GPR1/FUN34/yaaH family-domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPR1/FUN34/yaaH family, putative

Species:

Leishmania major

UniProt:

E9ACI3_LEIMA

TriTrypDb:

LmjF.03.0380 , LMJLV39_030008900 , LMJLV39_030009000 , LMJSD75_030009000

Length:

370

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Show entries

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	3
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

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Expansion

Sequence features

E9ACI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACI3

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006811	monoatomic ion transport	4	3
GO:0006820	monoatomic anion transport	5	3
GO:0006835	dicarboxylic acid transport	7	3
GO:0006846	acetate transport	6	3
GO:0009987	cellular process	1	3
GO:0015711	organic anion transport	5	3
GO:0015718	monocarboxylic acid transport	7	3
GO:0015740	C4-dicarboxylate transport	8	3
GO:0015744	succinate transport	6	3

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0005342	organic acid transmembrane transporter activity	3	3
GO:0008028	monocarboxylic acid transmembrane transporter activity	5	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0008509	monoatomic anion transmembrane transporter activity	4	3
GO:0008514	organic anion transmembrane transporter activity	5	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015078	proton transmembrane transporter activity	5	3
GO:0015123	acetate transmembrane transporter activity	6	3
GO:0015291	secondary active transmembrane transporter activity	4	3

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.570
CLV_C14_Caspase3-7	90	94	PF00656	0.627
CLV_NRD_NRD_1	143	145	PF00675	0.323
CLV_NRD_NRD_1	50	52	PF00675	0.453
CLV_NRD_NRD_1	80	82	PF00675	0.514
CLV_PCSK_FUR_1	48	52	PF00082	0.407
CLV_PCSK_KEX2_1	352	354	PF00082	0.349
CLV_PCSK_KEX2_1	50	52	PF00082	0.453
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.334
CLV_PCSK_SKI1_1	324	328	PF00082	0.338

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF6	Leptomonas seymouri	61%	100%
A0A3S5H538	Leishmania donovani	91%	100%
A0A3S5H540	Leishmania donovani	92%	100%
A0A451EJN9	Leishmania donovani	24%	100%
A4H3K6	Leishmania braziliensis	74%	100%
A4H3K7	Leishmania braziliensis	60%	100%
A4HRU7	Leishmania infantum	24%	100%
A4HRU8	Leishmania infantum	91%	100%
A4HRV0	Leishmania infantum	92%	100%
E9ACI2	Leishmania major	28%	100%

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