Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACH3_LEIMA

TriTrypDb:

LmjF.03.0260 , LMJLV39_030007600 , LMJSD75_030007600

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9ACH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.735
CLV_NRD_NRD_1	123	125	PF00675	0.472
CLV_NRD_NRD_1	54	56	PF00675	0.456
CLV_NRD_NRD_1	64	66	PF00675	0.495
CLV_PCSK_FUR_1	286	290	PF00082	0.621
CLV_PCSK_KEX2_1	123	125	PF00082	0.472
CLV_PCSK_KEX2_1	288	290	PF00082	0.626
CLV_PCSK_KEX2_1	54	56	PF00082	0.456
CLV_PCSK_KEX2_1	63	65	PF00082	0.494
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.623
CLV_PCSK_SKI1_1	124	128	PF00082	0.474
DOC_MAPK_gen_1	295	301	PF00069	0.484
DOC_PP1_RVXF_1	226	233	PF00149	0.444
DOC_WW_Pin1_4	141	146	PF00397	0.725
DOC_WW_Pin1_4	172	177	PF00397	0.604
DOC_WW_Pin1_4	74	79	PF00397	0.711
LIG_14-3-3_CanoR_1	123	129	PF00244	0.630
LIG_14-3-3_CanoR_1	136	145	PF00244	0.702
LIG_14-3-3_CanoR_1	153	161	PF00244	0.611
LIG_14-3-3_CanoR_1	182	188	PF00244	0.619
LIG_14-3-3_CanoR_1	64	74	PF00244	0.699
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BIR_III_2	71	75	PF00653	0.735
LIG_BRCT_BRCA1_1	36	40	PF00533	0.649
LIG_EVH1_2	150	154	PF00568	0.719
LIG_FHA_1	231	237	PF00498	0.362
LIG_FHA_2	45	51	PF00498	0.640
LIG_FHA_2	57	63	PF00498	0.640
LIG_LIR_Gen_1	229	240	PF02991	0.362
LIG_LIR_Nem_3	116	122	PF02991	0.670
LIG_LIR_Nem_3	155	161	PF02991	0.705
LIG_LIR_Nem_3	229	235	PF02991	0.362
LIG_LIR_Nem_3	87	93	PF02991	0.677
LIG_LYPXL_yS_3	158	161	PF13949	0.701
LIG_PCNA_PIPBox_1	219	228	PF02747	0.615
LIG_PCNA_PIPBox_1	45	54	PF02747	0.671
LIG_PCNA_yPIPBox_3	45	55	PF02747	0.672
LIG_Pex14_2	52	56	PF04695	0.695
LIG_Pex14_2	86	90	PF04695	0.677
LIG_SH2_SRC	267	270	PF00017	0.436
LIG_SH2_STAP1	267	271	PF00017	0.455
LIG_SH3_3	144	150	PF00018	0.722
LIG_SH3_3	233	239	PF00018	0.362
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.449
MOD_CK1_1	166	172	PF00069	0.699
MOD_Cter_Amidation	286	289	PF01082	0.624
MOD_GlcNHglycan	10	13	PF01048	0.483
MOD_GlcNHglycan	115	118	PF01048	0.482
MOD_GlcNHglycan	133	136	PF01048	0.406
MOD_GlcNHglycan	154	157	PF01048	0.594
MOD_GlcNHglycan	164	168	PF01048	0.551
MOD_GlcNHglycan	170	173	PF01048	0.471
MOD_GlcNHglycan	36	39	PF01048	0.448
MOD_GlcNHglycan	67	70	PF01048	0.532
MOD_GlcNHglycan	78	81	PF01048	0.422
MOD_GSK3_1	137	144	PF00069	0.668
MOD_GSK3_1	168	175	PF00069	0.634
MOD_GSK3_1	226	233	PF00069	0.516
MOD_GSK3_1	34	41	PF00069	0.705
MOD_GSK3_1	91	98	PF00069	0.670
MOD_N-GLC_1	137	142	PF02516	0.511
MOD_NEK2_1	168	173	PF00069	0.693
MOD_NEK2_1	189	194	PF00069	0.602
MOD_NEK2_1	226	231	PF00069	0.603
MOD_NEK2_1	36	41	PF00069	0.740
MOD_NEK2_1	56	61	PF00069	0.600
MOD_PIKK_1	111	117	PF00454	0.694
MOD_PIKK_1	40	46	PF00454	0.695
MOD_PKA_1	64	70	PF00069	0.717
MOD_PKA_2	152	158	PF00069	0.697
MOD_PKA_2	24	30	PF00069	0.796
MOD_PKA_2	64	70	PF00069	0.735
MOD_PKB_1	129	137	PF00069	0.704
MOD_PKB_1	63	71	PF00069	0.662
MOD_ProDKin_1	141	147	PF00069	0.723
MOD_ProDKin_1	172	178	PF00069	0.603
MOD_ProDKin_1	74	80	PF00069	0.707
TRG_DiLeu_BaEn_2	259	265	PF01217	0.450
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.399
TRG_ENDOCYTIC_2	158	161	PF00928	0.701
TRG_ENDOCYTIC_2	231	234	PF00928	0.381
TRG_ER_diArg_1	122	124	PF00400	0.669
TRG_ER_diArg_1	128	131	PF00400	0.657
TRG_ER_diArg_1	53	55	PF00400	0.627
TRG_ER_diArg_1	63	65	PF00400	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H529	Leishmania donovani	88%	100%
A4HRT7	Leishmania infantum	89%	100%
E9AJR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%