Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACF8_LEIMA

TriTrypDb:

LmjF.03.0110 , LMJLV39_030006100 , LMJSD75_030006100

Length:

955

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.670
CLV_C14_Caspase3-7	512	516	PF00656	0.749
CLV_C14_Caspase3-7	700	704	PF00656	0.789
CLV_C14_Caspase3-7	99	103	PF00656	0.475
CLV_NRD_NRD_1	142	144	PF00675	0.556
CLV_NRD_NRD_1	261	263	PF00675	0.728
CLV_NRD_NRD_1	276	278	PF00675	0.600
CLV_NRD_NRD_1	364	366	PF00675	0.713
CLV_NRD_NRD_1	387	389	PF00675	0.825
CLV_NRD_NRD_1	619	621	PF00675	0.643
CLV_NRD_NRD_1	753	755	PF00675	0.644
CLV_NRD_NRD_1	78	80	PF00675	0.457
CLV_NRD_NRD_1	902	904	PF00675	0.819
CLV_NRD_NRD_1	92	94	PF00675	0.425
CLV_PCSK_KEX2_1	142	144	PF00082	0.556
CLV_PCSK_KEX2_1	182	184	PF00082	0.577
CLV_PCSK_KEX2_1	260	262	PF00082	0.727
CLV_PCSK_KEX2_1	276	278	PF00082	0.583
CLV_PCSK_KEX2_1	364	366	PF00082	0.713
CLV_PCSK_KEX2_1	387	389	PF00082	0.825
CLV_PCSK_KEX2_1	546	548	PF00082	0.805
CLV_PCSK_KEX2_1	57	59	PF00082	0.535
CLV_PCSK_KEX2_1	753	755	PF00082	0.644
CLV_PCSK_KEX2_1	92	94	PF00082	0.532
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.577
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.731
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.535
CLV_PCSK_PC7_1	383	389	PF00082	0.821
CLV_PCSK_PC7_1	88	94	PF00082	0.534
CLV_PCSK_SKI1_1	255	259	PF00082	0.662
CLV_PCSK_SKI1_1	572	576	PF00082	0.699
CLV_PCSK_SKI1_1	67	71	PF00082	0.618
CLV_PCSK_SKI1_1	710	714	PF00082	0.465
CLV_PCSK_SKI1_1	80	84	PF00082	0.594
CLV_PCSK_SKI1_1	812	816	PF00082	0.515
CLV_PCSK_SKI1_1	939	943	PF00082	0.812
CLV_Separin_Metazoa	848	852	PF03568	0.602
DEG_COP1_1	18	27	PF00400	0.501
DEG_Nend_UBRbox_3	1	3	PF02207	0.540
DEG_SCF_FBW7_1	829	834	PF00400	0.529
DEG_SPOP_SBC_1	297	301	PF00917	0.783
DEG_SPOP_SBC_1	305	309	PF00917	0.779
DEG_SPOP_SBC_1	813	817	PF00917	0.636
DEG_SPOP_SBC_1	914	918	PF00917	0.740
DOC_CYCLIN_yClb5_NLxxxL_5	601	608	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	13	19	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.573
DOC_MAPK_gen_1	142	153	PF00069	0.451
DOC_MAPK_gen_1	67	77	PF00069	0.452
DOC_MAPK_gen_1	877	885	PF00069	0.554
DOC_MAPK_MEF2A_6	142	151	PF00069	0.562
DOC_MAPK_MEF2A_6	6	15	PF00069	0.450
DOC_MAPK_MEF2A_6	70	77	PF00069	0.599
DOC_MAPK_NFAT4_5	146	154	PF00069	0.572
DOC_MIT_MIM_1	138	147	PF04212	0.560
DOC_PP2B_LxvP_1	13	16	PF13499	0.475
DOC_PP2B_LxvP_1	147	150	PF13499	0.559
DOC_PP4_FxxP_1	153	156	PF00568	0.564
DOC_USP7_MATH_1	23	27	PF00917	0.505
DOC_USP7_MATH_1	297	301	PF00917	0.806
DOC_USP7_MATH_1	305	309	PF00917	0.756
DOC_USP7_MATH_1	32	36	PF00917	0.499
DOC_USP7_MATH_1	330	334	PF00917	0.700
DOC_USP7_MATH_1	390	394	PF00917	0.829
DOC_USP7_MATH_1	420	424	PF00917	0.810
DOC_USP7_MATH_1	426	430	PF00917	0.728
DOC_USP7_MATH_1	436	440	PF00917	0.567
DOC_USP7_MATH_1	443	447	PF00917	0.551
DOC_USP7_MATH_1	457	461	PF00917	0.464
DOC_USP7_MATH_1	666	670	PF00917	0.803
DOC_USP7_MATH_1	679	683	PF00917	0.595
DOC_USP7_MATH_1	714	718	PF00917	0.601
DOC_USP7_MATH_1	831	835	PF00917	0.756
DOC_USP7_MATH_1	859	863	PF00917	0.628
DOC_USP7_MATH_1	879	883	PF00917	0.522
DOC_USP7_MATH_1	887	891	PF00917	0.659
DOC_USP7_MATH_1	914	918	PF00917	0.722
DOC_WW_Pin1_4	298	303	PF00397	0.826
DOC_WW_Pin1_4	307	312	PF00397	0.695
DOC_WW_Pin1_4	316	321	PF00397	0.546
DOC_WW_Pin1_4	35	40	PF00397	0.509
DOC_WW_Pin1_4	497	502	PF00397	0.840
DOC_WW_Pin1_4	549	554	PF00397	0.858
DOC_WW_Pin1_4	691	696	PF00397	0.775
DOC_WW_Pin1_4	825	830	PF00397	0.709
LIG_14-3-3_CanoR_1	281	289	PF00244	0.733
LIG_14-3-3_CanoR_1	296	302	PF00244	0.565
LIG_14-3-3_CanoR_1	335	342	PF00244	0.849
LIG_14-3-3_CanoR_1	364	374	PF00244	0.812
LIG_14-3-3_CanoR_1	397	407	PF00244	0.607
LIG_14-3-3_CanoR_1	649	656	PF00244	0.695
LIG_14-3-3_CanoR_1	681	687	PF00244	0.807
LIG_14-3-3_CanoR_1	756	762	PF00244	0.622
LIG_14-3-3_CanoR_1	833	839	PF00244	0.661
LIG_14-3-3_CanoR_1	88	94	PF00244	0.611
LIG_14-3-3_CanoR_1	939	945	PF00244	0.765
LIG_Actin_WH2_2	147	162	PF00022	0.461
LIG_Actin_WH2_2	835	853	PF00022	0.616
LIG_BRCT_BRCA1_1	186	190	PF00533	0.593
LIG_CaM_IQ_9	745	761	PF13499	0.651
LIG_CaM_NSCaTE_8	626	633	PF13499	0.682
LIG_EVH1_1	36	40	PF00568	0.508
LIG_FHA_1	159	165	PF00498	0.495
LIG_FHA_1	168	174	PF00498	0.441
LIG_FHA_1	197	203	PF00498	0.559
LIG_FHA_1	208	214	PF00498	0.398
LIG_FHA_1	336	342	PF00498	0.846
LIG_FHA_1	517	523	PF00498	0.630
LIG_FHA_1	581	587	PF00498	0.706
LIG_FHA_1	591	597	PF00498	0.573
LIG_FHA_1	72	78	PF00498	0.582
LIG_FHA_1	800	806	PF00498	0.636
LIG_FHA_1	940	946	PF00498	0.808
LIG_FHA_2	236	242	PF00498	0.651
LIG_FHA_2	592	598	PF00498	0.730
LIG_FHA_2	778	784	PF00498	0.543
LIG_FHA_2	914	920	PF00498	0.583
LIG_GBD_Chelix_1	797	805	PF00786	0.558
LIG_Integrin_RGD_1	510	512	PF01839	0.823
LIG_LIR_Gen_1	165	176	PF02991	0.547
LIG_LIR_Gen_1	95	105	PF02991	0.485
LIG_LIR_Nem_3	138	144	PF02991	0.453
LIG_LIR_Nem_3	165	171	PF02991	0.554
LIG_LIR_Nem_3	755	761	PF02991	0.624
LIG_LIR_Nem_3	792	798	PF02991	0.643
LIG_LIR_Nem_3	95	100	PF02991	0.518
LIG_NRBOX	474	480	PF00104	0.659
LIG_NRBOX	940	946	PF00104	0.808
LIG_PCNA_yPIPBox_3	469	483	PF02747	0.642
LIG_PDZ_Class_2	950	955	PF00595	0.688
LIG_Pex14_1	137	141	PF04695	0.565
LIG_Pex14_2	110	114	PF04695	0.521
LIG_Pex14_2	186	190	PF04695	0.593
LIG_PTAP_UEV_1	376	381	PF05743	0.609
LIG_PTB_Apo_2	108	115	PF02174	0.555
LIG_SH2_CRK	97	101	PF00017	0.567
LIG_SH2_SRC	526	529	PF00017	0.419
LIG_SH2_STAP1	526	530	PF00017	0.644
LIG_SH2_STAP1	888	892	PF00017	0.695
LIG_SH2_STAP1	97	101	PF00017	0.489
LIG_SH2_STAT5	175	178	PF00017	0.500
LIG_SH2_STAT5	201	204	PF00017	0.476
LIG_SH3_1	547	553	PF00018	0.650
LIG_SH3_2	322	327	PF14604	0.727
LIG_SH3_3	219	225	PF00018	0.637
LIG_SH3_3	318	324	PF00018	0.831
LIG_SH3_3	34	40	PF00018	0.522
LIG_SH3_3	371	377	PF00018	0.773
LIG_SH3_3	416	422	PF00018	0.701
LIG_SH3_3	495	501	PF00018	0.713
LIG_SH3_3	547	553	PF00018	0.777
LIG_SH3_3	554	560	PF00018	0.814
LIG_SH3_3	683	689	PF00018	0.687
LIG_SH3_3	873	879	PF00018	0.592
LIG_Sin3_3	209	216	PF02671	0.567
LIG_SUMO_SIM_par_1	593	600	PF11976	0.642
LIG_SUMO_SIM_par_1	9	14	PF11976	0.436
LIG_TRAF2_1	245	248	PF00917	0.650
LIG_TRAF2_1	529	532	PF00917	0.412
LIG_TRAF2_1	780	783	PF00917	0.666
LIG_WRC_WIRS_1	24	29	PF05994	0.511
LIG_WRC_WIRS_1	82	87	PF05994	0.567
LIG_WW_3	320	324	PF00397	0.810
MOD_CDK_SPK_2	497	502	PF00069	0.817
MOD_CDK_SPxK_1	827	833	PF00069	0.537
MOD_CDK_SPxxK_3	307	314	PF00069	0.768
MOD_CDK_SPxxK_3	316	323	PF00069	0.647
MOD_CDK_SPxxK_3	497	504	PF00069	0.837
MOD_CK1_1	265	271	PF00069	0.796
MOD_CK1_1	280	286	PF00069	0.597
MOD_CK1_1	301	307	PF00069	0.820
MOD_CK1_1	333	339	PF00069	0.823
MOD_CK1_1	35	41	PF00069	0.714
MOD_CK1_1	375	381	PF00069	0.745
MOD_CK1_1	386	392	PF00069	0.780
MOD_CK1_1	393	399	PF00069	0.650
MOD_CK1_1	402	408	PF00069	0.588
MOD_CK1_1	411	417	PF00069	0.540
MOD_CK1_1	429	435	PF00069	0.626
MOD_CK1_1	439	445	PF00069	0.625
MOD_CK1_1	489	495	PF00069	0.706
MOD_CK1_1	551	557	PF00069	0.831
MOD_CK1_1	566	572	PF00069	0.542
MOD_CK1_1	682	688	PF00069	0.780
MOD_CK1_1	691	697	PF00069	0.673
MOD_CK1_1	834	840	PF00069	0.661
MOD_CK1_1	926	932	PF00069	0.815
MOD_CK1_1	95	101	PF00069	0.552
MOD_CK2_1	15	21	PF00069	0.492
MOD_CK2_1	235	241	PF00069	0.644
MOD_CK2_1	526	532	PF00069	0.418
MOD_CK2_1	777	783	PF00069	0.665
MOD_Cter_Amidation	77	80	PF01082	0.597
MOD_GlcNHglycan	185	189	PF01048	0.503
MOD_GlcNHglycan	264	267	PF01048	0.767
MOD_GlcNHglycan	286	289	PF01048	0.789
MOD_GlcNHglycan	303	306	PF01048	0.620
MOD_GlcNHglycan	367	370	PF01048	0.784
MOD_GlcNHglycan	388	391	PF01048	0.862
MOD_GlcNHglycan	404	407	PF01048	0.574
MOD_GlcNHglycan	411	414	PF01048	0.603
MOD_GlcNHglycan	428	431	PF01048	0.573
MOD_GlcNHglycan	433	436	PF01048	0.744
MOD_GlcNHglycan	441	444	PF01048	0.597
MOD_GlcNHglycan	488	491	PF01048	0.751
MOD_GlcNHglycan	565	568	PF01048	0.835
MOD_GlcNHglycan	651	654	PF01048	0.506
MOD_GlcNHglycan	668	671	PF01048	0.700
MOD_GlcNHglycan	690	693	PF01048	0.783
MOD_GlcNHglycan	716	719	PF01048	0.521
MOD_GlcNHglycan	885	888	PF01048	0.641
MOD_GlcNHglycan	904	907	PF01048	0.667
MOD_GlcNHglycan	926	929	PF01048	0.718
MOD_GlcNHglycan	931	934	PF01048	0.686
MOD_GSK3_1	11	18	PF00069	0.460
MOD_GSK3_1	123	130	PF00069	0.673
MOD_GSK3_1	197	204	PF00069	0.587
MOD_GSK3_1	23	30	PF00069	0.487
MOD_GSK3_1	280	287	PF00069	0.772
MOD_GSK3_1	297	304	PF00069	0.613
MOD_GSK3_1	330	337	PF00069	0.821
MOD_GSK3_1	359	366	PF00069	0.778
MOD_GSK3_1	382	389	PF00069	0.835
MOD_GSK3_1	392	399	PF00069	0.661
MOD_GSK3_1	405	412	PF00069	0.585
MOD_GSK3_1	439	446	PF00069	0.739
MOD_GSK3_1	489	496	PF00069	0.742
MOD_GSK3_1	510	517	PF00069	0.689
MOD_GSK3_1	56	63	PF00069	0.544
MOD_GSK3_1	694	701	PF00069	0.643
MOD_GSK3_1	710	717	PF00069	0.552
MOD_GSK3_1	757	764	PF00069	0.614
MOD_GSK3_1	769	776	PF00069	0.421
MOD_GSK3_1	823	830	PF00069	0.584
MOD_GSK3_1	879	886	PF00069	0.702
MOD_GSK3_1	88	95	PF00069	0.458
MOD_GSK3_1	924	931	PF00069	0.646
MOD_N-GLC_1	666	671	PF02516	0.670
MOD_NEK2_1	226	231	PF00069	0.622
MOD_NEK2_1	235	240	PF00069	0.512
MOD_NEK2_1	27	32	PF00069	0.531
MOD_NEK2_1	479	484	PF00069	0.669
MOD_NEK2_1	757	762	PF00069	0.616
MOD_NEK2_1	883	888	PF00069	0.558
MOD_NEK2_2	443	448	PF00069	0.529
MOD_NEK2_2	65	70	PF00069	0.525
MOD_PIKK_1	127	133	PF00454	0.619
MOD_PIKK_1	328	334	PF00454	0.743
MOD_PIKK_1	372	378	PF00454	0.852
MOD_PIKK_1	532	538	PF00454	0.660
MOD_PIKK_1	679	685	PF00454	0.810
MOD_PIKK_1	799	805	PF00454	0.639
MOD_PIKK_1	814	820	PF00454	0.518
MOD_PK_1	160	166	PF00069	0.485
MOD_PKA_1	260	266	PF00069	0.664
MOD_PKA_1	92	98	PF00069	0.526
MOD_PKA_2	260	266	PF00069	0.664
MOD_PKA_2	280	286	PF00069	0.514
MOD_PKA_2	334	340	PF00069	0.841
MOD_PKA_2	363	369	PF00069	0.720
MOD_PKA_2	382	388	PF00069	0.655
MOD_PKA_2	393	399	PF00069	0.666
MOD_PKA_2	409	415	PF00069	0.563
MOD_PKA_2	439	445	PF00069	0.705
MOD_PKA_2	50	56	PF00069	0.526
MOD_PKA_2	87	93	PF00069	0.614
MOD_PKA_2	902	908	PF00069	0.742
MOD_PKB_1	260	268	PF00069	0.754
MOD_Plk_1	196	202	PF00069	0.591
MOD_Plk_1	710	716	PF00069	0.694
MOD_Plk_1	95	101	PF00069	0.503
MOD_Plk_2-3	81	87	PF00069	0.573
MOD_Plk_2-3	96	102	PF00069	0.491
MOD_Plk_4	167	173	PF00069	0.327
MOD_Plk_4	197	203	PF00069	0.587
MOD_Plk_4	207	213	PF00069	0.392
MOD_Plk_4	474	480	PF00069	0.659
MOD_Plk_4	591	597	PF00069	0.660
MOD_Plk_4	71	77	PF00069	0.508
MOD_Plk_4	761	767	PF00069	0.607
MOD_Plk_4	834	840	PF00069	0.649
MOD_Plk_4	940	946	PF00069	0.808
MOD_ProDKin_1	298	304	PF00069	0.827
MOD_ProDKin_1	307	313	PF00069	0.700
MOD_ProDKin_1	316	322	PF00069	0.543
MOD_ProDKin_1	35	41	PF00069	0.511
MOD_ProDKin_1	497	503	PF00069	0.834
MOD_ProDKin_1	549	555	PF00069	0.857
MOD_ProDKin_1	691	697	PF00069	0.775
MOD_ProDKin_1	825	831	PF00069	0.706
MOD_SUMO_rev_2	917	926	PF00179	0.698
TRG_DiLeu_BaEn_1	600	605	PF01217	0.669
TRG_DiLeu_BaEn_3	792	798	PF01217	0.409
TRG_DiLeu_BaEn_3	844	850	PF01217	0.449
TRG_ENDOCYTIC_2	254	257	PF00928	0.649
TRG_ENDOCYTIC_2	795	798	PF00928	0.636
TRG_ENDOCYTIC_2	97	100	PF00928	0.567
TRG_ER_diArg_1	117	120	PF00400	0.606
TRG_ER_diArg_1	141	143	PF00400	0.559
TRG_ER_diArg_1	260	262	PF00400	0.723
TRG_ER_diArg_1	364	367	PF00400	0.832
TRG_ER_diArg_1	447	450	PF00400	0.502
TRG_ER_diArg_1	501	504	PF00400	0.597
TRG_ER_diArg_1	617	620	PF00400	0.742
TRG_ER_diArg_1	752	754	PF00400	0.646
TRG_ER_diArg_1	788	791	PF00400	0.646
TRG_ER_diArg_1	92	94	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H523	Leishmania donovani	89%	100%
A4H3I3	Leishmania braziliensis	75%	100%
E9AG30	Leishmania infantum	89%	100%
E9AJP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%