Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACJ1_LEIMA

TriTrypDb:

LmjF.03.0460 , LMJLV39_030009800 , LMJSD75_030009800

Length:

1062

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	595	599	PF00656	0.581
CLV_C14_Caspase3-7	772	776	PF00656	0.688
CLV_C14_Caspase3-7	90	94	PF00656	0.779
CLV_NRD_NRD_1	126	128	PF00675	0.760
CLV_NRD_NRD_1	206	208	PF00675	0.837
CLV_NRD_NRD_1	533	535	PF00675	0.594
CLV_NRD_NRD_1	923	925	PF00675	0.780
CLV_PCSK_FUR_1	921	925	PF00082	0.777
CLV_PCSK_KEX2_1	126	128	PF00082	0.760
CLV_PCSK_KEX2_1	205	207	PF00082	0.850
CLV_PCSK_KEX2_1	533	535	PF00082	0.594
CLV_PCSK_KEX2_1	923	925	PF00082	0.780
CLV_PCSK_PC7_1	201	207	PF00082	0.878
CLV_PCSK_SKI1_1	1009	1013	PF00082	0.731
CLV_PCSK_SKI1_1	139	143	PF00082	0.854
CLV_PCSK_SKI1_1	172	176	PF00082	0.707
CLV_PCSK_SKI1_1	556	560	PF00082	0.831
CLV_PCSK_SKI1_1	923	927	PF00082	0.781
DEG_APCC_DBOX_1	590	598	PF00400	0.706
DEG_COP1_1	486	495	PF00400	0.565
DEG_COP1_1	652	662	PF00400	0.584
DEG_Nend_Nbox_1	1	3	PF02207	0.791
DEG_SPOP_SBC_1	576	580	PF00917	0.748
DEG_SPOP_SBC_1	693	697	PF00917	0.690
DOC_CKS1_1	234	239	PF01111	0.852
DOC_CKS1_1	377	382	PF01111	0.691
DOC_CKS1_1	43	48	PF01111	0.744
DOC_CKS1_1	453	458	PF01111	0.797
DOC_CKS1_1	460	465	PF01111	0.766
DOC_CKS1_1	540	545	PF01111	0.811
DOC_CKS1_1	75	80	PF01111	0.745
DOC_CKS1_1	785	790	PF01111	0.823
DOC_CYCLIN_RxL_1	136	146	PF00134	0.848
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.611
DOC_MAPK_gen_1	205	216	PF00069	0.790
DOC_MAPK_MEF2A_6	176	183	PF00069	0.733
DOC_MAPK_MEF2A_6	209	218	PF00069	0.782
DOC_PP2B_LxvP_1	1012	1015	PF13499	0.798
DOC_PP2B_LxvP_1	132	135	PF13499	0.839
DOC_PP2B_LxvP_1	216	219	PF13499	0.717
DOC_PP2B_LxvP_1	255	258	PF13499	0.751
DOC_PP2B_LxvP_1	490	493	PF13499	0.678
DOC_PP2B_PxIxI_1	542	548	PF00149	0.772
DOC_PP4_MxPP_1	245	248	PF00568	0.749
DOC_USP7_MATH_1	108	112	PF00917	0.645
DOC_USP7_MATH_1	113	117	PF00917	0.613
DOC_USP7_MATH_1	137	141	PF00917	0.735
DOC_USP7_MATH_1	232	236	PF00917	0.617
DOC_USP7_MATH_1	273	277	PF00917	0.856
DOC_USP7_MATH_1	35	39	PF00917	0.692
DOC_USP7_MATH_1	434	438	PF00917	0.794
DOC_USP7_MATH_1	527	531	PF00917	0.839
DOC_USP7_MATH_1	575	579	PF00917	0.771
DOC_USP7_MATH_1	630	634	PF00917	0.807
DOC_USP7_MATH_1	682	686	PF00917	0.661
DOC_USP7_MATH_1	693	697	PF00917	0.678
DOC_USP7_MATH_1	698	702	PF00917	0.749
DOC_USP7_MATH_1	839	843	PF00917	0.757
DOC_USP7_MATH_1	855	859	PF00917	0.499
DOC_USP7_MATH_1	939	943	PF00917	0.721
DOC_USP7_MATH_1	962	966	PF00917	0.718
DOC_USP7_MATH_1	997	1001	PF00917	0.726
DOC_WW_Pin1_4	109	114	PF00397	0.684
DOC_WW_Pin1_4	233	238	PF00397	0.854
DOC_WW_Pin1_4	27	32	PF00397	0.808
DOC_WW_Pin1_4	275	280	PF00397	0.622
DOC_WW_Pin1_4	33	38	PF00397	0.788
DOC_WW_Pin1_4	337	342	PF00397	0.694
DOC_WW_Pin1_4	362	367	PF00397	0.797
DOC_WW_Pin1_4	371	376	PF00397	0.599
DOC_WW_Pin1_4	380	385	PF00397	0.691
DOC_WW_Pin1_4	387	392	PF00397	0.552
DOC_WW_Pin1_4	402	407	PF00397	0.594
DOC_WW_Pin1_4	42	47	PF00397	0.650
DOC_WW_Pin1_4	426	431	PF00397	0.784
DOC_WW_Pin1_4	448	453	PF00397	0.837
DOC_WW_Pin1_4	459	464	PF00397	0.637
DOC_WW_Pin1_4	506	511	PF00397	0.790
DOC_WW_Pin1_4	516	521	PF00397	0.682
DOC_WW_Pin1_4	539	544	PF00397	0.810
DOC_WW_Pin1_4	548	553	PF00397	0.670
DOC_WW_Pin1_4	694	699	PF00397	0.692
DOC_WW_Pin1_4	703	708	PF00397	0.690
DOC_WW_Pin1_4	723	728	PF00397	0.515
DOC_WW_Pin1_4	74	79	PF00397	0.764
DOC_WW_Pin1_4	764	769	PF00397	0.793
DOC_WW_Pin1_4	784	789	PF00397	0.820
DOC_WW_Pin1_4	801	806	PF00397	0.555
DOC_WW_Pin1_4	848	853	PF00397	0.806
DOC_WW_Pin1_4	868	873	PF00397	0.831
DOC_WW_Pin1_4	876	881	PF00397	0.725
DOC_WW_Pin1_4	932	937	PF00397	0.607
DOC_WW_Pin1_4	99	104	PF00397	0.833
DOC_WW_Pin1_4	998	1003	PF00397	0.673
LIG_14-3-3_CanoR_1	1050	1056	PF00244	0.592
LIG_14-3-3_CanoR_1	109	113	PF00244	0.696
LIG_14-3-3_CanoR_1	11	16	PF00244	0.615
LIG_14-3-3_CanoR_1	126	136	PF00244	0.855
LIG_14-3-3_CanoR_1	139	144	PF00244	0.525
LIG_14-3-3_CanoR_1	147	151	PF00244	0.715
LIG_14-3-3_CanoR_1	378	384	PF00244	0.647
LIG_14-3-3_CanoR_1	436	441	PF00244	0.832
LIG_14-3-3_CanoR_1	591	600	PF00244	0.743
LIG_14-3-3_CanoR_1	691	700	PF00244	0.750
LIG_14-3-3_CanoR_1	743	749	PF00244	0.743
LIG_APCC_ABBA_1	615	620	PF00400	0.714
LIG_BIR_III_4	775	779	PF00653	0.734
LIG_deltaCOP1_diTrp_1	800	808	PF00928	0.675
LIG_EVH1_1	132	136	PF00568	0.834
LIG_FHA_1	10	16	PF00498	0.645
LIG_FHA_1	113	119	PF00498	0.689
LIG_FHA_1	162	168	PF00498	0.793
LIG_FHA_1	296	302	PF00498	0.679
LIG_FHA_1	540	546	PF00498	0.812
LIG_FHA_1	654	660	PF00498	0.704
LIG_FHA_1	724	730	PF00498	0.805
LIG_FHA_1	743	749	PF00498	0.642
LIG_FHA_1	891	897	PF00498	0.801
LIG_FHA_1	961	967	PF00498	0.600
LIG_FHA_2	234	240	PF00498	0.776
LIG_FHA_2	507	513	PF00498	0.819
LIG_FHA_2	552	558	PF00498	0.747
LIG_FHA_2	933	939	PF00498	0.622
LIG_Integrin_RGD_1	663	665	PF01839	0.576
LIG_LIR_Apic_2	374	380	PF02991	0.800
LIG_LIR_Apic_2	402	406	PF02991	0.780
LIG_LIR_Apic_2	701	707	PF02991	0.819
LIG_LIR_Apic_2	800	805	PF02991	0.835
LIG_LIR_Gen_1	851	862	PF02991	0.678
LIG_LIR_Gen_1	904	912	PF02991	0.744
LIG_LIR_Nem_3	249	253	PF02991	0.749
LIG_LIR_Nem_3	303	309	PF02991	0.786
LIG_LIR_Nem_3	632	638	PF02991	0.699
LIG_LIR_Nem_3	851	857	PF02991	0.692
LIG_LIR_Nem_3	858	862	PF02991	0.726
LIG_LIR_Nem_3	904	908	PF02991	0.743
LIG_NRBOX	905	911	PF00104	0.747
LIG_SH2_CRK	377	381	PF00017	0.807
LIG_SH2_CRK	854	858	PF00017	0.692
LIG_SH2_NCK_1	854	858	PF00017	0.769
LIG_SH2_STAP1	892	896	PF00017	0.567
LIG_SH2_STAT3	166	169	PF00017	0.641
LIG_SH2_STAT3	705	708	PF00017	0.810
LIG_SH2_STAT5	166	169	PF00017	0.719
LIG_SH2_STAT5	635	638	PF00017	0.693
LIG_SH2_STAT5	892	895	PF00017	0.574
LIG_SH3_1	231	237	PF00018	0.661
LIG_SH3_1	40	46	PF00018	0.777
LIG_SH3_3	107	113	PF00018	0.681
LIG_SH3_3	130	136	PF00018	0.789
LIG_SH3_3	231	237	PF00018	0.739
LIG_SH3_3	305	311	PF00018	0.792
LIG_SH3_3	40	46	PF00018	0.738
LIG_SH3_3	450	456	PF00018	0.746
LIG_SH3_3	457	463	PF00018	0.831
LIG_SH3_3	745	751	PF00018	0.702
LIG_SH3_3	80	86	PF00018	0.668
LIG_SH3_3	996	1002	PF00018	0.718
LIG_SUMO_SIM_anti_2	904	910	PF11976	0.746
LIG_SUMO_SIM_par_1	865	871	PF11976	0.663
LIG_SUMO_SIM_par_1	892	897	PF11976	0.797
LIG_TRAF2_1	185	188	PF00917	0.847
LIG_TRAF2_1	496	499	PF00917	0.726
LIG_TRAF2_1	880	883	PF00917	0.615
LIG_TRAF2_2	810	815	PF00917	0.783
LIG_UBA3_1	295	300	PF00899	0.804
LIG_WW_1	247	250	PF00397	0.746
LIG_WW_1	85	88	PF00397	0.854
MOD_CDC14_SPxK_1	365	368	PF00782	0.789
MOD_CDK_SPK_2	104	109	PF00069	0.768
MOD_CDK_SPK_2	459	464	PF00069	0.787
MOD_CDK_SPK_2	74	79	PF00069	0.744
MOD_CDK_SPxK_1	362	368	PF00069	0.791
MOD_CDK_SPxK_1	452	458	PF00069	0.797
MOD_CDK_SPxK_1	764	770	PF00069	0.796
MOD_CDK_SPxxK_3	27	34	PF00069	0.754
MOD_CDK_SPxxK_3	371	378	PF00069	0.837
MOD_CDK_SPxxK_3	42	49	PF00069	0.618
MOD_CDK_SPxxK_3	723	730	PF00069	0.729
MOD_CDK_SPxxK_3	99	106	PF00069	0.771
MOD_CK1_1	1000	1006	PF00069	0.817
MOD_CK1_1	112	118	PF00069	0.627
MOD_CK1_1	170	176	PF00069	0.659
MOD_CK1_1	225	231	PF00069	0.648
MOD_CK1_1	25	31	PF00069	0.782
MOD_CK1_1	277	283	PF00069	0.849
MOD_CK1_1	342	348	PF00069	0.634
MOD_CK1_1	38	44	PF00069	0.713
MOD_CK1_1	451	457	PF00069	0.694
MOD_CK1_1	491	497	PF00069	0.697
MOD_CK1_1	596	602	PF00069	0.643
MOD_CK1_1	685	691	PF00069	0.832
MOD_CK1_1	692	698	PF00069	0.719
MOD_CK1_1	749	755	PF00069	0.741
MOD_CK1_1	762	768	PF00069	0.563
MOD_CK1_1	846	852	PF00069	0.706
MOD_CK1_1	853	859	PF00069	0.742
MOD_CK1_1	89	95	PF00069	0.705
MOD_CK1_1	890	896	PF00069	0.704
MOD_CK1_1	943	949	PF00069	0.812
MOD_CK2_1	2	8	PF00069	0.706
MOD_CK2_1	356	362	PF00069	0.741
MOD_CK2_1	506	512	PF00069	0.819
MOD_CK2_1	876	882	PF00069	0.840
MOD_CK2_1	93	99	PF00069	0.777
MOD_CK2_1	932	938	PF00069	0.625
MOD_DYRK1A_RPxSP_1	109	113	PF00069	0.618
MOD_GlcNHglycan	1023	1026	PF01048	0.706
MOD_GlcNHglycan	1051	1054	PF01048	0.713
MOD_GlcNHglycan	168	172	PF01048	0.791
MOD_GlcNHglycan	190	193	PF01048	0.738
MOD_GlcNHglycan	24	27	PF01048	0.741
MOD_GlcNHglycan	318	321	PF01048	0.694
MOD_GlcNHglycan	358	361	PF01048	0.761
MOD_GlcNHglycan	396	399	PF01048	0.717
MOD_GlcNHglycan	4	7	PF01048	0.736
MOD_GlcNHglycan	521	524	PF01048	0.726
MOD_GlcNHglycan	573	576	PF01048	0.740
MOD_GlcNHglycan	600	603	PF01048	0.802
MOD_GlcNHglycan	632	635	PF01048	0.798
MOD_GlcNHglycan	691	694	PF01048	0.770
MOD_GlcNHglycan	717	720	PF01048	0.757
MOD_GlcNHglycan	789	792	PF01048	0.770
MOD_GlcNHglycan	918	921	PF01048	0.746
MOD_GlcNHglycan	945	948	PF01048	0.645
MOD_GlcNHglycan	95	98	PF01048	0.686
MOD_GSK3_1	10	17	PF00069	0.671
MOD_GSK3_1	104	111	PF00069	0.783
MOD_GSK3_1	137	144	PF00069	0.774
MOD_GSK3_1	188	195	PF00069	0.754
MOD_GSK3_1	2	9	PF00069	0.761
MOD_GSK3_1	205	212	PF00069	0.664
MOD_GSK3_1	221	228	PF00069	0.663
MOD_GSK3_1	273	280	PF00069	0.845
MOD_GSK3_1	358	365	PF00069	0.643
MOD_GSK3_1	376	383	PF00069	0.772
MOD_GSK3_1	38	45	PF00069	0.743
MOD_GSK3_1	425	432	PF00069	0.823
MOD_GSK3_1	436	443	PF00069	0.719
MOD_GSK3_1	448	455	PF00069	0.616
MOD_GSK3_1	560	567	PF00069	0.640
MOD_GSK3_1	571	578	PF00069	0.671
MOD_GSK3_1	589	596	PF00069	0.578
MOD_GSK3_1	683	690	PF00069	0.771
MOD_GSK3_1	694	701	PF00069	0.699
MOD_GSK3_1	715	722	PF00069	0.688
MOD_GSK3_1	742	749	PF00069	0.652
MOD_GSK3_1	755	762	PF00069	0.677
MOD_GSK3_1	783	790	PF00069	0.761
MOD_GSK3_1	839	846	PF00069	0.653
MOD_GSK3_1	89	96	PF00069	0.716
MOD_GSK3_1	939	946	PF00069	0.784
MOD_GSK3_1	950	957	PF00069	0.546
MOD_GSK3_1	998	1005	PF00069	0.821
MOD_LATS_1	125	131	PF00433	0.871
MOD_LATS_1	203	209	PF00433	0.879
MOD_N-GLC_1	225	230	PF02516	0.619
MOD_N-GLC_1	342	347	PF02516	0.678
MOD_N-GLC_1	876	881	PF02516	0.624
MOD_N-GLC_1	916	921	PF02516	0.746
MOD_NEK2_1	10	15	PF00069	0.674
MOD_NEK2_1	2	7	PF00069	0.764
MOD_NEK2_1	295	300	PF00069	0.685
MOD_NEK2_1	435	440	PF00069	0.834
MOD_NEK2_1	559	564	PF00069	0.828
MOD_NEK2_1	571	576	PF00069	0.618
MOD_NEK2_1	628	633	PF00069	0.812
MOD_NEK2_1	683	688	PF00069	0.690
MOD_NEK2_1	715	720	PF00069	0.716
MOD_NEK2_1	769	774	PF00069	0.726
MOD_NEK2_2	6	11	PF00069	0.706
MOD_PIKK_1	278	284	PF00454	0.860
MOD_PIKK_1	746	752	PF00454	0.818
MOD_PIKK_1	887	893	PF00454	0.818
MOD_PK_1	436	442	PF00069	0.832
MOD_PK_1	885	891	PF00069	0.784
MOD_PKA_1	205	211	PF00069	0.847
MOD_PKA_2	10	16	PF00069	0.621
MOD_PKA_2	1049	1055	PF00069	0.634
MOD_PKA_2	108	114	PF00069	0.692
MOD_PKA_2	128	134	PF00069	0.859
MOD_PKA_2	146	152	PF00069	0.564
MOD_PKA_2	20	26	PF00069	0.684
MOD_PKA_2	205	211	PF00069	0.845
MOD_PKA_2	435	441	PF00069	0.832
MOD_PKA_2	590	596	PF00069	0.747
MOD_PKA_2	742	748	PF00069	0.744
MOD_PKA_2	769	775	PF00069	0.725
MOD_PKB_1	207	215	PF00069	0.634
MOD_Plk_1	683	689	PF00069	0.586
MOD_Plk_1	885	891	PF00069	0.769
MOD_Plk_4	113	119	PF00069	0.627
MOD_Plk_4	541	547	PF00069	0.810
MOD_Plk_4	699	705	PF00069	0.747
MOD_Plk_4	755	761	PF00069	0.659
MOD_Plk_4	956	962	PF00069	0.694
MOD_ProDKin_1	109	115	PF00069	0.685
MOD_ProDKin_1	233	239	PF00069	0.855
MOD_ProDKin_1	27	33	PF00069	0.809
MOD_ProDKin_1	275	281	PF00069	0.622
MOD_ProDKin_1	337	343	PF00069	0.691
MOD_ProDKin_1	362	368	PF00069	0.799
MOD_ProDKin_1	371	377	PF00069	0.602
MOD_ProDKin_1	38	44	PF00069	0.721
MOD_ProDKin_1	380	386	PF00069	0.690
MOD_ProDKin_1	387	393	PF00069	0.551
MOD_ProDKin_1	402	408	PF00069	0.595
MOD_ProDKin_1	426	432	PF00069	0.783
MOD_ProDKin_1	448	454	PF00069	0.837
MOD_ProDKin_1	459	465	PF00069	0.636
MOD_ProDKin_1	506	512	PF00069	0.819
MOD_ProDKin_1	516	522	PF00069	0.682
MOD_ProDKin_1	539	545	PF00069	0.810
MOD_ProDKin_1	548	554	PF00069	0.669
MOD_ProDKin_1	694	700	PF00069	0.688
MOD_ProDKin_1	703	709	PF00069	0.691
MOD_ProDKin_1	723	729	PF00069	0.515
MOD_ProDKin_1	74	80	PF00069	0.765
MOD_ProDKin_1	764	770	PF00069	0.796
MOD_ProDKin_1	784	790	PF00069	0.821
MOD_ProDKin_1	801	807	PF00069	0.555
MOD_ProDKin_1	848	854	PF00069	0.806
MOD_ProDKin_1	868	874	PF00069	0.833
MOD_ProDKin_1	876	882	PF00069	0.726
MOD_ProDKin_1	932	938	PF00069	0.612
MOD_ProDKin_1	99	105	PF00069	0.833
MOD_ProDKin_1	998	1004	PF00069	0.673
MOD_SUMO_rev_2	224	232	PF00179	0.739
TRG_DiLeu_BaEn_1	904	909	PF01217	0.746
TRG_ENDOCYTIC_2	854	857	PF00928	0.733
TRG_ER_diArg_1	1041	1044	PF00400	0.675
TRG_ER_diArg_1	1048	1051	PF00400	0.591
TRG_ER_diArg_1	126	128	PF00400	0.877
TRG_ER_diArg_1	205	207	PF00400	0.648
TRG_ER_diArg_1	367	370	PF00400	0.614
TRG_ER_diArg_1	729	732	PF00400	0.722
TRG_ER_diArg_1	921	924	PF00400	0.776
TRG_Pf-PMV_PEXEL_1	924	928	PF00026	0.784

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJP7	Leishmania donovani	86%	100%
A4H3R6	Leishmania braziliensis	64%	100%
E9AG35	Leishmania infantum	86%	100%
E9AJS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%