Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACF9_LEIMA

TriTrypDb:

LmjF.03.0120 , LMJLV39_030006200 , LMJSD75_030006200

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	4
GO:0005930	axoneme	2	2
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	4

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Expansion

Sequence features

E9ACF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACF9

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0019900	kinase binding	4	2
GO:0019901	protein kinase binding	5	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	747	751	PF00656	0.593
CLV_C14_Caspase3-7	80	84	PF00656	0.544
CLV_C14_Caspase3-7	921	925	PF00656	0.561
CLV_NRD_NRD_1	194	196	PF00675	0.531
CLV_NRD_NRD_1	298	300	PF00675	0.629
CLV_NRD_NRD_1	339	341	PF00675	0.707
CLV_NRD_NRD_1	503	505	PF00675	0.538
CLV_NRD_NRD_1	517	519	PF00675	0.525
CLV_NRD_NRD_1	588	590	PF00675	0.546
CLV_NRD_NRD_1	723	725	PF00675	0.771

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H524	Leishmania donovani	90%	100%
A4H3I4	Leishmania braziliensis	71%	100%
E9AG31	Leishmania infantum	91%	100%
E9AJP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%

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