Putative acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyltransferase, putative

Species:

Leishmania major

UniProt:

E9ACG0_LEIMA

TriTrypDb:

LmjF.03.0130 , LMJLV39_030006300 , LMJSD75_030006300

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031248	protein acetyltransferase complex	3	2
GO:0031414	N-terminal protein acetyltransferase complex	4	2
GO:0031415	NatA complex	5	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902493	acetyltransferase complex	4	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

E9ACG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACG0

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	2
GO:0006475	internal protein amino acid acetylation	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	2
GO:0007062	sister chromatid cohesion	3	2
GO:0007064	mitotic sister chromatid cohesion	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016570	histone modification	5	2
GO:0016573	histone acetylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0018393	internal peptidyl-lysine acetylation	8	2
GO:0018394	peptidyl-lysine acetylation	7	2
GO:0019538	protein metabolic process	3	2
GO:0022402	cell cycle process	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0051276	chromosome organization	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1903047	mitotic cell cycle process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008080	N-acetyltransferase activity	6	2
GO:0016407	acetyltransferase activity	5	11
GO:0016410	N-acyltransferase activity	5	2
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.395
CLV_NRD_NRD_1	167	169	PF00675	0.385
CLV_PCSK_KEX2_1	167	169	PF00082	0.465
CLV_PCSK_SKI1_1	78	82	PF00082	0.329
DOC_CYCLIN_yClb1_LxF_4	58	64	PF00134	0.332
DOC_MAPK_gen_1	120	128	PF00069	0.297
DOC_MAPK_MEF2A_6	120	128	PF00069	0.303
DOC_WW_Pin1_4	131	136	PF00397	0.297
LIG_14-3-3_CanoR_1	106	112	PF00244	0.352
LIG_14-3-3_CanoR_1	52	56	PF00244	0.342
LIG_Actin_WH2_2	87	104	PF00022	0.426
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_FHA_1	125	131	PF00498	0.375
LIG_FHA_1	71	77	PF00498	0.253
LIG_FHA_1	89	95	PF00498	0.271
LIG_FHA_2	154	160	PF00498	0.417
LIG_FHA_2	77	83	PF00498	0.273
LIG_GBD_Chelix_1	68	76	PF00786	0.332
LIG_LIR_Apic_2	34	39	PF02991	0.338
LIG_LIR_Gen_1	152	163	PF02991	0.422
LIG_LIR_Gen_1	54	63	PF02991	0.396
LIG_LIR_Nem_3	152	158	PF02991	0.426
LIG_LIR_Nem_3	44	50	PF02991	0.260
LIG_LIR_Nem_3	54	58	PF02991	0.337
LIG_LIR_Nem_3	7	13	PF02991	0.493
LIG_LIR_Nem_3	96	101	PF02991	0.316
LIG_MAD2	31	39	PF02301	0.383
LIG_SH2_CRK	36	40	PF00017	0.379
LIG_SH2_GRB2like	46	49	PF00017	0.336
LIG_SH2_STAP1	42	46	PF00017	0.267
LIG_SH2_STAP1	5	9	PF00017	0.297
LIG_SH2_STAT5	155	158	PF00017	0.481
LIG_SH2_STAT5	36	39	PF00017	0.330
LIG_SH2_STAT5	42	45	PF00017	0.255
LIG_SH2_STAT5	50	53	PF00017	0.224
LIG_SH2_STAT5	88	91	PF00017	0.246
LIG_SH3_3	129	135	PF00018	0.297
LIG_SH3_3	167	173	PF00018	0.396
LIG_SUMO_SIM_par_1	122	127	PF11976	0.388
LIG_TRAF2_1	4	7	PF00917	0.419
MOD_CDK_SPxxK_3	131	138	PF00069	0.256
MOD_CK2_1	51	57	PF00069	0.457
MOD_CK2_1	78	84	PF00069	0.271
MOD_GlcNHglycan	112	115	PF01048	0.358
MOD_LATS_1	100	106	PF00433	0.281
MOD_N-GLC_1	116	121	PF02516	0.329
MOD_N-GLC_1	21	26	PF02516	0.456
MOD_NEK2_1	107	112	PF00069	0.304
MOD_NEK2_1	21	26	PF00069	0.456
MOD_NEK2_1	68	73	PF00069	0.267
MOD_NEK2_1	76	81	PF00069	0.307
MOD_NEK2_2	70	75	PF00069	0.253
MOD_PKA_2	51	57	PF00069	0.365
MOD_Plk_1	21	27	PF00069	0.411
MOD_Plk_4	107	113	PF00069	0.288
MOD_Plk_4	42	48	PF00069	0.311
MOD_ProDKin_1	131	137	PF00069	0.297
MOD_SUMO_rev_2	2	10	PF00179	0.447
TRG_DiLeu_BaEn_1	146	151	PF01217	0.457
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.273
TRG_ENDOCYTIC_2	140	143	PF00928	0.253
TRG_ENDOCYTIC_2	155	158	PF00928	0.332
TRG_ENDOCYTIC_2	64	67	PF00928	0.356
TRG_ENDOCYTIC_2	98	101	PF00928	0.253
TRG_ER_diArg_1	120	123	PF00400	0.388
TRG_ER_diArg_1	166	168	PF00400	0.443
TRG_ER_diLys_1	179	182	PF00400	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L1	Leptomonas seymouri	78%	100%
A0A0S4JJ81	Bodo saltans	48%	100%
A0A1X0P8P4	Trypanosomatidae	56%	88%
A0A422N7F8	Trypanosoma rangeli	55%	90%
A0A451EJL8	Leishmania donovani	98%	100%
A3KPA3	Danio rerio	27%	75%
A4H3I5	Leishmania braziliensis	93%	100%
A8E5V7	Xenopus tropicalis	27%	75%
D0A220	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	89%
E9AG32	Leishmania infantum	98%	100%
E9AJP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q0IIJ0	Bos taurus	32%	100%
Q17QK9	Bos taurus	26%	75%
Q3MHC1	Rattus norvegicus	26%	75%
Q5RF28	Pongo abelii	32%	100%
Q5XGA9	Xenopus tropicalis	34%	100%
Q6DBY2	Danio rerio	33%	100%
Q6GP53	Xenopus laevis	34%	100%
Q6PGB6	Mus musculus	32%	100%
Q9DBU2	Mus musculus	26%	75%
Q9GZZ1	Homo sapiens	32%	100%
Q9H7X0	Homo sapiens	26%	75%
Q9NHD5	Drosophila melanogaster	33%	99%