GPR1/FUN34/yaaH family-domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPR1/FUN34/yaaH family, putative

Species:

Leishmania major

UniProt:

E9ACI3_LEIMA

TriTrypDb:

LmjF.03.0380 , LMJLV39_030008900 , LMJLV39_030009000 , LMJSD75_030009000

Length:

370

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	3
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9ACI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACI3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006811	monoatomic ion transport	4	3
GO:0006820	monoatomic anion transport	5	3
GO:0006835	dicarboxylic acid transport	7	3
GO:0006846	acetate transport	6	3
GO:0009987	cellular process	1	3
GO:0015711	organic anion transport	5	3
GO:0015718	monocarboxylic acid transport	7	3
GO:0015740	C4-dicarboxylate transport	8	3
GO:0015744	succinate transport	6	3
GO:0015849	organic acid transport	5	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0035433	acetate transmembrane transport	5	3
GO:0046942	carboxylic acid transport	6	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0055085	transmembrane transport	2	3
GO:0071422	succinate transmembrane transport	5	3
GO:0071702	organic substance transport	4	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:1903825	organic acid transmembrane transport	3	3
GO:1905039	carboxylic acid transmembrane transport	4	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0005342	organic acid transmembrane transporter activity	3	3
GO:0008028	monocarboxylic acid transmembrane transporter activity	5	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0008509	monoatomic anion transmembrane transporter activity	4	3
GO:0008514	organic anion transmembrane transporter activity	5	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015078	proton transmembrane transporter activity	5	3
GO:0015123	acetate transmembrane transporter activity	6	3
GO:0015291	secondary active transmembrane transporter activity	4	3
GO:0015293	symporter activity	5	3
GO:0015294	solute:monoatomic cation symporter activity	5	3
GO:0015295	solute:proton symporter activity	6	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	5	3
GO:0015360	acetate:proton symporter activity	7	3
GO:0022804	active transmembrane transporter activity	3	3
GO:0022853	active monoatomic ion transmembrane transporter activity	4	3
GO:0022857	transmembrane transporter activity	2	3
GO:0022890	inorganic cation transmembrane transporter activity	4	3
GO:0043893	acetate:monoatomic cation symporter activity	6	3
GO:0046943	carboxylic acid transmembrane transporter activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.570
CLV_C14_Caspase3-7	90	94	PF00656	0.627
CLV_NRD_NRD_1	143	145	PF00675	0.323
CLV_NRD_NRD_1	50	52	PF00675	0.453
CLV_NRD_NRD_1	80	82	PF00675	0.514
CLV_PCSK_FUR_1	48	52	PF00082	0.407
CLV_PCSK_KEX2_1	352	354	PF00082	0.349
CLV_PCSK_KEX2_1	50	52	PF00082	0.453
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.334
CLV_PCSK_SKI1_1	324	328	PF00082	0.338
DEG_APCC_DBOX_1	323	331	PF00400	0.538
DEG_Kelch_Keap1_1	119	124	PF01344	0.523
DOC_CYCLIN_yClb5_NLxxxL_5	264	271	PF00134	0.495
DOC_MAPK_DCC_7	144	154	PF00069	0.492
DOC_MAPK_DCC_7	324	332	PF00069	0.588
DOC_MAPK_MEF2A_6	264	273	PF00069	0.500
DOC_MAPK_MEF2A_6	324	332	PF00069	0.538
DOC_PP2B_LxvP_1	235	238	PF13499	0.217
DOC_USP7_MATH_1	136	140	PF00917	0.424
DOC_USP7_MATH_1	208	212	PF00917	0.402
DOC_USP7_MATH_1	230	234	PF00917	0.342
DOC_USP7_MATH_1	49	53	PF00917	0.610
DOC_WW_Pin1_4	8	13	PF00397	0.612
LIG_14-3-3_CanoR_1	200	205	PF00244	0.538
LIG_14-3-3_CanoR_1	51	57	PF00244	0.613
LIG_BIR_II_1	1	5	PF00653	0.719
LIG_BRCT_BRCA1_1	239	243	PF00533	0.306
LIG_BRCT_BRCA1_1	71	75	PF00533	0.665
LIG_deltaCOP1_diTrp_1	197	204	PF00928	0.538
LIG_FHA_1	1	7	PF00498	0.653
LIG_FHA_1	159	165	PF00498	0.326
LIG_FHA_1	174	180	PF00498	0.336
LIG_FHA_1	212	218	PF00498	0.288
LIG_FHA_1	230	236	PF00498	0.290
LIG_FHA_1	273	279	PF00498	0.404
LIG_FHA_1	331	337	PF00498	0.616
LIG_FHA_1	34	40	PF00498	0.612
LIG_FHA_2	346	352	PF00498	0.558
LIG_LIR_Gen_1	203	212	PF02991	0.358
LIG_LIR_Gen_1	214	224	PF02991	0.330
LIG_LIR_Gen_1	255	263	PF02991	0.385
LIG_LIR_Gen_1	277	288	PF02991	0.393
LIG_LIR_Gen_1	55	62	PF02991	0.625
LIG_LIR_Nem_3	203	209	PF02991	0.341
LIG_LIR_Nem_3	210	215	PF02991	0.352
LIG_LIR_Nem_3	240	246	PF02991	0.306
LIG_LIR_Nem_3	255	259	PF02991	0.329
LIG_LIR_Nem_3	277	283	PF02991	0.347
LIG_LIR_Nem_3	55	59	PF02991	0.624
LIG_MLH1_MIPbox_1	239	243	PF16413	0.338
LIG_NRP_CendR_1	369	370	PF00754	0.407
LIG_PALB2_WD40_1	334	342	PF16756	0.476
LIG_SH2_CRK	56	60	PF00017	0.689
LIG_SH2_SRC	91	94	PF00017	0.622
LIG_SH2_STAP1	56	60	PF00017	0.668
LIG_SH2_STAT5	206	209	PF00017	0.412
LIG_SH2_STAT5	242	245	PF00017	0.375
LIG_SH2_STAT5	247	250	PF00017	0.381
LIG_SH2_STAT5	311	314	PF00017	0.341
LIG_SH2_STAT5	58	61	PF00017	0.687
LIG_SH2_STAT5	91	94	PF00017	0.670
LIG_SH3_3	17	23	PF00018	0.639
LIG_SH3_3	325	331	PF00018	0.510
LIG_SH3_3	9	15	PF00018	0.631
LIG_SUMO_SIM_anti_2	255	262	PF11976	0.351
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.412
LIG_WRC_WIRS_1	212	217	PF05994	0.242
LIG_WRC_WIRS_1	253	258	PF05994	0.412
MOD_CK1_1	139	145	PF00069	0.385
MOD_CK1_1	211	217	PF00069	0.337
MOD_CK1_1	361	367	PF00069	0.708
MOD_CK1_1	52	58	PF00069	0.775
MOD_CK2_1	21	27	PF00069	0.697
MOD_GlcNHglycan	121	124	PF01048	0.358
MOD_GlcNHglycan	138	141	PF01048	0.221
MOD_GlcNHglycan	290	293	PF01048	0.531
MOD_GlcNHglycan	7	11	PF01048	0.476
MOD_GSK3_1	115	122	PF00069	0.715
MOD_GSK3_1	136	143	PF00069	0.385
MOD_GSK3_1	207	214	PF00069	0.292
MOD_GSK3_1	225	232	PF00069	0.275
MOD_GSK3_1	284	291	PF00069	0.476
MOD_GSK3_1	354	361	PF00069	0.583
MOD_GSK3_1	60	67	PF00069	0.718
MOD_GSK3_1	81	88	PF00069	0.797
MOD_N-GLC_1	353	358	PF02516	0.387
MOD_N-GLC_1	69	74	PF02516	0.415
MOD_NEK2_1	157	162	PF00069	0.315
MOD_NEK2_1	166	171	PF00069	0.323
MOD_NEK2_1	215	220	PF00069	0.341
MOD_NEK2_1	259	264	PF00069	0.341
MOD_NEK2_1	274	279	PF00069	0.288
MOD_NEK2_1	283	288	PF00069	0.321
MOD_NEK2_1	68	73	PF00069	0.598
MOD_NEK2_2	338	343	PF00069	0.486
MOD_PIKK_1	330	336	PF00454	0.538
MOD_PIKK_1	345	351	PF00454	0.636
MOD_PIKK_1	358	364	PF00454	0.539
MOD_PKA_1	81	87	PF00069	0.708
MOD_PKA_2	354	360	PF00069	0.568
MOD_PKA_2	49	55	PF00069	0.723
MOD_PKA_2	97	103	PF00069	0.677
MOD_Plk_1	322	328	PF00069	0.536
MOD_Plk_4	158	164	PF00069	0.323
MOD_Plk_4	173	179	PF00069	0.275
MOD_Plk_4	211	217	PF00069	0.364
MOD_Plk_4	274	280	PF00069	0.412
MOD_ProDKin_1	8	14	PF00069	0.612
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.474
TRG_ENDOCYTIC_2	206	209	PF00928	0.343
TRG_ENDOCYTIC_2	212	215	PF00928	0.306
TRG_ENDOCYTIC_2	247	250	PF00928	0.343
TRG_ENDOCYTIC_2	300	303	PF00928	0.358
TRG_ENDOCYTIC_2	311	314	PF00928	0.358
TRG_ENDOCYTIC_2	56	59	PF00928	0.690
TRG_ER_diArg_1	368	370	PF00400	0.614
TRG_ER_diArg_1	47	50	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF6	Leptomonas seymouri	61%	100%
A0A3S5H538	Leishmania donovani	91%	100%
A0A3S5H540	Leishmania donovani	92%	100%
A0A451EJN9	Leishmania donovani	24%	100%
A4H3K6	Leishmania braziliensis	74%	100%
A4H3K7	Leishmania braziliensis	60%	100%
A4HRU7	Leishmania infantum	24%	100%
A4HRU8	Leishmania infantum	91%	100%
A4HRV0	Leishmania infantum	92%	100%
E9ACI2	Leishmania major	28%	100%
E9ACI5	Leishmania major	81%	100%
E9AJS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AJS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
E9AJS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
P25613	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
V5BCC6	Trypanosoma cruzi	35%	100%