LeishMANIAdb
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DDRGK_domain_containing_protein_-_putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DDRGK_domain_containing_protein_-_putative
Gene product:
DDRGK domain containing protein, putative
Species:
Leishmania major
UniProt:
E9ACH9_LEIMA
TriTrypDb:
LmjF.03.0340 * , LMJLV39_030008500 * , LMJSD75_030008600
Length:
377

Annotations

LeishMANIAdb annotations

Similar to distant Eukaryotic DDRGK proteins. Likely bound to the ER.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9ACH9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACH9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 204 208 PF00656 0.677
CLV_C14_Caspase3-7 98 102 PF00656 0.710
CLV_MEL_PAP_1 357 363 PF00089 0.288
CLV_NRD_NRD_1 119 121 PF00675 0.519
CLV_NRD_NRD_1 129 131 PF00675 0.461
CLV_NRD_NRD_1 139 141 PF00675 0.440
CLV_NRD_NRD_1 172 174 PF00675 0.403
CLV_NRD_NRD_1 185 187 PF00675 0.341
CLV_NRD_NRD_1 229 231 PF00675 0.449
CLV_NRD_NRD_1 282 284 PF00675 0.400
CLV_PCSK_FUR_1 117 121 PF00082 0.567
CLV_PCSK_FUR_1 127 131 PF00082 0.520
CLV_PCSK_FUR_1 280 284 PF00082 0.304
CLV_PCSK_KEX2_1 117 119 PF00082 0.527
CLV_PCSK_KEX2_1 127 129 PF00082 0.461
CLV_PCSK_KEX2_1 139 141 PF00082 0.496
CLV_PCSK_KEX2_1 185 187 PF00082 0.393
CLV_PCSK_KEX2_1 229 231 PF00082 0.362
CLV_PCSK_KEX2_1 282 284 PF00082 0.400
CLV_PCSK_SKI1_1 175 179 PF00082 0.461
CLV_PCSK_SKI1_1 308 312 PF00082 0.264
CLV_PCSK_SKI1_1 339 343 PF00082 0.275
CLV_PCSK_SKI1_1 72 76 PF00082 0.444
DEG_SPOP_SBC_1 28 32 PF00917 0.399
DOC_MAPK_gen_1 356 363 PF00069 0.536
DOC_MAPK_MEF2A_6 18 25 PF00069 0.398
DOC_PP1_RVXF_1 11 17 PF00149 0.371
DOC_PP2B_LxvP_1 23 26 PF13499 0.401
DOC_PP4_FxxP_1 16 19 PF00568 0.400
DOC_PP4_FxxP_1 342 345 PF00568 0.536
DOC_USP7_MATH_1 281 285 PF00917 0.655
DOC_USP7_MATH_1 64 68 PF00917 0.693
DOC_USP7_MATH_1 86 90 PF00917 0.784
DOC_USP7_UBL2_3 174 178 PF12436 0.593
DOC_WW_Pin1_4 288 293 PF00397 0.668
DOC_WW_Pin1_4 29 34 PF00397 0.398
DOC_WW_Pin1_4 6 11 PF00397 0.363
LIG_14-3-3_CanoR_1 265 270 PF00244 0.638
LIG_14-3-3_CanoR_1 358 364 PF00244 0.453
LIG_Actin_WH2_2 295 313 PF00022 0.527
LIG_Actin_WH2_2 41 59 PF00022 0.406
LIG_BIR_III_4 154 158 PF00653 0.660
LIG_BIR_III_4 162 166 PF00653 0.657
LIG_LIR_Nem_3 346 351 PF02991 0.453
LIG_PCNA_PIPBox_1 263 272 PF02747 0.586
LIG_PCNA_yPIPBox_3 260 270 PF02747 0.595
LIG_SH2_PTP2 340 343 PF00017 0.536
LIG_SH2_STAP1 240 244 PF00017 0.574
LIG_SH2_STAT5 340 343 PF00017 0.516
LIG_SUMO_SIM_par_1 299 305 PF11976 0.482
LIG_TRAF2_1 219 222 PF00917 0.625
LIG_TRAF2_1 292 295 PF00917 0.716
LIG_TRAF2_1 313 316 PF00917 0.536
LIG_TRAF2_1 362 365 PF00917 0.536
LIG_WRC_WIRS_1 266 271 PF05994 0.557
MOD_CDK_SPxxK_3 6 13 PF00069 0.461
MOD_CK1_1 290 296 PF00069 0.612
MOD_CK1_1 37 43 PF00069 0.460
MOD_CK2_1 288 294 PF00069 0.688
MOD_CK2_1 310 316 PF00069 0.418
MOD_CK2_1 359 365 PF00069 0.319
MOD_Cter_Amidation 115 118 PF01082 0.765
MOD_DYRK1A_RPxSP_1 6 10 PF00069 0.456
MOD_GlcNHglycan 283 286 PF01048 0.602
MOD_GlcNHglycan 36 39 PF01048 0.634
MOD_GlcNHglycan 66 69 PF01048 0.716
MOD_GlcNHglycan 86 89 PF01048 0.717
MOD_GSK3_1 261 268 PF00069 0.475
MOD_GSK3_1 80 87 PF00069 0.735
MOD_N-GLC_1 84 89 PF02516 0.742
MOD_N-GLC_1 99 104 PF02516 0.703
MOD_NEK2_1 80 85 PF00069 0.682
MOD_PIKK_1 322 328 PF00454 0.460
MOD_PIKK_1 57 63 PF00454 0.547
MOD_PIKK_1 80 86 PF00454 0.688
MOD_PKA_2 261 267 PF00069 0.528
MOD_PKA_2 281 287 PF00069 0.312
MOD_PKA_2 359 365 PF00069 0.305
MOD_PKA_2 80 86 PF00069 0.705
MOD_Plk_1 146 152 PF00069 0.683
MOD_Plk_2-3 146 152 PF00069 0.683
MOD_Plk_4 265 271 PF00069 0.530
MOD_Plk_4 37 43 PF00069 0.457
MOD_ProDKin_1 288 294 PF00069 0.604
MOD_ProDKin_1 29 35 PF00069 0.500
MOD_ProDKin_1 6 12 PF00069 0.458
MOD_SUMO_rev_2 214 220 PF00179 0.496
TRG_DiLeu_BaEn_4 250 256 PF01217 0.660
TRG_DiLeu_LyEn_5 346 351 PF01217 0.460
TRG_ENDOCYTIC_2 340 343 PF00928 0.349
TRG_ER_diArg_1 117 120 PF00400 0.675
TRG_ER_diArg_1 126 129 PF00400 0.599
TRG_ER_diArg_1 197 200 PF00400 0.478
TRG_ER_diArg_1 228 230 PF00400 0.606
TRG_ER_diArg_1 280 283 PF00400 0.527
TRG_ER_diArg_1 355 358 PF00400 0.418
TRG_ER_diArg_1 79 82 PF00400 0.712
TRG_NLS_MonoExtN_4 170 177 PF00514 0.603
TRG_Pf-PMV_PEXEL_1 57 61 PF00026 0.536

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1I6 Leptomonas seymouri 54% 100%
A0A3R7MKY1 Trypanosoma rangeli 44% 100%
A0A3S5H536 Leishmania donovani 92% 100%
A4H3K4 Leishmania braziliensis 78% 100%
A4HRU4 Leishmania infantum 92% 100%
B4PQC4 Drosophila yakuba 26% 100%
D0A242 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AJR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5C2C3 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS