Putative 60S acidic ribosomal protein P2

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S acidic ribosomal protein P2, putative

Species:

Leishmania major

UniProt:

E9ACI8_LEIMA

TriTrypDb:

LmjF.03.0440 , LMJLV39_030009600 , LMJSD75_030009600

Length:

111

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S acidic ribosomal P2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0032991	protein-containing complex	1	12
GO:0044391	ribosomal subunit	3	2
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005840	ribosome	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

E9ACI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACI8

Function

Biological processes
Term	Name	Level	Count
GO:0002181	cytoplasmic translation	5	2
GO:0006412	translation	4	2
GO:0006414	translational elongation	5	11
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	2
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	2
GO:0043604	amide biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11
GO:0005488	binding	1	2
GO:0008047	enzyme activator activity	3	2
GO:0019207	kinase regulator activity	3	2
GO:0019209	kinase activator activity	4	2
GO:0019887	protein kinase regulator activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0030295	protein kinase activator activity	5	2
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0044877	protein-containing complex binding	2	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	38	46	PF00400	0.404
DOC_MAPK_MEF2A_6	39	46	PF00069	0.431
DOC_USP7_UBL2_3	88	92	PF12436	0.474
DOC_WW_Pin1_4	71	76	PF00397	0.421
LIG_BIR_II_1	1	5	PF00653	0.372
LIG_FHA_1	39	45	PF00498	0.419
LIG_FHA_2	20	26	PF00498	0.329
LIG_LIR_Gen_1	9	18	PF02991	0.347
LIG_LIR_Nem_3	104	110	PF02991	0.417
LIG_LIR_Nem_3	9	13	PF02991	0.335
LIG_SH2_CRK	10	14	PF00017	0.324
LIG_SH2_STAP1	10	14	PF00017	0.324
LIG_SH3_3	37	43	PF00018	0.475
LIG_TRAF2_1	97	100	PF00917	0.427
MOD_CK1_1	2	8	PF00069	0.383
MOD_CK1_1	54	60	PF00069	0.441
MOD_CK1_1	71	77	PF00069	0.421
MOD_CK2_1	19	25	PF00069	0.455
MOD_GlcNHglycan	1	4	PF01048	0.454
MOD_GlcNHglycan	22	25	PF01048	0.382
MOD_GlcNHglycan	70	73	PF01048	0.279
MOD_GlcNHglycan	80	83	PF01048	0.313
MOD_GSK3_1	2	9	PF00069	0.316
MOD_NEK2_1	6	11	PF00069	0.340
MOD_PKA_2	38	44	PF00069	0.419
MOD_Plk_2-3	51	57	PF00069	0.468
MOD_Plk_4	54	60	PF00069	0.374
MOD_ProDKin_1	71	77	PF00069	0.421
TRG_ENDOCYTIC_2	10	13	PF00928	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K6	Leptomonas seymouri	41%	100%
A0A0S4IV06	Bodo saltans	55%	100%
A0A1X0P9L8	Trypanosomatidae	60%	96%
A0A3R7KRR7	Trypanosoma rangeli	44%	100%
A0A3R7NK96	Trypanosoma rangeli	58%	97%
A0A451EJP5	Leishmania donovani	99%	100%
A1XQU7	Sus scrofa	37%	97%
A4H3L0	Leishmania braziliensis	71%	100%
A4H3L1	Leishmania braziliensis	75%	100%
A4HRV3	Leishmania infantum	64%	99%
A4HRV4	Leishmania infantum	100%	100%
E9AJS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AJS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AQ39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
H2E5X2	Penicillium crustosum	42%	100%
O01359	Oscheius tipulae	39%	99%
O23095	Arabidopsis thaliana	44%	98%
O46313	Leishmania peruviana	75%	100%
P05386	Homo sapiens	39%	97%
P08570	Drosophila melanogaster	43%	99%
P17476	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
P17477	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P18660	Gallus gallus	40%	97%
P19944	Rattus norvegicus	38%	97%
P22684	Dictyostelium discoideum	37%	98%
P47955	Mus musculus	40%	97%
P49148	Alternaria alternata	39%	100%
P50344	Davidiella tassiana	42%	100%
P52855	Zea mays	47%	100%
P91913	Caenorhabditis elegans	45%	100%
Q49KL9	Penicillium brevicompactum	41%	100%
Q56K14	Bos taurus	39%	97%
Q8LCW9	Arabidopsis thaliana	45%	99%
Q8LEQ0	Arabidopsis thaliana	46%	98%
Q9HGV0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	100%
Q9UU78	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%