LeishMANIAdb
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Putative MFS transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative MFS transporter
Gene product:
MFS transporter, putative
Species:
Leishmania major
UniProt:
E9ACI6_LEIMA
TriTrypDb:
LmjF.03.0410 , LMJLV39_030009300 , LMJSD75_030009300
Length:
683

Annotations

LeishMANIAdb annotations

A transporter protein family expanded in Kinetoplastids. Distantly similar to animal hem transporters (human FLVCR).

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 17
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0020016 ciliary pocket 2 2
GO:0110165 cellular anatomical entity 1 19

Expansion

Sequence features

E9ACI6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACI6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 19
GO:0022857 transmembrane transporter activity 2 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 314 318 PF00656 0.649
CLV_C14_Caspase3-7 376 380 PF00656 0.752
CLV_NRD_NRD_1 10 12 PF00675 0.587
CLV_NRD_NRD_1 276 278 PF00675 0.306
CLV_NRD_NRD_1 295 297 PF00675 0.462
CLV_NRD_NRD_1 306 308 PF00675 0.510
CLV_NRD_NRD_1 475 477 PF00675 0.285
CLV_NRD_NRD_1 623 625 PF00675 0.430
CLV_PCSK_KEX2_1 10 12 PF00082 0.487
CLV_PCSK_KEX2_1 276 278 PF00082 0.305
CLV_PCSK_KEX2_1 295 297 PF00082 0.409
CLV_PCSK_KEX2_1 306 308 PF00082 0.456
CLV_PCSK_KEX2_1 327 329 PF00082 0.557
CLV_PCSK_KEX2_1 475 477 PF00082 0.270
CLV_PCSK_KEX2_1 609 611 PF00082 0.261
CLV_PCSK_PC1ET2_1 327 329 PF00082 0.557
CLV_PCSK_PC1ET2_1 609 611 PF00082 0.312
CLV_PCSK_SKI1_1 478 482 PF00082 0.255
CLV_PCSK_SKI1_1 605 609 PF00082 0.318
CLV_PCSK_SKI1_1 69 73 PF00082 0.468
DEG_MDM2_SWIB_1 407 415 PF02201 0.473
DEG_SCF_FBW7_1 26 32 PF00400 0.655
DEG_SIAH_1 19 27 PF03145 0.611
DEG_SPOP_SBC_1 547 551 PF00917 0.469
DOC_CKS1_1 200 205 PF01111 0.296
DOC_CKS1_1 26 31 PF01111 0.639
DOC_CYCLIN_RxL_1 472 485 PF00134 0.546
DOC_CYCLIN_RxL_1 64 75 PF00134 0.533
DOC_MAPK_DCC_7 386 396 PF00069 0.590
DOC_MAPK_FxFP_2 272 275 PF00069 0.424
DOC_MAPK_gen_1 472 481 PF00069 0.454
DOC_MAPK_RevD_3 263 277 PF00069 0.424
DOC_PP4_FxxP_1 241 244 PF00568 0.271
DOC_PP4_FxxP_1 272 275 PF00568 0.303
DOC_PP4_FxxP_1 465 468 PF00568 0.382
DOC_PP4_FxxP_1 530 533 PF00568 0.297
DOC_SPAK_OSR1_1 88 92 PF12202 0.469
DOC_USP7_MATH_1 188 192 PF00917 0.405
DOC_USP7_MATH_1 2 6 PF00917 0.619
DOC_USP7_MATH_1 20 24 PF00917 0.647
DOC_USP7_MATH_1 363 367 PF00917 0.728
DOC_USP7_MATH_1 417 421 PF00917 0.283
DOC_USP7_UBL2_3 246 250 PF12436 0.285
DOC_USP7_UBL2_3 605 609 PF12436 0.546
DOC_WW_Pin1_4 107 112 PF00397 0.307
DOC_WW_Pin1_4 199 204 PF00397 0.296
DOC_WW_Pin1_4 25 30 PF00397 0.778
DOC_WW_Pin1_4 574 579 PF00397 0.337
LIG_14-3-3_CanoR_1 408 414 PF00244 0.565
LIG_14-3-3_CanoR_1 627 636 PF00244 0.695
LIG_AP2alpha_2 85 87 PF02296 0.555
LIG_APCC_ABBAyCdc20_2 69 75 PF00400 0.531
LIG_BRCT_BRCA1_1 190 194 PF00533 0.291
LIG_Clathr_ClatBox_1 71 75 PF01394 0.533
LIG_deltaCOP1_diTrp_1 85 89 PF00928 0.565
LIG_FHA_1 130 136 PF00498 0.315
LIG_FHA_1 193 199 PF00498 0.295
LIG_FHA_1 200 206 PF00498 0.295
LIG_FHA_1 237 243 PF00498 0.303
LIG_FHA_1 494 500 PF00498 0.355
LIG_FHA_1 556 562 PF00498 0.353
LIG_FHA_1 598 604 PF00498 0.411
LIG_FHA_1 66 72 PF00498 0.712
LIG_FHA_2 575 581 PF00498 0.275
LIG_FHA_2 609 615 PF00498 0.546
LIG_GBD_Chelix_1 265 273 PF00786 0.291
LIG_GBD_Chelix_1 490 498 PF00786 0.376
LIG_Integrin_RGD_1 83 85 PF01839 0.326
LIG_IRF3_LxIS_1 413 419 PF10401 0.424
LIG_IRF3_LxIS_1 94 101 PF10401 0.343
LIG_LIR_Apic_2 239 244 PF02991 0.274
LIG_LIR_Gen_1 191 201 PF02991 0.414
LIG_LIR_Gen_1 409 418 PF02991 0.457
LIG_LIR_Nem_3 191 197 PF02991 0.466
LIG_LIR_Nem_3 402 407 PF02991 0.513
LIG_LIR_Nem_3 409 414 PF02991 0.487
LIG_LIR_Nem_3 567 573 PF02991 0.317
LIG_MYND_1 61 65 PF01753 0.726
LIG_NRBOX 166 172 PF00104 0.382
LIG_NRBOX 493 499 PF00104 0.400
LIG_Pex14_2 252 256 PF04695 0.262
LIG_Pex14_2 407 411 PF04695 0.600
LIG_PTB_Apo_2 205 212 PF02174 0.455
LIG_SH2_CRK 262 266 PF00017 0.375
LIG_SH2_CRK 477 481 PF00017 0.467
LIG_SH2_PTP2 138 141 PF00017 0.316
LIG_SH2_SRC 134 137 PF00017 0.260
LIG_SH2_STAP1 262 266 PF00017 0.424
LIG_SH2_STAT3 186 189 PF00017 0.297
LIG_SH2_STAT5 119 122 PF00017 0.255
LIG_SH2_STAT5 134 137 PF00017 0.276
LIG_SH2_STAT5 138 141 PF00017 0.297
LIG_SH2_STAT5 186 189 PF00017 0.343
LIG_SH2_STAT5 512 515 PF00017 0.310
LIG_SH2_STAT5 538 541 PF00017 0.541
LIG_SH3_3 23 29 PF00018 0.784
LIG_SH3_3 232 238 PF00018 0.334
LIG_SH3_3 272 278 PF00018 0.301
LIG_SH3_3 458 464 PF00018 0.367
LIG_SH3_3 654 660 PF00018 0.816
LIG_SH3_4 605 612 PF00018 0.546
LIG_SUMO_SIM_anti_2 485 490 PF11976 0.366
LIG_SUMO_SIM_par_1 195 202 PF11976 0.319
LIG_SUMO_SIM_par_1 414 420 PF11976 0.330
LIG_SUMO_SIM_par_1 491 496 PF11976 0.350
LIG_SUMO_SIM_par_1 537 543 PF11976 0.459
LIG_SUMO_SIM_par_1 96 101 PF11976 0.297
LIG_TYR_ITIM 136 141 PF00017 0.293
LIG_Vh1_VBS_1 479 497 PF01044 0.451
LIG_WRC_WIRS_1 237 242 PF05994 0.368
LIG_WRC_WIRS_1 584 589 PF05994 0.421
LIG_WRC_WIRS_1 592 597 PF05994 0.424
MOD_CK1_1 409 415 PF00069 0.517
MOD_CK1_1 668 674 PF00069 0.760
MOD_CK2_1 190 196 PF00069 0.281
MOD_CK2_1 330 336 PF00069 0.760
MOD_CK2_1 379 385 PF00069 0.772
MOD_CK2_1 417 423 PF00069 0.290
MOD_CK2_1 574 580 PF00069 0.317
MOD_CK2_1 608 614 PF00069 0.528
MOD_Cter_Amidation 473 476 PF01082 0.346
MOD_GlcNHglycan 20 23 PF01048 0.556
MOD_GlcNHglycan 224 227 PF01048 0.351
MOD_GlcNHglycan 365 368 PF01048 0.502
MOD_GlcNHglycan 419 422 PF01048 0.297
MOD_GlcNHglycan 550 553 PF01048 0.254
MOD_GlcNHglycan 629 632 PF01048 0.489
MOD_GlcNHglycan 654 657 PF01048 0.591
MOD_GlcNHglycan 667 670 PF01048 0.604
MOD_GSK3_1 188 195 PF00069 0.330
MOD_GSK3_1 218 225 PF00069 0.281
MOD_GSK3_1 25 32 PF00069 0.760
MOD_GSK3_1 555 562 PF00069 0.375
MOD_GSK3_1 572 579 PF00069 0.289
MOD_GSK3_1 597 604 PF00069 0.422
MOD_GSK3_1 661 668 PF00069 0.816
MOD_N-GLC_1 122 127 PF02516 0.453
MOD_N-GLC_1 409 414 PF02516 0.329
MOD_N-GLC_2 360 362 PF02516 0.537
MOD_NEK2_1 122 127 PF00069 0.277
MOD_NEK2_1 129 134 PF00069 0.341
MOD_NEK2_1 416 421 PF00069 0.335
MOD_NEK2_1 546 551 PF00069 0.459
MOD_NEK2_1 555 560 PF00069 0.302
MOD_NEK2_1 564 569 PF00069 0.197
MOD_NEK2_1 601 606 PF00069 0.368
MOD_NEK2_1 98 103 PF00069 0.284
MOD_NEK2_2 20 25 PF00069 0.648
MOD_NEK2_2 597 602 PF00069 0.395
MOD_OFUCOSY 346 351 PF10250 0.430
MOD_PIKK_1 122 128 PF00454 0.312
MOD_PKA_1 306 312 PF00069 0.594
MOD_PKA_2 306 312 PF00069 0.719
MOD_PKA_2 665 671 PF00069 0.755
MOD_Plk_1 122 128 PF00069 0.252
MOD_Plk_1 409 415 PF00069 0.488
MOD_Plk_1 540 546 PF00069 0.468
MOD_Plk_2-3 379 385 PF00069 0.641
MOD_Plk_4 130 136 PF00069 0.317
MOD_Plk_4 218 224 PF00069 0.333
MOD_Plk_4 236 242 PF00069 0.298
MOD_Plk_4 29 35 PF00069 0.726
MOD_Plk_4 429 435 PF00069 0.281
MOD_Plk_4 457 463 PF00069 0.321
MOD_Plk_4 482 488 PF00069 0.325
MOD_Plk_4 493 499 PF00069 0.322
MOD_Plk_4 564 570 PF00069 0.312
MOD_Plk_4 588 594 PF00069 0.281
MOD_Plk_4 597 603 PF00069 0.274
MOD_ProDKin_1 107 113 PF00069 0.307
MOD_ProDKin_1 199 205 PF00069 0.296
MOD_ProDKin_1 25 31 PF00069 0.774
MOD_ProDKin_1 574 580 PF00069 0.337
MOD_SUMO_rev_2 576 584 PF00179 0.239
MOD_SUMO_rev_2 674 683 PF00179 0.608
TRG_DiLeu_BaLyEn_6 201 206 PF01217 0.328
TRG_DiLeu_BaLyEn_6 58 63 PF01217 0.716
TRG_ENDOCYTIC_2 119 122 PF00928 0.268
TRG_ENDOCYTIC_2 138 141 PF00928 0.288
TRG_ENDOCYTIC_2 262 265 PF00928 0.375
TRG_ENDOCYTIC_2 477 480 PF00928 0.466
TRG_ER_diArg_1 275 277 PF00400 0.409
TRG_ER_diArg_1 295 298 PF00400 0.638
TRG_ER_diArg_1 475 477 PF00400 0.476
TRG_NLS_Bipartite_1 609 628 PF00514 0.674

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I416 Leptomonas seymouri 28% 96%
A0A0N1IHM9 Leptomonas seymouri 69% 97%
A0A0S4J2T0 Bodo saltans 34% 100%
A0A1X0NWR8 Trypanosomatidae 27% 100%
A0A1X0PA49 Trypanosomatidae 51% 100%
A0A3Q8IBI9 Leishmania donovani 27% 93%
A0A3S5H541 Leishmania donovani 94% 100%
A0A422NQJ7 Trypanosoma rangeli 52% 100%
A4H3K8 Leishmania braziliensis 82% 99%
A4HRV1 Leishmania infantum 94% 100%
A4HYN7 Leishmania infantum 26% 93%
D0A244 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9AJS4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9AUH8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 94%
Q4QD06 Leishmania major 27% 94%
V5BCB7 Trypanosoma cruzi 55% 100%
V5BQV3 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS