Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACK8_LEIMA

TriTrypDb:

LmjF.03.0630 , LMJLV39_030011600 , LMJSD75_030011700

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACK8

PDB structure(s): 7ane_ak

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.798
CLV_C14_Caspase3-7	310	314	PF00656	0.624
CLV_NRD_NRD_1	138	140	PF00675	0.553
CLV_NRD_NRD_1	191	193	PF00675	0.580
CLV_NRD_NRD_1	269	271	PF00675	0.416
CLV_NRD_NRD_1	274	276	PF00675	0.418
CLV_NRD_NRD_1	288	290	PF00675	0.340
CLV_PCSK_FUR_1	189	193	PF00082	0.484
CLV_PCSK_KEX2_1	138	140	PF00082	0.602
CLV_PCSK_KEX2_1	191	193	PF00082	0.600
CLV_PCSK_KEX2_1	274	276	PF00082	0.477
CLV_PCSK_KEX2_1	288	290	PF00082	0.395
CLV_PCSK_KEX2_1	301	303	PF00082	0.440
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.428
CLV_PCSK_PC7_1	270	276	PF00082	0.535
CLV_PCSK_SKI1_1	126	130	PF00082	0.404
CLV_PCSK_SKI1_1	16	20	PF00082	0.336
DEG_APCC_DBOX_1	288	296	PF00400	0.528
DEG_SPOP_SBC_1	89	93	PF00917	0.604
DOC_MAPK_gen_1	212	219	PF00069	0.587
DOC_PP2B_LxvP_1	238	241	PF13499	0.419
DOC_PP4_FxxP_1	182	185	PF00568	0.392
DOC_SPAK_OSR1_1	181	185	PF12202	0.447
DOC_USP7_MATH_1	231	235	PF00917	0.370
DOC_USP7_MATH_1	44	48	PF00917	0.495
DOC_USP7_MATH_1	84	88	PF00917	0.745
DOC_USP7_MATH_1	89	93	PF00917	0.706
DOC_USP7_UBL2_3	297	301	PF12436	0.461
DOC_WW_Pin1_4	74	79	PF00397	0.745
DOC_WW_Pin1_4	82	87	PF00397	0.707
LIG_14-3-3_CanoR_1	28	32	PF00244	0.469
LIG_14-3-3_CanoR_1	288	296	PF00244	0.511
LIG_14-3-3_CterR_2	322	325	PF00244	0.520
LIG_Actin_WH2_2	308	324	PF00022	0.549
LIG_APCC_ABBAyCdc20_2	14	20	PF00400	0.462
LIG_BIR_II_1	1	5	PF00653	0.406
LIG_Clathr_ClatBox_1	243	247	PF01394	0.371
LIG_CtBP_PxDLS_1	104	109	PF00389	0.529
LIG_deltaCOP1_diTrp_1	175	182	PF00928	0.412
LIG_FHA_1	214	220	PF00498	0.525
LIG_FHA_1	4	10	PF00498	0.366
LIG_FHA_2	101	107	PF00498	0.470
LIG_FHA_2	308	314	PF00498	0.596
LIG_GBD_Chelix_1	9	17	PF00786	0.383
LIG_LIR_Gen_1	118	127	PF02991	0.488
LIG_LIR_Gen_1	278	287	PF02991	0.511
LIG_LIR_Nem_3	118	122	PF02991	0.428
LIG_LIR_Nem_3	261	266	PF02991	0.477
LIG_LIR_Nem_3	278	284	PF02991	0.413
LIG_LIR_Nem_3	30	34	PF02991	0.392
LIG_LIR_Nem_3	43	48	PF02991	0.267
LIG_Pex14_1	59	63	PF04695	0.373
LIG_PTAP_UEV_1	77	82	PF05743	0.574
LIG_SH2_CRK	190	194	PF00017	0.569
LIG_SH2_CRK	45	49	PF00017	0.335
LIG_SH2_GRB2like	5	8	PF00017	0.367
LIG_SH2_STAP1	153	157	PF00017	0.380
LIG_SH2_STAP1	304	308	PF00017	0.471
LIG_SH2_STAP1	5	9	PF00017	0.363
LIG_SH2_STAT5	5	8	PF00017	0.381
LIG_SH3_3	181	187	PF00018	0.512
LIG_SH3_3	55	61	PF00018	0.518
LIG_SH3_3	75	81	PF00018	0.760
LIG_SH3_3	83	89	PF00018	0.705
LIG_SUMO_SIM_anti_2	103	109	PF11976	0.433
LIG_SUMO_SIM_anti_2	215	224	PF11976	0.452
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.379
LIG_TRAF2_1	128	131	PF00917	0.426
LIG_TRAF2_1	314	317	PF00917	0.562
LIG_TYR_ITSM	41	48	PF00017	0.359
MOD_CDC14_SPxK_1	85	88	PF00782	0.603
MOD_CDK_SPxK_1	82	88	PF00069	0.605
MOD_CK1_1	87	93	PF00069	0.725
MOD_CK1_1	94	100	PF00069	0.626
MOD_CK2_1	311	317	PF00069	0.664
MOD_GlcNHglycan	110	113	PF01048	0.404
MOD_GlcNHglycan	99	102	PF01048	0.642
MOD_GSK3_1	129	136	PF00069	0.447
MOD_GSK3_1	251	258	PF00069	0.596
MOD_GSK3_1	287	294	PF00069	0.556
MOD_GSK3_1	307	314	PF00069	0.610
MOD_GSK3_1	40	47	PF00069	0.357
MOD_GSK3_1	84	91	PF00069	0.704
MOD_GSK3_1	93	100	PF00069	0.636
MOD_N-GLC_1	68	73	PF02516	0.678
MOD_NEK2_1	110	115	PF00069	0.383
MOD_NEK2_1	3	8	PF00069	0.369
MOD_NEK2_1	307	312	PF00069	0.529
MOD_NEK2_1	9	14	PF00069	0.334
MOD_NEK2_2	231	236	PF00069	0.366
MOD_OFUCOSY	35	42	PF10250	0.390
MOD_PIKK_1	287	293	PF00454	0.519
MOD_PKA_2	213	219	PF00069	0.545
MOD_PKA_2	27	33	PF00069	0.395
MOD_PKA_2	287	293	PF00069	0.519
MOD_PKA_2	3	9	PF00069	0.369
MOD_PKA_2	87	93	PF00069	0.604
MOD_Plk_4	44	50	PF00069	0.355
MOD_ProDKin_1	74	80	PF00069	0.746
MOD_ProDKin_1	82	88	PF00069	0.706
MOD_SUMO_for_1	128	131	PF00179	0.426
MOD_SUMO_rev_2	205	213	PF00179	0.589
MOD_SUMO_rev_2	313	319	PF00179	0.557
TRG_AP2beta_CARGO_1	261	270	PF09066	0.325
TRG_DiLeu_BaEn_1	282	287	PF01217	0.379
TRG_DiLeu_BaEn_4	316	322	PF01217	0.548
TRG_ENDOCYTIC_2	304	307	PF00928	0.633
TRG_ENDOCYTIC_2	45	48	PF00928	0.335
TRG_ER_diArg_1	137	139	PF00400	0.602
TRG_ER_diArg_1	190	192	PF00400	0.612
TRG_ER_diArg_1	273	275	PF00400	0.517
TRG_ER_diArg_1	287	289	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.670
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B1	Leptomonas seymouri	64%	100%
A0A0S4JDA3	Bodo saltans	31%	100%
A0A1X0P8U5	Trypanosomatidae	45%	100%
A0A3S5H551	Leishmania donovani	96%	100%
A0A422NMF2	Trypanosoma rangeli	44%	100%
D0A266	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AG52	Leishmania infantum	94%	99%
E9AJU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BCA0	Trypanosoma cruzi	44%	100%