Kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinase-like protein

Gene product:

kinase-like protein

Species:

Leishmania major

UniProt:

E9ACK6_LEIMA

TriTrypDb:

LmjF.03.0610 , LMJLV39_030011400 , LMJSD75_030011500

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACK6

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0044237	cellular metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0003924	GTPase activity	7	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.263
CLV_NRD_NRD_1	213	215	PF00675	0.296
CLV_NRD_NRD_1	24	26	PF00675	0.433
CLV_NRD_NRD_1	277	279	PF00675	0.293
CLV_NRD_NRD_1	298	300	PF00675	0.480
CLV_PCSK_KEX2_1	213	215	PF00082	0.387
CLV_PCSK_KEX2_1	24	26	PF00082	0.444
CLV_PCSK_KEX2_1	277	279	PF00082	0.293
CLV_PCSK_KEX2_1	298	300	PF00082	0.480
CLV_PCSK_KEX2_1	347	349	PF00082	0.486
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.486
CLV_PCSK_SKI1_1	173	177	PF00082	0.263
CLV_PCSK_SKI1_1	29	33	PF00082	0.312
CLV_PCSK_SKI1_1	298	302	PF00082	0.370
CLV_PCSK_SKI1_1	63	67	PF00082	0.348
DEG_COP1_1	246	256	PF00400	0.328
DOC_CYCLIN_yCln2_LP_2	182	185	PF00134	0.263
DOC_MAPK_gen_1	195	201	PF00069	0.263
DOC_MAPK_gen_1	88	95	PF00069	0.322
DOC_MAPK_MEF2A_6	173	182	PF00069	0.263
DOC_MAPK_MEF2A_6	88	95	PF00069	0.369
DOC_PP2B_LxvP_1	181	184	PF13499	0.263
DOC_PP2B_PxIxI_1	240	246	PF00149	0.299
DOC_PP4_FxxP_1	238	241	PF00568	0.322
DOC_SPAK_OSR1_1	154	158	PF12202	0.197
DOC_USP7_MATH_1	129	133	PF00917	0.263
DOC_USP7_MATH_1	34	38	PF00917	0.410
DOC_USP7_MATH_1	39	43	PF00917	0.247
DOC_WW_Pin1_4	127	132	PF00397	0.263
DOC_WW_Pin1_4	315	320	PF00397	0.450
DOC_WW_Pin1_4	66	71	PF00397	0.263
LIG_14-3-3_CanoR_1	13	17	PF00244	0.391
LIG_14-3-3_CanoR_1	24	28	PF00244	0.314
LIG_14-3-3_CanoR_1	277	286	PF00244	0.369
LIG_APCC_ABBAyCdc20_2	227	233	PF00400	0.322
LIG_deltaCOP1_diTrp_1	255	264	PF00928	0.265
LIG_eIF4E_1	288	294	PF01652	0.263
LIG_FHA_1	160	166	PF00498	0.285
LIG_FHA_2	112	118	PF00498	0.263
LIG_FHA_2	206	212	PF00498	0.263
LIG_FHA_2	299	305	PF00498	0.332
LIG_FHA_2	30	36	PF00498	0.295
LIG_FHA_2	316	322	PF00498	0.404
LIG_FHA_2	328	334	PF00498	0.460
LIG_LIR_Apic_2	125	129	PF02991	0.332
LIG_LIR_Gen_1	141	152	PF02991	0.406
LIG_LIR_Gen_1	255	263	PF02991	0.322
LIG_LIR_Nem_3	141	147	PF02991	0.406
LIG_LIR_Nem_3	282	288	PF02991	0.359
LIG_NRBOX	44	50	PF00104	0.328
LIG_PCNA_PIPBox_1	116	125	PF02747	0.284
LIG_Pex14_2	155	159	PF04695	0.322
LIG_Pex14_2	285	289	PF04695	0.263
LIG_RPA_C_Fungi	262	274	PF08784	0.197
LIG_SH2_PTP2	126	129	PF00017	0.322
LIG_SH2_STAP1	225	229	PF00017	0.370
LIG_SH2_STAT5	126	129	PF00017	0.322
LIG_SH2_STAT5	231	234	PF00017	0.316
LIG_SH2_STAT5	288	291	PF00017	0.306
LIG_SH2_STAT5	84	87	PF00017	0.302
LIG_SH3_3	2	8	PF00018	0.597
LIG_SH3_4	215	222	PF00018	0.284
LIG_SUMO_SIM_anti_2	324	330	PF11976	0.449
LIG_SUMO_SIM_par_1	197	203	PF11976	0.263
LIG_SUMO_SIM_par_1	241	246	PF11976	0.263
LIG_SUMO_SIM_par_1	94	99	PF11976	0.263
LIG_TRAF2_1	246	249	PF00917	0.328
MOD_CDK_SPK_2	315	320	PF00069	0.450
MOD_CK1_1	102	108	PF00069	0.263
MOD_CK1_1	69	75	PF00069	0.284
MOD_CK2_1	111	117	PF00069	0.263
MOD_CK2_1	184	190	PF00069	0.263
MOD_CK2_1	243	249	PF00069	0.415
MOD_CK2_1	29	35	PF00069	0.295
MOD_CK2_1	298	304	PF00069	0.332
MOD_CK2_1	315	321	PF00069	0.418
MOD_CK2_1	327	333	PF00069	0.458
MOD_Cter_Amidation	211	214	PF01082	0.284
MOD_Cter_Amidation	345	348	PF01082	0.437
MOD_GlcNHglycan	131	134	PF01048	0.322
MOD_GlcNHglycan	186	189	PF01048	0.263
MOD_GlcNHglycan	222	225	PF01048	0.328
MOD_GlcNHglycan	245	248	PF01048	0.322
MOD_GlcNHglycan	269	272	PF01048	0.271
MOD_GlcNHglycan	66	69	PF01048	0.263
MOD_GlcNHglycan	71	74	PF01048	0.263
MOD_GSK3_1	118	125	PF00069	0.142
MOD_GSK3_1	29	36	PF00069	0.301
MOD_GSK3_1	69	76	PF00069	0.303
MOD_GSK3_1	98	105	PF00069	0.263
MOD_NEK2_1	159	164	PF00069	0.287
MOD_NEK2_1	33	38	PF00069	0.370
MOD_NEK2_1	64	69	PF00069	0.322
MOD_NEK2_1	77	82	PF00069	0.322
MOD_PIKK_1	167	173	PF00454	0.322
MOD_PKA_1	298	304	PF00069	0.332
MOD_PKA_2	12	18	PF00069	0.462
MOD_PKA_2	23	29	PF00069	0.340
MOD_PKA_2	298	304	PF00069	0.332
MOD_Plk_1	111	117	PF00069	0.283
MOD_Plk_1	40	46	PF00069	0.274
MOD_Plk_4	105	111	PF00069	0.263
MOD_Plk_4	122	128	PF00069	0.263
MOD_Plk_4	73	79	PF00069	0.357
MOD_ProDKin_1	127	133	PF00069	0.263
MOD_ProDKin_1	315	321	PF00069	0.449
MOD_ProDKin_1	66	72	PF00069	0.263
TRG_ENDOCYTIC_2	286	289	PF00928	0.369
TRG_ER_diArg_1	276	278	PF00400	0.293
TRG_ER_diArg_1	298	300	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P9	Leptomonas seymouri	78%	100%
A0A0S4JDW1	Bodo saltans	54%	86%
A0A451EJR1	Leishmania donovani	94%	100%
A4H3M2	Leishmania braziliensis	87%	99%
A8XGZ9	Caenorhabditis briggsae	40%	85%
E9AG50	Leishmania infantum	94%	100%
E9AJU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O28980	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	29%	100%
O58012	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	32%	100%
P27254	Escherichia coli (strain K12)	42%	100%
P37895	Caulobacter vibrioides (strain ATCC 19089 / CB15)	43%	100%
P63578	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	40%	100%
P9WPZ0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	40%	100%
P9WPZ1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	40%	100%
Q22111	Caenorhabditis elegans	37%	87%
Q8C7H1	Mus musculus	38%	84%
Q8IVH4	Homo sapiens	38%	83%
Q9V225	Pyrococcus abyssi (strain GE5 / Orsay)	30%	100%