Putative quinone oxidoreductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

quinone oxidoreductase, putative

Species:

Leishmania major

UniProt:

E9ACK2_LEIMA

TriTrypDb:

LmjF.03.0570 , LMJLV39_030011000 , LMJSD75_030011000

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACK2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	12
GO:0003960	NADPH:quinone reductase activity	5	6
GO:0005488	binding	1	3
GO:0016491	oxidoreductase activity	2	12
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	6
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	6
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	2
GO:0050661	NADP binding	4	2
GO:0070402	NADPH binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2
GO:0008270	zinc ion binding	6	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.412
CLV_NRD_NRD_1	283	285	PF00675	0.366
CLV_NRD_NRD_1	319	321	PF00675	0.518
CLV_PCSK_KEX2_1	283	285	PF00082	0.368
CLV_PCSK_KEX2_1	85	87	PF00082	0.404
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.396
CLV_PCSK_SKI1_1	325	329	PF00082	0.324
DEG_Nend_UBRbox_2	1	3	PF02207	0.390
DOC_ANK_TNKS_1	110	117	PF00023	0.208
DOC_CKS1_1	198	203	PF01111	0.396
DOC_CKS1_1	275	280	PF01111	0.416
DOC_CYCLIN_RxL_1	320	332	PF00134	0.390
DOC_MAPK_gen_1	166	175	PF00069	0.268
DOC_MAPK_gen_1	235	243	PF00069	0.268
DOC_MAPK_gen_1	320	328	PF00069	0.461
DOC_USP7_UBL2_3	321	325	PF12436	0.471
DOC_WW_Pin1_4	19	24	PF00397	0.572
DOC_WW_Pin1_4	197	202	PF00397	0.347
DOC_WW_Pin1_4	251	256	PF00397	0.253
DOC_WW_Pin1_4	274	279	PF00397	0.371
LIG_14-3-3_CanoR_1	283	292	PF00244	0.398
LIG_14-3-3_CanoR_1	320	328	PF00244	0.336
LIG_BRCT_BRCA1_1	285	289	PF00533	0.517
LIG_CtBP_PxDLS_1	255	259	PF00389	0.396
LIG_FHA_1	145	151	PF00498	0.405
LIG_FHA_1	155	161	PF00498	0.271
LIG_FHA_1	283	289	PF00498	0.497
LIG_FHA_1	321	327	PF00498	0.350
LIG_FHA_1	45	51	PF00498	0.425
LIG_FHA_2	116	122	PF00498	0.280
LIG_FHA_2	24	30	PF00498	0.461
LIG_FHA_2	268	274	PF00498	0.295
LIG_FHA_2	275	281	PF00498	0.403
LIG_LIR_Apic_2	51	57	PF02991	0.243
LIG_LIR_Gen_1	286	297	PF02991	0.288
LIG_LIR_Gen_1	96	107	PF02991	0.299
LIG_LIR_Nem_3	200	206	PF02991	0.384
LIG_LIR_Nem_3	216	222	PF02991	0.153
LIG_LIR_Nem_3	286	292	PF02991	0.319
LIG_LIR_Nem_3	96	102	PF02991	0.290
LIG_SH2_CRK	219	223	PF00017	0.274
LIG_SH2_CRK	39	43	PF00017	0.277
LIG_SH2_CRK	54	58	PF00017	0.203
LIG_SH2_STAT5	134	137	PF00017	0.253
LIG_SH2_STAT5	197	200	PF00017	0.312
LIG_SH2_STAT5	265	268	PF00017	0.287
LIG_SH2_STAT5	48	51	PF00017	0.273
LIG_SH2_STAT5	61	64	PF00017	0.216
LIG_SH2_STAT5	89	92	PF00017	0.304
LIG_SH3_1	54	60	PF00018	0.253
LIG_SH3_3	138	144	PF00018	0.381
LIG_SH3_3	195	201	PF00018	0.329
LIG_SH3_3	230	236	PF00018	0.310
LIG_SH3_3	249	255	PF00018	0.321
LIG_SH3_3	54	60	PF00018	0.253
LIG_SUMO_SIM_anti_2	230	235	PF11976	0.287
LIG_SUMO_SIM_par_1	254	259	PF11976	0.275
LIG_TRAF2_1	277	280	PF00917	0.535
LIG_WRC_WIRS_1	240	245	PF05994	0.253
MOD_CK1_1	19	25	PF00069	0.460
MOD_CK1_1	319	325	PF00069	0.405
MOD_CK2_1	115	121	PF00069	0.378
MOD_CK2_1	23	29	PF00069	0.459
MOD_CK2_1	251	257	PF00069	0.396
MOD_CK2_1	274	280	PF00069	0.395
MOD_Cter_Amidation	83	86	PF01082	0.404
MOD_GlcNHglycan	107	110	PF01048	0.352
MOD_GlcNHglycan	246	249	PF01048	0.256
MOD_GlcNHglycan	50	53	PF01048	0.299
MOD_GSK3_1	180	187	PF00069	0.287
MOD_GSK3_1	19	26	PF00069	0.513
MOD_GSK3_1	223	230	PF00069	0.307
MOD_GSK3_1	256	263	PF00069	0.317
MOD_GSK3_1	316	323	PF00069	0.422
MOD_GSK3_1	44	51	PF00069	0.276
MOD_N-GLC_1	244	249	PF02516	0.253
MOD_NEK2_1	135	140	PF00069	0.373
MOD_NEK2_1	184	189	PF00069	0.395
MOD_NEK2_1	227	232	PF00069	0.305
MOD_NEK2_1	256	261	PF00069	0.314
MOD_NEK2_1	44	49	PF00069	0.321
MOD_PIKK_1	23	29	PF00454	0.459
MOD_PK_1	260	266	PF00069	0.396
MOD_PKA_1	283	289	PF00069	0.418
MOD_PKA_1	320	326	PF00069	0.404
MOD_PKA_2	16	22	PF00069	0.562
MOD_PKA_2	267	273	PF00069	0.351
MOD_PKA_2	282	288	PF00069	0.434
MOD_PKA_2	319	325	PF00069	0.338
MOD_Plk_1	136	142	PF00069	0.442
MOD_Plk_1	23	29	PF00069	0.489
MOD_Plk_2-3	115	121	PF00069	0.280
MOD_Plk_4	144	150	PF00069	0.419
MOD_Plk_4	229	235	PF00069	0.279
MOD_Plk_4	260	266	PF00069	0.288
MOD_Plk_4	44	50	PF00069	0.287
MOD_Plk_4	78	84	PF00069	0.354
MOD_ProDKin_1	19	25	PF00069	0.575
MOD_ProDKin_1	197	203	PF00069	0.347
MOD_ProDKin_1	251	257	PF00069	0.253
MOD_ProDKin_1	274	280	PF00069	0.371
TRG_ENDOCYTIC_2	219	222	PF00928	0.274
TRG_ENDOCYTIC_2	39	42	PF00928	0.274
TRG_ENDOCYTIC_2	99	102	PF00928	0.314
TRG_ER_diArg_1	234	237	PF00400	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I0	Leptomonas seymouri	34%	98%
A0A0N0P6Q4	Leptomonas seymouri	25%	97%
A0A0N1I4X2	Leptomonas seymouri	25%	71%
A0A0N1I913	Leptomonas seymouri	34%	96%
A0A0N1I9E8	Leptomonas seymouri	27%	100%
A0A0N1PB21	Leptomonas seymouri	74%	97%
A0A0N1PDX1	Leptomonas seymouri	26%	95%
A0A0S4ILS9	Bodo saltans	27%	99%
A0A0S4IT20	Bodo saltans	26%	97%
A0A0S4IUY2	Bodo saltans	53%	100%
A0A0S4JJT8	Bodo saltans	25%	85%
A0A0S4JMB1	Bodo saltans	33%	95%
A0A0S4KHW9	Bodo saltans	45%	97%
A0A1X0NRR2	Trypanosomatidae	24%	68%
A0A1X0NZZ5	Trypanosomatidae	27%	98%
A0A1X0P0B2	Trypanosomatidae	31%	98%
A0A1X0P8R2	Trypanosomatidae	58%	100%
A0A3Q8ICJ5	Leishmania donovani	25%	98%
A0A3Q8IRG0	Leishmania donovani	31%	98%
A0A3R7L374	Trypanosoma rangeli	61%	99%
A0A3S7WSH2	Leishmania donovani	31%	97%
A0A3S7X2E3	Leishmania donovani	26%	95%
A0A422NF38	Trypanosoma rangeli	31%	99%
A0A451EJQ8	Leishmania donovani	97%	100%
A4H3L9	Leishmania braziliensis	88%	100%
A4H648	Leishmania braziliensis	28%	89%
A4H761	Leishmania braziliensis	30%	96%
A4HCV8	Leishmania braziliensis	24%	98%
A4HHB3	Leishmania braziliensis	28%	95%
A4HPT6	Leishmania braziliensis	30%	98%
A4HVK0	Leishmania infantum	31%	97%
A4I0D8	Leishmania infantum	25%	98%
A4I4G0	Leishmania infantum	27%	95%
A4IE56	Leishmania infantum	31%	98%
A4YGN2	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	26%	100%
A6QQF5	Bos taurus	30%	95%
A7RK30	Nematostella vectensis	28%	91%
B0BNC9	Rattus norvegicus	30%	95%
C9ZLK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
D0A480	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	99%
E5AE42	Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)	25%	93%
E9ADV9	Leishmania major	26%	95%
E9AG46	Leishmania infantum	98%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9ALX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	95%
E9AP96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	96%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	98%
E9AWA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	98%
F2Z678	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	95%
K4BW79	Solanum lycopersicum	30%	86%
O00097	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	26%	95%
O13309	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	28%	95%
O23939	Fragaria vesca	28%	100%
O31186	Rhizobium meliloti (strain 1021)	28%	98%
O35017	Bacillus subtilis (strain 168)	23%	100%
O42909	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	96%
O45903	Caenorhabditis elegans	24%	97%
O74489	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O94038	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	95%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	96%
O97764	Bos taurus	28%	100%
P00330	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	95%
P00331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	95%
P00332	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	95%
P07246	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	89%
P07754	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	29%	94%
P08843	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	95%
P0DN30	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	29%	100%
P11415	Cavia porcellus	29%	100%
P12311	Geobacillus stearothermophilus	26%	99%
P14940	Cupriavidus necator	30%	91%
P19333	Tetronarce californica	28%	88%
P20368	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	24%	99%
P20369	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	95%
P28304	Escherichia coli (strain K12)	40%	100%
P34055	Hypocrea atroviridis	27%	98%
P38113	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	95%
P38230	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	99%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	38%	100%
P41747	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	29%	95%
P42327	Geobacillus stearothermophilus	26%	98%
P42328	Geobacillus stearothermophilus	26%	98%
P42865	Leishmania amazonensis	30%	98%
P43067	Candida albicans	26%	95%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	42%	100%
P47199	Mus musculus	30%	100%
P49383	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	95%
P49384	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	89%
P49385	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	89%
P54202	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	90%
P76113	Escherichia coli (strain K12)	28%	96%
P97584	Rattus norvegicus	27%	100%
Q07288	Kluyveromyces marxianus	27%	95%
Q08257	Homo sapiens	27%	100%
Q0CJC5	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	31%	93%
Q0KDL6	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	30%	91%
Q0MVN8	Sus scrofa	28%	100%
Q1PSI9	Vitis vinifera	25%	91%
Q24K16	Bos taurus	37%	88%
Q28452	Lama guanicoe	28%	100%
Q32L99	Bos taurus	27%	95%
Q3IZ91	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	25%	77%
Q3MIE4	Rattus norvegicus	28%	82%
Q3UNZ8	Mus musculus	30%	95%
Q4Q0Z7	Leishmania major	31%	98%
Q4QB77	Leishmania major	25%	98%
Q4QG82	Leishmania major	31%	85%
Q53865	Streptomyces collinus	25%	74%
Q53FA7	Homo sapiens	24%	100%
Q54YT4	Dictyostelium discoideum	25%	95%
Q59I44	Burkholderia sp.	36%	100%
Q5HM44	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	25%	99%
Q5R4S7	Pongo abelii	27%	100%
Q5R806	Pongo abelii	27%	95%
Q62465	Mus musculus	29%	82%
Q6AYT0	Rattus norvegicus	30%	100%
Q6XQ67	Saccharomyces pastorianus	29%	95%
Q80TB8	Mus musculus	23%	80%
Q82LU9	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	26%	75%
Q84V25	Fragaria ananassa	26%	100%
Q8BGC4	Mus musculus	30%	88%
Q8CQ56	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	21%	98%
Q8CRJ7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	25%	99%
Q8GIX7	Moraxella sp. (strain TAE123)	25%	98%
Q8H0M1	Spinacia oleracea	27%	100%
Q8JFV8	Danio rerio	25%	69%
Q8KQL2	Enterococcus avium	29%	94%
Q8N4Q0	Homo sapiens	35%	88%
Q8N8N7	Homo sapiens	26%	95%
Q941I0	Fragaria ananassa	28%	100%
Q96XE0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	24%	96%
Q975C8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	24%	99%
Q99536	Homo sapiens	27%	84%
Q9HCJ6	Homo sapiens	23%	79%
Q9P4C2	Kluyveromyces marxianus	27%	95%
Q9P6C8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	94%
Q9SV68	Arabidopsis thaliana	29%	100%
Q9Z311	Rattus norvegicus	27%	89%
Q9ZUC1	Arabidopsis thaliana	26%	86%
V5B1P3	Trypanosoma cruzi	27%	99%
V5BXF0	Trypanosoma cruzi	60%	99%