Flagellar associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACH7_LEIMA

TriTrypDb:

LmjF.03.0320 , LMJLV39_030008300 , LMJSD75_030008400

Length:

1032

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ACH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.545
CLV_C14_Caspase3-7	750	754	PF00656	0.420
CLV_C14_Caspase3-7	893	897	PF00656	0.553
CLV_NRD_NRD_1	265	267	PF00675	0.500
CLV_NRD_NRD_1	412	414	PF00675	0.684
CLV_NRD_NRD_1	443	445	PF00675	0.616
CLV_NRD_NRD_1	459	461	PF00675	0.398
CLV_NRD_NRD_1	494	496	PF00675	0.463
CLV_NRD_NRD_1	766	768	PF00675	0.527
CLV_NRD_NRD_1	814	816	PF00675	0.411
CLV_NRD_NRD_1	914	916	PF00675	0.702
CLV_NRD_NRD_1	991	993	PF00675	0.677
CLV_PCSK_FUR_1	492	496	PF00082	0.562
CLV_PCSK_KEX2_1	265	267	PF00082	0.542
CLV_PCSK_KEX2_1	345	347	PF00082	0.574
CLV_PCSK_KEX2_1	371	373	PF00082	0.546
CLV_PCSK_KEX2_1	443	445	PF00082	0.566
CLV_PCSK_KEX2_1	494	496	PF00082	0.585
CLV_PCSK_KEX2_1	914	916	PF00082	0.702
CLV_PCSK_KEX2_1	990	992	PF00082	0.676
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.574
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.585
CLV_PCSK_PC7_1	987	993	PF00082	0.598
CLV_PCSK_SKI1_1	145	149	PF00082	0.510
CLV_PCSK_SKI1_1	177	181	PF00082	0.532
CLV_PCSK_SKI1_1	246	250	PF00082	0.623
CLV_PCSK_SKI1_1	283	287	PF00082	0.525
CLV_PCSK_SKI1_1	371	375	PF00082	0.599
CLV_PCSK_SKI1_1	400	404	PF00082	0.684
CLV_PCSK_SKI1_1	510	514	PF00082	0.430
CLV_PCSK_SKI1_1	56	60	PF00082	0.344
CLV_PCSK_SKI1_1	632	636	PF00082	0.389
CLV_PCSK_SKI1_1	675	679	PF00082	0.400
CLV_PCSK_SKI1_1	684	688	PF00082	0.372
CLV_PCSK_SKI1_1	695	699	PF00082	0.262
CLV_PCSK_SKI1_1	76	80	PF00082	0.419
CLV_Separin_Metazoa	450	454	PF03568	0.581
CLV_Separin_Metazoa	53	57	PF03568	0.462
DEG_APCC_DBOX_1	144	152	PF00400	0.507
DEG_APCC_DBOX_1	694	702	PF00400	0.377
DEG_APCC_DBOX_1	789	797	PF00400	0.470
DEG_SPOP_SBC_1	13	17	PF00917	0.768
DOC_CYCLIN_RxL_1	142	150	PF00134	0.455
DOC_CYCLIN_RxL_1	672	685	PF00134	0.394
DOC_CYCLIN_RxL_1	73	83	PF00134	0.536
DOC_MAPK_gen_1	183	193	PF00069	0.576
DOC_MAPK_gen_1	345	353	PF00069	0.603
DOC_MAPK_gen_1	441	451	PF00069	0.651
DOC_MAPK_gen_1	691	698	PF00069	0.352
DOC_PP1_RVXF_1	586	592	PF00149	0.526
DOC_SPAK_OSR1_1	308	312	PF12202	0.543
DOC_USP7_MATH_1	14	18	PF00917	0.687
DOC_USP7_MATH_1	425	429	PF00917	0.643
DOC_USP7_MATH_1	439	443	PF00917	0.526
DOC_USP7_MATH_1	605	609	PF00917	0.484
DOC_USP7_MATH_1	904	908	PF00917	0.773
DOC_USP7_MATH_1	948	952	PF00917	0.675
DOC_USP7_MATH_1	963	967	PF00917	0.698
DOC_USP7_MATH_1	973	977	PF00917	0.549
DOC_USP7_UBL2_3	282	286	PF12436	0.524
DOC_USP7_UBL2_3	345	349	PF12436	0.536
DOC_USP7_UBL2_3	764	768	PF12436	0.519
DOC_WW_Pin1_4	17	22	PF00397	0.684
DOC_WW_Pin1_4	37	42	PF00397	0.534
DOC_WW_Pin1_4	919	924	PF00397	0.710
LIG_14-3-3_CanoR_1	152	162	PF00244	0.551
LIG_14-3-3_CanoR_1	372	379	PF00244	0.567
LIG_14-3-3_CanoR_1	382	387	PF00244	0.538
LIG_14-3-3_CanoR_1	413	419	PF00244	0.608
LIG_14-3-3_CanoR_1	492	501	PF00244	0.564
LIG_14-3-3_CanoR_1	526	533	PF00244	0.409
LIG_14-3-3_CanoR_1	56	64	PF00244	0.567
LIG_14-3-3_CanoR_1	914	923	PF00244	0.593
LIG_14-3-3_CanoR_1	936	941	PF00244	0.632
LIG_Actin_WH2_2	599	616	PF00022	0.510
LIG_BIR_II_1	1	5	PF00653	0.710
LIG_CaM_IQ_9	292	308	PF13499	0.551
LIG_FHA_1	163	169	PF00498	0.648
LIG_FHA_1	257	263	PF00498	0.509
LIG_FHA_1	325	331	PF00498	0.514
LIG_FHA_1	557	563	PF00498	0.535
LIG_FHA_1	641	647	PF00498	0.350
LIG_FHA_1	707	713	PF00498	0.440
LIG_FHA_1	774	780	PF00498	0.442
LIG_FHA_1	821	827	PF00498	0.547
LIG_FHA_2	134	140	PF00498	0.584
LIG_FHA_2	154	160	PF00498	0.546
LIG_FHA_2	198	204	PF00498	0.540
LIG_FHA_2	235	241	PF00498	0.470
LIG_FHA_2	289	295	PF00498	0.627
LIG_FHA_2	452	458	PF00498	0.622
LIG_FHA_2	534	540	PF00498	0.479
LIG_FHA_2	914	920	PF00498	0.610
LIG_GBD_Chelix_1	995	1003	PF00786	0.521
LIG_Integrin_isoDGR_2	988	990	PF01839	0.610
LIG_LIR_Gen_1	48	58	PF02991	0.411
LIG_LIR_Gen_1	70	79	PF02991	0.396
LIG_LIR_Gen_1	783	794	PF02991	0.445
LIG_LIR_Nem_3	48	54	PF02991	0.410
LIG_LIR_Nem_3	70	74	PF02991	0.397
LIG_LIR_Nem_3	783	789	PF02991	0.426
LIG_MYND_1	62	66	PF01753	0.529
LIG_NRBOX	175	181	PF00104	0.534
LIG_NRBOX	73	79	PF00104	0.540
LIG_PCNA_PIPBox_1	228	237	PF02747	0.338
LIG_PCNA_yPIPBox_3	356	369	PF02747	0.489
LIG_PCNA_yPIPBox_3	672	681	PF02747	0.524
LIG_RPA_C_Fungi	194	206	PF08784	0.412
LIG_RPA_C_Fungi	717	729	PF08784	0.536
LIG_SH2_CRK	786	790	PF00017	0.484
LIG_SH2_STAP1	620	624	PF00017	0.444
LIG_SH2_STAT3	465	468	PF00017	0.608
LIG_SH2_STAT5	175	178	PF00017	0.496
LIG_SH2_STAT5	703	706	PF00017	0.504
LIG_SH3_3	1004	1010	PF00018	0.722
LIG_SH3_3	938	944	PF00018	0.711
LIG_SUMO_SIM_anti_2	539	544	PF11976	0.383
LIG_SUMO_SIM_anti_2	649	657	PF11976	0.486
LIG_SUMO_SIM_par_1	40	45	PF11976	0.444
LIG_TRAF2_1	291	294	PF00917	0.477
LIG_TRAF2_1	394	397	PF00917	0.546
LIG_TRAF2_1	402	405	PF00917	0.665
LIG_TRAF2_1	500	503	PF00917	0.628
LIG_TRAF2_1	549	552	PF00917	0.506
LIG_TRAF2_1	801	804	PF00917	0.651
LIG_TRAF2_1	829	832	PF00917	0.507
LIG_WW_3	984	988	PF00397	0.564
MOD_CK1_1	17	23	PF00069	0.736
MOD_CK1_1	520	526	PF00069	0.502
MOD_CK1_1	556	562	PF00069	0.518
MOD_CK1_1	668	674	PF00069	0.409
MOD_CK1_1	743	749	PF00069	0.523
MOD_CK1_1	907	913	PF00069	0.725
MOD_CK2_1	133	139	PF00069	0.589
MOD_CK2_1	234	240	PF00069	0.540
MOD_CK2_1	288	294	PF00069	0.551
MOD_CK2_1	37	43	PF00069	0.620
MOD_CK2_1	426	432	PF00069	0.685
MOD_CK2_1	451	457	PF00069	0.592
MOD_CK2_1	533	539	PF00069	0.393
MOD_CK2_1	546	552	PF00069	0.377
MOD_CK2_1	598	604	PF00069	0.417
MOD_CK2_1	822	828	PF00069	0.546
MOD_Cter_Amidation	988	991	PF01082	0.610
MOD_GlcNHglycan	2	5	PF01048	0.658
MOD_GlcNHglycan	355	359	PF01048	0.475
MOD_GlcNHglycan	667	670	PF01048	0.514
MOD_GlcNHglycan	7	11	PF01048	0.669
MOD_GlcNHglycan	887	890	PF01048	0.678
MOD_GlcNHglycan	906	909	PF01048	0.747
MOD_GlcNHglycan	923	926	PF01048	0.721
MOD_GlcNHglycan	929	932	PF01048	0.708
MOD_GlcNHglycan	936	939	PF01048	0.609
MOD_GlcNHglycan	950	953	PF01048	0.593
MOD_GlcNHglycan	965	968	PF01048	0.718
MOD_GlcNHglycan	971	974	PF01048	0.685
MOD_GlcNHglycan	975	978	PF01048	0.633
MOD_GSK3_1	13	20	PF00069	0.674
MOD_GSK3_1	162	169	PF00069	0.574
MOD_GSK3_1	378	385	PF00069	0.562
MOD_GSK3_1	388	395	PF00069	0.460
MOD_GSK3_1	419	426	PF00069	0.656
MOD_GSK3_1	885	892	PF00069	0.702
MOD_GSK3_1	915	922	PF00069	0.726
MOD_GSK3_1	948	955	PF00069	0.740
MOD_GSK3_1	965	972	PF00069	0.574
MOD_N-GLC_1	197	202	PF02516	0.560
MOD_N-GLC_1	980	985	PF02516	0.626
MOD_NEK2_1	147	152	PF00069	0.522
MOD_NEK2_1	354	359	PF00069	0.565
MOD_NEK2_1	423	428	PF00069	0.727
MOD_NEK2_1	518	523	PF00069	0.541
MOD_NEK2_1	718	723	PF00069	0.527
MOD_NEK2_1	77	82	PF00069	0.553
MOD_NEK2_1	822	827	PF00069	0.503
MOD_NEK2_2	119	124	PF00069	0.450
MOD_PIKK_1	110	116	PF00454	0.467
MOD_PIKK_1	32	38	PF00454	0.648
MOD_PIKK_1	640	646	PF00454	0.351
MOD_PIKK_1	716	722	PF00454	0.510
MOD_PIKK_1	936	942	PF00454	0.659
MOD_PK_1	249	255	PF00069	0.489
MOD_PK_1	382	388	PF00069	0.535
MOD_PKA_1	371	377	PF00069	0.521
MOD_PKA_2	256	262	PF00069	0.472
MOD_PKA_2	371	377	PF00069	0.559
MOD_PKA_2	412	418	PF00069	0.692
MOD_PKA_2	493	499	PF00069	0.559
MOD_PKA_2	533	539	PF00069	0.529
MOD_PKA_2	665	671	PF00069	0.427
MOD_PKA_2	913	919	PF00069	0.605
MOD_PKA_2	969	975	PF00069	0.635
MOD_PKB_1	544	552	PF00069	0.456
MOD_Plk_1	249	255	PF00069	0.622
MOD_Plk_1	321	327	PF00069	0.605
MOD_Plk_1	662	668	PF00069	0.314
MOD_Plk_2-3	392	398	PF00069	0.610
MOD_Plk_4	321	327	PF00069	0.571
MOD_ProDKin_1	17	23	PF00069	0.683
MOD_ProDKin_1	37	43	PF00069	0.529
MOD_ProDKin_1	919	925	PF00069	0.711
MOD_SUMO_for_1	344	347	PF00179	0.580
MOD_SUMO_for_1	557	560	PF00179	0.525
MOD_SUMO_rev_2	275	285	PF00179	0.455
MOD_SUMO_rev_2	342	351	PF00179	0.557
MOD_SUMO_rev_2	392	399	PF00179	0.547
MOD_SUMO_rev_2	496	501	PF00179	0.534
TRG_DiLeu_BaEn_1	188	193	PF01217	0.555
TRG_DiLeu_BaEn_1	364	369	PF01217	0.575
TRG_DiLeu_BaEn_1	537	542	PF01217	0.514
TRG_DiLeu_BaEn_1	650	655	PF01217	0.354
TRG_DiLeu_BaEn_1	682	687	PF01217	0.378
TRG_DiLeu_BaEn_1	774	779	PF01217	0.429
TRG_DiLeu_BaEn_4	188	194	PF01217	0.571
TRG_DiLeu_BaEn_4	502	508	PF01217	0.426
TRG_DiLeu_BaEn_4	845	851	PF01217	0.505
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.409
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.384
TRG_ENDOCYTIC_2	232	235	PF00928	0.425
TRG_ENDOCYTIC_2	71	74	PF00928	0.529
TRG_ENDOCYTIC_2	786	789	PF00928	0.435
TRG_ER_diArg_1	264	266	PF00400	0.480
TRG_ER_diArg_1	443	445	PF00400	0.676
TRG_ER_diArg_1	491	494	PF00400	0.579
TRG_ER_diArg_1	543	546	PF00400	0.487
TRG_ER_diArg_1	588	591	PF00400	0.525
TRG_ER_diArg_1	692	695	PF00400	0.364
TRG_ER_diArg_1	699	702	PF00400	0.382
TRG_ER_diArg_1	722	725	PF00400	0.511
TRG_ER_diArg_1	990	992	PF00400	0.710
TRG_NES_CRM1_1	690	705	PF08389	0.490
TRG_NES_CRM1_1	750	762	PF08389	0.534
TRG_NLS_Bipartite_1	494	514	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	576	581	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	590	594	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	678	682	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	684	689	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V1	Leptomonas seymouri	63%	100%
A0A0S4JMK5	Bodo saltans	34%	100%
A0A0S4KGN1	Bodo saltans	25%	100%
A0A1X0P9K9	Trypanosomatidae	40%	100%
A0A381MLP4	Leishmania infantum	25%	100%
A0A3Q8IAS8	Leishmania donovani	25%	100%
A0A3R7L4Y2	Trypanosoma rangeli	37%	100%
A0A3S5H534	Leishmania donovani	93%	99%
A0A451EJK4	Leishmania donovani	25%	100%
A4H3K2	Leishmania braziliensis	79%	100%
A4HRU2	Leishmania infantum	93%	99%
A8HUA1	Chlamydomonas reinhardtii	27%	100%
B2RW38	Mus musculus	28%	100%
C9ZJ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A240	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AJR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q5T655	Homo sapiens	27%	100%
V5BCD1	Trypanosoma cruzi	40%	98%