Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACF9_LEIMA

TriTrypDb:

LmjF.03.0120 , LMJLV39_030006200 , LMJSD75_030006200

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	6
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

E9ACF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACF9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0019900	kinase binding	4	2
GO:0019901	protein kinase binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	747	751	PF00656	0.593
CLV_C14_Caspase3-7	80	84	PF00656	0.544
CLV_C14_Caspase3-7	921	925	PF00656	0.561
CLV_NRD_NRD_1	194	196	PF00675	0.531
CLV_NRD_NRD_1	298	300	PF00675	0.629
CLV_NRD_NRD_1	339	341	PF00675	0.707
CLV_NRD_NRD_1	503	505	PF00675	0.538
CLV_NRD_NRD_1	517	519	PF00675	0.525
CLV_NRD_NRD_1	588	590	PF00675	0.546
CLV_NRD_NRD_1	723	725	PF00675	0.771
CLV_NRD_NRD_1	764	766	PF00675	0.632
CLV_PCSK_FUR_1	192	196	PF00082	0.526
CLV_PCSK_KEX2_1	194	196	PF00082	0.531
CLV_PCSK_KEX2_1	298	300	PF00082	0.629
CLV_PCSK_KEX2_1	339	341	PF00082	0.755
CLV_PCSK_KEX2_1	503	505	PF00082	0.628
CLV_PCSK_KEX2_1	507	509	PF00082	0.613
CLV_PCSK_KEX2_1	517	519	PF00082	0.525
CLV_PCSK_KEX2_1	552	554	PF00082	0.569
CLV_PCSK_KEX2_1	588	590	PF00082	0.546
CLV_PCSK_KEX2_1	723	725	PF00082	0.771
CLV_PCSK_KEX2_1	764	766	PF00082	0.632
CLV_PCSK_KEX2_1	907	909	PF00082	0.603
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.653
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.569
CLV_PCSK_PC1ET2_1	907	909	PF00082	0.603
CLV_PCSK_PC7_1	503	509	PF00082	0.537
CLV_PCSK_SKI1_1	250	254	PF00082	0.716
CLV_PCSK_SKI1_1	339	343	PF00082	0.724
CLV_PCSK_SKI1_1	359	363	PF00082	0.513
CLV_PCSK_SKI1_1	534	538	PF00082	0.583
CLV_PCSK_SKI1_1	67	71	PF00082	0.553
CLV_PCSK_SKI1_1	724	728	PF00082	0.667
CLV_PCSK_SKI1_1	764	768	PF00082	0.623
CLV_PCSK_SKI1_1	913	917	PF00082	0.705
CLV_Separin_Metazoa	134	138	PF03568	0.467
DEG_APCC_DBOX_1	129	137	PF00400	0.491
DEG_APCC_DBOX_1	196	204	PF00400	0.525
DEG_APCC_DBOX_1	268	276	PF00400	0.668
DEG_APCC_DBOX_1	53	61	PF00400	0.485
DEG_APCC_DBOX_1	594	602	PF00400	0.516
DOC_ANK_TNKS_1	673	680	PF00023	0.591
DOC_CKS1_1	246	251	PF01111	0.709
DOC_CKS1_1	35	40	PF01111	0.507
DOC_CKS1_1	425	430	PF01111	0.694
DOC_CYCLIN_RxL_1	594	602	PF00134	0.516
DOC_CYCLIN_RxL_1	721	731	PF00134	0.664
DOC_MAPK_gen_1	22	31	PF00069	0.476
DOC_PP2B_LxvP_1	894	897	PF13499	0.639
DOC_PP4_FxxP_1	35	38	PF00568	0.508
DOC_PP4_FxxP_1	462	465	PF00568	0.639
DOC_USP7_MATH_1	305	309	PF00917	0.704
DOC_USP7_MATH_1	311	315	PF00917	0.629
DOC_USP7_MATH_1	5	9	PF00917	0.626
DOC_USP7_MATH_1	649	653	PF00917	0.757
DOC_USP7_MATH_1	65	69	PF00917	0.509
DOC_USP7_MATH_1	655	659	PF00917	0.629
DOC_USP7_MATH_1	662	666	PF00917	0.558
DOC_USP7_MATH_1	681	685	PF00917	0.575
DOC_USP7_MATH_1	717	721	PF00917	0.625
DOC_USP7_MATH_1	730	734	PF00917	0.554
DOC_USP7_MATH_1	745	749	PF00917	0.621
DOC_USP7_MATH_1	752	756	PF00917	0.579
DOC_USP7_MATH_1	810	814	PF00917	0.734
DOC_USP7_MATH_1	844	848	PF00917	0.721
DOC_USP7_UBL2_3	913	917	PF12436	0.609
DOC_WW_Pin1_4	174	179	PF00397	0.491
DOC_WW_Pin1_4	239	244	PF00397	0.704
DOC_WW_Pin1_4	245	250	PF00397	0.669
DOC_WW_Pin1_4	292	297	PF00397	0.641
DOC_WW_Pin1_4	322	327	PF00397	0.761
DOC_WW_Pin1_4	34	39	PF00397	0.517
DOC_WW_Pin1_4	386	391	PF00397	0.699
DOC_WW_Pin1_4	424	429	PF00397	0.693
DOC_WW_Pin1_4	440	445	PF00397	0.715
DOC_WW_Pin1_4	461	466	PF00397	0.790
DOC_WW_Pin1_4	624	629	PF00397	0.658
DOC_WW_Pin1_4	657	662	PF00397	0.844
DOC_WW_Pin1_4	666	671	PF00397	0.707
DOC_WW_Pin1_4	791	796	PF00397	0.602
DOC_WW_Pin1_4	803	808	PF00397	0.616
DOC_WW_Pin1_4	840	845	PF00397	0.679
DOC_WW_Pin1_4	872	877	PF00397	0.716
LIG_14-3-3_CanoR_1	120	125	PF00244	0.475
LIG_14-3-3_CanoR_1	156	161	PF00244	0.474
LIG_14-3-3_CanoR_1	195	201	PF00244	0.480
LIG_14-3-3_CanoR_1	229	237	PF00244	0.670
LIG_14-3-3_CanoR_1	470	478	PF00244	0.597
LIG_14-3-3_CanoR_1	517	527	PF00244	0.525
LIG_14-3-3_CanoR_1	556	566	PF00244	0.578
LIG_14-3-3_CanoR_1	575	580	PF00244	0.342
LIG_14-3-3_CanoR_1	664	670	PF00244	0.711
LIG_14-3-3_CanoR_1	71	77	PF00244	0.537
LIG_14-3-3_CanoR_1	723	727	PF00244	0.764
LIG_14-3-3_CanoR_1	78	82	PF00244	0.442
LIG_14-3-3_CanoR_1	845	854	PF00244	0.713
LIG_14-3-3_CanoR_1	899	909	PF00244	0.558
LIG_Actin_WH2_2	523	540	PF00022	0.533
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BIR_III_4	809	813	PF00653	0.656
LIG_Clathr_ClatBox_1	207	211	PF01394	0.491
LIG_CtBP_PxDLS_1	86	90	PF00389	0.402
LIG_DLG_GKlike_1	120	127	PF00625	0.475
LIG_eIF4E_1	76	82	PF01652	0.482
LIG_EVH1_1	894	898	PF00568	0.639
LIG_FHA_1	120	126	PF00498	0.332
LIG_FHA_1	144	150	PF00498	0.605
LIG_FHA_1	175	181	PF00498	0.523
LIG_FHA_1	225	231	PF00498	0.534
LIG_FHA_1	480	486	PF00498	0.693
LIG_FHA_1	613	619	PF00498	0.553
LIG_FHA_1	642	648	PF00498	0.678
LIG_FHA_1	691	697	PF00498	0.595
LIG_FHA_1	714	720	PF00498	0.627
LIG_FHA_1	869	875	PF00498	0.707
LIG_FHA_2	197	203	PF00498	0.553
LIG_FHA_2	35	41	PF00498	0.506
LIG_FHA_2	401	407	PF00498	0.736
LIG_FHA_2	46	52	PF00498	0.469
LIG_FHA_2	541	547	PF00498	0.598
LIG_FHA_2	569	575	PF00498	0.521
LIG_FHA_2	576	582	PF00498	0.489
LIG_FHA_2	585	591	PF00498	0.399
LIG_FHA_2	804	810	PF00498	0.668
LIG_FHA_2	864	870	PF00498	0.704
LIG_GBD_Chelix_1	688	696	PF00786	0.620
LIG_GBD_Chelix_1	718	726	PF00786	0.639
LIG_LIR_Gen_1	115	125	PF02991	0.461
LIG_LIR_Gen_1	571	580	PF02991	0.465
LIG_LIR_Gen_1	694	703	PF02991	0.641
LIG_LIR_Gen_1	75	82	PF02991	0.568
LIG_LIR_Nem_3	115	121	PF02991	0.570
LIG_LIR_Nem_3	694	700	PF02991	0.655
LIG_LIR_Nem_3	75	79	PF02991	0.558
LIG_PCNA_TLS_4	764	771	PF02747	0.622
LIG_RPA_C_Fungi	513	525	PF08784	0.477
LIG_RPA_C_Fungi	584	596	PF08784	0.540
LIG_SH2_CRK	437	441	PF00017	0.702
LIG_SH2_CRK	697	701	PF00017	0.589
LIG_SH2_CRK	76	80	PF00017	0.602
LIG_SH2_GRB2like	221	224	PF00017	0.589
LIG_SH2_NCK_1	221	225	PF00017	0.512
LIG_SH2_NCK_1	76	80	PF00017	0.481
LIG_SH2_SRC	221	224	PF00017	0.589
LIG_SH2_STAP1	221	225	PF00017	0.585
LIG_SH2_STAP1	580	584	PF00017	0.541
LIG_SH2_STAT3	580	583	PF00017	0.541
LIG_SH2_STAT5	164	167	PF00017	0.628
LIG_SH3_1	331	337	PF00018	0.685
LIG_SH3_2	334	339	PF14604	0.734
LIG_SH3_2	465	470	PF14604	0.643
LIG_SH3_3	183	189	PF00018	0.608
LIG_SH3_3	272	278	PF00018	0.696
LIG_SH3_3	331	337	PF00018	0.805
LIG_SH3_3	347	353	PF00018	0.579
LIG_SH3_3	380	386	PF00018	0.827
LIG_SH3_3	422	428	PF00018	0.707
LIG_SH3_3	462	468	PF00018	0.687
LIG_SH3_3	789	795	PF00018	0.583
LIG_SH3_3	799	805	PF00018	0.613
LIG_SH3_3	838	844	PF00018	0.672
LIG_SH3_3	870	876	PF00018	0.697
LIG_SH3_3	892	898	PF00018	0.575
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.467
LIG_SUMO_SIM_anti_2	869	875	PF11976	0.613
LIG_SUMO_SIM_par_1	206	211	PF11976	0.498
LIG_SUMO_SIM_par_1	42	48	PF11976	0.467
LIG_SUMO_SIM_par_1	85	90	PF11976	0.399
LIG_SUMO_SIM_par_1	869	875	PF11976	0.678
LIG_TRAF2_1	37	40	PF00917	0.506
LIG_TRAF2_2	782	787	PF00917	0.717
LIG_TYR_ITIM	435	440	PF00017	0.723
LIG_UBA3_1	544	552	PF00899	0.569
LIG_WRC_WIRS_1	576	581	PF05994	0.535
LIG_WRC_WIRS_1	767	772	PF05994	0.571
LIG_WW_3	896	900	PF00397	0.544
MOD_CDC14_SPxK_1	295	298	PF00782	0.558
MOD_CDC14_SPxK_1	389	392	PF00782	0.718
MOD_CDC14_SPxK_1	467	470	PF00782	0.692
MOD_CDC14_SPxK_1	669	672	PF00782	0.712
MOD_CDK_SPK_2	245	250	PF00069	0.708
MOD_CDK_SPK_2	840	845	PF00069	0.633
MOD_CDK_SPxK_1	292	298	PF00069	0.561
MOD_CDK_SPxK_1	386	392	PF00069	0.715
MOD_CDK_SPxK_1	464	470	PF00069	0.690
MOD_CDK_SPxK_1	666	672	PF00069	0.719
MOD_CDK_SPxxK_3	292	299	PF00069	0.625
MOD_CDK_SPxxK_3	322	329	PF00069	0.767
MOD_CDK_SPxxK_3	657	664	PF00069	0.729
MOD_CK1_1	206	212	PF00069	0.507
MOD_CK1_1	287	293	PF00069	0.699
MOD_CK1_1	318	324	PF00069	0.686
MOD_CK1_1	424	430	PF00069	0.698
MOD_CK1_1	464	470	PF00069	0.726
MOD_CK1_1	540	546	PF00069	0.476
MOD_CK1_1	554	560	PF00069	0.578
MOD_CK1_1	660	666	PF00069	0.782
MOD_CK1_1	731	737	PF00069	0.700
MOD_CK1_1	755	761	PF00069	0.588
MOD_CK1_1	8	14	PF00069	0.631
MOD_CK1_1	813	819	PF00069	0.720
MOD_CK2_1	196	202	PF00069	0.541
MOD_CK2_1	264	270	PF00069	0.700
MOD_CK2_1	322	328	PF00069	0.686
MOD_CK2_1	34	40	PF00069	0.521
MOD_CK2_1	50	56	PF00069	0.462
MOD_CK2_1	540	546	PF00069	0.476
MOD_CK2_1	568	574	PF00069	0.522
MOD_CK2_1	575	581	PF00069	0.491
MOD_CK2_1	584	590	PF00069	0.398
MOD_CK2_1	603	609	PF00069	0.556
MOD_CK2_1	863	869	PF00069	0.716
MOD_DYRK1A_RPxSP_1	657	661	PF00069	0.576
MOD_GlcNHglycan	10	13	PF01048	0.627
MOD_GlcNHglycan	146	149	PF01048	0.436
MOD_GlcNHglycan	266	269	PF01048	0.723
MOD_GlcNHglycan	281	284	PF01048	0.643
MOD_GlcNHglycan	292	295	PF01048	0.612
MOD_GlcNHglycan	362	365	PF01048	0.683
MOD_GlcNHglycan	366	369	PF01048	0.677
MOD_GlcNHglycan	376	379	PF01048	0.647
MOD_GlcNHglycan	454	457	PF01048	0.801
MOD_GlcNHglycan	553	556	PF01048	0.573
MOD_GlcNHglycan	651	654	PF01048	0.661
MOD_GlcNHglycan	664	667	PF01048	0.733
MOD_GlcNHglycan	729	733	PF01048	0.663
MOD_GlcNHglycan	747	750	PF01048	0.561
MOD_GlcNHglycan	787	791	PF01048	0.596
MOD_GlcNHglycan	812	815	PF01048	0.617
MOD_GlcNHglycan	847	850	PF01048	0.675
MOD_GlcNHglycan	902	905	PF01048	0.654
MOD_GSK3_1	1	8	PF00069	0.607
MOD_GSK3_1	172	179	PF00069	0.515
MOD_GSK3_1	224	231	PF00069	0.610
MOD_GSK3_1	284	291	PF00069	0.745
MOD_GSK3_1	311	318	PF00069	0.700
MOD_GSK3_1	339	346	PF00069	0.831
MOD_GSK3_1	360	367	PF00069	0.714
MOD_GSK3_1	436	443	PF00069	0.724
MOD_GSK3_1	575	582	PF00069	0.538
MOD_GSK3_1	599	606	PF00069	0.511
MOD_GSK3_1	660	667	PF00069	0.792
MOD_GSK3_1	713	720	PF00069	0.649
MOD_GSK3_1	752	759	PF00069	0.569
MOD_GSK3_1	835	842	PF00069	0.678
MOD_GSK3_1	845	852	PF00069	0.614
MOD_GSK3_1	868	875	PF00069	0.744
MOD_GSK3_1	918	925	PF00069	0.620
MOD_N-GLC_1	311	316	PF02516	0.579
MOD_N-GLC_1	374	379	PF02516	0.678
MOD_N-GLC_1	400	405	PF02516	0.589
MOD_N-GLC_1	603	608	PF02516	0.504
MOD_N-GLC_1	641	646	PF02516	0.713
MOD_N-GLC_1	72	77	PF02516	0.461
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	114	119	PF00069	0.441
MOD_NEK2_1	172	177	PF00069	0.497
MOD_NEK2_1	251	256	PF00069	0.596
MOD_NEK2_1	355	360	PF00069	0.736
MOD_NEK2_1	478	483	PF00069	0.577
MOD_NEK2_1	485	490	PF00069	0.472
MOD_NEK2_1	50	55	PF00069	0.459
MOD_NEK2_1	579	584	PF00069	0.540
MOD_NEK2_1	599	604	PF00069	0.661
MOD_NEK2_1	696	701	PF00069	0.633
MOD_NEK2_1	72	77	PF00069	0.461
MOD_NEK2_1	722	727	PF00069	0.725
MOD_NEK2_1	87	92	PF00069	0.321
MOD_NEK2_2	271	276	PF00069	0.567
MOD_NEK2_2	436	441	PF00069	0.675
MOD_PIKK_1	103	109	PF00454	0.431
MOD_PIKK_1	253	259	PF00454	0.737
MOD_PIKK_1	471	477	PF00454	0.596
MOD_PIKK_1	518	524	PF00454	0.524
MOD_PIKK_1	525	531	PF00454	0.459
MOD_PIKK_1	568	574	PF00454	0.507
MOD_PIKK_1	579	585	PF00454	0.465
MOD_PIKK_1	740	746	PF00454	0.681
MOD_PIKK_1	813	819	PF00454	0.674
MOD_PIKK_1	87	93	PF00454	0.487
MOD_PKA_1	339	345	PF00069	0.724
MOD_PKA_2	119	125	PF00069	0.470
MOD_PKA_2	144	150	PF00069	0.465
MOD_PKA_2	196	202	PF00069	0.481
MOD_PKA_2	228	234	PF00069	0.742
MOD_PKA_2	339	345	PF00069	0.824
MOD_PKA_2	537	543	PF00069	0.542
MOD_PKA_2	557	563	PF00069	0.581
MOD_PKA_2	599	605	PF00069	0.603
MOD_PKA_2	722	728	PF00069	0.661
MOD_PKA_2	77	83	PF00069	0.490
MOD_PKA_2	8	14	PF00069	0.631
MOD_PKA_2	844	850	PF00069	0.703
MOD_Plk_1	114	120	PF00069	0.448
MOD_Plk_1	311	317	PF00069	0.652
MOD_Plk_1	421	427	PF00069	0.700
MOD_Plk_1	525	531	PF00069	0.531
MOD_Plk_1	58	64	PF00069	0.526
MOD_Plk_1	72	78	PF00069	0.465
MOD_Plk_1	868	874	PF00069	0.650
MOD_Plk_1	885	891	PF00069	0.562
MOD_Plk_2-3	394	400	PF00069	0.626
MOD_Plk_2-3	863	869	PF00069	0.701
MOD_Plk_4	120	126	PF00069	0.365
MOD_Plk_4	203	209	PF00069	0.516
MOD_Plk_4	485	491	PF00069	0.561
MOD_Plk_4	540	546	PF00069	0.590
MOD_Plk_4	575	581	PF00069	0.538
MOD_Plk_4	691	697	PF00069	0.576
MOD_Plk_4	766	772	PF00069	0.542
MOD_Plk_4	868	874	PF00069	0.719
MOD_Plk_4	918	924	PF00069	0.712
MOD_ProDKin_1	174	180	PF00069	0.486
MOD_ProDKin_1	239	245	PF00069	0.704
MOD_ProDKin_1	292	298	PF00069	0.643
MOD_ProDKin_1	322	328	PF00069	0.764
MOD_ProDKin_1	34	40	PF00069	0.512
MOD_ProDKin_1	386	392	PF00069	0.703
MOD_ProDKin_1	424	430	PF00069	0.695
MOD_ProDKin_1	440	446	PF00069	0.715
MOD_ProDKin_1	461	467	PF00069	0.790
MOD_ProDKin_1	624	630	PF00069	0.659
MOD_ProDKin_1	657	663	PF00069	0.846
MOD_ProDKin_1	666	672	PF00069	0.710
MOD_ProDKin_1	791	797	PF00069	0.604
MOD_ProDKin_1	803	809	PF00069	0.618
MOD_ProDKin_1	840	846	PF00069	0.682
MOD_ProDKin_1	872	878	PF00069	0.716
TRG_DiLeu_BaEn_1	594	599	PF01217	0.554
TRG_DiLeu_LyEn_5	594	599	PF01217	0.554
TRG_ENDOCYTIC_2	437	440	PF00928	0.726
TRG_ENDOCYTIC_2	573	576	PF00928	0.539
TRG_ENDOCYTIC_2	697	700	PF00928	0.664
TRG_ENDOCYTIC_2	76	79	PF00928	0.594
TRG_ER_diArg_1	192	195	PF00400	0.540
TRG_ER_diArg_1	298	301	PF00400	0.629
TRG_ER_diArg_1	338	340	PF00400	0.708
TRG_ER_diArg_1	458	461	PF00400	0.743
TRG_ER_diArg_1	502	504	PF00400	0.546
TRG_ER_diArg_1	517	519	PF00400	0.525
TRG_ER_diArg_1	595	598	PF00400	0.554
TRG_ER_diArg_1	722	724	PF00400	0.768
TRG_ER_diArg_1	763	765	PF00400	0.736
TRG_NES_CRM1_1	100	115	PF08389	0.431
TRG_NES_CRM1_1	42	56	PF08389	0.453
TRG_NES_CRM1_1	522	535	PF08389	0.530
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	518	522	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	589	594	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	724	729	PF00026	0.670
TRG_Pf-PMV_PEXEL_1	764	768	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H524	Leishmania donovani	90%	100%
A4H3I4	Leishmania braziliensis	71%	100%
E9AG31	Leishmania infantum	91%	100%
E9AJP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%