Putative arginine N-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginine N-methyltransferase, putative

Species:

Leishmania major

UniProt:

E9ACK5_LEIMA

TriTrypDb:

LmjF.03.0600 , LMJLV39_030011300 , LMJSD75_030011400

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACK5

Function

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Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0008213	protein alkylation	5	16
GO:0009987	cellular process	1	16
GO:0018193	peptidyl-amino acid modification	5	16
GO:0018195	peptidyl-arginine modification	6	16
GO:0018216	peptidyl-arginine methylation	5	16
GO:0019538	protein metabolic process	3	16
GO:0032259	methylation	2	16

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0008168	methyltransferase activity	4	16
GO:0008170	N-methyltransferase activity	5	16
GO:0008276	protein methyltransferase activity	3	16
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	16
GO:0016273	arginine N-methyltransferase activity	6	16
GO:0016274	protein-arginine N-methyltransferase activity	4	16
GO:0016740	transferase activity	2	16
GO:0016741	transferase activity, transferring one-carbon groups	3	16
GO:0140096	catalytic activity, acting on a protein	2	16

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	126	130	PF00082	0.421
CLV_PCSK_SKI1_1	164	168	PF00082	0.443
CLV_PCSK_SKI1_1	25	29	PF00082	0.610
CLV_PCSK_SKI1_1	306	310	PF00082	0.488
CLV_PCSK_SKI1_1	80	84	PF00082	0.365
CLV_Separin_Metazoa	221	225	PF03568	0.533
DEG_APCC_DBOX_1	131	139	PF00400	0.243
DEG_APCC_DBOX_1	186	194	PF00400	0.364
DOC_CDC14_PxL_1	237	245	PF14671	0.398
DOC_CKS1_1	176	181	PF01111	0.416

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A7	Leptomonas seymouri	80%	100%
A0A0N0P7Z0	Leptomonas seymouri	24%	100%
A0A0S4JDH7	Bodo saltans	42%	100%
A0A0S4JWH9	Bodo saltans	26%	100%
A0A1X0NMC6	Trypanosomatidae	29%	100%
A0A1X0PA69	Trypanosomatidae	52%	97%
A0A3R7NHM3	Trypanosoma rangeli	52%	100%
A0A3S5H6M7	Leishmania donovani	30%	100%
A0A451EJR0	Leishmania donovani	96%	100%
A2Y953	Oryza sativa subsp. indica	26%	100%

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