF00069	0.635
MOD_PK_1	170	176	PF00069	0.627
MOD_PK_1	492	498	PF00069	0.725
MOD_PKA_1	100	106	PF00069	0.666
MOD_PKA_1	256	262	PF00069	0.540
MOD_PKA_2	100	106	PF00069	0.666
MOD_PKA_2	116	122	PF00069	0.716
MOD_PKA_2	125	131	PF00069	0.679
MOD_PKA_2	147	153	PF00069	0.627
MOD_PKA_2	256	262	PF00069	0.661
MOD_PKA_2	41	47	PF00069	0.809
MOD_PKA_2	412	418	PF00069	0.682
MOD_PKA_2	561	567	PF00069	0.707
MOD_PKA_2	745	751	PF00069	0.667
MOD_PKB_1	395	403	PF00069	0.614
MOD_PKB_1	744	752	PF00069	0.632
MOD_Plk_1	229	235	PF00069	0.364
MOD_Plk_1	42	48	PF00069	0.739
MOD_Plk_1	456	462	PF00069	0.604
MOD_Plk_1	584	590	PF00069	0.663
MOD_Plk_1	75	81	PF00069	0.727
MOD_Plk_2-3	724	730	PF00069	0.677
MOD_Plk_4	159	165	PF00069	0.641
MOD_Plk_4	170	176	PF00069	0.597
MOD_Plk_4	280	286	PF00069	0.405
MOD_Plk_4	327	333	PF00069	0.519
MOD_Plk_4	340	346	PF00069	0.320
MOD_Plk_4	375	381	PF00069	0.491
MOD_Plk_4	422	428	PF00069	0.732
MOD_Plk_4	584	590	PF00069	0.519
MOD_Plk_4	595	601	PF00069	0.292
MOD_Plk_4	670	676	PF00069	0.525
MOD_Plk_4	75	81	PF00069	0.762
MOD_ProDKin_1	120	126	PF00069	0.699
MOD_ProDKin_1	134	140	PF00069	0.659
MOD_ProDKin_1	224	230	PF00069	0.430
MOD_ProDKin_1	416	422	PF00069	0.750
MOD_ProDKin_1	436	442	PF00069	0.594
MOD_ProDKin_1	527	533	PF00069	0.760
MOD_ProDKin_1	677	683	PF00069	0.405
MOD_ProDKin_1	698	704	PF00069	0.512
MOD_SUMO_rev_2	735	740	PF00179	0.565
TRG_DiLeu_BaEn_1	751	756	PF01217	0.626
TRG_ENDOCYTIC_2	231	234	PF00928	0.445
TRG_ENDOCYTIC_2	252	255	PF00928	0.465
TRG_ENDOCYTIC_2	308	311	PF00928	0.502
TRG_ENDOCYTIC_2	323	326	PF00928	0.524
TRG_ENDOCYTIC_2	345	348	PF00928	0.490
TRG_ENDOCYTIC_2	380	383	PF00928	0.555
TRG_ENDOCYTIC_2	646	649	PF00928	0.503
TRG_ENDOCYTIC_2	704	707	PF00928	0.432
TRG_ER_diArg_1	255	257	PF00400	0.645
TRG_ER_diArg_1	321	323	PF00400	0.549
TRG_ER_diArg_1	394	397	PF00400	0.597
TRG_ER_diArg_1	743	746	PF00400	0.592
TRG_ER_diArg_1	99	101	PF00400	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJR6	Leishmania donovani	88%	95%
A4H3M7	Leishmania braziliensis	67%	95%
E9AG55	Leishmania infantum	88%	95%
E9AJU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	93%