Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACK9_LEIMA

TriTrypDb:

LmjF.03.0640 , LMJLV39_030011700 , LMJSD75_030011800

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ACK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.610
CLV_C14_Caspase3-7	461	465	PF00656	0.542
CLV_C14_Caspase3-7	47	51	PF00656	0.414
CLV_NRD_NRD_1	3	5	PF00675	0.622
CLV_NRD_NRD_1	427	429	PF00675	0.511
CLV_NRD_NRD_1	506	508	PF00675	0.441
CLV_PCSK_KEX2_1	164	166	PF00082	0.558
CLV_PCSK_KEX2_1	3	5	PF00082	0.621
CLV_PCSK_KEX2_1	354	356	PF00082	0.503
CLV_PCSK_KEX2_1	505	507	PF00082	0.448
CLV_PCSK_KEX2_1	606	608	PF00082	0.526
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.558
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.637
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.526
CLV_PCSK_SKI1_1	113	117	PF00082	0.486
CLV_PCSK_SKI1_1	170	174	PF00082	0.449
CLV_PCSK_SKI1_1	262	266	PF00082	0.704
CLV_PCSK_SKI1_1	297	301	PF00082	0.585
CLV_PCSK_SKI1_1	324	328	PF00082	0.395
CLV_PCSK_SKI1_1	471	475	PF00082	0.426
CLV_PCSK_SKI1_1	514	518	PF00082	0.426
CLV_PCSK_SKI1_1	561	565	PF00082	0.541
CLV_Separin_Metazoa	294	298	PF03568	0.512
DEG_APCC_DBOX_1	316	324	PF00400	0.482
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DEG_SPOP_SBC_1	232	236	PF00917	0.763
DEG_SPOP_SBC_1	239	243	PF00917	0.799
DEG_SPOP_SBC_1	251	255	PF00917	0.724
DEG_SPOP_SBC_1	482	486	PF00917	0.386
DOC_CKS1_1	258	263	PF01111	0.532
DOC_CYCLIN_RxL_1	319	328	PF00134	0.432
DOC_CYCLIN_RxL_1	468	475	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.497
DOC_MAPK_FxFP_2	29	32	PF00069	0.441
DOC_MAPK_gen_1	314	323	PF00069	0.438
DOC_MAPK_gen_1	354	360	PF00069	0.582
DOC_MAPK_JIP1_4	317	323	PF00069	0.445
DOC_MAPK_MEF2A_6	314	322	PF00069	0.385
DOC_MAPK_MEF2A_6	324	331	PF00069	0.382
DOC_MAPK_MEF2A_6	366	374	PF00069	0.428
DOC_MAPK_MEF2A_6	494	503	PF00069	0.504
DOC_PP2B_LxvP_1	327	330	PF13499	0.397
DOC_PP4_FxxP_1	29	32	PF00568	0.441
DOC_SPAK_OSR1_1	434	438	PF12202	0.439
DOC_USP7_MATH_1	221	225	PF00917	0.710
DOC_USP7_MATH_1	227	231	PF00917	0.732
DOC_USP7_MATH_1	239	243	PF00917	0.769
DOC_USP7_MATH_1	423	427	PF00917	0.636
DOC_USP7_MATH_1	483	487	PF00917	0.556
DOC_USP7_MATH_1	68	72	PF00917	0.752
DOC_USP7_MATH_1	74	78	PF00917	0.769
DOC_USP7_UBL2_3	109	113	PF12436	0.489
DOC_WW_Pin1_4	257	262	PF00397	0.751
DOC_WW_Pin1_4	462	467	PF00397	0.478
LIG_14-3-3_CanoR_1	13	18	PF00244	0.522
LIG_14-3-3_CanoR_1	3	7	PF00244	0.584
LIG_14-3-3_CanoR_1	494	503	PF00244	0.563
LIG_14-3-3_CanoR_1	87	93	PF00244	0.541
LIG_Actin_RPEL_3	359	378	PF02755	0.564
LIG_Actin_WH2_2	281	299	PF00022	0.481
LIG_APCC_ABBA_1	401	406	PF00400	0.565
LIG_BIR_III_2	609	613	PF00653	0.575
LIG_BIR_III_4	406	410	PF00653	0.526
LIG_BIR_III_4	50	54	PF00653	0.578
LIG_BRCT_BRCA1_1	464	468	PF00533	0.544
LIG_BRCT_BRCA1_1	486	490	PF00533	0.641
LIG_Clathr_ClatBox_1	115	119	PF01394	0.516
LIG_CtBP_PxDLS_1	24	28	PF00389	0.508
LIG_EH1_1	598	606	PF00400	0.475
LIG_FHA_1	193	199	PF00498	0.372
LIG_FHA_1	282	288	PF00498	0.470
LIG_FHA_1	326	332	PF00498	0.395
LIG_FHA_1	354	360	PF00498	0.422
LIG_FHA_1	87	93	PF00498	0.590
LIG_FHA_2	307	313	PF00498	0.556
LIG_FHA_2	415	421	PF00498	0.561
LIG_FHA_2	568	574	PF00498	0.495
LIG_LIR_Apic_2	26	32	PF02991	0.432
LIG_LIR_Apic_2	312	318	PF02991	0.431
LIG_LIR_Gen_1	279	288	PF02991	0.521
LIG_LIR_Gen_1	446	454	PF02991	0.453
LIG_LIR_Gen_1	487	496	PF02991	0.537
LIG_LIR_Nem_3	279	285	PF02991	0.523
LIG_LIR_Nem_3	446	450	PF02991	0.367
LIG_LIR_Nem_3	487	493	PF02991	0.544
LIG_LYPXL_S_1	522	526	PF13949	0.542
LIG_NRBOX	322	328	PF00104	0.482
LIG_NRBOX	373	379	PF00104	0.474
LIG_PCNA_yPIPBox_3	132	140	PF02747	0.459
LIG_PCNA_yPIPBox_3	289	297	PF02747	0.543
LIG_PDZ_Class_2	608	613	PF00595	0.565
LIG_Pex14_2	203	207	PF04695	0.371
LIG_SH2_CRK	375	379	PF00017	0.517
LIG_SH2_NCK_1	411	415	PF00017	0.558
LIG_SH2_SRC	348	351	PF00017	0.562
LIG_SH2_SRC	411	414	PF00017	0.599
LIG_SH2_SRC	549	552	PF00017	0.410
LIG_SH2_STAP1	144	148	PF00017	0.415
LIG_SH2_STAP1	162	166	PF00017	0.372
LIG_SH2_STAP1	440	444	PF00017	0.369
LIG_SH2_STAP1	447	451	PF00017	0.358
LIG_SH2_STAP1	582	586	PF00017	0.393
LIG_SH2_STAT5	282	285	PF00017	0.520
LIG_SH2_STAT5	30	33	PF00017	0.431
LIG_SH2_STAT5	348	351	PF00017	0.497
LIG_SH2_STAT5	549	552	PF00017	0.410
LIG_SH3_3	128	134	PF00018	0.583
LIG_SH3_3	211	217	PF00018	0.641
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.513
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.508
LIG_SUMO_SIM_par_1	114	119	PF11976	0.513
LIG_SUMO_SIM_par_1	478	487	PF11976	0.492
LIG_TRAF2_1	590	593	PF00917	0.457
LIG_TRFH_1	474	478	PF08558	0.531
LIG_TYR_ITIM	580	585	PF00017	0.382
LIG_UBA3_1	320	324	PF00899	0.367
LIG_UBA3_1	359	364	PF00899	0.572
LIG_WRC_WIRS_1	17	22	PF05994	0.543
MOD_CDK_SPK_2	257	262	PF00069	0.541
MOD_CK1_1	16	22	PF00069	0.544
MOD_CK1_1	230	236	PF00069	0.772
MOD_CK1_1	240	246	PF00069	0.780
MOD_CK1_1	249	255	PF00069	0.510
MOD_CK1_1	256	262	PF00069	0.550
MOD_CK1_1	59	65	PF00069	0.681
MOD_CK1_1	66	72	PF00069	0.679
MOD_CK1_1	77	83	PF00069	0.735
MOD_CK2_1	100	106	PF00069	0.532
MOD_CK2_1	306	312	PF00069	0.529
MOD_CK2_1	452	458	PF00069	0.357
MOD_CK2_1	567	573	PF00069	0.471
MOD_CK2_1	587	593	PF00069	0.267
MOD_CK2_1	59	65	PF00069	0.667
MOD_CK2_1	70	76	PF00069	0.747
MOD_GlcNHglycan	223	226	PF01048	0.743
MOD_GlcNHglycan	255	258	PF01048	0.717
MOD_GlcNHglycan	557	560	PF01048	0.390
MOD_GlcNHglycan	68	71	PF01048	0.767
MOD_GlcNHglycan	72	75	PF01048	0.771
MOD_GlcNHglycan	76	79	PF01048	0.740
MOD_GlcNHglycan	92	95	PF01048	0.409
MOD_GSK3_1	12	19	PF00069	0.497
MOD_GSK3_1	226	233	PF00069	0.774
MOD_GSK3_1	234	241	PF00069	0.791
MOD_GSK3_1	242	249	PF00069	0.680
MOD_GSK3_1	252	259	PF00069	0.590
MOD_GSK3_1	325	332	PF00069	0.366
MOD_GSK3_1	458	465	PF00069	0.589
MOD_GSK3_1	478	485	PF00069	0.309
MOD_GSK3_1	59	66	PF00069	0.701
MOD_GSK3_1	70	77	PF00069	0.753
MOD_GSK3_1	83	90	PF00069	0.603
MOD_GSK3_1	92	99	PF00069	0.660
MOD_N-GLC_1	151	156	PF02516	0.567
MOD_N-GLC_1	249	254	PF02516	0.773
MOD_N-GLC_1	415	420	PF02516	0.634
MOD_N-GLC_1	494	499	PF02516	0.525
MOD_NEK2_1	193	198	PF00069	0.413
MOD_NEK2_1	2	7	PF00069	0.647
MOD_NEK2_1	283	288	PF00069	0.441
MOD_NEK2_1	452	457	PF00069	0.343
MOD_NEK2_1	550	555	PF00069	0.403
MOD_NEK2_1	567	572	PF00069	0.397
MOD_PIKK_1	227	233	PF00454	0.721
MOD_PK_1	13	19	PF00069	0.598
MOD_PKA_1	505	511	PF00069	0.437
MOD_PKA_2	12	18	PF00069	0.480
MOD_PKA_2	2	8	PF00069	0.584
MOD_PKA_2	505	511	PF00069	0.490
MOD_PKA_2	56	62	PF00069	0.622
MOD_PKA_2	86	92	PF00069	0.535
MOD_Plk_1	100	106	PF00069	0.609
MOD_Plk_1	193	199	PF00069	0.427
MOD_Plk_1	415	421	PF00069	0.670
MOD_Plk_1	568	574	PF00069	0.385
MOD_Plk_4	100	106	PF00069	0.644
MOD_Plk_4	111	117	PF00069	0.521
MOD_Plk_4	16	22	PF00069	0.488
MOD_Plk_4	283	289	PF00069	0.425
MOD_Plk_4	484	490	PF00069	0.594
MOD_Plk_4	532	538	PF00069	0.396
MOD_ProDKin_1	257	263	PF00069	0.746
MOD_ProDKin_1	462	468	PF00069	0.467
MOD_SUMO_rev_2	422	431	PF00179	0.622
MOD_SUMO_rev_2	590	597	PF00179	0.431
TRG_DiLeu_BaEn_1	600	605	PF01217	0.443
TRG_DiLeu_BaEn_4	293	299	PF01217	0.514
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.470
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.499
TRG_ENDOCYTIC_2	282	285	PF00928	0.520
TRG_ENDOCYTIC_2	375	378	PF00928	0.515
TRG_ENDOCYTIC_2	447	450	PF00928	0.387
TRG_ENDOCYTIC_2	523	526	PF00928	0.546
TRG_ENDOCYTIC_2	582	585	PF00928	0.397
TRG_ER_diArg_1	2	4	PF00400	0.634
TRG_ER_diArg_1	505	507	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	520	525	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q3	Leptomonas seymouri	65%	100%
A0A1X0P9P0	Trypanosomatidae	47%	100%
A0A422NMG4	Trypanosoma rangeli	47%	100%
A0A451EJR4	Leishmania donovani	95%	100%
A4H3M5	Leishmania braziliensis	87%	100%
D0A267	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	97%
E9AG53	Leishmania infantum	95%	100%
E9AJU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BSR7	Trypanosoma cruzi	47%	100%