Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACK1_LEIMA

TriTrypDb:

LmjF.03.0560 , LMJLV39_030010900 , LMJSD75_030010900

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.634
CLV_C14_Caspase3-7	671	675	PF00656	0.589
CLV_NRD_NRD_1	19	21	PF00675	0.523
CLV_NRD_NRD_1	23	25	PF00675	0.489
CLV_NRD_NRD_1	250	252	PF00675	0.610
CLV_NRD_NRD_1	308	310	PF00675	0.647
CLV_NRD_NRD_1	349	351	PF00675	0.560
CLV_NRD_NRD_1	391	393	PF00675	0.475
CLV_NRD_NRD_1	440	442	PF00675	0.626
CLV_NRD_NRD_1	49	51	PF00675	0.447
CLV_NRD_NRD_1	528	530	PF00675	0.719
CLV_NRD_NRD_1	569	571	PF00675	0.576
CLV_NRD_NRD_1	63	65	PF00675	0.485
CLV_NRD_NRD_1	709	711	PF00675	0.529
CLV_NRD_NRD_1	77	79	PF00675	0.416
CLV_PCSK_FUR_1	567	571	PF00082	0.569
CLV_PCSK_KEX2_1	18	20	PF00082	0.503
CLV_PCSK_KEX2_1	23	25	PF00082	0.500
CLV_PCSK_KEX2_1	250	252	PF00082	0.607
CLV_PCSK_KEX2_1	308	310	PF00082	0.643
CLV_PCSK_KEX2_1	349	351	PF00082	0.560
CLV_PCSK_KEX2_1	367	369	PF00082	0.505
CLV_PCSK_KEX2_1	391	393	PF00082	0.475
CLV_PCSK_KEX2_1	439	441	PF00082	0.631
CLV_PCSK_KEX2_1	49	51	PF00082	0.447
CLV_PCSK_KEX2_1	528	530	PF00082	0.719
CLV_PCSK_KEX2_1	569	571	PF00082	0.576
CLV_PCSK_KEX2_1	63	65	PF00082	0.485
CLV_PCSK_KEX2_1	709	711	PF00082	0.529
CLV_PCSK_KEX2_1	77	79	PF00082	0.436
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.528
CLV_PCSK_PC7_1	19	25	PF00082	0.487
CLV_PCSK_SKI1_1	189	193	PF00082	0.566
CLV_PCSK_SKI1_1	384	388	PF00082	0.407
CLV_PCSK_SKI1_1	63	67	PF00082	0.521
DEG_ODPH_VHL_1	554	565	PF01847	0.345
DEG_ODPH_VHL_1	638	649	PF01847	0.628
DEG_SPOP_SBC_1	167	171	PF00917	0.703
DEG_SPOP_SBC_1	195	199	PF00917	0.788
DEG_SPOP_SBC_1	532	536	PF00917	0.542
DEG_SPOP_SBC_1	611	615	PF00917	0.671
DOC_ANK_TNKS_1	53	60	PF00023	0.683
DOC_CDC14_PxL_1	657	665	PF14671	0.557
DOC_CKS1_1	148	153	PF01111	0.734
DOC_CKS1_1	355	360	PF01111	0.663
DOC_CKS1_1	601	606	PF01111	0.682
DOC_CYCLIN_RxL_1	381	390	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	421	427	PF00134	0.395
DOC_MAPK_MEF2A_6	636	644	PF00069	0.604
DOC_MAPK_MEF2A_6	650	658	PF00069	0.588
DOC_PP2B_LxvP_1	421	424	PF13499	0.395
DOC_PP2B_LxvP_1	553	556	PF13499	0.395
DOC_PP2B_LxvP_1	658	661	PF13499	0.624
DOC_PP2B_LxvP_1	678	681	PF13499	0.614
DOC_USP7_MATH_1	173	177	PF00917	0.773
DOC_USP7_MATH_1	195	199	PF00917	0.697
DOC_USP7_MATH_1	260	264	PF00917	0.782
DOC_USP7_MATH_1	274	278	PF00917	0.648
DOC_USP7_MATH_1	301	305	PF00917	0.788
DOC_USP7_MATH_1	313	317	PF00917	0.675
DOC_USP7_MATH_1	320	324	PF00917	0.627
DOC_USP7_MATH_1	375	379	PF00917	0.658
DOC_USP7_MATH_1	451	455	PF00917	0.524
DOC_USP7_MATH_1	472	476	PF00917	0.517
DOC_USP7_MATH_1	532	536	PF00917	0.523
DOC_USP7_MATH_1	545	549	PF00917	0.264
DOC_USP7_MATH_1	599	603	PF00917	0.762
DOC_USP7_MATH_1	611	615	PF00917	0.659
DOC_USP7_MATH_1	65	69	PF00917	0.717
DOC_USP7_MATH_1	690	694	PF00917	0.674
DOC_USP7_MATH_1	698	702	PF00917	0.665
DOC_USP7_UBL2_3	363	367	PF12436	0.678
DOC_WW_Pin1_4	147	152	PF00397	0.838
DOC_WW_Pin1_4	262	267	PF00397	0.763
DOC_WW_Pin1_4	354	359	PF00397	0.747
DOC_WW_Pin1_4	368	373	PF00397	0.730
DOC_WW_Pin1_4	457	462	PF00397	0.446
DOC_WW_Pin1_4	588	593	PF00397	0.746
DOC_WW_Pin1_4	600	605	PF00397	0.658
DOC_WW_Pin1_4	704	709	PF00397	0.758
DOC_WW_Pin1_4	95	100	PF00397	0.703
LIG_14-3-3_CanoR_1	189	194	PF00244	0.758
LIG_14-3-3_CanoR_1	23	29	PF00244	0.664
LIG_14-3-3_CanoR_1	54	58	PF00244	0.699
LIG_14-3-3_CanoR_1	609	618	PF00244	0.635
LIG_14-3-3_CanoR_1	697	703	PF00244	0.729
LIG_APCC_ABBA_1	638	643	PF00400	0.508
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BRCT_BRCA1_1	1	5	PF00533	0.658
LIG_Clathr_ClatBox_1	427	431	PF01394	0.395
LIG_deltaCOP1_diTrp_1	671	676	PF00928	0.678
LIG_eIF4E_1	285	291	PF01652	0.749
LIG_FHA_1	106	112	PF00498	0.652
LIG_FHA_1	132	138	PF00498	0.705
LIG_FHA_1	143	149	PF00498	0.709
LIG_FHA_1	195	201	PF00498	0.783
LIG_FHA_1	285	291	PF00498	0.692
LIG_FHA_1	418	424	PF00498	0.395
LIG_FHA_1	447	453	PF00498	0.438
LIG_FHA_1	701	707	PF00498	0.727
LIG_FHA_1	89	95	PF00498	0.694
LIG_FHA_2	220	226	PF00498	0.670
LIG_FHA_2	33	39	PF00498	0.719
LIG_LIR_Gen_1	2	12	PF02991	0.672
LIG_LIR_Gen_1	411	422	PF02991	0.315
LIG_LIR_Gen_1	630	640	PF02991	0.567
LIG_LIR_Nem_3	2	8	PF02991	0.663
LIG_LIR_Nem_3	280	284	PF02991	0.720
LIG_LIR_Nem_3	411	417	PF02991	0.315
LIG_LIR_Nem_3	615	621	PF02991	0.662
LIG_LIR_Nem_3	630	635	PF02991	0.574
LIG_LIR_Nem_3	646	651	PF02991	0.647
LIG_PCNA_yPIPBox_3	557	570	PF02747	0.455
LIG_SH2_STAP1	651	655	PF00017	0.625
LIG_SH3_3	145	151	PF00018	0.792
LIG_SH3_3	188	194	PF00018	0.832
LIG_SH3_3	352	358	PF00018	0.689
LIG_SH3_3	366	372	PF00018	0.771
LIG_SH3_3	401	407	PF00018	0.700
LIG_SH3_3	598	604	PF00018	0.686
LIG_SH3_3	658	664	PF00018	0.581
LIG_TRAF2_1	395	398	PF00917	0.530
LIG_TRAF2_1	682	685	PF00917	0.800
LIG_TYR_ITIM	649	654	PF00017	0.444
LIG_WW_2	661	664	PF00397	0.455
MOD_CDC14_SPxK_1	707	710	PF00782	0.535
MOD_CDK_SPK_2	147	152	PF00069	0.677
MOD_CDK_SPK_2	704	709	PF00069	0.586
MOD_CDK_SPxK_1	704	710	PF00069	0.537
MOD_CDK_SPxxK_3	602	609	PF00069	0.627
MOD_CDK_SPxxK_3	95	102	PF00069	0.609
MOD_CK1_1	133	139	PF00069	0.624
MOD_CK1_1	160	166	PF00069	0.661
MOD_CK1_1	198	204	PF00069	0.758
MOD_CK1_1	205	211	PF00069	0.686
MOD_CK1_1	212	218	PF00069	0.608
MOD_CK1_1	25	31	PF00069	0.606
MOD_CK1_1	304	310	PF00069	0.699
MOD_CK1_1	371	377	PF00069	0.678
MOD_CK1_1	378	384	PF00069	0.648
MOD_CK1_1	455	461	PF00069	0.622
MOD_CK1_1	489	495	PF00069	0.787
MOD_CK1_1	513	519	PF00069	0.737
MOD_CK1_1	535	541	PF00069	0.613
MOD_CK1_1	602	608	PF00069	0.730
MOD_CK1_1	610	616	PF00069	0.608
MOD_CK1_1	670	676	PF00069	0.545
MOD_CK1_1	700	706	PF00069	0.546
MOD_CK2_1	182	188	PF00069	0.619
MOD_CK2_1	387	393	PF00069	0.660
MOD_CK2_1	611	617	PF00069	0.605
MOD_Cter_Amidation	365	368	PF01082	0.597
MOD_Cter_Amidation	75	78	PF01082	0.627
MOD_DYRK1A_RPxSP_1	368	372	PF00069	0.709
MOD_GlcNHglycan	162	165	PF01048	0.672
MOD_GlcNHglycan	175	178	PF01048	0.685
MOD_GlcNHglycan	204	207	PF01048	0.699
MOD_GlcNHglycan	211	214	PF01048	0.773
MOD_GlcNHglycan	276	279	PF01048	0.700
MOD_GlcNHglycan	315	318	PF01048	0.781
MOD_GlcNHglycan	373	376	PF01048	0.704
MOD_GlcNHglycan	449	452	PF01048	0.679
MOD_GlcNHglycan	454	457	PF01048	0.787
MOD_GlcNHglycan	488	491	PF01048	0.671
MOD_GlcNHglycan	503	506	PF01048	0.626
MOD_GlcNHglycan	512	515	PF01048	0.673
MOD_GlcNHglycan	516	519	PF01048	0.700
MOD_GlcNHglycan	538	541	PF01048	0.574
MOD_GlcNHglycan	55	58	PF01048	0.672
MOD_GlcNHglycan	609	612	PF01048	0.596
MOD_GlcNHglycan	71	74	PF01048	0.523
MOD_GlcNHglycan	79	82	PF01048	0.538
MOD_GSK3_1	105	112	PF00069	0.565
MOD_GSK3_1	122	129	PF00069	0.742
MOD_GSK3_1	162	169	PF00069	0.642
MOD_GSK3_1	194	201	PF00069	0.647
MOD_GSK3_1	205	212	PF00069	0.667
MOD_GSK3_1	215	222	PF00069	0.660
MOD_GSK3_1	262	269	PF00069	0.803
MOD_GSK3_1	371	378	PF00069	0.662
MOD_GSK3_1	413	420	PF00069	0.395
MOD_GSK3_1	442	449	PF00069	0.595
MOD_GSK3_1	451	458	PF00069	0.624
MOD_GSK3_1	496	503	PF00069	0.601
MOD_GSK3_1	510	517	PF00069	0.707
MOD_GSK3_1	531	538	PF00069	0.738
MOD_GSK3_1	590	597	PF00069	0.691
MOD_GSK3_1	607	614	PF00069	0.544
MOD_GSK3_1	65	72	PF00069	0.582
MOD_GSK3_1	696	703	PF00069	0.643
MOD_LATS_1	21	27	PF00433	0.532
MOD_LATS_1	695	701	PF00433	0.555
MOD_N-GLC_1	326	331	PF02516	0.644
MOD_N-GLC_1	486	491	PF02516	0.626
MOD_N-GLC_1	588	593	PF02516	0.541
MOD_N-GLC_1	691	696	PF02516	0.690
MOD_NEK2_1	144	149	PF00069	0.629
MOD_NEK2_1	209	214	PF00069	0.765
MOD_NEK2_1	284	289	PF00069	0.624
MOD_NEK2_1	326	331	PF00069	0.644
MOD_NEK2_1	387	392	PF00069	0.506
MOD_NEK2_1	417	422	PF00069	0.350
MOD_NEK2_1	500	505	PF00069	0.589
MOD_NEK2_1	594	599	PF00069	0.616
MOD_NEK2_1	607	612	PF00069	0.485
MOD_NEK2_2	127	132	PF00069	0.544
MOD_PKA_1	23	29	PF00069	0.525
MOD_PKA_1	376	382	PF00069	0.558
MOD_PKA_1	569	575	PF00069	0.766
MOD_PKA_1	709	715	PF00069	0.574
MOD_PKA_1	77	83	PF00069	0.650
MOD_PKA_2	22	28	PF00069	0.577
MOD_PKA_2	339	345	PF00069	0.629
MOD_PKA_2	53	59	PF00069	0.663
MOD_PKA_2	569	575	PF00069	0.766
MOD_PKA_2	696	702	PF00069	0.537
MOD_PKA_2	709	715	PF00069	0.634
MOD_PKA_2	77	83	PF00069	0.697
MOD_PKB_1	567	575	PF00069	0.753
MOD_Plk_1	195	201	PF00069	0.743
MOD_Plk_1	326	332	PF00069	0.645
MOD_Plk_1	442	448	PF00069	0.627
MOD_Plk_1	583	589	PF00069	0.597
MOD_Plk_1	691	697	PF00069	0.540
MOD_Plk_2-3	182	188	PF00069	0.543
MOD_Plk_2-3	225	231	PF00069	0.597
MOD_Plk_2-3	32	38	PF00069	0.656
MOD_Plk_2-3	393	399	PF00069	0.405
MOD_Plk_4	144	150	PF00069	0.703
MOD_Plk_4	182	188	PF00069	0.556
MOD_Plk_4	326	332	PF00069	0.695
MOD_Plk_4	413	419	PF00069	0.333
MOD_Plk_4	545	551	PF00069	0.348
MOD_Plk_4	583	589	PF00069	0.688
MOD_ProDKin_1	147	153	PF00069	0.817
MOD_ProDKin_1	262	268	PF00069	0.715
MOD_ProDKin_1	354	360	PF00069	0.690
MOD_ProDKin_1	368	374	PF00069	0.666
MOD_ProDKin_1	457	463	PF00069	0.549
MOD_ProDKin_1	588	594	PF00069	0.692
MOD_ProDKin_1	600	606	PF00069	0.567
MOD_ProDKin_1	704	710	PF00069	0.709
MOD_ProDKin_1	95	101	PF00069	0.631
MOD_SUMO_rev_2	684	689	PF00179	0.622
TRG_DiLeu_BaEn_1	182	187	PF01217	0.555
TRG_DiLeu_BaEn_4	397	403	PF01217	0.401
TRG_ENDOCYTIC_2	618	621	PF00928	0.649
TRG_ENDOCYTIC_2	632	635	PF00928	0.401
TRG_ENDOCYTIC_2	651	654	PF00928	0.599
TRG_ER_diArg_1	17	20	PF00400	0.617
TRG_ER_diArg_1	250	252	PF00400	0.731
TRG_ER_diArg_1	308	310	PF00400	0.774
TRG_ER_diArg_1	348	350	PF00400	0.672
TRG_ER_diArg_1	438	441	PF00400	0.527
TRG_ER_diArg_1	48	50	PF00400	0.550
TRG_ER_diArg_1	527	529	PF00400	0.646
TRG_ER_diArg_1	567	570	PF00400	0.713
TRG_ER_diArg_1	708	710	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	619	624	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4E7	Leptomonas seymouri	29%	100%
A0A3S5H548	Leishmania donovani	85%	100%
A4H3L8	Leishmania braziliensis	58%	100%
E9AG45	Leishmania infantum	86%	100%
E9AJT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%