LeishMANIAdb
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GPR1/FUN34/yaaH family-domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GPR1/FUN34/yaaH family-domain-containing protein
Gene product:
GPR1/FUN34/yaaH family, putative
Species:
Leishmania major
UniProt:
E9ACI5_LEIMA
TriTrypDb:
LmjF.03.0400 , LMJLV39_030009100 * , LMJLV39_030009200 * , LMJSD75_030009200 *
Length:
303

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 3
GO:0016020 membrane 2 17
GO:0110165 cellular anatomical entity 1 17

Expansion

Sequence features

E9ACI5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACI5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0006811 monoatomic ion transport 4 3
GO:0006820 monoatomic anion transport 5 3
GO:0006835 dicarboxylic acid transport 7 3
GO:0006846 acetate transport 6 3
GO:0009987 cellular process 1 3
GO:0015711 organic anion transport 5 3
GO:0015718 monocarboxylic acid transport 7 3
GO:0015740 C4-dicarboxylate transport 8 3
GO:0015744 succinate transport 6 3
GO:0015849 organic acid transport 5 3
GO:0034220 monoatomic ion transmembrane transport 3 3
GO:0035433 acetate transmembrane transport 5 3
GO:0046942 carboxylic acid transport 6 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
GO:0071422 succinate transmembrane transport 5 3
GO:0071702 organic substance transport 4 3
GO:0098656 monoatomic anion transmembrane transport 4 3
GO:1903825 organic acid transmembrane transport 3 3
GO:1905039 carboxylic acid transmembrane transport 4 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0005342 organic acid transmembrane transporter activity 3 3
GO:0008028 monocarboxylic acid transmembrane transporter activity 5 3
GO:0008324 monoatomic cation transmembrane transporter activity 4 3
GO:0008509 monoatomic anion transmembrane transporter activity 4 3
GO:0008514 organic anion transmembrane transporter activity 5 3
GO:0015075 monoatomic ion transmembrane transporter activity 3 3
GO:0015078 proton transmembrane transporter activity 5 3
GO:0015123 acetate transmembrane transporter activity 6 3
GO:0015291 secondary active transmembrane transporter activity 4 3
GO:0015293 symporter activity 5 3
GO:0015294 solute:monoatomic cation symporter activity 5 3
GO:0015295 solute:proton symporter activity 6 3
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 3
GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5 3
GO:0015360 acetate:proton symporter activity 7 3
GO:0022804 active transmembrane transporter activity 3 3
GO:0022853 active monoatomic ion transmembrane transporter activity 4 3
GO:0022857 transmembrane transporter activity 2 3
GO:0022890 inorganic cation transmembrane transporter activity 4 3
GO:0043893 acetate:monoatomic cation symporter activity 6 3
GO:0046943 carboxylic acid transmembrane transporter activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 58 60 PF00675 0.419
CLV_NRD_NRD_1 66 68 PF00675 0.394
CLV_NRD_NRD_1 85 87 PF00675 0.260
CLV_PCSK_FUR_1 64 68 PF00082 0.328
CLV_PCSK_KEX2_1 66 68 PF00082 0.452
CLV_PCSK_KEX2_1 85 87 PF00082 0.137
CLV_PCSK_PC1ET2_1 66 68 PF00082 0.443
CLV_PCSK_PC7_1 64 70 PF00082 0.338
CLV_PCSK_SKI1_1 265 269 PF00082 0.343
DEG_APCC_DBOX_1 264 272 PF00400 0.568
DEG_APCC_DBOX_1 66 74 PF00400 0.593
DOC_CYCLIN_yClb5_NLxxxL_5 205 212 PF00134 0.526
DOC_MAPK_DCC_7 265 273 PF00069 0.568
DOC_MAPK_DCC_7 85 95 PF00069 0.472
DOC_MAPK_gen_1 56 65 PF00069 0.504
DOC_MAPK_MEF2A_6 205 214 PF00069 0.497
DOC_MAPK_MEF2A_6 265 273 PF00069 0.568
DOC_PP2B_LxvP_1 176 179 PF13499 0.196
DOC_USP7_MATH_1 149 153 PF00917 0.307
DOC_USP7_MATH_1 15 19 PF00917 0.710
DOC_USP7_MATH_1 171 175 PF00917 0.289
DOC_USP7_MATH_1 287 291 PF00917 0.641
DOC_USP7_UBL2_3 56 60 PF12436 0.640
DOC_WW_Pin1_4 280 285 PF00397 0.647
LIG_14-3-3_CanoR_1 141 146 PF00244 0.480
LIG_14-3-3_CanoR_1 59 64 PF00244 0.625
LIG_BIR_II_1 1 5 PF00653 0.676
LIG_BRCT_BRCA1_1 180 184 PF00533 0.346
LIG_deltaCOP1_diTrp_1 138 145 PF00928 0.546
LIG_FHA_1 100 106 PF00498 0.307
LIG_FHA_1 115 121 PF00498 0.266
LIG_FHA_1 153 159 PF00498 0.313
LIG_FHA_1 171 177 PF00498 0.326
LIG_FHA_1 214 220 PF00498 0.332
LIG_FHA_1 272 278 PF00498 0.583
LIG_LIR_Gen_1 144 153 PF02991 0.339
LIG_LIR_Gen_1 155 165 PF02991 0.341
LIG_LIR_Gen_1 196 204 PF02991 0.354
LIG_LIR_Gen_1 218 229 PF02991 0.435
LIG_LIR_Nem_3 144 150 PF02991 0.312
LIG_LIR_Nem_3 151 156 PF02991 0.292
LIG_LIR_Nem_3 181 187 PF02991 0.258
LIG_LIR_Nem_3 196 200 PF02991 0.287
LIG_LIR_Nem_3 218 224 PF02991 0.366
LIG_MLH1_MIPbox_1 180 184 PF16413 0.346
LIG_SH2_STAT3 295 298 PF00017 0.521
LIG_SH2_STAT5 147 150 PF00017 0.313
LIG_SH2_STAT5 183 186 PF00017 0.313
LIG_SH2_STAT5 188 191 PF00017 0.304
LIG_SH2_STAT5 252 255 PF00017 0.311
LIG_SH3_3 266 272 PF00018 0.472
LIG_SUMO_SIM_anti_2 196 203 PF11976 0.410
LIG_SUMO_SIM_anti_2 216 221 PF11976 0.363
LIG_SUMO_SIM_par_1 47 53 PF11976 0.524
LIG_WRC_WIRS_1 153 158 PF05994 0.259
LIG_WRC_WIRS_1 194 199 PF05994 0.373
MOD_CDC14_SPxK_1 283 286 PF00782 0.545
MOD_CDK_SPxK_1 280 286 PF00069 0.551
MOD_CK1_1 152 158 PF00069 0.288
MOD_CK1_1 2 8 PF00069 0.737
MOD_GlcNHglycan 17 20 PF01048 0.454
MOD_GlcNHglycan 231 234 PF01048 0.502
MOD_GlcNHglycan 289 292 PF01048 0.446
MOD_GlcNHglycan 4 7 PF01048 0.534
MOD_GSK3_1 148 155 PF00069 0.250
MOD_GSK3_1 166 173 PF00069 0.302
MOD_GSK3_1 225 232 PF00069 0.439
MOD_GSK3_1 50 57 PF00069 0.639
MOD_N-GLC_1 36 41 PF02516 0.458
MOD_NEK2_1 107 112 PF00069 0.284
MOD_NEK2_1 156 161 PF00069 0.350
MOD_NEK2_1 200 205 PF00069 0.312
MOD_NEK2_1 215 220 PF00069 0.355
MOD_NEK2_1 224 229 PF00069 0.327
MOD_NEK2_1 98 103 PF00069 0.317
MOD_PIKK_1 271 277 PF00454 0.528
MOD_PIKK_1 36 42 PF00454 0.628
MOD_PKA_1 59 65 PF00069 0.630
MOD_Plk_1 263 269 PF00069 0.544
MOD_Plk_4 114 120 PF00069 0.257
MOD_Plk_4 152 158 PF00069 0.313
MOD_Plk_4 215 221 PF00069 0.366
MOD_Plk_4 99 105 PF00069 0.311
MOD_ProDKin_1 280 286 PF00069 0.651
TRG_ENDOCYTIC_2 147 150 PF00928 0.319
TRG_ENDOCYTIC_2 153 156 PF00928 0.319
TRG_ENDOCYTIC_2 188 191 PF00928 0.338
TRG_ENDOCYTIC_2 241 244 PF00928 0.364
TRG_ENDOCYTIC_2 252 255 PF00928 0.271
TRG_ER_diArg_1 67 70 PF00400 0.604
TRG_ER_diArg_1 84 86 PF00400 0.557
TRG_NLS_MonoCore_2 65 70 PF00514 0.499
TRG_NLS_MonoExtC_3 66 72 PF00514 0.479
TRG_NLS_MonoExtN_4 64 71 PF00514 0.507
TRG_Pf-PMV_PEXEL_1 68 72 PF00026 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1I5 Leptomonas seymouri 50% 77%
A0A0N1PAF6 Leptomonas seymouri 65% 83%
A0A1X0P8X4 Trypanosomatidae 39% 100%
A0A1X0P9Q6 Trypanosomatidae 51% 100%
A0A3R7M294 Trypanosoma rangeli 37% 100%
A0A3R7MT82 Trypanosoma rangeli 50% 100%
A0A3S5H538 Leishmania donovani 82% 82%
A0A3S5H540 Leishmania donovani 91% 100%
A0A451EJN9 Leishmania donovani 26% 98%
A4H3K6 Leishmania braziliensis 70% 100%
A4H3K7 Leishmania braziliensis 74% 85%
A4HRU7 Leishmania infantum 26% 98%
A4HRU8 Leishmania infantum 82% 82%
A4HRV0 Leishmania infantum 92% 100%
B0YBR5 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 29% 100%
E9ACI2 Leishmania major 25% 100%
E9ACI3 Leishmania major 81% 100%
E9AJS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 81%
E9AJS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
O14201 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
P32907 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
Q24JP1 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 29% 100%
Q5B2K4 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS