Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACH5_LEIMA

TriTrypDb:

LmjF.03.0280 , LMJLV39_030007900 , LMJSD75_030007900

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACH5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005543	phospholipid binding	3	2
GO:0008289	lipid binding	2	2
GO:0035091	phosphatidylinositol binding	4	2
GO:1901981	phosphatidylinositol phosphate binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	529	533	PF00656	0.584
CLV_C14_Caspase3-7	808	812	PF00656	0.598
CLV_NRD_NRD_1	109	111	PF00675	0.558
CLV_NRD_NRD_1	191	193	PF00675	0.677
CLV_NRD_NRD_1	330	332	PF00675	0.657
CLV_NRD_NRD_1	522	524	PF00675	0.674
CLV_NRD_NRD_1	619	621	PF00675	0.673
CLV_NRD_NRD_1	896	898	PF00675	0.589
CLV_PCSK_KEX2_1	108	110	PF00082	0.553
CLV_PCSK_KEX2_1	191	193	PF00082	0.677
CLV_PCSK_KEX2_1	330	332	PF00082	0.659
CLV_PCSK_KEX2_1	521	523	PF00082	0.686
CLV_PCSK_KEX2_1	619	621	PF00082	0.669
CLV_PCSK_KEX2_1	895	897	PF00082	0.600
CLV_PCSK_PC7_1	891	897	PF00082	0.591
CLV_PCSK_SKI1_1	109	113	PF00082	0.594
CLV_PCSK_SKI1_1	268	272	PF00082	0.485
CLV_PCSK_SKI1_1	537	541	PF00082	0.661
CLV_PCSK_SKI1_1	793	797	PF00082	0.581
DEG_APCC_DBOX_1	107	115	PF00400	0.590
DEG_APCC_DBOX_1	246	254	PF00400	0.671
DEG_MDM2_SWIB_1	113	121	PF02201	0.579
DEG_SCF_FBW7_1	362	369	PF00400	0.560
DEG_SCF_FBW7_1	914	920	PF00400	0.577
DEG_SPOP_SBC_1	57	61	PF00917	0.707
DEG_SPOP_SBC_1	917	921	PF00917	0.616
DEG_SPOP_SBC_1	94	98	PF00917	0.602
DOC_CDC14_PxL_1	692	700	PF14671	0.663
DOC_CDC14_PxL_1	709	717	PF14671	0.510
DOC_CDC14_PxL_1	726	734	PF14671	0.385
DOC_CKS1_1	241	246	PF01111	0.570
DOC_CKS1_1	458	463	PF01111	0.506
DOC_CKS1_1	841	846	PF01111	0.672
DOC_CKS1_1	914	919	PF01111	0.566
DOC_CYCLIN_RxL_1	107	116	PF00134	0.588
DOC_MAPK_gen_1	108	114	PF00069	0.583
DOC_MAPK_gen_1	333	341	PF00069	0.549
DOC_MAPK_gen_1	737	744	PF00069	0.542
DOC_MAPK_MEF2A_6	965	972	PF00069	0.550
DOC_PP1_RVXF_1	107	114	PF00149	0.594
DOC_PP2B_LxvP_1	219	222	PF13499	0.621
DOC_PP2B_LxvP_1	387	390	PF13499	0.704
DOC_PP2B_LxvP_1	684	687	PF13499	0.568
DOC_PP2B_LxvP_1	884	887	PF13499	0.671
DOC_PP2B_LxvP_1	968	971	PF13499	0.544
DOC_PP4_FxxP_1	258	261	PF00568	0.642
DOC_PP4_FxxP_1	458	461	PF00568	0.645
DOC_PP4_FxxP_1	81	84	PF00568	0.556
DOC_USP7_MATH_1	168	172	PF00917	0.614
DOC_USP7_MATH_1	208	212	PF00917	0.541
DOC_USP7_MATH_1	230	234	PF00917	0.645
DOC_USP7_MATH_1	439	443	PF00917	0.631
DOC_USP7_MATH_1	469	473	PF00917	0.678
DOC_USP7_MATH_1	477	481	PF00917	0.599
DOC_USP7_MATH_1	503	507	PF00917	0.556
DOC_USP7_MATH_1	541	545	PF00917	0.576
DOC_USP7_MATH_1	635	639	PF00917	0.690
DOC_USP7_MATH_1	71	75	PF00917	0.665
DOC_USP7_MATH_1	731	735	PF00917	0.480
DOC_USP7_MATH_1	786	790	PF00917	0.691
DOC_USP7_MATH_1	795	799	PF00917	0.641
DOC_USP7_MATH_1	809	813	PF00917	0.593
DOC_USP7_MATH_1	826	830	PF00917	0.567
DOC_USP7_MATH_1	831	835	PF00917	0.656
DOC_USP7_MATH_1	84	88	PF00917	0.603
DOC_USP7_MATH_1	851	855	PF00917	0.505
DOC_USP7_MATH_1	917	921	PF00917	0.609
DOC_USP7_MATH_1	926	930	PF00917	0.530
DOC_USP7_UBL2_3	793	797	PF12436	0.581
DOC_WW_Pin1_4	234	239	PF00397	0.705
DOC_WW_Pin1_4	240	245	PF00397	0.631
DOC_WW_Pin1_4	28	33	PF00397	0.598
DOC_WW_Pin1_4	362	367	PF00397	0.558
DOC_WW_Pin1_4	434	439	PF00397	0.632
DOC_WW_Pin1_4	457	462	PF00397	0.551
DOC_WW_Pin1_4	510	515	PF00397	0.573
DOC_WW_Pin1_4	557	562	PF00397	0.698
DOC_WW_Pin1_4	584	589	PF00397	0.666
DOC_WW_Pin1_4	631	636	PF00397	0.682
DOC_WW_Pin1_4	663	668	PF00397	0.662
DOC_WW_Pin1_4	72	77	PF00397	0.672
DOC_WW_Pin1_4	796	801	PF00397	0.674
DOC_WW_Pin1_4	840	845	PF00397	0.694
DOC_WW_Pin1_4	866	871	PF00397	0.587
DOC_WW_Pin1_4	913	918	PF00397	0.568
DOC_WW_Pin1_4	927	932	PF00397	0.503
DOC_WW_Pin1_4	95	100	PF00397	0.621
LIG_14-3-3_CanoR_1	183	188	PF00244	0.631
LIG_14-3-3_CanoR_1	206	211	PF00244	0.575
LIG_14-3-3_CanoR_1	306	314	PF00244	0.483
LIG_14-3-3_CanoR_1	355	362	PF00244	0.574
LIG_14-3-3_CanoR_1	542	550	PF00244	0.694
LIG_14-3-3_CanoR_1	606	616	PF00244	0.603
LIG_14-3-3_CanoR_1	644	650	PF00244	0.699
LIG_14-3-3_CanoR_1	68	76	PF00244	0.651
LIG_14-3-3_CanoR_1	739	745	PF00244	0.537
LIG_14-3-3_CanoR_1	837	842	PF00244	0.698
LIG_14-3-3_CanoR_1	85	93	PF00244	0.513
LIG_14-3-3_CanoR_1	872	879	PF00244	0.559
LIG_14-3-3_CanoR_1	913	917	PF00244	0.523
LIG_APCC_ABBAyCdc20_2	191	197	PF00400	0.534
LIG_BRCT_BRCA1_1	30	34	PF00533	0.511
LIG_BRCT_BRCA1_1	391	395	PF00533	0.628
LIG_BRCT_BRCA1_1	441	445	PF00533	0.614
LIG_BRCT_BRCA1_1	811	815	PF00533	0.599
LIG_EVH1_2	514	518	PF00568	0.570
LIG_FHA_1	298	304	PF00498	0.609
LIG_FHA_1	324	330	PF00498	0.610
LIG_FHA_1	491	497	PF00498	0.658
LIG_FHA_1	506	512	PF00498	0.534
LIG_FHA_1	563	569	PF00498	0.658
LIG_FHA_1	817	823	PF00498	0.610
LIG_FHA_1	844	850	PF00498	0.638
LIG_FHA_2	173	179	PF00498	0.611
LIG_FHA_2	200	206	PF00498	0.542
LIG_FHA_2	212	218	PF00498	0.623
LIG_FHA_2	241	247	PF00498	0.532
LIG_FHA_2	261	267	PF00498	0.533
LIG_FHA_2	396	402	PF00498	0.560
LIG_FHA_2	435	441	PF00498	0.598
LIG_FHA_2	60	66	PF00498	0.729
LIG_FHA_2	95	101	PF00498	0.642
LIG_LIR_Apic_2	256	261	PF02991	0.603
LIG_LIR_Apic_2	493	498	PF02991	0.591
LIG_LIR_Gen_1	31	41	PF02991	0.477
LIG_LIR_Gen_1	449	458	PF02991	0.580
LIG_LIR_Gen_1	603	612	PF02991	0.734
LIG_LIR_Gen_1	724	733	PF02991	0.562
LIG_LIR_Gen_1	940	949	PF02991	0.525
LIG_LIR_Nem_3	31	37	PF02991	0.490
LIG_LIR_Nem_3	442	448	PF02991	0.695
LIG_LIR_Nem_3	449	455	PF02991	0.625
LIG_LIR_Nem_3	603	607	PF02991	0.730
LIG_LIR_Nem_3	724	729	PF02991	0.574
LIG_LIR_Nem_3	812	818	PF02991	0.606
LIG_MYND_1	667	671	PF01753	0.643
LIG_Pex14_1	751	755	PF04695	0.546
LIG_Pex14_2	113	117	PF04695	0.576
LIG_Rb_pABgroove_1	710	718	PF01858	0.628
LIG_Rb_pABgroove_1	936	944	PF01858	0.485
LIG_SH2_CRK	125	129	PF00017	0.621
LIG_SH2_GRB2like	199	202	PF00017	0.561
LIG_SH2_PTP2	495	498	PF00017	0.576
LIG_SH2_PTP2	726	729	PF00017	0.553
LIG_SH2_SRC	125	128	PF00017	0.595
LIG_SH2_STAP1	716	720	PF00017	0.585
LIG_SH2_STAT5	199	202	PF00017	0.537
LIG_SH2_STAT5	313	316	PF00017	0.610
LIG_SH2_STAT5	452	455	PF00017	0.619
LIG_SH2_STAT5	495	498	PF00017	0.576
LIG_SH2_STAT5	697	700	PF00017	0.638
LIG_SH2_STAT5	726	729	PF00017	0.553
LIG_SH2_STAT5	816	819	PF00017	0.684
LIG_SH2_STAT5	898	901	PF00017	0.566
LIG_SH3_3	124	130	PF00018	0.641
LIG_SH3_3	235	241	PF00018	0.702
LIG_SH3_3	251	257	PF00018	0.507
LIG_SH3_3	26	32	PF00018	0.612
LIG_SH3_3	280	286	PF00018	0.610
LIG_SH3_3	553	559	PF00018	0.571
LIG_SH3_3	684	690	PF00018	0.679
LIG_SH3_3	717	723	PF00018	0.516
LIG_SH3_3	724	730	PF00018	0.427
LIG_SH3_3	782	788	PF00018	0.664
LIG_SH3_3	819	825	PF00018	0.606
LIG_SH3_3	838	844	PF00018	0.545
LIG_SH3_3	961	967	PF00018	0.609
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.611
LIG_SUMO_SIM_anti_2	717	722	PF11976	0.470
LIG_SUMO_SIM_par_1	882	888	PF11976	0.525
LIG_SUMO_SIM_par_1	929	937	PF11976	0.551
LIG_TRAF2_1	132	135	PF00917	0.552
LIG_TRAF2_1	497	500	PF00917	0.598
LIG_TRAF2_1	638	641	PF00917	0.592
LIG_TRAF2_1	671	674	PF00917	0.612
MOD_CDC14_SPxK_1	869	872	PF00782	0.561
MOD_CDK_SPK_2	240	245	PF00069	0.572
MOD_CDK_SPxK_1	866	872	PF00069	0.568
MOD_CDK_SPxxK_3	240	247	PF00069	0.569
MOD_CK1_1	211	217	PF00069	0.626
MOD_CK1_1	233	239	PF00069	0.702
MOD_CK1_1	28	34	PF00069	0.594
MOD_CK1_1	297	303	PF00069	0.613
MOD_CK1_1	342	348	PF00069	0.613
MOD_CK1_1	427	433	PF00069	0.743
MOD_CK1_1	472	478	PF00069	0.644
MOD_CK1_1	507	513	PF00069	0.745
MOD_CK1_1	59	65	PF00069	0.726
MOD_CK1_1	631	637	PF00069	0.713
MOD_CK1_1	798	804	PF00069	0.569
MOD_CK1_1	833	839	PF00069	0.680
MOD_CK1_1	840	846	PF00069	0.650
MOD_CK1_1	850	856	PF00069	0.553
MOD_CK1_1	858	864	PF00069	0.532
MOD_CK1_1	918	924	PF00069	0.635
MOD_CK1_1	98	104	PF00069	0.592
MOD_CK2_1	260	266	PF00069	0.589
MOD_CK2_1	343	349	PF00069	0.675
MOD_CK2_1	395	401	PF00069	0.553
MOD_CK2_1	59	65	PF00069	0.726
MOD_CK2_1	635	641	PF00069	0.691
MOD_CK2_1	761	767	PF00069	0.571
MOD_GlcNHglycan	130	133	PF01048	0.571
MOD_GlcNHglycan	172	175	PF01048	0.664
MOD_GlcNHglycan	296	299	PF01048	0.666
MOD_GlcNHglycan	346	349	PF01048	0.640
MOD_GlcNHglycan	474	477	PF01048	0.734
MOD_GlcNHglycan	479	482	PF01048	0.664
MOD_GlcNHglycan	534	537	PF01048	0.610
MOD_GlcNHglycan	574	577	PF01048	0.715
MOD_GlcNHglycan	609	612	PF01048	0.647
MOD_GlcNHglycan	624	627	PF01048	0.524
MOD_GlcNHglycan	637	640	PF01048	0.586
MOD_GlcNHglycan	661	664	PF01048	0.693
MOD_GlcNHglycan	69	72	PF01048	0.706
MOD_GlcNHglycan	698	701	PF01048	0.584
MOD_GlcNHglycan	733	736	PF01048	0.434
MOD_GlcNHglycan	763	766	PF01048	0.587
MOD_GlcNHglycan	807	810	PF01048	0.674
MOD_GlcNHglycan	811	814	PF01048	0.630
MOD_GlcNHglycan	833	836	PF01048	0.688
MOD_GlcNHglycan	849	852	PF01048	0.588
MOD_GlcNHglycan	86	89	PF01048	0.522
MOD_GlcNHglycan	860	863	PF01048	0.628
MOD_GlcNHglycan	874	877	PF01048	0.546
MOD_GlcNHglycan	921	924	PF01048	0.647
MOD_GSK3_1	168	175	PF00069	0.619
MOD_GSK3_1	206	213	PF00069	0.543
MOD_GSK3_1	230	237	PF00069	0.650
MOD_GSK3_1	302	309	PF00069	0.573
MOD_GSK3_1	321	328	PF00069	0.593
MOD_GSK3_1	339	346	PF00069	0.561
MOD_GSK3_1	353	360	PF00069	0.583
MOD_GSK3_1	362	369	PF00069	0.694
MOD_GSK3_1	409	416	PF00069	0.678
MOD_GSK3_1	503	510	PF00069	0.643
MOD_GSK3_1	564	571	PF00069	0.686
MOD_GSK3_1	631	638	PF00069	0.684
MOD_GSK3_1	659	666	PF00069	0.693
MOD_GSK3_1	67	74	PF00069	0.663
MOD_GSK3_1	805	812	PF00069	0.610
MOD_GSK3_1	826	833	PF00069	0.678
MOD_GSK3_1	84	91	PF00069	0.575
MOD_GSK3_1	843	850	PF00069	0.554
MOD_GSK3_1	851	858	PF00069	0.583
MOD_GSK3_1	912	919	PF00069	0.598
MOD_GSK3_1	933	940	PF00069	0.398
MOD_GSK3_1	94	101	PF00069	0.559
MOD_N-GLC_1	826	831	PF02516	0.630
MOD_N-GLC_1	858	863	PF02516	0.646
MOD_N-GLC_1	950	955	PF02516	0.503
MOD_N-GLC_2	36	38	PF02516	0.507
MOD_N-GLC_2	950	952	PF02516	0.501
MOD_NEK2_1	307	312	PF00069	0.576
MOD_NEK2_1	314	319	PF00069	0.532
MOD_NEK2_1	339	344	PF00069	0.715
MOD_NEK2_1	395	400	PF00069	0.546
MOD_NEK2_1	568	573	PF00069	0.666
MOD_NEK2_2	564	569	PF00069	0.583
MOD_NEK2_2	788	793	PF00069	0.581
MOD_OFUCOSY	304	311	PF10250	0.589
MOD_OFUCOSY	312	318	PF10250	0.544
MOD_PIKK_1	149	155	PF00454	0.548
MOD_PIKK_1	816	822	PF00454	0.612
MOD_PIKK_1	851	857	PF00454	0.678
MOD_PK_1	183	189	PF00069	0.677
MOD_PK_1	206	212	PF00069	0.544
MOD_PK_1	299	305	PF00069	0.460
MOD_PK_1	837	843	PF00069	0.672
MOD_PKA_2	305	311	PF00069	0.481
MOD_PKA_2	342	348	PF00069	0.661
MOD_PKA_2	354	360	PF00069	0.600
MOD_PKA_2	413	419	PF00069	0.612
MOD_PKA_2	541	547	PF00069	0.613
MOD_PKA_2	568	574	PF00069	0.589
MOD_PKA_2	628	634	PF00069	0.695
MOD_PKA_2	645	651	PF00069	0.746
MOD_PKA_2	67	73	PF00069	0.675
MOD_PKA_2	740	746	PF00069	0.488
MOD_PKA_2	84	90	PF00069	0.506
MOD_PKA_2	912	918	PF00069	0.481
MOD_PKB_1	642	650	PF00069	0.600
MOD_Plk_1	439	445	PF00069	0.623
MOD_Plk_1	602	608	PF00069	0.648
MOD_Plk_1	716	722	PF00069	0.590
MOD_Plk_1	826	832	PF00069	0.630
MOD_Plk_1	950	956	PF00069	0.403
MOD_Plk_2-3	904	910	PF00069	0.567
MOD_Plk_2-3	937	943	PF00069	0.480
MOD_Plk_4	221	227	PF00069	0.539
MOD_Plk_4	439	445	PF00069	0.623
MOD_Plk_4	716	722	PF00069	0.560
MOD_Plk_4	740	746	PF00069	0.422
MOD_Plk_4	937	943	PF00069	0.528
MOD_ProDKin_1	234	240	PF00069	0.704
MOD_ProDKin_1	28	34	PF00069	0.594
MOD_ProDKin_1	362	368	PF00069	0.559
MOD_ProDKin_1	434	440	PF00069	0.631
MOD_ProDKin_1	457	463	PF00069	0.552
MOD_ProDKin_1	510	516	PF00069	0.573
MOD_ProDKin_1	557	563	PF00069	0.702
MOD_ProDKin_1	584	590	PF00069	0.665
MOD_ProDKin_1	631	637	PF00069	0.684
MOD_ProDKin_1	663	669	PF00069	0.666
MOD_ProDKin_1	72	78	PF00069	0.673
MOD_ProDKin_1	796	802	PF00069	0.668
MOD_ProDKin_1	840	846	PF00069	0.696
MOD_ProDKin_1	866	872	PF00069	0.587
MOD_ProDKin_1	913	919	PF00069	0.580
MOD_ProDKin_1	927	933	PF00069	0.496
MOD_ProDKin_1	95	101	PF00069	0.616
TRG_DiLeu_BaEn_1	107	112	PF01217	0.600
TRG_DiLeu_BaEn_1	135	140	PF01217	0.502
TRG_DiLeu_BaEn_1	401	406	PF01217	0.688
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.530
TRG_DiLeu_BaLyEn_6	929	934	PF01217	0.533
TRG_DiLeu_LyEn_5	107	112	PF01217	0.600
TRG_ENDOCYTIC_2	125	128	PF00928	0.643
TRG_ENDOCYTIC_2	452	455	PF00928	0.571
TRG_ENDOCYTIC_2	726	729	PF00928	0.577
TRG_ER_diArg_1	108	110	PF00400	0.602
TRG_ER_diArg_1	191	193	PF00400	0.677
TRG_ER_diArg_1	329	331	PF00400	0.666
TRG_ER_diArg_1	520	523	PF00400	0.679
TRG_ER_diArg_1	736	739	PF00400	0.491
TRG_ER_diArg_1	895	897	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	897	901	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H531	Leishmania donovani	84%	97%
A4H3K0	Leishmania braziliensis	55%	98%
A4HRT9	Leishmania infantum	84%	97%
E9AJR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%