LeishMANIAdb
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GPR1/FUN34/yaaH family-domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GPR1/FUN34/yaaH family-domain-containing protein
Gene product:
GPR1/FUN34/yaaH family, putative
Species:
Leishmania major
UniProt:
E9ACI3_LEIMA
TriTrypDb:
LmjF.03.0380 , LMJLV39_030008900 * , LMJLV39_030009000 * , LMJSD75_030009000 *
Length:
370

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 3
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

E9ACI3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACI3

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0006811 monoatomic ion transport 4 3
GO:0006820 monoatomic anion transport 5 3
GO:0006835 dicarboxylic acid transport 7 3
GO:0006846 acetate transport 6 3
GO:0009987 cellular process 1 3
GO:0015711 organic anion transport 5 3
GO:0015718 monocarboxylic acid transport 7 3
GO:0015740 C4-dicarboxylate transport 8 3
GO:0015744 succinate transport 6 3
GO:0015849 organic acid transport 5 3
GO:0034220 monoatomic ion transmembrane transport 3 3
GO:0035433 acetate transmembrane transport 5 3
GO:0046942 carboxylic acid transport 6 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
GO:0071422 succinate transmembrane transport 5 3
GO:0071702 organic substance transport 4 3
GO:0098656 monoatomic anion transmembrane transport 4 3
GO:1903825 organic acid transmembrane transport 3 3
GO:1905039 carboxylic acid transmembrane transport 4 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0005342 organic acid transmembrane transporter activity 3 3
GO:0008028 monocarboxylic acid transmembrane transporter activity 5 3
GO:0008324 monoatomic cation transmembrane transporter activity 4 3
GO:0008509 monoatomic anion transmembrane transporter activity 4 3
GO:0008514 organic anion transmembrane transporter activity 5 3
GO:0015075 monoatomic ion transmembrane transporter activity 3 3
GO:0015078 proton transmembrane transporter activity 5 3
GO:0015123 acetate transmembrane transporter activity 6 3
GO:0015291 secondary active transmembrane transporter activity 4 3
GO:0015293 symporter activity 5 3
GO:0015294 solute:monoatomic cation symporter activity 5 3
GO:0015295 solute:proton symporter activity 6 3
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 3
GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5 3
GO:0015360 acetate:proton symporter activity 7 3
GO:0022804 active transmembrane transporter activity 3 3
GO:0022853 active monoatomic ion transmembrane transporter activity 4 3
GO:0022857 transmembrane transporter activity 2 3
GO:0022890 inorganic cation transmembrane transporter activity 4 3
GO:0043893 acetate:monoatomic cation symporter activity 6 3
GO:0046943 carboxylic acid transmembrane transporter activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 118 122 PF00656 0.570
CLV_C14_Caspase3-7 90 94 PF00656 0.627
CLV_NRD_NRD_1 143 145 PF00675 0.323
CLV_NRD_NRD_1 50 52 PF00675 0.453
CLV_NRD_NRD_1 80 82 PF00675 0.514
CLV_PCSK_FUR_1 48 52 PF00082 0.407
CLV_PCSK_KEX2_1 352 354 PF00082 0.349
CLV_PCSK_KEX2_1 50 52 PF00082 0.453
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.334
CLV_PCSK_SKI1_1 324 328 PF00082 0.338
DEG_APCC_DBOX_1 323 331 PF00400 0.538
DEG_Kelch_Keap1_1 119 124 PF01344 0.523
DOC_CYCLIN_yClb5_NLxxxL_5 264 271 PF00134 0.495
DOC_MAPK_DCC_7 144 154 PF00069 0.492
DOC_MAPK_DCC_7 324 332 PF00069 0.588
DOC_MAPK_MEF2A_6 264 273 PF00069 0.500
DOC_MAPK_MEF2A_6 324 332 PF00069 0.538
DOC_PP2B_LxvP_1 235 238 PF13499 0.217
DOC_USP7_MATH_1 136 140 PF00917 0.424
DOC_USP7_MATH_1 208 212 PF00917 0.402
DOC_USP7_MATH_1 230 234 PF00917 0.342
DOC_USP7_MATH_1 49 53 PF00917 0.610
DOC_WW_Pin1_4 8 13 PF00397 0.612
LIG_14-3-3_CanoR_1 200 205 PF00244 0.538
LIG_14-3-3_CanoR_1 51 57 PF00244 0.613
LIG_BIR_II_1 1 5 PF00653 0.719
LIG_BRCT_BRCA1_1 239 243 PF00533 0.306
LIG_BRCT_BRCA1_1 71 75 PF00533 0.665
LIG_deltaCOP1_diTrp_1 197 204 PF00928 0.538
LIG_FHA_1 1 7 PF00498 0.653
LIG_FHA_1 159 165 PF00498 0.326
LIG_FHA_1 174 180 PF00498 0.336
LIG_FHA_1 212 218 PF00498 0.288
LIG_FHA_1 230 236 PF00498 0.290
LIG_FHA_1 273 279 PF00498 0.404
LIG_FHA_1 331 337 PF00498 0.616
LIG_FHA_1 34 40 PF00498 0.612
LIG_FHA_2 346 352 PF00498 0.558
LIG_LIR_Gen_1 203 212 PF02991 0.358
LIG_LIR_Gen_1 214 224 PF02991 0.330
LIG_LIR_Gen_1 255 263 PF02991 0.385
LIG_LIR_Gen_1 277 288 PF02991 0.393
LIG_LIR_Gen_1 55 62 PF02991 0.625
LIG_LIR_Nem_3 203 209 PF02991 0.341
LIG_LIR_Nem_3 210 215 PF02991 0.352
LIG_LIR_Nem_3 240 246 PF02991 0.306
LIG_LIR_Nem_3 255 259 PF02991 0.329
LIG_LIR_Nem_3 277 283 PF02991 0.347
LIG_LIR_Nem_3 55 59 PF02991 0.624
LIG_MLH1_MIPbox_1 239 243 PF16413 0.338
LIG_NRP_CendR_1 369 370 PF00754 0.407
LIG_PALB2_WD40_1 334 342 PF16756 0.476
LIG_SH2_CRK 56 60 PF00017 0.689
LIG_SH2_SRC 91 94 PF00017 0.622
LIG_SH2_STAP1 56 60 PF00017 0.668
LIG_SH2_STAT5 206 209 PF00017 0.412
LIG_SH2_STAT5 242 245 PF00017 0.375
LIG_SH2_STAT5 247 250 PF00017 0.381
LIG_SH2_STAT5 311 314 PF00017 0.341
LIG_SH2_STAT5 58 61 PF00017 0.687
LIG_SH2_STAT5 91 94 PF00017 0.670
LIG_SH3_3 17 23 PF00018 0.639
LIG_SH3_3 325 331 PF00018 0.510
LIG_SH3_3 9 15 PF00018 0.631
LIG_SUMO_SIM_anti_2 255 262 PF11976 0.351
LIG_SUMO_SIM_anti_2 275 280 PF11976 0.412
LIG_WRC_WIRS_1 212 217 PF05994 0.242
LIG_WRC_WIRS_1 253 258 PF05994 0.412
MOD_CK1_1 139 145 PF00069 0.385
MOD_CK1_1 211 217 PF00069 0.337
MOD_CK1_1 361 367 PF00069 0.708
MOD_CK1_1 52 58 PF00069 0.775
MOD_CK2_1 21 27 PF00069 0.697
MOD_GlcNHglycan 121 124 PF01048 0.358
MOD_GlcNHglycan 138 141 PF01048 0.221
MOD_GlcNHglycan 290 293 PF01048 0.531
MOD_GlcNHglycan 7 11 PF01048 0.476
MOD_GSK3_1 115 122 PF00069 0.715
MOD_GSK3_1 136 143 PF00069 0.385
MOD_GSK3_1 207 214 PF00069 0.292
MOD_GSK3_1 225 232 PF00069 0.275
MOD_GSK3_1 284 291 PF00069 0.476
MOD_GSK3_1 354 361 PF00069 0.583
MOD_GSK3_1 60 67 PF00069 0.718
MOD_GSK3_1 81 88 PF00069 0.797
MOD_N-GLC_1 353 358 PF02516 0.387
MOD_N-GLC_1 69 74 PF02516 0.415
MOD_NEK2_1 157 162 PF00069 0.315
MOD_NEK2_1 166 171 PF00069 0.323
MOD_NEK2_1 215 220 PF00069 0.341
MOD_NEK2_1 259 264 PF00069 0.341
MOD_NEK2_1 274 279 PF00069 0.288
MOD_NEK2_1 283 288 PF00069 0.321
MOD_NEK2_1 68 73 PF00069 0.598
MOD_NEK2_2 338 343 PF00069 0.486
MOD_PIKK_1 330 336 PF00454 0.538
MOD_PIKK_1 345 351 PF00454 0.636
MOD_PIKK_1 358 364 PF00454 0.539
MOD_PKA_1 81 87 PF00069 0.708
MOD_PKA_2 354 360 PF00069 0.568
MOD_PKA_2 49 55 PF00069 0.723
MOD_PKA_2 97 103 PF00069 0.677
MOD_Plk_1 322 328 PF00069 0.536
MOD_Plk_4 158 164 PF00069 0.323
MOD_Plk_4 173 179 PF00069 0.275
MOD_Plk_4 211 217 PF00069 0.364
MOD_Plk_4 274 280 PF00069 0.412
MOD_ProDKin_1 8 14 PF00069 0.612
TRG_DiLeu_BaLyEn_6 129 134 PF01217 0.474
TRG_ENDOCYTIC_2 206 209 PF00928 0.343
TRG_ENDOCYTIC_2 212 215 PF00928 0.306
TRG_ENDOCYTIC_2 247 250 PF00928 0.343
TRG_ENDOCYTIC_2 300 303 PF00928 0.358
TRG_ENDOCYTIC_2 311 314 PF00928 0.358
TRG_ENDOCYTIC_2 56 59 PF00928 0.690
TRG_ER_diArg_1 368 370 PF00400 0.614
TRG_ER_diArg_1 47 50 PF00400 0.604

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAF6 Leptomonas seymouri 61% 100%
A0A3S5H538 Leishmania donovani 91% 100%
A0A3S5H540 Leishmania donovani 92% 100%
A0A451EJN9 Leishmania donovani 24% 100%
A4H3K6 Leishmania braziliensis 74% 100%
A4H3K7 Leishmania braziliensis 60% 100%
A4HRU7 Leishmania infantum 24% 100%
A4HRU8 Leishmania infantum 91% 100%
A4HRV0 Leishmania infantum 92% 100%
E9ACI2 Leishmania major 28% 100%
E9ACI5 Leishmania major 81% 100%
E9AJS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AJS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 99%
E9AJS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
P25613 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
V5BCC6 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS