Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPR1/FUN34/yaaH family, putative

Species:

Leishmania major

UniProt:

E9ACI4_LEIMA

TriTrypDb:

LmjF.03.0390 , LMJLV39_030009100 , LMJSD75_030009100

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACI4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006820	monoatomic anion transport	5	2
GO:0006835	dicarboxylic acid transport	7	2
GO:0006846	acetate transport	6	2
GO:0009987	cellular process	1	2
GO:0015711	organic anion transport	5	2
GO:0015718	monocarboxylic acid transport	7	2
GO:0015740	C4-dicarboxylate transport	8	2
GO:0015744	succinate transport	6	2
GO:0015849	organic acid transport	5	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0035433	acetate transmembrane transport	5	2
GO:0046942	carboxylic acid transport	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071422	succinate transmembrane transport	5	2
GO:0071702	organic substance transport	4	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	5	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015078	proton transmembrane transporter activity	5	2
GO:0015123	acetate transmembrane transporter activity	6	2
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015293	symporter activity	5	2
GO:0015294	solute:monoatomic cation symporter activity	5	2
GO:0015295	solute:proton symporter activity	6	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	5	2
GO:0015360	acetate:proton symporter activity	7	2
GO:0022804	active transmembrane transporter activity	3	2
GO:0022853	active monoatomic ion transmembrane transporter activity	4	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0043893	acetate:monoatomic cation symporter activity	6	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.837
CLV_C14_Caspase3-7	76	80	PF00656	0.795
CLV_NRD_NRD_1	101	103	PF00675	0.449
CLV_NRD_NRD_1	225	227	PF00675	0.639
CLV_NRD_NRD_1	229	231	PF00675	0.581
CLV_NRD_NRD_1	339	341	PF00675	0.609
CLV_NRD_NRD_1	349	351	PF00675	0.514
CLV_NRD_NRD_1	38	40	PF00675	0.645
CLV_NRD_NRD_1	8	10	PF00675	0.633
CLV_PCSK_KEX2_1	229	231	PF00082	0.631
CLV_PCSK_KEX2_1	298	300	PF00082	0.656
CLV_PCSK_KEX2_1	339	341	PF00082	0.609
CLV_PCSK_KEX2_1	349	351	PF00082	0.514
CLV_PCSK_KEX2_1	8	10	PF00082	0.633
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.656
DEG_Kelch_Keap1_1	77	82	PF01344	0.781
DEG_Nend_UBRbox_1	1	4	PF02207	0.844
DEG_SPOP_SBC_1	391	395	PF00917	0.804
DOC_ANK_TNKS_1	324	331	PF00023	0.842
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.804
DOC_MAPK_DCC_7	102	112	PF00069	0.650
DOC_MAPK_gen_1	339	346	PF00069	0.810
DOC_MAPK_MEF2A_6	339	346	PF00069	0.810
DOC_MAPK_MEF2A_6	366	375	PF00069	0.805
DOC_MAPK_NFAT4_5	339	347	PF00069	0.811
DOC_PP2B_LxvP_1	440	443	PF13499	0.803
DOC_USP7_MATH_1	255	259	PF00917	0.834
DOC_USP7_MATH_1	356	360	PF00917	0.846
DOC_USP7_MATH_1	391	395	PF00917	0.804
DOC_USP7_MATH_1	414	418	PF00917	0.835
DOC_USP7_MATH_1	94	98	PF00917	0.650
DOC_WW_Pin1_4	201	206	PF00397	0.831
DOC_WW_Pin1_4	245	250	PF00397	0.824
DOC_WW_Pin1_4	282	287	PF00397	0.846
DOC_WW_Pin1_4	400	405	PF00397	0.829
DOC_WW_Pin1_4	412	417	PF00397	0.679
LIG_14-3-3_CanoR_1	229	238	PF00244	0.822
LIG_14-3-3_CanoR_1	243	249	PF00244	0.643
LIG_14-3-3_CanoR_1	325	329	PF00244	0.842
LIG_14-3-3_CanoR_1	339	345	PF00244	0.633
LIG_14-3-3_CanoR_1	405	409	PF00244	0.838
LIG_14-3-3_CanoR_1	9	15	PF00244	0.835
LIG_BRCT_BRCA1_1	29	33	PF00533	0.850
LIG_BRCT_BRCA1_1	395	399	PF00533	0.814
LIG_Clathr_ClatBox_1	165	169	PF01394	0.794
LIG_CtBP_PxDLS_1	437	441	PF00389	0.802
LIG_DLG_GKlike_1	340	347	PF00625	0.811
LIG_eIF4E_1	384	390	PF01652	0.794
LIG_FHA_1	117	123	PF00498	0.549
LIG_FHA_1	132	138	PF00498	0.287
LIG_FHA_1	172	178	PF00498	0.770
LIG_FHA_1	268	274	PF00498	0.808
LIG_GSK3_LRP6_1	412	417	PF00069	0.829
LIG_LIR_Apic_2	361	367	PF02991	0.834
LIG_LIR_Gen_1	13	20	PF02991	0.836
LIG_LIR_Gen_1	396	406	PF02991	0.826
LIG_LIR_Nem_3	13	17	PF02991	0.835
LIG_LIR_Nem_3	396	402	PF02991	0.822
LIG_RPA_C_Fungi	335	347	PF08784	0.778
LIG_SH2_CRK	14	18	PF00017	0.809
LIG_SH2_CRK	364	368	PF00017	0.793
LIG_SH2_NCK_1	364	368	PF00017	0.793
LIG_SH2_SRC	49	52	PF00017	0.809
LIG_SH2_STAP1	14	18	PF00017	0.809
LIG_SH2_STAT5	16	19	PF00017	0.808
LIG_SH2_STAT5	364	367	PF00017	0.796
LIG_SH2_STAT5	384	387	PF00017	0.395
LIG_SH2_STAT5	49	52	PF00017	0.809
LIG_SH3_3	243	249	PF00018	0.785
LIG_SH3_3	283	289	PF00018	0.824
LIG_SH3_3	410	416	PF00018	0.800
LIG_SH3_3	432	438	PF00018	0.775
LIG_SUMO_SIM_anti_2	343	348	PF11976	0.784
LIG_SUMO_SIM_par_1	265	272	PF11976	0.763
MOD_CDK_SPK_2	245	250	PF00069	0.794
MOD_CDK_SPK_2	400	405	PF00069	0.800
MOD_CK1_1	10	16	PF00069	0.808
MOD_CK1_1	157	163	PF00069	0.732
MOD_CK1_1	164	170	PF00069	0.627
MOD_CK1_1	200	206	PF00069	0.802
MOD_CK1_1	284	290	PF00069	0.823
MOD_CK1_1	392	398	PF00069	0.770
MOD_CK1_1	97	103	PF00069	0.549
MOD_CK2_1	255	261	PF00069	0.804
MOD_GlcNHglycan	160	163	PF01048	0.741
MOD_GlcNHglycan	198	202	PF01048	0.799
MOD_GlcNHglycan	408	411	PF01048	0.811
MOD_GlcNHglycan	463	466	PF01048	0.789
MOD_GlcNHglycan	470	474	PF01048	0.653
MOD_GlcNHglycan	79	82	PF01048	0.715
MOD_GlcNHglycan	96	99	PF01048	0.252
MOD_GSK3_1	154	161	PF00069	0.719
MOD_GSK3_1	167	174	PF00069	0.512
MOD_GSK3_1	18	25	PF00069	0.814
MOD_GSK3_1	184	191	PF00069	0.408
MOD_GSK3_1	197	204	PF00069	0.568
MOD_GSK3_1	217	224	PF00069	0.480
MOD_GSK3_1	358	365	PF00069	0.821
MOD_GSK3_1	389	396	PF00069	0.768
MOD_GSK3_1	39	46	PF00069	0.821
MOD_GSK3_1	400	407	PF00069	0.610
MOD_GSK3_1	73	80	PF00069	0.766
MOD_GSK3_1	94	101	PF00069	0.549
MOD_N-GLC_1	27	32	PF02516	0.822
MOD_N-GLC_2	4	6	PF02516	0.797
MOD_NEK2_1	115	120	PF00069	0.549
MOD_NEK2_1	124	129	PF00069	0.392
MOD_NEK2_1	158	163	PF00069	0.733
MOD_NEK2_1	182	187	PF00069	0.681
MOD_NEK2_1	188	193	PF00069	0.638
MOD_NEK2_1	26	31	PF00069	0.818
MOD_NEK2_1	274	279	PF00069	0.811
MOD_NEK2_1	358	363	PF00069	0.826
MOD_NEK2_1	389	394	PF00069	0.770
MOD_NEK2_1	406	411	PF00069	0.514
MOD_NEK2_1	471	476	PF00069	0.769
MOD_NEK2_2	205	210	PF00069	0.823
MOD_PIKK_1	188	194	PF00454	0.749
MOD_PKA_1	229	235	PF00069	0.799
MOD_PKA_1	39	45	PF00069	0.821
MOD_PKA_2	229	235	PF00069	0.799
MOD_PKA_2	256	262	PF00069	0.801
MOD_PKA_2	324	330	PF00069	0.818
MOD_PKA_2	404	410	PF00069	0.811
MOD_PKA_2	425	431	PF00069	0.820
MOD_PKA_2	55	61	PF00069	0.813
MOD_PKA_2	7	13	PF00069	0.808
MOD_Plk_1	188	194	PF00069	0.749
MOD_Plk_4	116	122	PF00069	0.549
MOD_Plk_4	131	137	PF00069	0.287
MOD_Plk_4	154	160	PF00069	0.719
MOD_Plk_4	161	167	PF00069	0.625
MOD_Plk_4	269	275	PF00069	0.777
MOD_Plk_4	380	386	PF00069	0.746
MOD_Plk_4	393	399	PF00069	0.546
MOD_Plk_4	414	420	PF00069	0.812
MOD_ProDKin_1	201	207	PF00069	0.807
MOD_ProDKin_1	245	251	PF00069	0.795
MOD_ProDKin_1	282	288	PF00069	0.827
MOD_ProDKin_1	400	406	PF00069	0.802
MOD_ProDKin_1	412	418	PF00069	0.594
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.769
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.665
TRG_ENDOCYTIC_2	14	17	PF00928	0.809
TRG_ER_diArg_1	240	243	PF00400	0.779
TRG_ER_diArg_1	339	341	PF00400	0.773
TRG_ER_diArg_1	349	351	PF00400	0.640
TRG_ER_diArg_1	8	11	PF00400	0.809
TRG_NLS_MonoExtC_3	225	230	PF00514	0.811
TRG_NLS_MonoExtN_4	294	301	PF00514	0.843

Homologs


Protein	Taxonomy	Sequence identity	Coverage
O26317	METTH	64%	100%
P0AC98	ECOLI	61%	100%
P0AC99	ECO57	61%	100%
P0ACA0	SHIFL	61%	100%