zf-C2H2_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of acetyl-transferase ESCO, putative

Species:

Leishmania major

UniProt:

E9ACG5_LEIMA

TriTrypDb:

LmjF.03.0180 , LMJLV39_030006800 , LMJSD75_030006800

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACG5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.633
CLV_C14_Caspase3-7	3	7	PF00656	0.517
CLV_C14_Caspase3-7	337	341	PF00656	0.564
CLV_NRD_NRD_1	141	143	PF00675	0.275
CLV_NRD_NRD_1	151	153	PF00675	0.582
CLV_NRD_NRD_1	170	172	PF00675	0.560
CLV_NRD_NRD_1	219	221	PF00675	0.717
CLV_NRD_NRD_1	225	227	PF00675	0.806
CLV_NRD_NRD_1	380	382	PF00675	0.474
CLV_NRD_NRD_1	391	393	PF00675	0.450
CLV_NRD_NRD_1	55	57	PF00675	0.678
CLV_PCSK_FUR_1	148	152	PF00082	0.536
CLV_PCSK_FUR_1	168	172	PF00082	0.583
CLV_PCSK_KEX2_1	141	143	PF00082	0.275
CLV_PCSK_KEX2_1	150	152	PF00082	0.576
CLV_PCSK_KEX2_1	170	172	PF00082	0.560
CLV_PCSK_KEX2_1	219	221	PF00082	0.718
CLV_PCSK_KEX2_1	224	226	PF00082	0.788
CLV_PCSK_KEX2_1	380	382	PF00082	0.466
CLV_PCSK_KEX2_1	391	393	PF00082	0.450
CLV_PCSK_KEX2_1	55	57	PF00082	0.678
CLV_PCSK_PC7_1	220	226	PF00082	0.702
CLV_PCSK_SKI1_1	121	125	PF00082	0.226
CLV_PCSK_SKI1_1	357	361	PF00082	0.427
CLV_PCSK_SKI1_1	392	396	PF00082	0.475
CLV_PCSK_SKI1_1	429	433	PF00082	0.461
CLV_PCSK_SKI1_1	5	9	PF00082	0.553
CLV_Separin_Metazoa	91	95	PF03568	0.624
DEG_APCC_DBOX_1	120	128	PF00400	0.512
DEG_APCC_DBOX_1	356	364	PF00400	0.431
DEG_SPOP_SBC_1	261	265	PF00917	0.502
DOC_CYCLIN_RxL_1	295	306	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	271	277	PF00134	0.474
DOC_MAPK_MEF2A_6	370	378	PF00069	0.499
DOC_MAPK_MEF2A_6	429	436	PF00069	0.397
DOC_USP7_MATH_1	166	170	PF00917	0.629
DOC_USP7_MATH_1	180	184	PF00917	0.630
DOC_USP7_MATH_1	250	254	PF00917	0.671
DOC_USP7_MATH_1	261	265	PF00917	0.706
DOC_USP7_MATH_1	323	327	PF00917	0.645
DOC_USP7_MATH_1	424	428	PF00917	0.447
DOC_USP7_MATH_1	513	517	PF00917	0.592
DOC_USP7_MATH_1	85	89	PF00917	0.696
DOC_WW_Pin1_4	127	132	PF00397	0.426
DOC_WW_Pin1_4	176	181	PF00397	0.637
DOC_WW_Pin1_4	183	188	PF00397	0.413
DOC_WW_Pin1_4	203	208	PF00397	0.576
DOC_WW_Pin1_4	265	270	PF00397	0.645
DOC_WW_Pin1_4	303	308	PF00397	0.471
DOC_WW_Pin1_4	403	408	PF00397	0.475
DOC_WW_Pin1_4	521	526	PF00397	0.738
LIG_14-3-3_CanoR_1	170	180	PF00244	0.677
LIG_14-3-3_CanoR_1	260	269	PF00244	0.503
LIG_14-3-3_CanoR_1	279	283	PF00244	0.347
LIG_14-3-3_CanoR_1	391	399	PF00244	0.470
LIG_14-3-3_CanoR_1	488	493	PF00244	0.494
LIG_Actin_WH2_2	295	313	PF00022	0.432
LIG_APCC_ABBA_1	537	542	PF00400	0.547
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_BIR_III_4	556	560	PF00653	0.608
LIG_FHA_1	106	112	PF00498	0.475
LIG_FHA_1	118	124	PF00498	0.475
LIG_FHA_1	213	219	PF00498	0.681
LIG_FHA_1	239	245	PF00498	0.675
LIG_FHA_1	249	255	PF00498	0.510
LIG_FHA_1	304	310	PF00498	0.409
LIG_FHA_1	343	349	PF00498	0.370
LIG_FHA_1	39	45	PF00498	0.661
LIG_FHA_2	105	111	PF00498	0.312
LIG_FHA_2	237	243	PF00498	0.650
LIG_FHA_2	244	250	PF00498	0.574
LIG_FHA_2	393	399	PF00498	0.457
LIG_FHA_2	413	419	PF00498	0.317
LIG_FHA_2	524	530	PF00498	0.593
LIG_LIR_Nem_3	304	308	PF02991	0.456
LIG_NRBOX	298	304	PF00104	0.406
LIG_NRBOX	355	361	PF00104	0.436
LIG_NRBOX	44	50	PF00104	0.689
LIG_PCNA_TLS_4	429	436	PF02747	0.517
LIG_REV1ctd_RIR_1	433	443	PF16727	0.514
LIG_SH2_CRK	157	161	PF00017	0.634
LIG_SH2_CRK	97	101	PF00017	0.543
LIG_SH2_NCK_1	157	161	PF00017	0.634
LIG_SH2_NCK_1	492	496	PF00017	0.597
LIG_SH2_NCK_1	97	101	PF00017	0.543
LIG_SH2_SRC	538	541	PF00017	0.546
LIG_SH2_STAP1	492	496	PF00017	0.521
LIG_SH2_STAT5	238	241	PF00017	0.634
LIG_SH2_STAT5	31	34	PF00017	0.535
LIG_SH2_STAT5	477	480	PF00017	0.451
LIG_SH2_STAT5	519	522	PF00017	0.510
LIG_SH2_STAT5	538	541	PF00017	0.615
LIG_SH3_3	11	17	PF00018	0.557
LIG_SH3_3	255	261	PF00018	0.535
LIG_SH3_3	330	336	PF00018	0.576
LIG_SH3_3	361	367	PF00018	0.454
LIG_SH3_3	401	407	PF00018	0.426
LIG_SH3_3	65	71	PF00018	0.601
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.607
LIG_SUMO_SIM_par_1	249	256	PF11976	0.510
LIG_SUMO_SIM_par_1	298	304	PF11976	0.445
MOD_CDK_SPK_2	523	528	PF00069	0.618
MOD_CDK_SPxxK_3	521	528	PF00069	0.614
MOD_CK1_1	161	167	PF00069	0.736
MOD_CK1_1	183	189	PF00069	0.531
MOD_CK1_1	253	259	PF00069	0.501
MOD_CK1_1	263	269	PF00069	0.711
MOD_CK1_1	341	347	PF00069	0.474
MOD_CK1_1	447	453	PF00069	0.608
MOD_CK2_1	403	409	PF00069	0.454
MOD_CK2_1	412	418	PF00069	0.394
MOD_CK2_1	523	529	PF00069	0.620
MOD_CK2_1	85	91	PF00069	0.616
MOD_Cter_Amidation	53	56	PF01082	0.627
MOD_GlcNHglycan	227	230	PF01048	0.663
MOD_GlcNHglycan	340	343	PF01048	0.559
MOD_GlcNHglycan	409	413	PF01048	0.433
MOD_GlcNHglycan	446	449	PF01048	0.612
MOD_GlcNHglycan	81	84	PF01048	0.695
MOD_GlcNHglycan	87	90	PF01048	0.621
MOD_GSK3_1	176	183	PF00069	0.636
MOD_GSK3_1	234	241	PF00069	0.640
MOD_GSK3_1	260	267	PF00069	0.589
MOD_GSK3_1	319	326	PF00069	0.618
MOD_GSK3_1	334	341	PF00069	0.495
MOD_GSK3_1	383	390	PF00069	0.524
MOD_GSK3_1	408	415	PF00069	0.368
MOD_GSK3_1	443	450	PF00069	0.632
MOD_GSK3_1	480	487	PF00069	0.492
MOD_GSK3_1	55	62	PF00069	0.598
MOD_GSK3_1	79	86	PF00069	0.742
MOD_N-GLC_1	212	217	PF02516	0.600
MOD_N-GLC_1	392	397	PF02516	0.391
MOD_N-GLC_2	283	285	PF02516	0.531
MOD_NEK2_1	104	109	PF00069	0.285
MOD_NEK2_1	278	283	PF00069	0.417
MOD_NEK2_1	425	430	PF00069	0.519
MOD_NEK2_1	435	440	PF00069	0.504
MOD_NEK2_1	490	495	PF00069	0.552
MOD_NEK2_1	60	65	PF00069	0.565
MOD_NEK2_1	95	100	PF00069	0.656
MOD_NEK2_2	342	347	PF00069	0.457
MOD_OFUCOSY	511	518	PF10250	0.515
MOD_PIKK_1	102	108	PF00454	0.618
MOD_PIKK_1	22	28	PF00454	0.584
MOD_PIKK_1	490	496	PF00454	0.549
MOD_PKA_1	225	231	PF00069	0.578
MOD_PKA_1	55	61	PF00069	0.541
MOD_PKA_2	225	231	PF00069	0.602
MOD_PKA_2	261	267	PF00069	0.499
MOD_PKA_2	278	284	PF00069	0.323
MOD_PKA_2	338	344	PF00069	0.517
MOD_PKA_2	55	61	PF00069	0.574
MOD_PKA_2	95	101	PF00069	0.713
MOD_PKB_1	171	179	PF00069	0.633
MOD_PKB_1	260	268	PF00069	0.486
MOD_Plk_1	248	254	PF00069	0.586
MOD_Plk_2-3	545	551	PF00069	0.695
MOD_Plk_4	323	329	PF00069	0.637
MOD_Plk_4	351	357	PF00069	0.360
MOD_Plk_4	6	12	PF00069	0.607
MOD_ProDKin_1	127	133	PF00069	0.243
MOD_ProDKin_1	176	182	PF00069	0.635
MOD_ProDKin_1	183	189	PF00069	0.402
MOD_ProDKin_1	203	209	PF00069	0.580
MOD_ProDKin_1	265	271	PF00069	0.643
MOD_ProDKin_1	303	309	PF00069	0.469
MOD_ProDKin_1	403	409	PF00069	0.479
MOD_ProDKin_1	521	527	PF00069	0.740
MOD_SUMO_rev_2	550	560	PF00179	0.539
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.465
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.398
TRG_ER_diArg_1	141	143	PF00400	0.312
TRG_ER_diArg_1	148	151	PF00400	0.560
TRG_ER_diArg_1	168	171	PF00400	0.569
TRG_ER_diArg_1	218	220	PF00400	0.717
TRG_ER_diArg_1	223	226	PF00400	0.785
TRG_ER_diArg_1	259	262	PF00400	0.426
TRG_ER_diArg_1	367	370	PF00400	0.535
TRG_ER_diArg_1	93	96	PF00400	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD4	Leptomonas seymouri	34%	80%
A0A3S5H526	Leishmania donovani	86%	77%
A4H3J0	Leishmania braziliensis	66%	100%
A4HRS9	Leishmania infantum	86%	77%
E9AJQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%