DUF1989 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACK3_LEIMA

TriTrypDb:

LmjF.03.0580 , LMJLV39_030011100 , LMJSD75_030011100

Length:

178


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

E9ACK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACK3


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.631
CLV_NRD_NRD_1	168	170	PF00675	0.693
CLV_NRD_NRD_1	172	174	PF00675	0.699
CLV_PCSK_FUR_1	146	150	PF00082	0.574
CLV_PCSK_KEX2_1	148	150	PF00082	0.502
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.500
CLV_PCSK_SKI1_1	124	128	PF00082	0.507
CLV_PCSK_SKI1_1	2	6	PF00082	0.386
CLV_PCSK_SKI1_1	92	96	PF00082	0.538
DEG_Nend_UBRbox_1	1	4	PF02207	0.418
DOC_PP1_RVXF_1	22	28	PF00149	0.534
DOC_PP2B_LxvP_1	73	76	PF13499	0.448
DOC_USP7_MATH_1	126	130	PF00917	0.614
DOC_USP7_MATH_1	37	41	PF00917	0.481
DOC_USP7_MATH_1	49	53	PF00917	0.488
DOC_USP7_MATH_1	82	86	PF00917	0.732
DOC_USP7_UBL2_3	124	128	PF12436	0.529
DOC_USP7_UBL2_3	170	174	PF12436	0.637
DOC_WW_Pin1_4	44	49	PF00397	0.577
LIG_14-3-3_CanoR_1	116	120	PF00244	0.596
LIG_14-3-3_CanoR_1	92	99	PF00244	0.594
LIG_BRCT_BRCA1_1	85	89	PF00533	0.595
LIG_CSL_BTD_1	25	28	PF09270	0.452
LIG_FHA_1	67	73	PF00498	0.559
LIG_FHA_2	12	18	PF00498	0.561
LIG_FHA_2	93	99	PF00498	0.518
LIG_LIR_Nem_3	52	58	PF02991	0.437
LIG_SH3_3	162	168	PF00018	0.602
LIG_SUMO_SIM_par_1	69	78	PF11976	0.445
MOD_CK1_1	129	135	PF00069	0.644
MOD_CK1_1	47	53	PF00069	0.583
MOD_CK1_1	85	91	PF00069	0.589
MOD_CK2_1	161	167	PF00069	0.749
MOD_GlcNHglycan	128	131	PF01048	0.633
MOD_GlcNHglycan	51	54	PF01048	0.580
MOD_GlcNHglycan	85	88	PF01048	0.606
MOD_GSK3_1	115	122	PF00069	0.546
MOD_GSK3_1	37	44	PF00069	0.397
MOD_PIKK_1	59	65	PF00454	0.324
MOD_PKA_2	115	121	PF00069	0.540
MOD_Plk_1	161	167	PF00069	0.595
MOD_Plk_4	161	167	PF00069	0.591
MOD_ProDKin_1	44	50	PF00069	0.574
MOD_SUMO_for_1	147	150	PF00179	0.543
MOD_SUMO_rev_2	167	176	PF00179	0.660
TRG_ENDOCYTIC_2	55	58	PF00928	0.392
TRG_NES_CRM1_1	63	77	PF08389	0.419


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ04	Leptomonas seymouri	64%	98%
A0A0S4INX7	Bodo saltans	42%	90%
A0A1X0P8U1	Trypanosomatidae	38%	91%
A0A3S5H549	Leishmania donovani	95%	100%
A0A422NMF6	Trypanosoma rangeli	41%	95%
A4H3M0	Leishmania braziliensis	86%	99%
D0A262	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	79%
E9AG47	Leishmania infantum	95%	100%
E9AJU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%