Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACG2_LEIMA

TriTrypDb:

LmjF.03.0150 , LMJLV39_030006500 , LMJSD75_030006500

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACG2

PDB structure(s): 7aih_Ae , 7am2_Ae , 7ane_Ae

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.407
CLV_NRD_NRD_1	108	110	PF00675	0.616
CLV_NRD_NRD_1	205	207	PF00675	0.408
CLV_PCSK_KEX2_1	103	105	PF00082	0.474
CLV_PCSK_KEX2_1	108	110	PF00082	0.493
CLV_PCSK_KEX2_1	158	160	PF00082	0.431
CLV_PCSK_KEX2_1	205	207	PF00082	0.408
CLV_PCSK_KEX2_1	296	298	PF00082	0.545
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.474
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.493
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.431
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.545
CLV_PCSK_PC7_1	104	110	PF00082	0.616
CLV_PCSK_SKI1_1	171	175	PF00082	0.411
CLV_PCSK_SKI1_1	198	202	PF00082	0.411
CLV_PCSK_SKI1_1	218	222	PF00082	0.199
CLV_PCSK_SKI1_1	296	300	PF00082	0.581
DEG_APCC_DBOX_1	108	116	PF00400	0.626
DEG_SCF_FBW7_1	148	155	PF00400	0.577
DEG_SCF_FBW7_2	228	233	PF00400	0.383
DEG_SIAH_1	159	167	PF03145	0.458
DOC_ANK_TNKS_1	268	275	PF00023	0.390
DOC_CKS1_1	62	67	PF01111	0.614
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.440
DOC_MAPK_DCC_7	180	190	PF00069	0.452
DOC_MAPK_gen_1	92	102	PF00069	0.425
DOC_PP2B_LxvP_1	135	138	PF13499	0.541
DOC_PP2B_LxvP_1	18	21	PF13499	0.534
DOC_PP2B_PxIxI_1	229	235	PF00149	0.368
DOC_USP7_MATH_1	166	170	PF00917	0.484
DOC_USP7_MATH_1	213	217	PF00917	0.334
DOC_USP7_UBL2_3	106	110	PF12436	0.498
DOC_USP7_UBL2_3	167	171	PF12436	0.576
DOC_USP7_UBL2_3	305	309	PF12436	0.639
DOC_WW_Pin1_4	148	153	PF00397	0.552
DOC_WW_Pin1_4	183	188	PF00397	0.378
DOC_WW_Pin1_4	209	214	PF00397	0.434
DOC_WW_Pin1_4	226	231	PF00397	0.312
DOC_WW_Pin1_4	61	66	PF00397	0.587
LIG_14-3-3_CanoR_1	205	215	PF00244	0.426
LIG_14-3-3_CanoR_1	269	277	PF00244	0.513
LIG_APCC_ABBA_1	174	179	PF00400	0.394
LIG_Clathr_ClatBox_1	175	179	PF01394	0.381
LIG_deltaCOP1_diTrp_1	283	293	PF00928	0.402
LIG_eIF4E_1	285	291	PF01652	0.392
LIG_FHA_1	180	186	PF00498	0.326
LIG_FHA_1	227	233	PF00498	0.390
LIG_FHA_2	233	239	PF00498	0.401
LIG_LIR_Apic_2	114	120	PF02991	0.572
LIG_LIR_Apic_2	130	134	PF02991	0.367
LIG_LIR_Apic_2	240	245	PF02991	0.410
LIG_LIR_Gen_1	284	293	PF02991	0.404
LIG_LIR_Gen_1	9	18	PF02991	0.553
LIG_LIR_Gen_1	96	107	PF02991	0.447
LIG_LIR_Nem_3	217	223	PF02991	0.392
LIG_LIR_Nem_3	284	290	PF02991	0.401
LIG_LIR_Nem_3	9	13	PF02991	0.543
LIG_LIR_Nem_3	96	102	PF02991	0.432
LIG_MYND_1	29	33	PF01753	0.503
LIG_SH2_NCK_1	60	64	PF00017	0.585
LIG_SH2_PTP2	117	120	PF00017	0.577
LIG_SH2_PTP2	242	245	PF00017	0.392
LIG_SH2_SRC	117	120	PF00017	0.562
LIG_SH2_SRC	242	245	PF00017	0.392
LIG_SH2_SRC	81	84	PF00017	0.490
LIG_SH2_STAT5	117	120	PF00017	0.531
LIG_SH2_STAT5	242	245	PF00017	0.392
LIG_SH2_STAT5	58	61	PF00017	0.500
LIG_SH2_STAT5	8	11	PF00017	0.504
LIG_SH3_3	142	148	PF00018	0.504
LIG_SH3_3	160	166	PF00018	0.289
LIG_SH3_3	238	244	PF00018	0.514
LIG_SH3_3	273	279	PF00018	0.436
LIG_SUMO_SIM_par_1	181	186	PF11976	0.306
LIG_SUMO_SIM_par_1	278	284	PF11976	0.424
LIG_UBA3_1	173	180	PF00899	0.382
MOD_CDK_SPK_2	226	231	PF00069	0.410
MOD_CDK_SPxK_1	61	67	PF00069	0.591
MOD_CK1_1	136	142	PF00069	0.500
MOD_CK1_1	209	215	PF00069	0.464
MOD_CK1_1	6	12	PF00069	0.512
MOD_CK2_1	136	142	PF00069	0.434
MOD_GlcNHglycan	135	138	PF01048	0.562
MOD_GlcNHglycan	208	211	PF01048	0.407
MOD_GlcNHglycan	270	273	PF01048	0.503
MOD_GSK3_1	148	155	PF00069	0.559
MOD_GSK3_1	179	186	PF00069	0.363
MOD_GSK3_1	209	216	PF00069	0.315
MOD_LATS_1	83	89	PF00433	0.442
MOD_NEK2_1	237	242	PF00069	0.430
MOD_PKA_2	268	274	PF00069	0.498
MOD_Plk_1	232	238	PF00069	0.375
MOD_Plk_4	136	142	PF00069	0.454
MOD_Plk_4	232	238	PF00069	0.366
MOD_Plk_4	72	78	PF00069	0.572
MOD_ProDKin_1	148	154	PF00069	0.558
MOD_ProDKin_1	183	189	PF00069	0.383
MOD_ProDKin_1	209	215	PF00069	0.430
MOD_ProDKin_1	226	232	PF00069	0.301
MOD_ProDKin_1	61	67	PF00069	0.591
MOD_SUMO_for_1	230	233	PF00179	0.459
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.486
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.455
TRG_ENDOCYTIC_2	222	225	PF00928	0.539
TRG_ENDOCYTIC_2	47	50	PF00928	0.406
TRG_ER_diArg_1	204	206	PF00400	0.415
TRG_ER_diArg_1	29	32	PF00400	0.477
TRG_NLS_MonoExtN_4	106	112	PF00514	0.619
TRG_NLS_MonoExtN_4	294	300	PF00514	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P502	Leptomonas seymouri	90%	99%
A0A0S4JH47	Bodo saltans	63%	100%
A0A1X0NTC0	Trypanosomatidae	75%	100%
A0A3R7M618	Trypanosoma rangeli	75%	100%
A0A451EJM0	Leishmania donovani	98%	100%
A4H3I7	Leishmania braziliensis	95%	100%
C9ZSG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
C9ZSK4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AG34	Leishmania infantum	98%	100%
E9AJQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5B5Z4	Trypanosoma cruzi	75%	100%