LeishMANIAdb
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FYVE-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
FYVE-type domain-containing protein
Gene product:
FYVE zinc finger/Apolipoprotein A1/A4/E domain containing protein, putative
Species:
Leishmania major
UniProt:
E9ACH4_LEIMA
TriTrypDb:
LmjF.03.0270 , LMJLV39_030007700 * , LMJLV39_030007800 * , LMJSD75_030007700 * , LMJSD75_030007800 *
Length:
2354

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0005576 extracellular region 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9ACH4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 4
GO:0006810 transport 3 4
GO:0006869 lipid transport 5 4
GO:0008152 metabolic process 1 4
GO:0019538 protein metabolic process 3 4
GO:0042157 lipoprotein metabolic process 4 4
GO:0043170 macromolecule metabolic process 3 4
GO:0044238 primary metabolic process 2 4
GO:0051179 localization 1 4
GO:0051234 establishment of localization 2 4
GO:0071702 organic substance transport 4 4
GO:0071704 organic substance metabolic process 2 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 5
GO:0008289 lipid binding 2 4
GO:0043167 ion binding 2 5
GO:0043169 cation binding 3 4
GO:0046872 metal ion binding 4 4
GO:0000166 nucleotide binding 3 1
GO:0003774 cytoskeletal motor activity 1 1
GO:0003777 microtubule motor activity 2 1
GO:0005515 protein binding 2 1
GO:0005524 ATP binding 5 1
GO:0008017 microtubule binding 5 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1
GO:0017076 purine nucleotide binding 4 1
GO:0030554 adenyl nucleotide binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032559 adenyl ribonucleotide binding 5 1
GO:0035639 purine ribonucleoside triphosphate binding 4 1
GO:0036094 small molecule binding 2 1
GO:0043168 anion binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:0097367 carbohydrate derivative binding 2 1
GO:0140657 ATP-dependent activity 1 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1826 1830 PF00656 0.292
CLV_C14_Caspase3-7 1948 1952 PF00656 0.593
CLV_NRD_NRD_1 1833 1835 PF00675 0.504
CLV_NRD_NRD_1 2092 2094 PF00675 0.511
CLV_NRD_NRD_1 2108 2110 PF00675 0.523
CLV_NRD_NRD_1 2339 2341 PF00675 0.405
CLV_PCSK_KEX2_1 1833 1835 PF00082 0.504
CLV_PCSK_KEX2_1 2092 2094 PF00082 0.511
CLV_PCSK_KEX2_1 2108 2110 PF00082 0.523
CLV_PCSK_KEX2_1 2339 2341 PF00082 0.405
CLV_PCSK_SKI1_1 188 192 PF00082 0.470
CLV_PCSK_SKI1_1 2259 2263 PF00082 0.453
CLV_PCSK_SKI1_1 2306 2310 PF00082 0.483
CLV_Separin_Metazoa 2227 2231 PF03568 0.582
DEG_APCC_DBOX_1 2305 2313 PF00400 0.487
DEG_SCF_FBW7_1 98 105 PF00400 0.535
DEG_SPOP_SBC_1 93 97 PF00917 0.489
DOC_ANK_TNKS_1 1115 1122 PF00023 0.257
DOC_ANK_TNKS_1 1232 1239 PF00023 0.257
DOC_ANK_TNKS_1 1522 1529 PF00023 0.257
DOC_ANK_TNKS_1 1600 1607 PF00023 0.257
DOC_ANK_TNKS_1 1717 1724 PF00023 0.268
DOC_ANK_TNKS_1 2064 2071 PF00023 0.477
DOC_ANK_TNKS_1 301 308 PF00023 0.257
DOC_ANK_TNKS_1 485 492 PF00023 0.257
DOC_CKS1_1 1 6 PF01111 0.475
DOC_CKS1_1 2180 2185 PF01111 0.660
DOC_CKS1_1 2291 2296 PF01111 0.507
DOC_MAPK_gen_1 2058 2066 PF00069 0.481
DOC_MAPK_gen_1 2132 2141 PF00069 0.510
DOC_MAPK_MEF2A_6 1748 1755 PF00069 0.257
DOC_USP7_MATH_1 102 106 PF00917 0.641
DOC_USP7_MATH_1 148 152 PF00917 0.470
DOC_USP7_MATH_1 157 161 PF00917 0.405
DOC_USP7_MATH_1 179 183 PF00917 0.589
DOC_USP7_MATH_1 1911 1915 PF00917 0.474
DOC_USP7_MATH_1 196 200 PF00917 0.236
DOC_USP7_MATH_1 1990 1994 PF00917 0.438
DOC_USP7_MATH_1 2018 2022 PF00917 0.523
DOC_USP7_MATH_1 2111 2115 PF00917 0.560
DOC_USP7_MATH_1 2214 2218 PF00917 0.550
DOC_USP7_UBL2_3 1864 1868 PF12436 0.438
DOC_WW_Pin1_4 111 116 PF00397 0.584
DOC_WW_Pin1_4 120 125 PF00397 0.559
DOC_WW_Pin1_4 2179 2184 PF00397 0.655
DOC_WW_Pin1_4 2189 2194 PF00397 0.575
DOC_WW_Pin1_4 2219 2224 PF00397 0.586
DOC_WW_Pin1_4 2290 2295 PF00397 0.511
DOC_WW_Pin1_4 85 90 PF00397 0.474
DOC_WW_Pin1_4 98 103 PF00397 0.456
LIG_14-3-3_CanoR_1 1910 1920 PF00244 0.536
LIG_14-3-3_CanoR_1 1935 1940 PF00244 0.521
LIG_14-3-3_CanoR_1 2003 2008 PF00244 0.486
LIG_14-3-3_CanoR_1 2092 2100 PF00244 0.549
LIG_14-3-3_CanoR_1 2162 2170 PF00244 0.488
LIG_14-3-3_CanoR_1 2250 2258 PF00244 0.492
LIG_Actin_WH2_2 1988 2005 PF00022 0.501
LIG_APCC_ABBA_1 1776 1781 PF00400 0.292
LIG_APCC_ABBA_1 1918 1923 PF00400 0.533
LIG_BIR_II_1 1 5 PF00653 0.490
LIG_CtBP_PxDLS_1 2070 2076 PF00389 0.477
LIG_FHA_1 112 118 PF00498 0.589
LIG_FHA_1 130 136 PF00498 0.488
LIG_FHA_1 1913 1919 PF00498 0.517
LIG_FHA_1 198 204 PF00498 0.292
LIG_FHA_1 2164 2170 PF00498 0.524
LIG_FHA_1 2291 2297 PF00498 0.553
LIG_FHA_1 53 59 PF00498 0.346
LIG_FHA_1 65 71 PF00498 0.283
LIG_FHA_2 1780 1786 PF00498 0.257
LIG_FHA_2 187 193 PF00498 0.304
LIG_FHA_2 1935 1941 PF00498 0.488
LIG_FHA_2 2239 2245 PF00498 0.553
LIG_Integrin_isoDGR_2 1952 1954 PF01839 0.537
LIG_LIR_Gen_1 2260 2267 PF02991 0.456
LIG_LIR_Nem_3 2255 2261 PF02991 0.452
LIG_LIR_Nem_3 2336 2341 PF02991 0.432
LIG_MYND_1 115 119 PF01753 0.547
LIG_PCNA_yPIPBox_3 1864 1876 PF02747 0.450
LIG_PDZ_Class_1 2349 2354 PF00595 0.367
LIG_REV1ctd_RIR_1 32 42 PF16727 0.316
LIG_SH2_GRB2like 63 66 PF00017 0.333
LIG_SH2_SRC 2263 2266 PF00017 0.461
LIG_SH2_SRC 2281 2284 PF00017 0.441
LIG_SH2_STAP1 2156 2160 PF00017 0.439
LIG_SH2_STAP1 2263 2267 PF00017 0.458
LIG_SH2_STAT5 2281 2284 PF00017 0.513
LIG_SH2_STAT5 91 94 PF00017 0.517
LIG_SH3_1 104 110 PF00018 0.576
LIG_SH3_2 2225 2230 PF14604 0.579
LIG_SH3_3 104 110 PF00018 0.666
LIG_SH3_3 116 122 PF00018 0.551
LIG_SH3_3 2177 2183 PF00018 0.643
LIG_SH3_3 2222 2228 PF00018 0.578
LIG_SH3_3 2291 2297 PF00018 0.501
LIG_SxIP_EBH_1 51 65 PF03271 0.333
LIG_TRAF2_1 138 141 PF00917 0.459
LIG_TRAF2_1 1782 1785 PF00917 0.257
LIG_TRAF2_1 1888 1891 PF00917 0.522
LIG_TRAF2_1 190 193 PF00917 0.302
LIG_TRAF2_1 1925 1928 PF00917 0.508
LIG_TRAF2_1 1983 1986 PF00917 0.483
LIG_TRAF2_1 2311 2314 PF00917 0.479
LIG_TRAF2_1 2329 2332 PF00917 0.401
LIG_TYR_ITIM 2261 2266 PF00017 0.459
LIG_Vh1_VBS_1 1817 1835 PF01044 0.266
LIG_WW_3 2227 2231 PF00397 0.582
MOD_CDK_SPK_2 2290 2295 PF00069 0.511
MOD_CDK_SPxK_1 2189 2195 PF00069 0.620
MOD_CDK_SPxK_1 98 104 PF00069 0.530
MOD_CDK_SPxxK_3 111 118 PF00069 0.545
MOD_CDK_SPxxK_3 2219 2226 PF00069 0.584
MOD_CK1_1 128 134 PF00069 0.479
MOD_CK1_1 1945 1951 PF00069 0.533
MOD_CK1_1 2011 2017 PF00069 0.508
MOD_CK1_1 2200 2206 PF00069 0.493
MOD_CK1_1 64 70 PF00069 0.331
MOD_CK2_1 146 152 PF00069 0.679
MOD_CK2_1 157 163 PF00069 0.495
MOD_CK2_1 1779 1785 PF00069 0.302
MOD_CK2_1 179 185 PF00069 0.571
MOD_CK2_1 186 192 PF00069 0.327
MOD_CK2_1 1911 1917 PF00069 0.526
MOD_CK2_1 1934 1940 PF00069 0.500
MOD_CK2_1 2092 2098 PF00069 0.554
MOD_CK2_1 2238 2244 PF00069 0.570
MOD_GlcNHglycan 1805 1809 PF01048 0.266
MOD_GlcNHglycan 181 184 PF01048 0.586
MOD_GlcNHglycan 1957 1960 PF01048 0.622
MOD_GlcNHglycan 2016 2019 PF01048 0.530
MOD_GlcNHglycan 2020 2023 PF01048 0.501
MOD_GlcNHglycan 2026 2029 PF01048 0.492
MOD_GlcNHglycan 2035 2038 PF01048 0.477
MOD_GlcNHglycan 2217 2220 PF01048 0.564
MOD_GlcNHglycan 2286 2289 PF01048 0.543
MOD_GlcNHglycan 2298 2301 PF01048 0.413
MOD_GlcNHglycan 2345 2348 PF01048 0.395
MOD_GlcNHglycan 5 8 PF01048 0.442
MOD_GlcNHglycan 98 101 PF01048 0.626
MOD_GSK3_1 125 132 PF00069 0.512
MOD_GSK3_1 142 149 PF00069 0.558
MOD_GSK3_1 157 164 PF00069 0.417
MOD_GSK3_1 192 199 PF00069 0.282
MOD_GSK3_1 1955 1962 PF00069 0.617
MOD_GSK3_1 2003 2010 PF00069 0.490
MOD_GSK3_1 2014 2021 PF00069 0.474
MOD_GSK3_1 2164 2171 PF00069 0.525
MOD_GSK3_1 2175 2182 PF00069 0.575
MOD_GSK3_1 2215 2222 PF00069 0.567
MOD_GSK3_1 2240 2247 PF00069 0.542
MOD_GSK3_1 2296 2303 PF00069 0.475
MOD_GSK3_1 92 99 PF00069 0.545
MOD_N-GLC_1 64 69 PF02516 0.266
MOD_N-GLC_2 1934 1936 PF02516 0.516
MOD_NEK2_1 178 183 PF00069 0.699
MOD_NEK2_1 197 202 PF00069 0.298
MOD_NEK2_1 2016 2021 PF00069 0.525
MOD_NEK2_1 2316 2321 PF00069 0.442
MOD_NEK2_1 34 39 PF00069 0.372
MOD_PIKK_1 1023 1029 PF00454 0.283
MOD_PIKK_1 1062 1068 PF00454 0.299
MOD_PIKK_1 1101 1107 PF00454 0.283
MOD_PIKK_1 1140 1146 PF00454 0.283
MOD_PIKK_1 1179 1185 PF00454 0.316
MOD_PIKK_1 1218 1224 PF00454 0.266
MOD_PIKK_1 1257 1263 PF00454 0.316
MOD_PIKK_1 1296 1302 PF00454 0.299
MOD_PIKK_1 1324 1330 PF00454 0.266
MOD_PIKK_1 1363 1369 PF00454 0.266
MOD_PIKK_1 1402 1408 PF00454 0.266
MOD_PIKK_1 1430 1436 PF00454 0.266
MOD_PIKK_1 1469 1475 PF00454 0.283
MOD_PIKK_1 1508 1514 PF00454 0.266
MOD_PIKK_1 1547 1553 PF00454 0.283
MOD_PIKK_1 1586 1592 PF00454 0.283
MOD_PIKK_1 1625 1631 PF00454 0.316
MOD_PIKK_1 1664 1670 PF00454 0.316
MOD_PIKK_1 1703 1709 PF00454 0.316
MOD_PIKK_1 1742 1748 PF00454 0.283
MOD_PIKK_1 209 215 PF00454 0.299
MOD_PIKK_1 2102 2108 PF00454 0.608
MOD_PIKK_1 2244 2250 PF00454 0.541
MOD_PIKK_1 248 254 PF00454 0.283
MOD_PIKK_1 287 293 PF00454 0.283
MOD_PIKK_1 326 332 PF00454 0.266
MOD_PIKK_1 365 371 PF00454 0.290
MOD_PIKK_1 404 410 PF00454 0.266
MOD_PIKK_1 432 438 PF00454 0.276
MOD_PIKK_1 471 477 PF00454 0.324
MOD_PIKK_1 510 516 PF00454 0.302
MOD_PIKK_1 538 544 PF00454 0.266
MOD_PIKK_1 577 583 PF00454 0.283
MOD_PIKK_1 605 611 PF00454 0.266
MOD_PIKK_1 644 650 PF00454 0.299
MOD_PIKK_1 683 689 PF00454 0.266
MOD_PIKK_1 722 728 PF00454 0.277
MOD_PIKK_1 761 767 PF00454 0.277
MOD_PIKK_1 800 806 PF00454 0.316
MOD_PIKK_1 839 845 PF00454 0.266
MOD_PIKK_1 878 884 PF00454 0.333
MOD_PIKK_1 906 912 PF00454 0.283
MOD_PIKK_1 945 951 PF00454 0.327
MOD_PIKK_1 984 990 PF00454 0.316
MOD_PK_1 2003 2009 PF00069 0.421
MOD_PKA_1 2092 2098 PF00069 0.538
MOD_PKA_2 1779 1785 PF00069 0.266
MOD_PKA_2 1934 1940 PF00069 0.486
MOD_PKA_2 2014 2020 PF00069 0.530
MOD_PKA_2 2091 2097 PF00069 0.526
MOD_PKA_2 2249 2255 PF00069 0.530
MOD_PKA_2 83 89 PF00069 0.465
MOD_Plk_1 192 198 PF00069 0.295
MOD_Plk_1 2174 2180 PF00069 0.565
MOD_Plk_1 2244 2250 PF00069 0.491
MOD_Plk_1 2331 2337 PF00069 0.453
MOD_Plk_1 64 70 PF00069 0.266
MOD_Plk_2-3 2175 2181 PF00069 0.572
MOD_Plk_4 125 131 PF00069 0.575
MOD_Plk_4 2008 2014 PF00069 0.512
MOD_Plk_4 2164 2170 PF00069 0.519
MOD_Plk_4 54 60 PF00069 0.333
MOD_ProDKin_1 111 117 PF00069 0.584
MOD_ProDKin_1 120 126 PF00069 0.556
MOD_ProDKin_1 2179 2185 PF00069 0.656
MOD_ProDKin_1 2189 2195 PF00069 0.570
MOD_ProDKin_1 2219 2225 PF00069 0.585
MOD_ProDKin_1 2290 2296 PF00069 0.508
MOD_ProDKin_1 85 91 PF00069 0.478
MOD_ProDKin_1 98 104 PF00069 0.460
MOD_SUMO_for_1 1789 1792 PF00179 0.266
MOD_SUMO_for_1 190 193 PF00179 0.266
MOD_SUMO_rev_2 1861 1866 PF00179 0.519
TRG_DiLeu_BaEn_1 1754 1759 PF01217 0.266
TRG_DiLeu_BaEn_1 2062 2067 PF01217 0.472
TRG_DiLeu_BaEn_4 1784 1790 PF01217 0.266
TRG_DiLeu_BaEn_4 1791 1797 PF01217 0.315
TRG_DiLeu_BaEn_4 192 198 PF01217 0.333
TRG_DiLeu_LyEn_5 2062 2067 PF01217 0.472
TRG_ENDOCYTIC_2 1921 1924 PF00928 0.535
TRG_ENDOCYTIC_2 2258 2261 PF00928 0.447
TRG_ENDOCYTIC_2 2263 2266 PF00928 0.436
TRG_ENDOCYTIC_2 75 78 PF00928 0.316
TRG_ER_diArg_1 1907 1910 PF00400 0.562
TRG_ER_diArg_1 2029 2032 PF00400 0.485
TRG_ER_diArg_1 2076 2079 PF00400 0.462
TRG_ER_diArg_1 2107 2109 PF00400 0.571
TRG_ER_diArg_1 2229 2232 PF00400 0.573
TRG_ER_diArg_1 2338 2340 PF00400 0.412
TRG_NES_CRM1_1 1855 1867 PF08389 0.333
TRG_NES_CRM1_1 2062 2075 PF08389 0.470
TRG_NES_CRM1_1 613 627 PF08389 0.266
TRG_Pf-PMV_PEXEL_1 159 163 PF00026 0.425
TRG_Pf-PMV_PEXEL_1 1922 1927 PF00026 0.538
TRG_Pf-PMV_PEXEL_1 2065 2069 PF00026 0.481
TRG_Pf-PMV_PEXEL_1 2082 2086 PF00026 0.426
TRG_Pf-PMV_PEXEL_1 2310 2314 PF00026 0.476

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H530 Leishmania donovani 79% 100%
A4HRT8 Leishmania infantum 83% 100%
A4HW58 Leishmania infantum 27% 80%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS