Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACJ2_LEIMA

TriTrypDb:

LmjF.03.0470 , LMJLV39_030010000 , LMJSD75_030010000

Length:

1005

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 2
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ACJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACJ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.717
CLV_NRD_NRD_1	371	373	PF00675	0.651
CLV_NRD_NRD_1	480	482	PF00675	0.695
CLV_NRD_NRD_1	499	501	PF00675	0.795
CLV_NRD_NRD_1	702	704	PF00675	0.362
CLV_NRD_NRD_1	733	735	PF00675	0.687
CLV_NRD_NRD_1	889	891	PF00675	0.438
CLV_PCSK_FUR_1	497	501	PF00082	0.744
CLV_PCSK_FUR_1	944	948	PF00082	0.494
CLV_PCSK_KEX2_1	157	159	PF00082	0.741
CLV_PCSK_KEX2_1	183	185	PF00082	0.717
CLV_PCSK_KEX2_1	304	306	PF00082	0.744
CLV_PCSK_KEX2_1	370	372	PF00082	0.666
CLV_PCSK_KEX2_1	479	481	PF00082	0.692
CLV_PCSK_KEX2_1	499	501	PF00082	0.836
CLV_PCSK_KEX2_1	702	704	PF00082	0.362
CLV_PCSK_KEX2_1	733	735	PF00082	0.687
CLV_PCSK_KEX2_1	889	891	PF00082	0.458
CLV_PCSK_KEX2_1	946	948	PF00082	0.457
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.734
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.744
CLV_PCSK_PC1ET2_1	946	948	PF00082	0.492
CLV_PCSK_SKI1_1	199	203	PF00082	0.643
CLV_PCSK_SKI1_1	372	376	PF00082	0.616
CLV_PCSK_SKI1_1	844	848	PF00082	0.349
CLV_PCSK_SKI1_1	957	961	PF00082	0.411
CLV_PCSK_SKI1_1	973	977	PF00082	0.521
DEG_APCC_DBOX_1	843	851	PF00400	0.335
DEG_APCC_DBOX_1	956	964	PF00400	0.608
DEG_MDM2_SWIB_1	627	635	PF02201	0.465
DEG_MDM2_SWIB_1	683	691	PF02201	0.313
DEG_Nend_Nbox_1	1	3	PF02207	0.617
DEG_SPOP_SBC_1	121	125	PF00917	0.543
DEG_SPOP_SBC_1	159	163	PF00917	0.557
DEG_SPOP_SBC_1	91	95	PF00917	0.479
DOC_CKS1_1	207	212	PF01111	0.485
DOC_CKS1_1	915	920	PF01111	0.702
DOC_CYCLIN_RxL_1	841	849	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	829	832	PF00134	0.383
DOC_MAPK_DCC_7	435	445	PF00069	0.454
DOC_MAPK_DCC_7	913	921	PF00069	0.747
DOC_MAPK_gen_1	370	379	PF00069	0.463
DOC_MAPK_gen_1	70	77	PF00069	0.617
DOC_MAPK_gen_1	889	896	PF00069	0.636
DOC_MAPK_HePTP_8	367	379	PF00069	0.462
DOC_MAPK_JIP1_4	639	645	PF00069	0.393
DOC_MAPK_MEF2A_6	370	379	PF00069	0.463
DOC_PP1_RVXF_1	197	204	PF00149	0.383
DOC_PP1_RVXF_1	433	440	PF00149	0.399
DOC_PP1_RVXF_1	842	849	PF00149	0.389
DOC_PP2B_LxvP_1	375	378	PF13499	0.326
DOC_PP2B_LxvP_1	829	832	PF13499	0.383
DOC_PP4_FxxP_1	884	887	PF00568	0.769
DOC_USP7_MATH_1	112	116	PF00917	0.487
DOC_USP7_MATH_1	120	124	PF00917	0.512
DOC_USP7_MATH_1	159	163	PF00917	0.473
DOC_USP7_MATH_1	16	20	PF00917	0.610
DOC_USP7_MATH_1	215	219	PF00917	0.559
DOC_USP7_MATH_1	235	239	PF00917	0.542
DOC_USP7_MATH_1	267	271	PF00917	0.482
DOC_USP7_MATH_1	295	299	PF00917	0.521
DOC_USP7_MATH_1	324	328	PF00917	0.456
DOC_USP7_MATH_1	357	361	PF00917	0.507
DOC_USP7_MATH_1	378	382	PF00917	0.369
DOC_USP7_MATH_1	454	458	PF00917	0.493
DOC_USP7_MATH_1	61	65	PF00917	0.689
DOC_USP7_MATH_1	91	95	PF00917	0.521
DOC_USP7_MATH_1	920	924	PF00917	0.715
DOC_USP7_MATH_1	925	929	PF00917	0.685
DOC_WW_Pin1_4	206	211	PF00397	0.468
DOC_WW_Pin1_4	507	512	PF00397	0.533
DOC_WW_Pin1_4	649	654	PF00397	0.458
DOC_WW_Pin1_4	878	883	PF00397	0.701
DOC_WW_Pin1_4	914	919	PF00397	0.711
LIG_14-3-3_CanoR_1	158	166	PF00244	0.514
LIG_14-3-3_CanoR_1	199	204	PF00244	0.526
LIG_14-3-3_CanoR_1	239	245	PF00244	0.446
LIG_14-3-3_CanoR_1	261	266	PF00244	0.446
LIG_14-3-3_CanoR_1	274	280	PF00244	0.455
LIG_14-3-3_CanoR_1	343	353	PF00244	0.462
LIG_14-3-3_CanoR_1	37	41	PF00244	0.641
LIG_14-3-3_CanoR_1	42	47	PF00244	0.635
LIG_14-3-3_CanoR_1	422	431	PF00244	0.426
LIG_14-3-3_CanoR_1	435	440	PF00244	0.411
LIG_14-3-3_CanoR_1	604	613	PF00244	0.513
LIG_14-3-3_CanoR_1	63	68	PF00244	0.690
LIG_14-3-3_CanoR_1	70	75	PF00244	0.619
LIG_14-3-3_CanoR_1	703	713	PF00244	0.555
LIG_14-3-3_CanoR_1	836	841	PF00244	0.383
LIG_14-3-3_CanoR_1	857	864	PF00244	0.482
LIG_14-3-3_CanoR_1	883	887	PF00244	0.713
LIG_14-3-3_CanoR_1	889	895	PF00244	0.711
LIG_Actin_WH2_2	822	838	PF00022	0.569
LIG_Actin_WH2_2	843	859	PF00022	0.453
LIG_BRCT_BRCA1_1	310	314	PF00533	0.475
LIG_BRCT_BRCA1_1	892	896	PF00533	0.702
LIG_BRCT_BRCA1_2	310	316	PF00533	0.402
LIG_deltaCOP1_diTrp_1	684	692	PF00928	0.326
LIG_DLG_GKlike_1	261	268	PF00625	0.495
LIG_EH1_1	76	84	PF00400	0.358
LIG_FHA_1	200	206	PF00498	0.477
LIG_FHA_1	286	292	PF00498	0.554
LIG_FHA_1	345	351	PF00498	0.500
LIG_FHA_1	756	762	PF00498	0.458
LIG_FHA_1	974	980	PF00498	0.580
LIG_FHA_2	148	154	PF00498	0.552
LIG_FHA_2	232	238	PF00498	0.491
LIG_FHA_2	890	896	PF00498	0.635
LIG_FHA_2	93	99	PF00498	0.499
LIG_FHA_2	991	997	PF00498	0.687
LIG_GBD_Chelix_1	709	717	PF00786	0.292
LIG_GBD_Chelix_1	863	871	PF00786	0.294
LIG_LIR_Apic_2	881	887	PF02991	0.749
LIG_LIR_Gen_1	222	232	PF02991	0.527
LIG_LIR_Gen_1	264	272	PF02991	0.495
LIG_LIR_Gen_1	30	40	PF02991	0.621
LIG_LIR_Gen_1	362	369	PF02991	0.473
LIG_LIR_Gen_1	680	691	PF02991	0.303
LIG_LIR_Gen_1	71	82	PF02991	0.508
LIG_LIR_Gen_1	767	778	PF02991	0.644
LIG_LIR_Gen_1	805	815	PF02991	0.599
LIG_LIR_Gen_1	933	943	PF02991	0.605
LIG_LIR_Nem_3	218	223	PF02991	0.464
LIG_LIR_Nem_3	264	268	PF02991	0.493
LIG_LIR_Nem_3	30	36	PF02991	0.619
LIG_LIR_Nem_3	336	341	PF02991	0.379
LIG_LIR_Nem_3	362	367	PF02991	0.394
LIG_LIR_Nem_3	438	442	PF02991	0.408
LIG_LIR_Nem_3	680	686	PF02991	0.303
LIG_LIR_Nem_3	71	77	PF02991	0.663
LIG_LIR_Nem_3	805	810	PF02991	0.599
LIG_LIR_Nem_3	838	843	PF02991	0.381
LIG_LIR_Nem_3	933	938	PF02991	0.624
LIG_MAD2	199	207	PF02301	0.370
LIG_NRBOX	720	726	PF00104	0.453
LIG_PCNA_PIPBox_1	706	715	PF02747	0.633
LIG_Pex14_1	364	368	PF04695	0.384
LIG_Pex14_2	220	224	PF04695	0.464
LIG_Pex14_2	5	9	PF04695	0.611
LIG_Pex14_2	627	631	PF04695	0.475
LIG_Pex14_2	683	687	PF04695	0.313
LIG_RPA_C_Fungi	475	487	PF08784	0.613
LIG_SH2_CRK	265	269	PF00017	0.570
LIG_SH2_CRK	935	939	PF00017	0.536
LIG_SH2_PTP2	915	918	PF00017	0.573
LIG_SH2_STAP1	155	159	PF00017	0.667
LIG_SH2_STAP1	955	959	PF00017	0.511
LIG_SH2_STAP1	974	978	PF00017	0.526
LIG_SH2_STAT5	223	226	PF00017	0.600
LIG_SH2_STAT5	341	344	PF00017	0.479
LIG_SH2_STAT5	730	733	PF00017	0.468
LIG_SH2_STAT5	770	773	PF00017	0.529
LIG_SH2_STAT5	915	918	PF00017	0.573
LIG_SH2_STAT5	955	958	PF00017	0.510
LIG_SH3_3	204	210	PF00018	0.552
LIG_SH3_3	318	324	PF00018	0.574
LIG_SH3_3	490	496	PF00018	0.711
LIG_SH3_3	505	511	PF00018	0.591
LIG_SH3_3	643	649	PF00018	0.495
LIG_SH3_3	895	901	PF00018	0.642
LIG_SUMO_SIM_anti_2	430	435	PF11976	0.458
LIG_SUMO_SIM_anti_2	718	724	PF11976	0.421
LIG_SUMO_SIM_anti_2	812	818	PF11976	0.364
LIG_SUMO_SIM_par_1	331	336	PF11976	0.568
LIG_SUMO_SIM_par_1	673	680	PF11976	0.571
LIG_SUMO_SIM_par_1	917	923	PF11976	0.736
LIG_TRAF2_1	150	153	PF00917	0.693
LIG_TRAF2_1	620	623	PF00917	0.572
LIG_TRAF2_1	676	679	PF00917	0.514
LIG_TRAF2_1	901	904	PF00917	0.647
LIG_TRAF2_1	995	998	PF00917	0.727
MOD_CDC14_SPxK_1	886	889	PF00782	0.535
MOD_CDK_SPK_2	878	883	PF00069	0.584
MOD_CDK_SPxK_1	883	889	PF00069	0.533
MOD_CDK_SPxxK_3	883	890	PF00069	0.629
MOD_CK1_1	106	112	PF00069	0.676
MOD_CK1_1	125	131	PF00069	0.628
MOD_CK1_1	160	166	PF00069	0.716
MOD_CK1_1	238	244	PF00069	0.695
MOD_CK1_1	279	285	PF00069	0.652
MOD_CK1_1	448	454	PF00069	0.753
MOD_CK1_1	534	540	PF00069	0.593
MOD_CK1_1	57	63	PF00069	0.694
MOD_CK1_1	799	805	PF00069	0.656
MOD_CK1_1	928	934	PF00069	0.671
MOD_CK1_1	937	943	PF00069	0.521
MOD_CK1_1	992	998	PF00069	0.616
MOD_CK2_1	147	153	PF00069	0.665
MOD_CK2_1	189	195	PF00069	0.631
MOD_CK2_1	231	237	PF00069	0.553
MOD_CK2_1	342	348	PF00069	0.564
MOD_CK2_1	62	68	PF00069	0.501
MOD_CK2_1	673	679	PF00069	0.524
MOD_CK2_1	771	777	PF00069	0.583
MOD_CK2_1	889	895	PF00069	0.601
MOD_CK2_1	92	98	PF00069	0.568
MOD_CK2_1	992	998	PF00069	0.607
MOD_CMANNOS	695	698	PF00535	0.453
MOD_CMANNOS	848	851	PF00535	0.389
MOD_CMANNOS	869	872	PF00535	0.543
MOD_Cter_Amidation	302	305	PF01082	0.695
MOD_Cter_Amidation	497	500	PF01082	0.687
MOD_GlcNHglycan	105	108	PF01048	0.739
MOD_GlcNHglycan	132	135	PF01048	0.703
MOD_GlcNHglycan	166	169	PF01048	0.698
MOD_GlcNHglycan	178	182	PF01048	0.556
MOD_GlcNHglycan	192	195	PF01048	0.556
MOD_GlcNHglycan	241	244	PF01048	0.658
MOD_GlcNHglycan	281	284	PF01048	0.665
MOD_GlcNHglycan	292	295	PF01048	0.783
MOD_GlcNHglycan	334	338	PF01048	0.658
MOD_GlcNHglycan	344	347	PF01048	0.495
MOD_GlcNHglycan	359	362	PF01048	0.583
MOD_GlcNHglycan	382	385	PF01048	0.586
MOD_GlcNHglycan	400	403	PF01048	0.588
MOD_GlcNHglycan	411	414	PF01048	0.615
MOD_GlcNHglycan	533	536	PF01048	0.712
MOD_GlcNHglycan	556	559	PF01048	0.689
MOD_GlcNHglycan	56	59	PF01048	0.708
MOD_GlcNHglycan	564	567	PF01048	0.426
MOD_GlcNHglycan	666	669	PF01048	0.533
MOD_GlcNHglycan	717	720	PF01048	0.411
MOD_GlcNHglycan	779	782	PF01048	0.651
MOD_GlcNHglycan	801	804	PF01048	0.618
MOD_GlcNHglycan	811	814	PF01048	0.326
MOD_GlcNHglycan	821	824	PF01048	0.306
MOD_GlcNHglycan	927	930	PF01048	0.638
MOD_GlcNHglycan	940	943	PF01048	0.433
MOD_GSK3_1	121	128	PF00069	0.676
MOD_GSK3_1	136	143	PF00069	0.679
MOD_GSK3_1	160	167	PF00069	0.627
MOD_GSK3_1	173	180	PF00069	0.737
MOD_GSK3_1	215	222	PF00069	0.631
MOD_GSK3_1	231	238	PF00069	0.525
MOD_GSK3_1	27	34	PF00069	0.511
MOD_GSK3_1	423	430	PF00069	0.520
MOD_GSK3_1	454	461	PF00069	0.567
MOD_GSK3_1	502	509	PF00069	0.718
MOD_GSK3_1	548	555	PF00069	0.593
MOD_GSK3_1	57	64	PF00069	0.656
MOD_GSK3_1	673	680	PF00069	0.465
MOD_GSK3_1	751	758	PF00069	0.313
MOD_GSK3_1	773	780	PF00069	0.625
MOD_GSK3_1	798	805	PF00069	0.606
MOD_GSK3_1	878	885	PF00069	0.551
MOD_GSK3_1	890	897	PF00069	0.619
MOD_GSK3_1	920	927	PF00069	0.702
MOD_GSK3_1	930	937	PF00069	0.514
MOD_N-GLC_1	225	230	PF02516	0.619
MOD_NEK2_1	136	141	PF00069	0.646
MOD_NEK2_1	216	221	PF00069	0.567
MOD_NEK2_1	225	230	PF00069	0.635
MOD_NEK2_1	35	40	PF00069	0.519
MOD_NEK2_1	423	428	PF00069	0.656
MOD_NEK2_1	458	463	PF00069	0.639
MOD_NEK2_1	588	593	PF00069	0.685
MOD_NEK2_1	600	605	PF00069	0.482
MOD_NEK2_1	663	668	PF00069	0.588
MOD_NEK2_1	677	682	PF00069	0.457
MOD_NEK2_1	735	740	PF00069	0.658
MOD_NEK2_1	751	756	PF00069	0.229
MOD_NEK2_1	835	840	PF00069	0.533
MOD_NEK2_1	846	851	PF00069	0.310
MOD_NEK2_1	867	872	PF00069	0.573
MOD_NEK2_1	919	924	PF00069	0.684
MOD_NEK2_1	938	943	PF00069	0.605
MOD_NEK2_2	31	36	PF00069	0.514
MOD_NEK2_2	602	607	PF00069	0.656
MOD_NEK2_2	934	939	PF00069	0.557
MOD_PIKK_1	446	452	PF00454	0.633
MOD_PIKK_1	47	53	PF00454	0.634
MOD_PK_1	552	558	PF00069	0.632
MOD_PK_1	890	896	PF00069	0.631
MOD_PKA_1	157	163	PF00069	0.611
MOD_PKA_1	889	895	PF00069	0.535
MOD_PKA_2	136	142	PF00069	0.705
MOD_PKA_2	157	163	PF00069	0.683
MOD_PKA_2	17	23	PF00069	0.501
MOD_PKA_2	173	179	PF00069	0.741
MOD_PKA_2	189	195	PF00069	0.501
MOD_PKA_2	238	244	PF00069	0.598
MOD_PKA_2	273	279	PF00069	0.598
MOD_PKA_2	285	291	PF00069	0.588
MOD_PKA_2	342	348	PF00069	0.580
MOD_PKA_2	36	42	PF00069	0.459
MOD_PKA_2	62	68	PF00069	0.560
MOD_PKA_2	835	841	PF00069	0.453
MOD_PKA_2	856	862	PF00069	0.482
MOD_PKA_2	882	888	PF00069	0.587
MOD_PKA_2	889	895	PF00069	0.507
MOD_PKA_2	938	944	PF00069	0.540
MOD_PKB_1	500	508	PF00069	0.703
MOD_Plk_1	235	241	PF00069	0.545
MOD_Plk_1	307	313	PF00069	0.700
MOD_Plk_1	466	472	PF00069	0.451
MOD_Plk_1	631	637	PF00069	0.559
MOD_Plk_1	859	865	PF00069	0.313
MOD_Plk_1	894	900	PF00069	0.634
MOD_Plk_2-3	679	685	PF00069	0.453
MOD_Plk_4	219	225	PF00069	0.581
MOD_Plk_4	324	330	PF00069	0.489
MOD_Plk_4	429	435	PF00069	0.505
MOD_Plk_4	454	460	PF00069	0.619
MOD_Plk_4	466	472	PF00069	0.454
MOD_Plk_4	517	523	PF00069	0.654
MOD_Plk_4	588	594	PF00069	0.710
MOD_Plk_4	623	629	PF00069	0.552
MOD_Plk_4	705	711	PF00069	0.512
MOD_Plk_4	802	808	PF00069	0.575
MOD_Plk_4	836	842	PF00069	0.561
MOD_Plk_4	859	865	PF00069	0.289
MOD_ProDKin_1	206	212	PF00069	0.592
MOD_ProDKin_1	507	513	PF00069	0.674
MOD_ProDKin_1	649	655	PF00069	0.567
MOD_ProDKin_1	878	884	PF00069	0.634
MOD_ProDKin_1	914	920	PF00069	0.641
MOD_SUMO_rev_2	395	401	PF00179	0.546
TRG_DiLeu_BaEn_1	467	472	PF01217	0.455
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.656
TRG_DiLeu_BaLyEn_6	974	979	PF01217	0.460
TRG_ENDOCYTIC_2	265	268	PF00928	0.570
TRG_ENDOCYTIC_2	770	773	PF00928	0.506
TRG_ENDOCYTIC_2	935	938	PF00928	0.525
TRG_ER_diArg_1	260	263	PF00400	0.572
TRG_ER_diArg_1	369	372	PF00400	0.581
TRG_ER_diArg_1	479	481	PF00400	0.616
TRG_ER_diArg_1	496	499	PF00400	0.550
TRG_ER_diArg_1	574	577	PF00400	0.573
TRG_ER_diArg_1	702	704	PF00400	0.433
TRG_ER_diArg_1	732	734	PF00400	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE8	Leptomonas seymouri	33%	100%
A0A451EJP9	Leishmania donovani	89%	100%
A4HGI2	Leishmania braziliensis	66%	100%
E9AG36	Leishmania infantum	89%	100%
E9AJT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%