Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9ACH5_LEIMA

TriTrypDb:

LmjF.03.0280 , LMJLV39_030007900 , LMJSD75_030007900

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9ACH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACH5

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005543	phospholipid binding	3	2
GO:0008289	lipid binding	2	2
GO:0035091	phosphatidylinositol binding	4	2
GO:1901981	phosphatidylinositol phosphate binding	5	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	529	533	PF00656	0.584
CLV_C14_Caspase3-7	808	812	PF00656	0.598
CLV_NRD_NRD_1	109	111	PF00675	0.558
CLV_NRD_NRD_1	191	193	PF00675	0.677
CLV_NRD_NRD_1	330	332	PF00675	0.657
CLV_NRD_NRD_1	522	524	PF00675	0.674
CLV_NRD_NRD_1	619	621	PF00675	0.673
CLV_NRD_NRD_1	896	898	PF00675	0.589
CLV_PCSK_KEX2_1	108	110	PF00082	0.553
CLV_PCSK_KEX2_1	191	193	PF00082	0.677

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H531	Leishmania donovani	84%	97%
A4H3K0	Leishmania braziliensis	55%	98%
A4HRT9	Leishmania infantum	84%	97%
E9AJR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%

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