Putative cytochrome c oxidase assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase assembly protein, putative

Species:

Leishmania major

UniProt:

E9ACF7_LEIMA

TriTrypDb:

LmjF.03.0100 , LMJLV39_030006000 , LMJSD75_030006000

Length:

164

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005743	mitochondrial inner membrane	5	7
GO:0019866	organelle inner membrane	4	7
GO:0031090	organelle membrane	3	7
GO:0031966	mitochondrial membrane	4	7

Expansion

Sequence features

E9ACF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACF7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	9
GO:0005507	copper ion binding	6	9
GO:0016491	oxidoreductase activity	2	4
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.368
CLV_PCSK_KEX2_1	22	24	PF00082	0.350
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.259
CLV_PCSK_SKI1_1	128	132	PF00082	0.253
CLV_PCSK_SKI1_1	34	38	PF00082	0.220
CLV_PCSK_SKI1_1	80	84	PF00082	0.219
DEG_Nend_Nbox_1	1	3	PF02207	0.259
DOC_CKS1_1	14	19	PF01111	0.236
DOC_MAPK_gen_1	34	41	PF00069	0.268
DOC_MAPK_gen_1	77	85	PF00069	0.219
DOC_MAPK_MEF2A_6	34	41	PF00069	0.292
DOC_PP1_RVXF_1	36	42	PF00149	0.241
DOC_PP4_FxxP_1	14	17	PF00568	0.231
DOC_USP7_UBL2_3	34	38	PF12436	0.219
DOC_WW_Pin1_4	13	18	PF00397	0.236
LIG_14-3-3_CanoR_1	40	49	PF00244	0.219
LIG_14-3-3_CanoR_1	77	83	PF00244	0.219
LIG_FHA_1	46	52	PF00498	0.219
LIG_FHA_1	94	100	PF00498	0.249
LIG_LIR_Apic_2	11	17	PF02991	0.241
LIG_LIR_Apic_2	27	33	PF02991	0.241
LIG_LIR_Nem_3	147	151	PF02991	0.219
LIG_PCNA_yPIPBox_3	128	139	PF02747	0.241
LIG_PTB_Apo_2	142	149	PF02174	0.287
LIG_SH2_CRK	2	6	PF00017	0.241
LIG_SH2_GRB2like	98	101	PF00017	0.219
LIG_SH2_NCK_1	88	92	PF00017	0.219
LIG_SH2_STAT5	125	128	PF00017	0.302
LIG_SH2_STAT5	146	149	PF00017	0.232
LIG_SH2_STAT5	15	18	PF00017	0.194
LIG_SH2_STAT5	157	160	PF00017	0.449
LIG_SH2_STAT5	2	5	PF00017	0.267
LIG_SH2_STAT5	88	91	PF00017	0.222
LIG_SH2_STAT5	98	101	PF00017	0.324
LIG_SH3_3	115	121	PF00018	0.219
LIG_SH3_3	61	67	PF00018	0.275
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.241
MOD_CK1_1	78	84	PF00069	0.219
MOD_CK1_1	86	92	PF00069	0.219
MOD_GlcNHglycan	72	75	PF01048	0.219
MOD_N-GLC_1	131	136	PF02516	0.243
MOD_N-GLC_1	144	149	PF02516	0.209
MOD_N-GLC_1	75	80	PF02516	0.219
MOD_NEK2_1	131	136	PF00069	0.286
MOD_NEK2_1	83	88	PF00069	0.219
MOD_Plk_1	131	137	PF00069	0.243
MOD_Plk_1	144	150	PF00069	0.209
MOD_Plk_1	26	32	PF00069	0.275
MOD_Plk_1	78	84	PF00069	0.266
MOD_Plk_4	131	137	PF00069	0.243
MOD_Plk_4	144	150	PF00069	0.209
MOD_ProDKin_1	13	19	PF00069	0.236
TRG_DiLeu_BaEn_1	59	64	PF01217	0.219
TRG_ENDOCYTIC_2	146	149	PF00928	0.219
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.219

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JH88	Bodo saltans	77%	66%
A0A1X0P9J0	Trypanosomatidae	93%	72%
A0A3R7N777	Trypanosoma rangeli	92%	72%
A0A3S5H522	Leishmania donovani	98%	100%
A1BA38	Paracoccus denitrificans (strain Pd 1222)	41%	84%
A3PGX7	Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)	42%	86%
A4WQ59	Cereibacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)	44%	85%
A4Z2D0	Bradyrhizobium sp. (strain ORS 278)	37%	75%
A5EAA0	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)	36%	76%
A5VP42	Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)	35%	82%
A6U6U8	Sinorhizobium medicae (strain WSM419)	30%	83%
A6WWG2	Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37)	35%	81%
A7IPB8	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)	37%	81%
A9M8Z5	Brucella canis (strain ATCC 23365 / NCTC 10854)	35%	82%
B0CKF6	Brucella suis (strain ATCC 23445 / NCTC 10510)	35%	82%
B3PSB4	Rhizobium etli (strain CIAT 652)	37%	81%
B3QF26	Rhodopseudomonas palustris (strain TIE-1)	37%	79%
B5ZSV4	Rhizobium leguminosarum bv. trifolii (strain WSM2304)	35%	81%
C0RHH8	Brucella melitensis biotype 2 (strain ATCC 23457)	35%	82%
C3MHJ5	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	31%	82%
D0A217	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	91%	71%
E9AG29	Leishmania infantum	98%	100%
E9AJP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O21243	Reclinomonas americana	45%	90%
P08303	Paracoccus denitrificans	41%	85%
P56939	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	39%	77%
P56940	Cereibacter sphaeroides	42%	86%
Q07HB0	Rhodopseudomonas palustris (strain BisA53)	37%	79%
Q11KD0	Chelativorans sp. (strain BNC1)	32%	81%
Q13CY3	Rhodopseudomonas palustris (strain BisB5)	40%	80%
Q167V9	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	40%	85%
Q1GE51	Ruegeria sp. (strain TM1040)	39%	84%
Q1MKI3	Rhizobium leguminosarum bv. viciae (strain 3841)	35%	81%
Q1QHV9	Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)	36%	76%
Q1RJ56	Rickettsia bellii (strain RML369-C)	38%	91%
Q20X23	Rhodopseudomonas palustris (strain BisB18)	40%	80%
Q2IR93	Rhodopseudomonas palustris (strain HaA2)	39%	79%
Q2KBM0	Rhizobium etli (strain CFN 42 / ATCC 51251)	36%	81%
Q3J5F7	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	42%	86%
Q4UM75	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	34%	88%
Q5FGG9	Ehrlichia ruminantium (strain Gardel)	31%	93%
Q5HA73	Ehrlichia ruminantium (strain Welgevonden)	31%	93%
Q5LNX9	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	41%	86%
Q8G261	Brucella suis biovar 1 (strain 1330)	35%	82%
Q8UHB2	Agrobacterium fabrum (strain C58 / ATCC 33970)	31%	81%
Q8YFQ7	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	35%	82%
Q92IL2	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	33%	87%
Q92RG6	Rhizobium meliloti (strain 1021)	31%	83%
Q985W8	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	32%	80%
Q9ZDM3	Rickettsia prowazekii (strain Madrid E)	34%	92%