Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate-Repressible Phosphate Permease-like protein

Species:

Leishmania major

UniProt:

E9ACJ5_LEIMA

TriTrypDb:

LmjF.03.0500 , LMJLV39_030010300 , LMJSD75_030010300

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

E9ACJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACJ5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	24
GO:0006811	monoatomic ion transport	4	24
GO:0006817	phosphate ion transport	7	24
GO:0006820	monoatomic anion transport	5	24
GO:0009987	cellular process	1	4
GO:0015698	inorganic anion transport	6	24
GO:0034220	monoatomic ion transmembrane transport	3	4
GO:0035435	phosphate ion transmembrane transport	6	4
GO:0051179	localization	1	24
GO:0051234	establishment of localization	2	24
GO:0055085	transmembrane transport	2	4
GO:0098656	monoatomic anion transmembrane transport	4	4
GO:0098660	inorganic ion transmembrane transport	4	4
GO:0098661	inorganic anion transmembrane transport	5	4

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	24
GO:0005315	inorganic phosphate transmembrane transporter activity	4	24
GO:0015291	secondary active transmembrane transporter activity	4	24
GO:0015293	symporter activity	5	24
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	24
GO:0022804	active transmembrane transporter activity	3	24
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.535
CLV_NRD_NRD_1	138	140	PF00675	0.511
CLV_NRD_NRD_1	247	249	PF00675	0.228
CLV_NRD_NRD_1	289	291	PF00675	0.239
CLV_NRD_NRD_1	302	304	PF00675	0.180
CLV_NRD_NRD_1	305	307	PF00675	0.169
CLV_NRD_NRD_1	530	532	PF00675	0.235
CLV_PCSK_KEX2_1	246	248	PF00082	0.274
CLV_PCSK_KEX2_1	289	291	PF00082	0.208
CLV_PCSK_KEX2_1	302	304	PF00082	0.180
CLV_PCSK_KEX2_1	530	532	PF00082	0.300
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.336
CLV_PCSK_SKI1_1	140	144	PF00082	0.394
CLV_PCSK_SKI1_1	175	179	PF00082	0.318
CLV_PCSK_SKI1_1	284	288	PF00082	0.169
CLV_PCSK_SKI1_1	329	333	PF00082	0.347
CLV_PCSK_SKI1_1	39	43	PF00082	0.316
DEG_Nend_Nbox_1	1	3	PF02207	0.329
DEG_ODPH_VHL_1	187	200	PF01847	0.416
DEG_SPOP_SBC_1	508	512	PF00917	0.288
DOC_CKS1_1	482	487	PF01111	0.564
DOC_CYCLIN_RxL_1	172	182	PF00134	0.243
DOC_CYCLIN_RxL_1	329	338	PF00134	0.403
DOC_MAPK_DCC_7	186	196	PF00069	0.416
DOC_MAPK_gen_1	246	254	PF00069	0.520
DOC_MAPK_gen_1	530	538	PF00069	0.444
DOC_MAPK_MEF2A_6	39	48	PF00069	0.504
DOC_MAPK_MEF2A_6	531	540	PF00069	0.562
DOC_MAPK_RevD_3	232	248	PF00069	0.326
DOC_MAPK_RevD_3	518	531	PF00069	0.361
DOC_PP1_RVXF_1	213	219	PF00149	0.297
DOC_PP1_RVXF_1	528	535	PF00149	0.283
DOC_PP4_FxxP_1	157	160	PF00568	0.329
DOC_PP4_FxxP_1	468	471	PF00568	0.243
DOC_USP7_MATH_1	110	114	PF00917	0.329
DOC_USP7_MATH_1	144	148	PF00917	0.300
DOC_USP7_MATH_1	278	282	PF00917	0.457
DOC_USP7_MATH_1	364	368	PF00917	0.533
DOC_USP7_MATH_1	413	417	PF00917	0.319
DOC_USP7_MATH_1	418	422	PF00917	0.337
DOC_USP7_MATH_1	508	512	PF00917	0.288
DOC_USP7_MATH_1	568	572	PF00917	0.531
DOC_USP7_MATH_2	317	323	PF00917	0.403
DOC_USP7_UBL2_3	300	304	PF12436	0.416
DOC_WW_Pin1_4	156	161	PF00397	0.329
DOC_WW_Pin1_4	305	310	PF00397	0.499
DOC_WW_Pin1_4	352	357	PF00397	0.525
DOC_WW_Pin1_4	481	486	PF00397	0.488
LIG_14-3-3_CanoR_1	213	219	PF00244	0.304
LIG_14-3-3_CanoR_1	279	286	PF00244	0.497
LIG_14-3-3_CanoR_1	39	44	PF00244	0.525
LIG_BRCT_BRCA1_1	554	558	PF00533	0.384
LIG_CaM_NSCaTE_8	452	459	PF13499	0.359
LIG_FHA_1	180	186	PF00498	0.515
LIG_FHA_1	313	319	PF00498	0.480
LIG_FHA_1	438	444	PF00498	0.313
LIG_FHA_1	465	471	PF00498	0.318
LIG_FHA_1	493	499	PF00498	0.328
LIG_FHA_1	510	516	PF00498	0.356
LIG_FHA_1	545	551	PF00498	0.337
LIG_FHA_2	375	381	PF00498	0.528
LIG_FHA_2	76	82	PF00498	0.203
LIG_GBD_Chelix_1	194	202	PF00786	0.352
LIG_GBD_Chelix_1	493	501	PF00786	0.243
LIG_HP1_1	193	197	PF01393	0.177
LIG_HP1_1	83	87	PF01393	0.237
LIG_LIR_Apic_2	155	160	PF02991	0.329
LIG_LIR_Apic_2	467	471	PF02991	0.243
LIG_LIR_Apic_2	503	508	PF02991	0.345
LIG_LIR_Gen_1	203	212	PF02991	0.330
LIG_LIR_Gen_1	380	388	PF02991	0.394
LIG_LIR_Gen_1	81	91	PF02991	0.248
LIG_LIR_Gen_1	97	107	PF02991	0.387
LIG_LIR_LC3C_4	495	499	PF02991	0.359
LIG_LIR_Nem_3	147	152	PF02991	0.283
LIG_LIR_Nem_3	203	209	PF02991	0.330
LIG_LIR_Nem_3	380	386	PF02991	0.529
LIG_LIR_Nem_3	401	407	PF02991	0.473
LIG_LIR_Nem_3	526	532	PF02991	0.319
LIG_LIR_Nem_3	97	103	PF02991	0.375
LIG_MYND_1	189	193	PF01753	0.416
LIG_NRP_CendR_1	569	572	PF00754	0.568
LIG_Pex14_2	200	204	PF04695	0.332
LIG_SH2_CRK	342	346	PF00017	0.403
LIG_SH2_CRK	431	435	PF00017	0.216
LIG_SH2_CRK	505	509	PF00017	0.387
LIG_SH2_CRK	88	92	PF00017	0.364
LIG_SH2_NCK_1	431	435	PF00017	0.216
LIG_SH2_SRC	388	391	PF00017	0.416
LIG_SH2_STAP1	431	435	PF00017	0.285
LIG_SH2_STAT5	145	148	PF00017	0.270
LIG_SH2_STAT5	190	193	PF00017	0.436
LIG_SH2_STAT5	385	388	PF00017	0.538
LIG_SH2_STAT5	5	8	PF00017	0.321
LIG_SH2_STAT5	541	544	PF00017	0.286
LIG_SH2_STAT5	84	87	PF00017	0.330
LIG_SH3_3	350	356	PF00018	0.408
LIG_SH3_3	479	485	PF00018	0.564
LIG_Sin3_3	166	173	PF02671	0.213
LIG_SUMO_SIM_anti_2	233	238	PF11976	0.371
LIG_SUMO_SIM_anti_2	478	484	PF11976	0.564
LIG_SUMO_SIM_par_1	150	155	PF11976	0.312
LIG_SUMO_SIM_par_1	497	504	PF11976	0.319
LIG_SUMO_SIM_par_1	518	523	PF11976	0.345
LIG_SUMO_SIM_par_1	546	551	PF11976	0.356
LIG_TRAF2_1	317	320	PF00917	0.416
LIG_TYR_ITIM	340	345	PF00017	0.403
LIG_TYR_ITIM	86	91	PF00017	0.319
LIG_UBA3_1	472	479	PF00899	0.512
LIG_WRC_WIRS_1	283	288	PF05994	0.416
LIG_WRC_WIRS_1	465	470	PF05994	0.387
LIG_WRC_WIRS_1	76	81	PF05994	0.203
MOD_CDK_SPxK_1	481	487	PF00069	0.488
MOD_CK1_1	217	223	PF00069	0.194
MOD_CK1_1	282	288	PF00069	0.503
MOD_CK1_1	35	41	PF00069	0.578
MOD_CK1_1	500	506	PF00069	0.345
MOD_CK2_1	364	370	PF00069	0.524
MOD_CK2_1	74	80	PF00069	0.207
MOD_Cter_Amidation	137	140	PF01082	0.416
MOD_GlcNHglycan	146	149	PF01048	0.592
MOD_GlcNHglycan	219	222	PF01048	0.533
MOD_GlcNHglycan	254	257	PF01048	0.327
MOD_GlcNHglycan	389	393	PF01048	0.374
MOD_GlcNHglycan	444	447	PF01048	0.533
MOD_GlcNHglycan	54	58	PF01048	0.400
MOD_GlcNHglycan	554	557	PF01048	0.342
MOD_GlcNHglycan	70	73	PF01048	0.470
MOD_GSK3_1	152	159	PF00069	0.340
MOD_GSK3_1	248	255	PF00069	0.528
MOD_GSK3_1	278	285	PF00069	0.547
MOD_GSK3_1	31	38	PF00069	0.443
MOD_GSK3_1	348	355	PF00069	0.527
MOD_GSK3_1	408	415	PF00069	0.243
MOD_GSK3_1	418	425	PF00069	0.315
MOD_GSK3_1	497	504	PF00069	0.384
MOD_GSK3_1	509	516	PF00069	0.328
MOD_GSK3_1	544	551	PF00069	0.361
MOD_GSK3_1	60	67	PF00069	0.345
MOD_GSK3_1	90	97	PF00069	0.363
MOD_NEK2_1	102	107	PF00069	0.215
MOD_NEK2_1	179	184	PF00069	0.530
MOD_NEK2_1	216	221	PF00069	0.297
MOD_NEK2_1	273	278	PF00069	0.465
MOD_NEK2_1	32	37	PF00069	0.490
MOD_NEK2_1	497	502	PF00069	0.345
MOD_NEK2_1	520	525	PF00069	0.243
MOD_NEK2_1	548	553	PF00069	0.379
MOD_NEK2_1	90	95	PF00069	0.303
MOD_PK_1	248	254	PF00069	0.403
MOD_PK_1	279	285	PF00069	0.403
MOD_PKA_2	214	220	PF00069	0.203
MOD_PKA_2	252	258	PF00069	0.574
MOD_PKA_2	278	284	PF00069	0.522
MOD_Plk_1	179	185	PF00069	0.416
MOD_Plk_2-3	348	354	PF00069	0.530
MOD_Plk_4	39	45	PF00069	0.407
MOD_Plk_4	94	100	PF00069	0.348
MOD_ProDKin_1	156	162	PF00069	0.329
MOD_ProDKin_1	305	311	PF00069	0.499
MOD_ProDKin_1	352	358	PF00069	0.525
MOD_ProDKin_1	481	487	PF00069	0.488
MOD_SUMO_for_1	313	316	PF00179	0.403
MOD_SUMO_rev_2	376	383	PF00179	0.369
TRG_AP2beta_CARGO_1	203	213	PF09066	0.177
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.319
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.459
TRG_ENDOCYTIC_2	342	345	PF00928	0.403
TRG_ENDOCYTIC_2	431	434	PF00928	0.217
TRG_ENDOCYTIC_2	5	8	PF00928	0.321
TRG_ENDOCYTIC_2	84	87	PF00928	0.332
TRG_ENDOCYTIC_2	88	91	PF00928	0.326
TRG_ER_diArg_1	213	216	PF00400	0.169
TRG_ER_diArg_1	247	249	PF00400	0.432
TRG_ER_diArg_1	529	531	PF00400	0.511
TRG_NLS_Bipartite_1	289	307	PF00514	0.369
TRG_NLS_MonoExtC_3	302	307	PF00514	0.369
TRG_NLS_MonoExtN_4	300	307	PF00514	0.369
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.216
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.246

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S5	Leptomonas seymouri	49%	100%
A0A0S4JEW4	Bodo saltans	26%	90%
A0A1X0NXY5	Trypanosomatidae	47%	100%
A0A1X0P0T2	Trypanosomatidae	25%	87%
A0A3Q8I8Y3	Leishmania donovani	48%	100%
A0A3Q8IBK1	Leishmania donovani	46%	100%
A0A3R7K4N2	Trypanosoma rangeli	44%	100%
A0A3R7L5P3	Trypanosoma rangeli	25%	95%
A0A3S5H545	Leishmania donovani	96%	100%
A4H5Y5	Leishmania braziliensis	47%	100%
A4H6C2	Leishmania braziliensis	47%	100%
A4HBH2	Leishmania braziliensis	45%	100%
A4HH06	Leishmania braziliensis	80%	100%
A4HUP5	Leishmania infantum	48%	100%
A4HYJ6	Leishmania infantum	46%	100%
C9ZHT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZHU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AG39	Leishmania infantum	96%	100%
E9AJT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AN09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9ANE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AUE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
P15710	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	97%
P38361	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q08357	Homo sapiens	26%	88%
Q28E01	Xenopus tropicalis	28%	88%
Q4QH82	Leishmania major	49%	100%
Q4QHL7	Leishmania major	49%	100%
Q80UP8	Mus musculus	28%	87%
V5DS90	Trypanosoma cruzi	45%	100%