RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACJ7_LEIMA

TriTrypDb:

LmjF.03.0520 , LMJLV39_030010500 , LMJSD75_030010500

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000243	commitment complex	5	2
GO:0005681	spliceosomal complex	3	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0016604	nuclear body	2	2
GO:0016607	nuclear speck	3	2
GO:0032991	protein-containing complex	1	2
GO:0071004	U2-type prespliceosome	5	2
GO:0071010	prespliceosome	4	2
GO:0089701	U2AF complex	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9ACJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACJ7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	9
GO:0003727	single-stranded RNA binding	5	2
GO:0005488	binding	1	10
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0030628	pre-mRNA 3'-splice site binding	6	2
GO:0036002	pre-mRNA binding	5	2
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.637
CLV_C14_Caspase3-7	409	413	PF00656	0.468
CLV_C14_Caspase3-7	477	481	PF00656	0.495
CLV_C14_Caspase3-7	8	12	PF00656	0.759
CLV_MEL_PAP_1	337	343	PF00089	0.480
CLV_NRD_NRD_1	292	294	PF00675	0.528
CLV_NRD_NRD_1	298	300	PF00675	0.432
CLV_NRD_NRD_1	326	328	PF00675	0.406
CLV_NRD_NRD_1	421	423	PF00675	0.431
CLV_NRD_NRD_1	48	50	PF00675	0.607
CLV_NRD_NRD_1	61	63	PF00675	0.689
CLV_NRD_NRD_1	669	671	PF00675	0.468
CLV_NRD_NRD_1	81	83	PF00675	0.756
CLV_NRD_NRD_1	84	86	PF00675	0.631
CLV_PCSK_FUR_1	46	50	PF00082	0.728
CLV_PCSK_FUR_1	82	86	PF00082	0.646
CLV_PCSK_KEX2_1	292	294	PF00082	0.528
CLV_PCSK_KEX2_1	298	300	PF00082	0.432
CLV_PCSK_KEX2_1	326	328	PF00082	0.406
CLV_PCSK_KEX2_1	421	423	PF00082	0.431
CLV_PCSK_KEX2_1	48	50	PF00082	0.596
CLV_PCSK_KEX2_1	61	63	PF00082	0.692
CLV_PCSK_KEX2_1	669	671	PF00082	0.509
CLV_PCSK_KEX2_1	81	83	PF00082	0.650
CLV_PCSK_KEX2_1	84	86	PF00082	0.634
CLV_PCSK_PC7_1	44	50	PF00082	0.628
CLV_PCSK_SKI1_1	404	408	PF00082	0.515
CLV_PCSK_SKI1_1	436	440	PF00082	0.418
CLV_PCSK_SKI1_1	452	456	PF00082	0.219
CLV_PCSK_SKI1_1	460	464	PF00082	0.279
CLV_PCSK_SKI1_1	479	483	PF00082	0.346
CLV_PCSK_SKI1_1	508	512	PF00082	0.493
CLV_PCSK_SKI1_1	588	592	PF00082	0.521
DEG_SCF_FBW7_1	104	109	PF00400	0.551
DEG_SPOP_SBC_1	260	264	PF00917	0.811
DEG_SPOP_SBC_1	818	822	PF00917	0.848
DOC_CKS1_1	103	108	PF01111	0.608
DOC_CKS1_1	623	628	PF01111	0.502
DOC_CYCLIN_RxL_1	273	282	PF00134	0.543
DOC_CYCLIN_RxL_1	401	410	PF00134	0.526
DOC_CYCLIN_RxL_1	457	465	PF00134	0.495
DOC_CYCLIN_RxL_1	585	594	PF00134	0.591
DOC_MAPK_FxFP_2	761	764	PF00069	0.557
DOC_MAPK_gen_1	376	385	PF00069	0.391
DOC_MAPK_gen_1	658	667	PF00069	0.401
DOC_MAPK_MEF2A_6	238	245	PF00069	0.686
DOC_MAPK_MEF2A_6	378	387	PF00069	0.403
DOC_MAPK_MEF2A_6	513	520	PF00069	0.539
DOC_MAPK_NFAT4_5	238	246	PF00069	0.691
DOC_PP1_RVXF_1	458	465	PF00149	0.573
DOC_PP2B_LxvP_1	281	284	PF13499	0.598
DOC_PP2B_LxvP_1	320	323	PF13499	0.498
DOC_PP2B_LxvP_1	665	668	PF13499	0.381
DOC_PP4_FxxP_1	141	144	PF00568	0.787
DOC_PP4_FxxP_1	595	598	PF00568	0.618
DOC_PP4_FxxP_1	60	63	PF00568	0.670
DOC_PP4_FxxP_1	761	764	PF00568	0.557
DOC_USP7_MATH_1	106	110	PF00917	0.743
DOC_USP7_MATH_1	144	148	PF00917	0.641
DOC_USP7_MATH_1	218	222	PF00917	0.596
DOC_USP7_MATH_1	259	263	PF00917	0.691
DOC_USP7_MATH_1	300	304	PF00917	0.466
DOC_USP7_MATH_1	447	451	PF00917	0.555
DOC_USP7_MATH_1	540	544	PF00917	0.733
DOC_USP7_MATH_1	566	570	PF00917	0.796
DOC_USP7_MATH_1	819	823	PF00917	0.801
DOC_USP7_MATH_1	828	832	PF00917	0.808
DOC_USP7_UBL2_3	529	533	PF12436	0.589
DOC_WW_Pin1_4	102	107	PF00397	0.601
DOC_WW_Pin1_4	160	165	PF00397	0.743
DOC_WW_Pin1_4	193	198	PF00397	0.724
DOC_WW_Pin1_4	622	627	PF00397	0.524
DOC_WW_Pin1_4	839	844	PF00397	0.606
LIG_14-3-3_CanoR_1	326	334	PF00244	0.546
LIG_14-3-3_CanoR_1	376	381	PF00244	0.458
LIG_14-3-3_CanoR_1	718	722	PF00244	0.568
LIG_14-3-3_CanoR_1	755	764	PF00244	0.425
LIG_AP2alpha_2	58	60	PF02296	0.650
LIG_APCC_ABBA_1	631	636	PF00400	0.411
LIG_APCC_ABBA_1	698	703	PF00400	0.364
LIG_BIR_III_2	425	429	PF00653	0.554
LIG_BRCT_BRCA1_1	378	382	PF00533	0.385
LIG_BRCT_BRCA1_1	759	763	PF00533	0.447
LIG_Clathr_ClatBox_1	278	282	PF01394	0.642
LIG_Clathr_ClatBox_1	461	465	PF01394	0.479
LIG_eIF4E_1	623	629	PF01652	0.382
LIG_FHA_1	221	227	PF00498	0.647
LIG_FHA_1	356	362	PF00498	0.715
LIG_FHA_1	413	419	PF00498	0.587
LIG_FHA_1	540	546	PF00498	0.617
LIG_FHA_1	623	629	PF00498	0.459
LIG_FHA_1	718	724	PF00498	0.495
LIG_FHA_1	757	763	PF00498	0.533
LIG_FHA_1	840	846	PF00498	0.806
LIG_FHA_2	307	313	PF00498	0.457
LIG_FHA_2	428	434	PF00498	0.595
LIG_FHA_2	517	523	PF00498	0.525
LIG_FHA_2	572	578	PF00498	0.503
LIG_FHA_2	594	600	PF00498	0.595
LIG_FHA_2	6	12	PF00498	0.564
LIG_FHA_2	734	740	PF00498	0.461
LIG_FHA_2	768	774	PF00498	0.600
LIG_Integrin_RGD_1	207	209	PF01839	0.660
LIG_LIR_Apic_2	140	144	PF02991	0.838
LIG_LIR_Apic_2	58	63	PF02991	0.659
LIG_LIR_Apic_2	592	598	PF02991	0.612
LIG_LIR_Apic_2	621	626	PF02991	0.526
LIG_LIR_Apic_2	759	764	PF02991	0.548
LIG_LIR_Gen_1	315	325	PF02991	0.426
LIG_LIR_Gen_1	379	390	PF02991	0.391
LIG_LIR_Gen_1	474	481	PF02991	0.503
LIG_LIR_Gen_1	642	652	PF02991	0.459
LIG_LIR_Gen_1	733	741	PF02991	0.413
LIG_LIR_Nem_3	230	235	PF02991	0.586
LIG_LIR_Nem_3	315	321	PF02991	0.407
LIG_LIR_Nem_3	379	385	PF02991	0.364
LIG_LIR_Nem_3	456	461	PF02991	0.486
LIG_LIR_Nem_3	474	478	PF02991	0.503
LIG_LIR_Nem_3	54	60	PF02991	0.552
LIG_LIR_Nem_3	642	648	PF02991	0.468
LIG_LIR_Nem_3	657	662	PF02991	0.447
LIG_LIR_Nem_3	733	737	PF02991	0.408
LIG_LIR_Nem_3	760	766	PF02991	0.459
LIG_LYPXL_S_1	607	611	PF13949	0.519
LIG_LYPXL_yS_3	416	419	PF13949	0.450
LIG_LYPXL_yS_3	608	611	PF13949	0.593
LIG_MAD2	436	444	PF02301	0.442
LIG_NRBOX	180	186	PF00104	0.608
LIG_NRBOX	506	512	PF00104	0.524
LIG_PCNA_TLS_4	311	318	PF02747	0.515
LIG_Pex14_2	141	145	PF04695	0.651
LIG_Rb_pABgroove_1	628	636	PF01858	0.395
LIG_SH2_CRK	458	462	PF00017	0.546
LIG_SH2_CRK	623	627	PF00017	0.581
LIG_SH2_CRK	645	649	PF00017	0.441
LIG_SH2_CRK	659	663	PF00017	0.358
LIG_SH2_CRK	727	731	PF00017	0.527
LIG_SH2_GRB2like	615	618	PF00017	0.600
LIG_SH2_GRB2like	715	718	PF00017	0.548
LIG_SH2_NCK_1	734	738	PF00017	0.424
LIG_SH2_SRC	470	473	PF00017	0.546
LIG_SH2_SRC	615	618	PF00017	0.529
LIG_SH2_STAP1	120	124	PF00017	0.548
LIG_SH2_STAP1	641	645	PF00017	0.444
LIG_SH2_STAP1	79	83	PF00017	0.546
LIG_SH2_STAT3	107	110	PF00017	0.620
LIG_SH2_STAT5	317	320	PF00017	0.410
LIG_SH2_STAT5	530	533	PF00017	0.659
LIG_SH3_3	194	200	PF00018	0.725
LIG_SH3_3	231	237	PF00018	0.575
LIG_SH3_3	437	443	PF00018	0.436
LIG_SH3_3	496	502	PF00018	0.439
LIG_SH3_3	671	677	PF00018	0.484
LIG_SH3_5	682	686	PF00018	0.604
LIG_SUMO_SIM_anti_2	433	441	PF11976	0.477
LIG_SUMO_SIM_anti_2	625	631	PF11976	0.353
LIG_SUMO_SIM_par_1	277	282	PF11976	0.717
LIG_SUMO_SIM_par_1	569	578	PF11976	0.698
LIG_TRAF2_1	228	231	PF00917	0.564
LIG_TRAF2_1	310	313	PF00917	0.479
LIG_TRAF2_1	770	773	PF00917	0.588
LIG_TRAF2_1	792	795	PF00917	0.661
LIG_TYR_ITIM	732	737	PF00017	0.400
LIG_UBA3_1	278	285	PF00899	0.524
LIG_UBA3_1	503	508	PF00899	0.379
LIG_WRC_WIRS_1	758	763	PF05994	0.484
LIG_WW_3	198	202	PF00397	0.666
LIG_WW_3	62	66	PF00397	0.659
MOD_CK1_1	21	27	PF00069	0.671
MOD_CK1_1	262	268	PF00069	0.744
MOD_CK1_1	618	624	PF00069	0.523
MOD_CK1_1	643	649	PF00069	0.458
MOD_CK1_1	844	850	PF00069	0.618
MOD_CK2_1	225	231	PF00069	0.653
MOD_CK2_1	306	312	PF00069	0.459
MOD_CK2_1	360	366	PF00069	0.705
MOD_CK2_1	378	384	PF00069	0.355
MOD_CK2_1	442	448	PF00069	0.569
MOD_CK2_1	571	577	PF00069	0.512
MOD_CK2_1	733	739	PF00069	0.407
MOD_CK2_1	767	773	PF00069	0.577
MOD_CK2_1	800	806	PF00069	0.675
MOD_GlcNHglycan	146	149	PF01048	0.642
MOD_GlcNHglycan	220	223	PF01048	0.658
MOD_GlcNHglycan	251	254	PF01048	0.666
MOD_GlcNHglycan	302	305	PF01048	0.518
MOD_GlcNHglycan	33	36	PF01048	0.615
MOD_GlcNHglycan	372	375	PF01048	0.407
MOD_GlcNHglycan	397	400	PF01048	0.574
MOD_GlcNHglycan	526	529	PF01048	0.520
MOD_GlcNHglycan	541	545	PF01048	0.596
MOD_GlcNHglycan	569	572	PF01048	0.820
MOD_GlcNHglycan	70	75	PF01048	0.711
MOD_GlcNHglycan	829	833	PF01048	0.773
MOD_GSK3_1	102	109	PF00069	0.598
MOD_GSK3_1	366	373	PF00069	0.554
MOD_GSK3_1	5	12	PF00069	0.830
MOD_GSK3_1	567	574	PF00069	0.565
MOD_GSK3_1	618	625	PF00069	0.512
MOD_GSK3_1	753	760	PF00069	0.452
MOD_N-GLC_1	407	412	PF02516	0.458
MOD_N-GLC_1	643	648	PF02516	0.461
MOD_NEK2_1	211	216	PF00069	0.614
MOD_NEK2_1	370	375	PF00069	0.418
MOD_NEK2_1	406	411	PF00069	0.454
MOD_NEK2_1	591	596	PF00069	0.497
MOD_NEK2_2	447	452	PF00069	0.555
MOD_PIKK_1	106	112	PF00454	0.616
MOD_PIKK_1	262	268	PF00454	0.651
MOD_PIKK_1	393	399	PF00454	0.430
MOD_PIKK_1	5	11	PF00454	0.570
MOD_PIKK_1	615	621	PF00454	0.607
MOD_PIKK_1	643	649	PF00454	0.458
MOD_PIKK_1	819	825	PF00454	0.672
MOD_PK_1	368	374	PF00069	0.445
MOD_PK_1	841	847	PF00069	0.572
MOD_PKA_2	3	9	PF00069	0.683
MOD_PKA_2	717	723	PF00069	0.559
MOD_Plk_1	407	413	PF00069	0.461
MOD_Plk_1	447	453	PF00069	0.495
MOD_Plk_1	516	522	PF00069	0.572
MOD_Plk_1	540	546	PF00069	0.689
MOD_Plk_1	591	597	PF00069	0.539
MOD_Plk_1	643	649	PF00069	0.444
MOD_Plk_1	753	759	PF00069	0.472
MOD_Plk_2-3	733	739	PF00069	0.407
MOD_Plk_2-3	790	796	PF00069	0.580
MOD_Plk_2-3	800	806	PF00069	0.549
MOD_Plk_4	236	242	PF00069	0.561
MOD_Plk_4	618	624	PF00069	0.545
MOD_Plk_4	757	763	PF00069	0.432
MOD_ProDKin_1	102	108	PF00069	0.600
MOD_ProDKin_1	160	166	PF00069	0.744
MOD_ProDKin_1	193	199	PF00069	0.721
MOD_ProDKin_1	622	628	PF00069	0.514
MOD_ProDKin_1	839	845	PF00069	0.606
MOD_SUMO_for_1	462	465	PF00179	0.495
MOD_SUMO_rev_2	363	370	PF00179	0.563
MOD_SUMO_rev_2	433	438	PF00179	0.517
TRG_DiLeu_BaEn_1	339	344	PF01217	0.584
TRG_ENDOCYTIC_2	120	123	PF00928	0.729
TRG_ENDOCYTIC_2	317	320	PF00928	0.467
TRG_ENDOCYTIC_2	416	419	PF00928	0.554
TRG_ENDOCYTIC_2	458	461	PF00928	0.506
TRG_ENDOCYTIC_2	472	475	PF00928	0.422
TRG_ENDOCYTIC_2	57	60	PF00928	0.552
TRG_ENDOCYTIC_2	608	611	PF00928	0.630
TRG_ENDOCYTIC_2	645	648	PF00928	0.411
TRG_ENDOCYTIC_2	659	662	PF00928	0.398
TRG_ENDOCYTIC_2	727	730	PF00928	0.447
TRG_ENDOCYTIC_2	734	737	PF00928	0.391
TRG_ER_diArg_1	292	295	PF00400	0.544
TRG_ER_diArg_1	325	327	PF00400	0.389
TRG_ER_diArg_1	420	422	PF00400	0.417
TRG_ER_diArg_1	44	47	PF00400	0.679
TRG_ER_diArg_1	60	62	PF00400	0.649
TRG_ER_diArg_1	668	670	PF00400	0.436
TRG_ER_diArg_1	81	84	PF00400	0.649
TRG_NES_CRM1_1	333	347	PF08389	0.474
TRG_NES_CRM1_1	585	599	PF08389	0.593
TRG_Pf-PMV_PEXEL_1	326	331	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWG2	Leptomonas seymouri	55%	100%
A0A0S4IUY1	Bodo saltans	32%	100%
A0A3R7MIS4	Trypanosoma rangeli	38%	97%
A0A3S5H546	Leishmania donovani	92%	100%
A4H3L4	Leishmania braziliensis	80%	100%
E9AG41	Leishmania infantum	91%	99%
E9AJT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DU29	Trypanosoma cruzi	42%	100%