LeishMANIAdb
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EamA domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
EamA domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania major
UniProt:
E9ACL0_LEIMA
TriTrypDb:
LmjF.03.0650 , LMJLV39_030011800 * , LMJSD75_030011900 *
Length:
893

Annotations

LeishMANIAdb annotations

This highly expanded family of Kinetoplastid transporters is likely responsible for the uptake of critical nutrients. Might be a thiamine transporter if relate to human SLC35F proteins.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9ACL0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACL0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 213 217 PF00656 0.813
CLV_C14_Caspase3-7 357 361 PF00656 0.412
CLV_C14_Caspase3-7 600 604 PF00656 0.672
CLV_C14_Caspase3-7 880 884 PF00656 0.698
CLV_C14_Caspase3-7 93 97 PF00656 0.679
CLV_MEL_PAP_1 297 303 PF00089 0.302
CLV_NRD_NRD_1 107 109 PF00675 0.498
CLV_NRD_NRD_1 258 260 PF00675 0.446
CLV_NRD_NRD_1 299 301 PF00675 0.348
CLV_NRD_NRD_1 399 401 PF00675 0.322
CLV_NRD_NRD_1 532 534 PF00675 0.484
CLV_NRD_NRD_1 70 72 PF00675 0.507
CLV_NRD_NRD_1 863 865 PF00675 0.489
CLV_NRD_NRD_1 868 870 PF00675 0.481
CLV_PCSK_FUR_1 861 865 PF00082 0.493
CLV_PCSK_KEX2_1 107 109 PF00082 0.498
CLV_PCSK_KEX2_1 258 260 PF00082 0.446
CLV_PCSK_KEX2_1 299 301 PF00082 0.363
CLV_PCSK_KEX2_1 399 401 PF00082 0.322
CLV_PCSK_KEX2_1 532 534 PF00082 0.484
CLV_PCSK_KEX2_1 69 71 PF00082 0.508
CLV_PCSK_KEX2_1 863 865 PF00082 0.489
CLV_PCSK_KEX2_1 867 869 PF00082 0.481
CLV_PCSK_PC7_1 863 869 PF00082 0.477
CLV_PCSK_SKI1_1 413 417 PF00082 0.389
CLV_PCSK_SKI1_1 457 461 PF00082 0.399
CLV_PCSK_SKI1_1 510 514 PF00082 0.594
DEG_APCC_DBOX_1 141 149 PF00400 0.698
DEG_SCF_FBW7_1 44 50 PF00400 0.701
DEG_SCF_TRCP1_1 834 840 PF00400 0.605
DEG_SPOP_SBC_1 12 16 PF00917 0.686
DEG_SPOP_SBC_1 301 305 PF00917 0.477
DEG_SPOP_SBC_1 347 351 PF00917 0.471
DOC_CKS1_1 168 173 PF01111 0.651
DOC_CKS1_1 44 49 PF01111 0.699
DOC_CKS1_1 593 598 PF01111 0.665
DOC_CYCLIN_RxL_1 454 462 PF00134 0.323
DOC_CYCLIN_yCln2_LP_2 29 35 PF00134 0.659
DOC_CYCLIN_yCln2_LP_2 749 755 PF00134 0.304
DOC_MAPK_gen_1 399 405 PF00069 0.515
DOC_MAPK_gen_1 532 540 PF00069 0.261
DOC_MAPK_MEF2A_6 464 473 PF00069 0.556
DOC_PP1_RVXF_1 411 417 PF00149 0.484
DOC_PP2B_LxvP_1 541 544 PF13499 0.369
DOC_PP4_FxxP_1 25 28 PF00568 0.697
DOC_USP7_MATH_1 33 37 PF00917 0.646
DOC_USP7_MATH_1 347 351 PF00917 0.469
DOC_USP7_MATH_1 369 373 PF00917 0.350
DOC_USP7_MATH_1 423 427 PF00917 0.369
DOC_USP7_MATH_1 483 487 PF00917 0.304
DOC_USP7_MATH_1 591 595 PF00917 0.663
DOC_USP7_MATH_1 601 605 PF00917 0.627
DOC_USP7_MATH_1 81 85 PF00917 0.784
DOC_USP7_MATH_1 884 888 PF00917 0.695
DOC_USP7_UBL2_3 457 461 PF12436 0.370
DOC_WW_Pin1_4 167 172 PF00397 0.640
DOC_WW_Pin1_4 259 264 PF00397 0.682
DOC_WW_Pin1_4 282 287 PF00397 0.629
DOC_WW_Pin1_4 34 39 PF00397 0.684
DOC_WW_Pin1_4 43 48 PF00397 0.677
DOC_WW_Pin1_4 433 438 PF00397 0.317
DOC_WW_Pin1_4 523 528 PF00397 0.503
DOC_WW_Pin1_4 57 62 PF00397 0.703
DOC_WW_Pin1_4 592 597 PF00397 0.663
DOC_WW_Pin1_4 610 615 PF00397 0.664
DOC_WW_Pin1_4 768 773 PF00397 0.393
DOC_WW_Pin1_4 77 82 PF00397 0.601
DOC_WW_Pin1_4 814 819 PF00397 0.582
LIG_14-3-3_CanoR_1 107 115 PF00244 0.739
LIG_14-3-3_CanoR_1 142 151 PF00244 0.674
LIG_14-3-3_CanoR_1 300 310 PF00244 0.503
LIG_14-3-3_CanoR_1 559 567 PF00244 0.548
LIG_14-3-3_CanoR_1 69 79 PF00244 0.703
LIG_14-3-3_CanoR_1 737 743 PF00244 0.496
LIG_Actin_WH2_2 390 406 PF00022 0.346
LIG_APCC_ABBA_1 514 519 PF00400 0.324
LIG_APCC_ABBA_1 789 794 PF00400 0.339
LIG_BIR_II_1 1 5 PF00653 0.714
LIG_BIR_III_2 683 687 PF00653 0.429
LIG_BIR_III_2 769 773 PF00653 0.343
LIG_BRCT_BRCA1_1 451 455 PF00533 0.304
LIG_BRCT_BRCA1_1 721 725 PF00533 0.304
LIG_BRCT_BRCA1_2 451 457 PF00533 0.304
LIG_Clathr_ClatBox_1 679 683 PF01394 0.284
LIG_deltaCOP1_diTrp_1 408 416 PF00928 0.521
LIG_EH1_1 386 394 PF00400 0.266
LIG_EVH1_2 289 293 PF00568 0.592
LIG_FHA_1 1 7 PF00498 0.693
LIG_FHA_1 155 161 PF00498 0.708
LIG_FHA_1 302 308 PF00498 0.540
LIG_FHA_1 373 379 PF00498 0.269
LIG_FHA_1 392 398 PF00498 0.313
LIG_FHA_1 434 440 PF00498 0.319
LIG_FHA_1 454 460 PF00498 0.346
LIG_FHA_1 593 599 PF00498 0.683
LIG_FHA_1 721 727 PF00498 0.369
LIG_FHA_1 752 758 PF00498 0.304
LIG_FHA_2 130 136 PF00498 0.686
LIG_FHA_2 171 177 PF00498 0.648
LIG_FHA_2 211 217 PF00498 0.700
LIG_FHA_2 235 241 PF00498 0.710
LIG_FHA_2 290 296 PF00498 0.569
LIG_FHA_2 44 50 PF00498 0.638
LIG_FHA_2 559 565 PF00498 0.520
LIG_FHA_2 795 801 PF00498 0.521
LIG_GBD_Chelix_1 389 397 PF00786 0.369
LIG_IBAR_NPY_1 468 470 PF08397 0.564
LIG_LIR_Apic_2 165 171 PF02991 0.701
LIG_LIR_Apic_2 465 469 PF02991 0.562
LIG_LIR_Gen_1 157 166 PF02991 0.674
LIG_LIR_Gen_1 211 219 PF02991 0.635
LIG_LIR_Gen_1 292 301 PF02991 0.644
LIG_LIR_Gen_1 372 382 PF02991 0.272
LIG_LIR_Gen_1 474 483 PF02991 0.292
LIG_LIR_Gen_1 486 492 PF02991 0.408
LIG_LIR_Gen_1 722 733 PF02991 0.304
LIG_LIR_Gen_1 771 782 PF02991 0.286
LIG_LIR_Gen_1 871 881 PF02991 0.670
LIG_LIR_Nem_3 203 207 PF02991 0.667
LIG_LIR_Nem_3 211 215 PF02991 0.638
LIG_LIR_Nem_3 292 296 PF02991 0.650
LIG_LIR_Nem_3 372 377 PF02991 0.310
LIG_LIR_Nem_3 474 478 PF02991 0.304
LIG_LIR_Nem_3 486 491 PF02991 0.382
LIG_LIR_Nem_3 722 728 PF02991 0.304
LIG_LIR_Nem_3 771 777 PF02991 0.286
LIG_LIR_Nem_3 871 876 PF02991 0.662
LIG_LYPXL_SIV_4 469 477 PF13949 0.469
LIG_PCNA_yPIPBox_3 559 570 PF02747 0.498
LIG_Pex14_1 333 337 PF04695 0.319
LIG_Pex14_1 412 416 PF04695 0.484
LIG_Pex14_1 535 539 PF04695 0.304
LIG_Pex14_1 552 556 PF04695 0.495
LIG_Pex14_2 325 329 PF04695 0.363
LIG_Pex14_2 384 388 PF04695 0.304
LIG_Pex14_2 405 409 PF04695 0.528
LIG_RPA_C_Fungi 295 307 PF08784 0.472
LIG_SH2_CRK 168 172 PF00017 0.630
LIG_SH2_CRK 451 455 PF00017 0.347
LIG_SH2_CRK 466 470 PF00017 0.432
LIG_SH2_CRK 717 721 PF00017 0.304
LIG_SH2_CRK 873 877 PF00017 0.604
LIG_SH2_GRB2like 466 469 PF00017 0.365
LIG_SH2_GRB2like 734 737 PF00017 0.336
LIG_SH2_NCK_1 431 435 PF00017 0.422
LIG_SH2_NCK_1 451 455 PF00017 0.347
LIG_SH2_NCK_1 466 470 PF00017 0.367
LIG_SH2_PTP2 470 473 PF00017 0.304
LIG_SH2_PTP2 774 777 PF00017 0.304
LIG_SH2_SRC 207 210 PF00017 0.559
LIG_SH2_SRC 466 469 PF00017 0.401
LIG_SH2_STAP1 200 204 PF00017 0.614
LIG_SH2_STAP1 374 378 PF00017 0.304
LIG_SH2_STAP1 451 455 PF00017 0.304
LIG_SH2_STAP1 738 742 PF00017 0.340
LIG_SH2_STAP1 873 877 PF00017 0.604
LIG_SH2_STAP1 98 102 PF00017 0.672
LIG_SH2_STAT5 374 377 PF00017 0.332
LIG_SH2_STAT5 470 473 PF00017 0.338
LIG_SH2_STAT5 560 563 PF00017 0.353
LIG_SH2_STAT5 569 572 PF00017 0.435
LIG_SH2_STAT5 717 720 PF00017 0.304
LIG_SH2_STAT5 729 732 PF00017 0.304
LIG_SH2_STAT5 734 737 PF00017 0.336
LIG_SH2_STAT5 774 777 PF00017 0.304
LIG_SH2_STAT5 790 793 PF00017 0.338
LIG_SH2_STAT5 865 868 PF00017 0.548
LIG_SH3_3 238 244 PF00018 0.638
LIG_SH3_3 257 263 PF00018 0.765
LIG_SH3_3 274 280 PF00018 0.514
LIG_SH3_3 283 289 PF00018 0.506
LIG_SH3_3 32 38 PF00018 0.637
LIG_SH3_3 379 385 PF00018 0.445
LIG_SH3_3 41 47 PF00018 0.727
LIG_SH3_3 621 627 PF00018 0.573
LIG_SH3_3 675 681 PF00018 0.347
LIG_SH3_3 846 852 PF00018 0.622
LIG_SUMO_SIM_anti_2 292 298 PF11976 0.418
LIG_SUMO_SIM_anti_2 754 760 PF11976 0.304
LIG_SUMO_SIM_anti_2 99 106 PF11976 0.515
LIG_SUMO_SIM_par_1 146 153 PF11976 0.662
LIG_SUMO_SIM_par_1 388 394 PF11976 0.237
LIG_SUMO_SIM_par_1 511 519 PF11976 0.459
LIG_SUMO_SIM_par_1 526 531 PF11976 0.336
LIG_SUMO_SIM_par_1 628 633 PF11976 0.465
LIG_SUMO_SIM_par_1 661 669 PF11976 0.396
LIG_TRAF2_1 237 240 PF00917 0.651
LIG_TRAF2_1 797 800 PF00917 0.383
LIG_WRC_WIRS_1 374 379 PF05994 0.304
LIG_WRC_WIRS_1 472 477 PF05994 0.369
MOD_CDK_SPK_2 814 819 PF00069 0.461
MOD_CDK_SPxxK_3 167 174 PF00069 0.634
MOD_CDK_SPxxK_3 57 64 PF00069 0.597
MOD_CK1_1 121 127 PF00069 0.689
MOD_CK1_1 129 135 PF00069 0.628
MOD_CK1_1 141 147 PF00069 0.549
MOD_CK1_1 282 288 PF00069 0.539
MOD_CK1_1 349 355 PF00069 0.604
MOD_CK1_1 36 42 PF00069 0.640
MOD_CK1_1 372 378 PF00069 0.371
MOD_CK1_1 518 524 PF00069 0.503
MOD_CK1_1 628 634 PF00069 0.528
MOD_CK1_1 73 79 PF00069 0.798
MOD_CK1_1 744 750 PF00069 0.304
MOD_CK1_1 784 790 PF00069 0.369
MOD_CK1_1 82 88 PF00069 0.671
MOD_CK1_1 841 847 PF00069 0.634
MOD_CK1_1 882 888 PF00069 0.633
MOD_CK1_1 90 96 PF00069 0.510
MOD_CK2_1 170 176 PF00069 0.617
MOD_CK2_1 234 240 PF00069 0.683
MOD_CK2_1 289 295 PF00069 0.454
MOD_CK2_1 690 696 PF00069 0.392
MOD_CK2_1 794 800 PF00069 0.374
MOD_CK2_1 820 826 PF00069 0.596
MOD_CMANNOS 409 412 PF00535 0.382
MOD_Cter_Amidation 256 259 PF01082 0.564
MOD_DYRK1A_RPxSP_1 259 263 PF00069 0.565
MOD_GlcNHglycan 145 148 PF01048 0.670
MOD_GlcNHglycan 203 207 PF01048 0.679
MOD_GlcNHglycan 281 284 PF01048 0.568
MOD_GlcNHglycan 351 354 PF01048 0.630
MOD_GlcNHglycan 356 359 PF01048 0.645
MOD_GlcNHglycan 362 365 PF01048 0.439
MOD_GlcNHglycan 379 382 PF01048 0.421
MOD_GlcNHglycan 425 428 PF01048 0.304
MOD_GlcNHglycan 451 454 PF01048 0.304
MOD_GlcNHglycan 499 504 PF01048 0.566
MOD_GlcNHglycan 599 602 PF01048 0.553
MOD_GlcNHglycan 731 734 PF01048 0.363
MOD_GlcNHglycan 749 752 PF01048 0.200
MOD_GlcNHglycan 81 84 PF01048 0.619
MOD_GlcNHglycan 834 837 PF01048 0.515
MOD_GlcNHglycan 846 849 PF01048 0.593
MOD_GlcNHglycan 87 90 PF01048 0.620
MOD_GlcNHglycan 870 873 PF01048 0.529
MOD_GlcNHglycan 883 887 PF01048 0.573
MOD_GSK3_1 117 124 PF00069 0.584
MOD_GSK3_1 134 141 PF00069 0.605
MOD_GSK3_1 150 157 PF00069 0.535
MOD_GSK3_1 347 354 PF00069 0.586
MOD_GSK3_1 356 363 PF00069 0.605
MOD_GSK3_1 369 376 PF00069 0.364
MOD_GSK3_1 43 50 PF00069 0.706
MOD_GSK3_1 449 456 PF00069 0.343
MOD_GSK3_1 495 502 PF00069 0.564
MOD_GSK3_1 515 522 PF00069 0.499
MOD_GSK3_1 539 546 PF00069 0.503
MOD_GSK3_1 597 604 PF00069 0.532
MOD_GSK3_1 628 635 PF00069 0.557
MOD_GSK3_1 7 14 PF00069 0.641
MOD_GSK3_1 73 80 PF00069 0.739
MOD_GSK3_1 747 754 PF00069 0.304
MOD_GSK3_1 760 767 PF00069 0.395
MOD_GSK3_1 81 88 PF00069 0.604
MOD_GSK3_1 837 844 PF00069 0.608
MOD_N-GLC_1 764 769 PF02516 0.401
MOD_N-GLC_1 837 842 PF02516 0.595
MOD_N-GLC_2 20 22 PF02516 0.632
MOD_NEK2_1 160 165 PF00069 0.590
MOD_NEK2_1 18 23 PF00069 0.595
MOD_NEK2_1 370 375 PF00069 0.380
MOD_NEK2_1 377 382 PF00069 0.304
MOD_NEK2_1 391 396 PF00069 0.304
MOD_NEK2_1 443 448 PF00069 0.304
MOD_NEK2_1 477 482 PF00069 0.369
MOD_NEK2_1 539 544 PF00069 0.304
MOD_NEK2_1 597 602 PF00069 0.525
MOD_NEK2_1 688 693 PF00069 0.443
MOD_NEK2_1 7 12 PF00069 0.595
MOD_NEK2_1 720 725 PF00069 0.308
MOD_NEK2_1 781 786 PF00069 0.369
MOD_NEK2_1 842 847 PF00069 0.582
MOD_NEK2_2 123 128 PF00069 0.622
MOD_NEK2_2 483 488 PF00069 0.304
MOD_NEK2_2 690 695 PF00069 0.436
MOD_NEK2_2 773 778 PF00069 0.304
MOD_PIKK_1 160 166 PF00454 0.664
MOD_PIKK_1 235 241 PF00454 0.553
MOD_PIKK_1 744 750 PF00454 0.304
MOD_PIKK_1 842 848 PF00454 0.604
MOD_PKA_1 70 76 PF00069 0.623
MOD_PKA_1 868 874 PF00069 0.563
MOD_PKA_2 106 112 PF00069 0.704
MOD_PKA_2 141 147 PF00069 0.592
MOD_PKA_2 234 240 PF00069 0.761
MOD_PKA_2 403 409 PF00069 0.389
MOD_PKA_2 558 564 PF00069 0.370
MOD_PKA_2 601 607 PF00069 0.610
MOD_PKA_2 70 76 PF00069 0.632
MOD_PKA_2 736 742 PF00069 0.341
MOD_PKA_2 868 874 PF00069 0.635
MOD_PKB_1 69 77 PF00069 0.625
MOD_Plk_1 202 208 PF00069 0.575
MOD_Plk_1 656 662 PF00069 0.364
MOD_Plk_1 7 13 PF00069 0.637
MOD_Plk_1 794 800 PF00069 0.439
MOD_Plk_2-3 794 800 PF00069 0.378
MOD_Plk_4 111 117 PF00069 0.784
MOD_Plk_4 289 295 PF00069 0.433
MOD_Plk_4 302 308 PF00069 0.390
MOD_Plk_4 373 379 PF00069 0.304
MOD_Plk_4 443 449 PF00069 0.304
MOD_Plk_4 471 477 PF00069 0.369
MOD_Plk_4 483 489 PF00069 0.304
MOD_Plk_4 543 549 PF00069 0.335
MOD_Plk_4 551 557 PF00069 0.405
MOD_Plk_4 625 631 PF00069 0.482
MOD_Plk_4 741 747 PF00069 0.304
MOD_Plk_4 773 779 PF00069 0.369
MOD_Plk_4 784 790 PF00069 0.266
MOD_ProDKin_1 167 173 PF00069 0.545
MOD_ProDKin_1 259 265 PF00069 0.602
MOD_ProDKin_1 282 288 PF00069 0.515
MOD_ProDKin_1 34 40 PF00069 0.597
MOD_ProDKin_1 43 49 PF00069 0.598
MOD_ProDKin_1 433 439 PF00069 0.369
MOD_ProDKin_1 523 529 PF00069 0.625
MOD_ProDKin_1 57 63 PF00069 0.627
MOD_ProDKin_1 592 598 PF00069 0.576
MOD_ProDKin_1 610 616 PF00069 0.578
MOD_ProDKin_1 768 774 PF00069 0.474
MOD_ProDKin_1 77 83 PF00069 0.488
MOD_ProDKin_1 814 820 PF00069 0.471
MOD_SUMO_rev_2 794 803 PF00179 0.442
TRG_DiLeu_BaLyEn_6 410 415 PF01217 0.368
TRG_DiLeu_BaLyEn_6 593 598 PF01217 0.578
TRG_ENDOCYTIC_2 374 377 PF00928 0.341
TRG_ENDOCYTIC_2 451 454 PF00928 0.294
TRG_ENDOCYTIC_2 470 473 PF00928 0.304
TRG_ENDOCYTIC_2 717 720 PF00928 0.304
TRG_ENDOCYTIC_2 774 777 PF00928 0.304
TRG_ENDOCYTIC_2 830 833 PF00928 0.614
TRG_ENDOCYTIC_2 873 876 PF00928 0.582
TRG_ER_diArg_1 258 260 PF00400 0.551
TRG_ER_diArg_1 298 300 PF00400 0.425
TRG_ER_diArg_1 398 400 PF00400 0.400
TRG_ER_diArg_1 532 534 PF00400 0.325
TRG_ER_diArg_1 69 71 PF00400 0.639
TRG_ER_diArg_1 861 864 PF00400 0.617
TRG_ER_diArg_1 867 869 PF00400 0.605
TRG_NES_CRM1_1 672 683 PF08389 0.304
TRG_Pf-PMV_PEXEL_1 53 57 PF00026 0.619

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I037 Leptomonas seymouri 53% 91%
A0A451EJR5 Leishmania donovani 90% 100%
A4H3M6 Leishmania braziliensis 68% 100%
E9AG54 Leishmania infantum 90% 100%
E9AJU8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS