Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACH8_LEIMA

TriTrypDb:

LmjF.03.0330 , LMJLV39_030008400 , LMJSD75_030008500

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.683
CLV_MEL_PAP_1	486	492	PF00089	0.456
CLV_NRD_NRD_1	10	12	PF00675	0.665
CLV_NRD_NRD_1	135	137	PF00675	0.531
CLV_NRD_NRD_1	220	222	PF00675	0.708
CLV_NRD_NRD_1	247	249	PF00675	0.755
CLV_NRD_NRD_1	424	426	PF00675	0.484
CLV_NRD_NRD_1	465	467	PF00675	0.505
CLV_NRD_NRD_1	599	601	PF00675	0.676
CLV_NRD_NRD_1	6	8	PF00675	0.702
CLV_PCSK_FUR_1	245	249	PF00082	0.569
CLV_PCSK_FUR_1	4	8	PF00082	0.586
CLV_PCSK_KEX2_1	10	12	PF00082	0.690
CLV_PCSK_KEX2_1	135	137	PF00082	0.563
CLV_PCSK_KEX2_1	247	249	PF00082	0.762
CLV_PCSK_KEX2_1	3	5	PF00082	0.747
CLV_PCSK_KEX2_1	424	426	PF00082	0.483
CLV_PCSK_KEX2_1	465	467	PF00082	0.577
CLV_PCSK_KEX2_1	6	8	PF00082	0.727
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.645
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.766
CLV_PCSK_PC7_1	6	12	PF00082	0.589
CLV_PCSK_SKI1_1	136	140	PF00082	0.583
CLV_PCSK_SKI1_1	168	172	PF00082	0.455
CLV_PCSK_SKI1_1	229	233	PF00082	0.623
CLV_PCSK_SKI1_1	248	252	PF00082	0.609
CLV_PCSK_SKI1_1	354	358	PF00082	0.780
CLV_PCSK_SKI1_1	449	453	PF00082	0.400
DEG_APCC_DBOX_1	267	275	PF00400	0.605
DEG_APCC_DBOX_1	327	335	PF00400	0.641
DEG_APCC_DBOX_1	448	456	PF00400	0.485
DEG_SPOP_SBC_1	108	112	PF00917	0.645
DEG_SPOP_SBC_1	237	241	PF00917	0.683
DOC_CYCLIN_RxL_1	287	297	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.521
DOC_MAPK_DCC_7	401	411	PF00069	0.476
DOC_MAPK_DCC_7	545	554	PF00069	0.458
DOC_MAPK_gen_1	165	174	PF00069	0.468
DOC_MAPK_gen_1	614	623	PF00069	0.474
DOC_MAPK_MEF2A_6	168	176	PF00069	0.450
DOC_MAPK_MEF2A_6	545	554	PF00069	0.456
DOC_PP2B_LxvP_1	526	529	PF13499	0.481
DOC_PP4_FxxP_1	521	524	PF00568	0.541
DOC_PP4_FxxP_1	595	598	PF00568	0.638
DOC_USP7_MATH_1	108	112	PF00917	0.647
DOC_USP7_MATH_1	204	208	PF00917	0.835
DOC_USP7_MATH_1	238	242	PF00917	0.683
DOC_USP7_MATH_1	280	284	PF00917	0.506
DOC_USP7_MATH_1	338	342	PF00917	0.755
DOC_USP7_MATH_1	395	399	PF00917	0.751
DOC_USP7_MATH_1	426	430	PF00917	0.676
DOC_USP7_MATH_1	488	492	PF00917	0.457
DOC_USP7_MATH_1	550	554	PF00917	0.552
DOC_USP7_MATH_2	325	331	PF00917	0.415
DOC_WW_Pin1_4	197	202	PF00397	0.562
DOC_WW_Pin1_4	321	326	PF00397	0.609
DOC_WW_Pin1_4	346	351	PF00397	0.715
DOC_WW_Pin1_4	433	438	PF00397	0.560
DOC_WW_Pin1_4	540	545	PF00397	0.526
DOC_WW_Pin1_4	98	103	PF00397	0.752
LIG_14-3-3_CanoR_1	208	212	PF00244	0.793
LIG_14-3-3_CanoR_1	248	253	PF00244	0.667
LIG_14-3-3_CanoR_1	328	332	PF00244	0.603
LIG_14-3-3_CanoR_1	365	371	PF00244	0.756
LIG_14-3-3_CanoR_1	416	426	PF00244	0.492
LIG_14-3-3_CanoR_1	489	496	PF00244	0.462
LIG_14-3-3_CanoR_1	545	549	PF00244	0.531
LIG_14-3-3_CanoR_1	569	577	PF00244	0.575
LIG_AP2alpha_2	580	582	PF02296	0.697
LIG_APCC_ABBA_1	292	297	PF00400	0.598
LIG_APCC_ABBA_1	88	93	PF00400	0.539
LIG_BIR_III_2	391	395	PF00653	0.674
LIG_BRCT_BRCA1_1	109	113	PF00533	0.607
LIG_deltaCOP1_diTrp_1	182	192	PF00928	0.614
LIG_deltaCOP1_diTrp_1	609	618	PF00928	0.668
LIG_EH_1	522	526	PF12763	0.358
LIG_FHA_1	122	128	PF00498	0.554
LIG_FHA_1	238	244	PF00498	0.688
LIG_FHA_1	511	517	PF00498	0.494
LIG_FHA_1	532	538	PF00498	0.435
LIG_FHA_1	59	65	PF00498	0.474
LIG_FHA_2	112	118	PF00498	0.496
LIG_FHA_2	201	207	PF00498	0.791
LIG_FHA_2	267	273	PF00498	0.604
LIG_FHA_2	321	327	PF00498	0.576
LIG_FHA_2	386	392	PF00498	0.763
LIG_LIR_Apic_2	519	524	PF02991	0.510
LIG_LIR_Gen_1	443	453	PF02991	0.442
LIG_LIR_Nem_3	443	448	PF02991	0.420
LIG_LIR_Nem_3	615	621	PF02991	0.555
LIG_NRBOX	227	233	PF00104	0.631
LIG_NRBOX	447	453	PF00104	0.439
LIG_Pex14_2	181	185	PF04695	0.607
LIG_Pex14_2	521	525	PF04695	0.359
LIG_SH2_SRC	332	335	PF00017	0.636
LIG_SH2_STAT3	84	87	PF00017	0.465
LIG_SH2_STAT5	417	420	PF00017	0.467
LIG_SH2_STAT5	548	551	PF00017	0.475
LIG_SH3_3	180	186	PF00018	0.525
LIG_SH3_3	247	253	PF00018	0.778
LIG_SH3_3	400	406	PF00018	0.573
LIG_SH3_3	455	461	PF00018	0.573
LIG_SH3_3	99	105	PF00018	0.707
LIG_SUMO_SIM_par_1	290	297	PF11976	0.440
LIG_SUMO_SIM_par_1	407	413	PF11976	0.526
LIG_TRAF2_1	324	327	PF00917	0.645
MOD_CDK_SPK_2	540	545	PF00069	0.519
MOD_CDK_SPxxK_3	321	328	PF00069	0.572
MOD_CK1_1	107	113	PF00069	0.610
MOD_CK1_1	116	122	PF00069	0.405
MOD_CK1_1	207	213	PF00069	0.711
MOD_CK1_1	255	261	PF00069	0.777
MOD_CK1_1	491	497	PF00069	0.468
MOD_CK1_1	540	546	PF00069	0.574
MOD_CK1_1	98	104	PF00069	0.644
MOD_CK2_1	111	117	PF00069	0.579
MOD_CK2_1	18	24	PF00069	0.724
MOD_CK2_1	196	202	PF00069	0.767
MOD_CK2_1	320	326	PF00069	0.543
MOD_CK2_1	338	344	PF00069	0.660
MOD_CK2_1	619	625	PF00069	0.701
MOD_GlcNHglycan	106	109	PF01048	0.551
MOD_GlcNHglycan	240	243	PF01048	0.684
MOD_GlcNHglycan	255	258	PF01048	0.652
MOD_GlcNHglycan	309	312	PF01048	0.607
MOD_GlcNHglycan	351	354	PF01048	0.711
MOD_GlcNHglycan	382	385	PF01048	0.735
MOD_GlcNHglycan	412	415	PF01048	0.514
MOD_GSK3_1	104	111	PF00069	0.680
MOD_GSK3_1	196	203	PF00069	0.711
MOD_GSK3_1	248	255	PF00069	0.759
MOD_GSK3_1	266	273	PF00069	0.571
MOD_GSK3_1	366	373	PF00069	0.781
MOD_GSK3_1	527	534	PF00069	0.451
MOD_GSK3_1	540	547	PF00069	0.516
MOD_GSK3_1	619	626	PF00069	0.689
MOD_GSK3_1	94	101	PF00069	0.678
MOD_LATS_1	246	252	PF00433	0.587
MOD_NEK2_1	106	111	PF00069	0.649
MOD_NEK2_1	307	312	PF00069	0.541
MOD_NEK2_1	432	437	PF00069	0.634
MOD_NEK2_1	474	479	PF00069	0.530
MOD_NEK2_1	517	522	PF00069	0.611
MOD_NEK2_1	582	587	PF00069	0.621
MOD_NEK2_1	623	628	PF00069	0.492
MOD_NEK2_1	83	88	PF00069	0.466
MOD_NEK2_2	224	229	PF00069	0.575
MOD_PIKK_1	266	272	PF00454	0.689
MOD_PIKK_1	280	286	PF00454	0.543
MOD_PIKK_1	417	423	PF00454	0.538
MOD_PIKK_1	42	48	PF00454	0.686
MOD_PIKK_1	488	494	PF00454	0.498
MOD_PIKK_1	83	89	PF00454	0.455
MOD_PKA_1	10	16	PF00069	0.630
MOD_PKA_1	248	254	PF00069	0.662
MOD_PKA_2	10	16	PF00069	0.745
MOD_PKA_2	164	170	PF00069	0.521
MOD_PKA_2	207	213	PF00069	0.748
MOD_PKA_2	215	221	PF00069	0.701
MOD_PKA_2	327	333	PF00069	0.603
MOD_PKA_2	488	494	PF00069	0.462
MOD_PKA_2	544	550	PF00069	0.549
MOD_PKA_2	568	574	PF00069	0.564
MOD_Plk_1	116	122	PF00069	0.510
MOD_Plk_1	224	230	PF00069	0.603
MOD_Plk_1	550	556	PF00069	0.545
MOD_Plk_1	608	614	PF00069	0.679
MOD_Plk_1	72	78	PF00069	0.593
MOD_Plk_4	227	233	PF00069	0.631
MOD_Plk_4	327	333	PF00069	0.484
MOD_Plk_4	338	344	PF00069	0.631
MOD_Plk_4	366	372	PF00069	0.678
MOD_Plk_4	395	401	PF00069	0.704
MOD_Plk_4	560	566	PF00069	0.471
MOD_Plk_4	608	614	PF00069	0.733
MOD_ProDKin_1	197	203	PF00069	0.564
MOD_ProDKin_1	321	327	PF00069	0.608
MOD_ProDKin_1	346	352	PF00069	0.715
MOD_ProDKin_1	433	439	PF00069	0.546
MOD_ProDKin_1	540	546	PF00069	0.520
MOD_ProDKin_1	98	104	PF00069	0.752
MOD_SUMO_rev_2	164	172	PF00179	0.461
TRG_DiLeu_BaEn_4	326	332	PF01217	0.650
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.509
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.497
TRG_DiLeu_BaLyEn_6	436	441	PF01217	0.638
TRG_ER_diArg_1	134	136	PF00400	0.484
TRG_ER_diArg_1	4	7	PF00400	0.743
TRG_ER_diArg_1	424	426	PF00400	0.579
TRG_ER_diArg_1	464	466	PF00400	0.509
TRG_ER_diArg_1	573	576	PF00400	0.603
TRG_ER_diArg_1	591	594	PF00400	0.559
TRG_ER_diArg_1	9	11	PF00400	0.709
TRG_NES_CRM1_1	161	173	PF08389	0.565
TRG_NLS_MonoCore_2	2	7	PF00514	0.762
TRG_NLS_MonoExtC_3	2	7	PF00514	0.765
TRG_NLS_MonoExtN_4	245	251	PF00514	0.682
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.747

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I3	Leptomonas seymouri	55%	88%
A0A1X0P8P7	Trypanosomatidae	43%	100%
A0A3S5H535	Leishmania donovani	92%	100%
A4H3K3	Leishmania braziliensis	75%	93%
A4HRU3	Leishmania infantum	93%	100%
D0A241	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AJR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%