Glycerol-3-phosphate acyl transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerol-3-phosphate acyl transferase

Species:

Leishmania major

UniProt:

E9ACF5_LEIMA

TriTrypDb:

LmjF.03.0080 , LMJLV39_030005800 , LMJSD75_030005800

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9ACF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACF5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004366	glycerol-3-phosphate O-acyltransferase activity	6	6
GO:0008374	O-acyltransferase activity	5	6
GO:0016287	glycerone-phosphate O-acyltransferase activity	7	3
GO:0016407	acetyltransferase activity	5	3
GO:0016413	O-acetyltransferase activity	6	3
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6
GO:0043772	acyl-phosphate glycerol-3-phosphate acyltransferase activity	5	2
GO:0102420	sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.448
CLV_NRD_NRD_1	325	327	PF00675	0.534
CLV_NRD_NRD_1	380	382	PF00675	0.479
CLV_NRD_NRD_1	389	391	PF00675	0.528
CLV_NRD_NRD_1	44	46	PF00675	0.470
CLV_NRD_NRD_1	440	442	PF00675	0.498
CLV_NRD_NRD_1	571	573	PF00675	0.314
CLV_NRD_NRD_1	622	624	PF00675	0.408
CLV_PCSK_KEX2_1	18	20	PF00082	0.435
CLV_PCSK_KEX2_1	325	327	PF00082	0.523
CLV_PCSK_KEX2_1	380	382	PF00082	0.475
CLV_PCSK_KEX2_1	423	425	PF00082	0.598
CLV_PCSK_KEX2_1	440	442	PF00082	0.480
CLV_PCSK_KEX2_1	475	477	PF00082	0.376
CLV_PCSK_KEX2_1	571	573	PF00082	0.312
CLV_PCSK_KEX2_1	621	623	PF00082	0.405
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.534
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.481
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.401
CLV_PCSK_PC7_1	617	623	PF00082	0.448
CLV_PCSK_SKI1_1	21	25	PF00082	0.407
CLV_PCSK_SKI1_1	326	330	PF00082	0.505
CLV_PCSK_SKI1_1	341	345	PF00082	0.461
CLV_PCSK_SKI1_1	423	427	PF00082	0.624
CLV_PCSK_SKI1_1	440	444	PF00082	0.367
CLV_PCSK_SKI1_1	475	479	PF00082	0.316
CLV_PCSK_SKI1_1	495	499	PF00082	0.117
CLV_PCSK_SKI1_1	521	525	PF00082	0.459
CLV_PCSK_SKI1_1	549	553	PF00082	0.290
CLV_PCSK_SKI1_1	623	627	PF00082	0.484
CLV_PCSK_SKI1_1	78	82	PF00082	0.473
DEG_APCC_DBOX_1	40	48	PF00400	0.617
DEG_APCC_DBOX_1	520	528	PF00400	0.309
DEG_APCC_DBOX_1	548	556	PF00400	0.597
DOC_CKS1_1	218	223	PF01111	0.329
DOC_CYCLIN_RxL_1	420	429	PF00134	0.431
DOC_CYCLIN_RxL_1	464	474	PF00134	0.431
DOC_MAPK_gen_1	298	307	PF00069	0.286
DOC_MAPK_gen_1	325	333	PF00069	0.300
DOC_MAPK_gen_1	41	49	PF00069	0.586
DOC_MAPK_gen_1	440	447	PF00069	0.248
DOC_MAPK_MEF2A_6	521	528	PF00069	0.259
DOC_MAPK_MEF2A_6	549	556	PF00069	0.509
DOC_MAPK_NFAT4_5	549	557	PF00069	0.508
DOC_PP1_RVXF_1	114	121	PF00149	0.248
DOC_PP1_RVXF_1	349	356	PF00149	0.378
DOC_PP1_RVXF_1	493	499	PF00149	0.553
DOC_PP1_RVXF_1	71	78	PF00149	0.475
DOC_PP4_FxxP_1	127	130	PF00568	0.259
DOC_PP4_FxxP_1	311	314	PF00568	0.301
DOC_PP4_FxxP_1	528	531	PF00568	0.335
DOC_USP7_MATH_1	123	127	PF00917	0.245
DOC_USP7_MATH_1	195	199	PF00917	0.343
DOC_USP7_MATH_1	600	604	PF00917	0.588
DOC_WW_Pin1_4	217	222	PF00397	0.285
DOC_WW_Pin1_4	309	314	PF00397	0.305
LIG_14-3-3_CanoR_1	12	22	PF00244	0.666
LIG_14-3-3_CanoR_1	137	143	PF00244	0.309
LIG_14-3-3_CanoR_1	199	208	PF00244	0.309
LIG_14-3-3_CanoR_1	280	285	PF00244	0.273
LIG_14-3-3_CanoR_1	390	398	PF00244	0.358
LIG_14-3-3_CanoR_1	45	50	PF00244	0.612
LIG_14-3-3_CanoR_1	476	485	PF00244	0.588
LIG_14-3-3_CanoR_1	55	61	PF00244	0.522
LIG_Actin_WH2_2	458	474	PF00022	0.484
LIG_Actin_WH2_2	533	551	PF00022	0.401
LIG_Actin_WH2_2	57	75	PF00022	0.527
LIG_APCC_ABBA_1	249	254	PF00400	0.247
LIG_APCC_ABBA_1	514	519	PF00400	0.461
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_BRCT_BRCA1_1	391	395	PF00533	0.403
LIG_BRCT_BRCA1_1	73	77	PF00533	0.476
LIG_DLG_GKlike_1	609	616	PF00625	0.607
LIG_EH1_1	445	453	PF00400	0.316
LIG_FHA_1	2	8	PF00498	0.573
LIG_FHA_1	207	213	PF00498	0.277
LIG_FHA_1	259	265	PF00498	0.243
LIG_FHA_1	342	348	PF00498	0.287
LIG_FHA_1	509	515	PF00498	0.391
LIG_FHA_1	520	526	PF00498	0.264
LIG_FHA_1	89	95	PF00498	0.243
LIG_FHA_2	199	205	PF00498	0.316
LIG_LIR_Apic_2	124	130	PF02991	0.259
LIG_LIR_Apic_2	184	188	PF02991	0.270
LIG_LIR_Apic_2	309	314	PF02991	0.304
LIG_LIR_Gen_1	172	182	PF02991	0.317
LIG_LIR_Gen_1	233	243	PF02991	0.248
LIG_LIR_Gen_1	301	311	PF02991	0.343
LIG_LIR_Gen_1	374	382	PF02991	0.297
LIG_LIR_Gen_1	392	402	PF02991	0.193
LIG_LIR_Gen_1	403	413	PF02991	0.310
LIG_LIR_Gen_1	511	517	PF02991	0.359
LIG_LIR_Nem_3	172	177	PF02991	0.317
LIG_LIR_Nem_3	233	239	PF02991	0.248
LIG_LIR_Nem_3	301	307	PF02991	0.337
LIG_LIR_Nem_3	349	353	PF02991	0.344
LIG_LIR_Nem_3	358	362	PF02991	0.306
LIG_LIR_Nem_3	374	378	PF02991	0.207
LIG_LIR_Nem_3	392	398	PF02991	0.195
LIG_LIR_Nem_3	403	408	PF02991	0.285
LIG_LIR_Nem_3	491	497	PF02991	0.461
LIG_LIR_Nem_3	511	515	PF02991	0.410
LIG_LIR_Nem_3	74	80	PF02991	0.382
LIG_MLH1_MIPbox_1	73	77	PF16413	0.476
LIG_NRBOX	421	427	PF00104	0.429
LIG_Pex14_2	307	311	PF04695	0.394
LIG_Pex14_2	355	359	PF04695	0.275
LIG_Pex14_2	494	498	PF04695	0.553
LIG_Rb_pABgroove_1	315	323	PF01858	0.404
LIG_SH2_CRK	236	240	PF00017	0.241
LIG_SH2_CRK	350	354	PF00017	0.357
LIG_SH2_CRK	363	367	PF00017	0.294
LIG_SH2_NCK_1	236	240	PF00017	0.248
LIG_SH2_PTP2	535	538	PF00017	0.300
LIG_SH2_SRC	293	296	PF00017	0.385
LIG_SH2_SRC	363	366	PF00017	0.337
LIG_SH2_STAP1	226	230	PF00017	0.313
LIG_SH2_STAP1	236	240	PF00017	0.179
LIG_SH2_STAT3	586	589	PF00017	0.595
LIG_SH2_STAT5	293	296	PF00017	0.299
LIG_SH2_STAT5	304	307	PF00017	0.270
LIG_SH2_STAT5	375	378	PF00017	0.293
LIG_SH2_STAT5	446	449	PF00017	0.421
LIG_SH2_STAT5	468	471	PF00017	0.552
LIG_SH2_STAT5	535	538	PF00017	0.409
LIG_SH2_STAT5	76	79	PF00017	0.301
LIG_SH3_3	141	147	PF00018	0.248
LIG_SH3_3	205	211	PF00018	0.277
LIG_SH3_3	215	221	PF00018	0.233
LIG_SH3_3	455	461	PF00018	0.306
LIG_SUMO_SIM_anti_2	522	529	PF11976	0.349
LIG_SUMO_SIM_anti_2	537	543	PF11976	0.224
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.248
LIG_SUMO_SIM_par_1	522	529	PF11976	0.372
LIG_SUMO_SIM_par_1	537	543	PF11976	0.209
LIG_TRAF2_1	202	205	PF00917	0.353
LIG_TRAF2_1	33	36	PF00917	0.636
LIG_TYR_ITIM	466	471	PF00017	0.481
LIG_UBA3_1	263	267	PF00899	0.300
LIG_UBA3_1	465	472	PF00899	0.434
LIG_WRC_WIRS_1	356	361	PF05994	0.467
LIG_WRC_WIRS_1	509	514	PF05994	0.382
MOD_CK1_1	175	181	PF00069	0.459
MOD_CK1_1	198	204	PF00069	0.447
MOD_CK1_1	479	485	PF00069	0.482
MOD_CK1_1	557	563	PF00069	0.429
MOD_CK1_1	612	618	PF00069	0.531
MOD_CK2_1	198	204	PF00069	0.339
MOD_CK2_1	45	51	PF00069	0.418
MOD_GlcNHglycan	370	373	PF01048	0.494
MOD_GlcNHglycan	391	394	PF01048	0.575
MOD_GlcNHglycan	4	7	PF01048	0.662
MOD_GSK3_1	13	20	PF00069	0.607
MOD_GSK3_1	195	202	PF00069	0.402
MOD_GSK3_1	220	227	PF00069	0.399
MOD_GSK3_1	254	261	PF00069	0.300
MOD_GSK3_1	351	358	PF00069	0.464
MOD_GSK3_1	414	421	PF00069	0.405
MOD_GSK3_1	515	522	PF00069	0.391
MOD_N-GLC_1	403	408	PF02516	0.463
MOD_N-GLC_2	246	248	PF02516	0.316
MOD_NEK2_1	109	114	PF00069	0.421
MOD_NEK2_1	224	229	PF00069	0.361
MOD_NEK2_1	355	360	PF00069	0.485
MOD_NEK2_1	471	476	PF00069	0.404
MOD_NEK2_1	478	483	PF00069	0.428
MOD_NEK2_1	508	513	PF00069	0.348
MOD_NEK2_1	534	539	PF00069	0.316
MOD_NEK2_1	554	559	PF00069	0.215
MOD_NEK2_1	56	61	PF00069	0.366
MOD_PIKK_1	414	420	PF00454	0.389
MOD_PIKK_1	557	563	PF00454	0.576
MOD_PK_1	280	286	PF00069	0.335
MOD_PKA_1	326	332	PF00069	0.405
MOD_PKA_1	45	51	PF00069	0.564
MOD_PKA_2	17	23	PF00069	0.582
MOD_PKA_2	175	181	PF00069	0.417
MOD_PKA_2	198	204	PF00069	0.436
MOD_PKA_2	389	395	PF00069	0.491
MOD_PKA_2	414	420	PF00069	0.401
MOD_PKB_1	43	51	PF00069	0.464
MOD_Plk_1	123	129	PF00069	0.300
MOD_Plk_1	206	212	PF00069	0.336
MOD_Plk_1	258	264	PF00069	0.300
MOD_Plk_1	479	485	PF00069	0.477
MOD_Plk_1	51	57	PF00069	0.515
MOD_Plk_1	78	84	PF00069	0.321
MOD_Plk_4	259	265	PF00069	0.292
MOD_Plk_4	289	295	PF00069	0.342
MOD_Plk_4	351	357	PF00069	0.486
MOD_Plk_4	45	51	PF00069	0.525
MOD_Plk_4	508	514	PF00069	0.300
MOD_Plk_4	534	540	PF00069	0.335
MOD_Plk_4	554	560	PF00069	0.215
MOD_Plk_4	56	62	PF00069	0.312
MOD_Plk_4	609	615	PF00069	0.564
MOD_Plk_4	78	84	PF00069	0.382
MOD_ProDKin_1	217	223	PF00069	0.353
MOD_ProDKin_1	309	315	PF00069	0.387
MOD_SUMO_rev_2	154	160	PF00179	0.370
MOD_SUMO_rev_2	587	596	PF00179	0.564
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.469
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.342
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.528
TRG_DiLeu_BaLyEn_6	577	582	PF01217	0.523
TRG_ENDOCYTIC_2	236	239	PF00928	0.288
TRG_ENDOCYTIC_2	240	243	PF00928	0.288
TRG_ENDOCYTIC_2	304	307	PF00928	0.417
TRG_ENDOCYTIC_2	350	353	PF00928	0.460
TRG_ENDOCYTIC_2	375	378	PF00928	0.361
TRG_ENDOCYTIC_2	405	408	PF00928	0.478
TRG_ENDOCYTIC_2	468	471	PF00928	0.482
TRG_ENDOCYTIC_2	535	538	PF00928	0.374
TRG_ER_diArg_1	299	302	PF00400	0.368
TRG_ER_diArg_1	379	381	PF00400	0.347
TRG_ER_diArg_1	439	441	PF00400	0.375
TRG_ER_diArg_1	620	623	PF00400	0.505
TRG_NES_CRM1_1	334	349	PF08389	0.445
TRG_Pf-PMV_PEXEL_1	119	124	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I239	Leptomonas seymouri	80%	87%
A0A0S4JH62	Bodo saltans	55%	86%
A0A1X0P8Y7	Trypanosomatidae	61%	89%
A0A3R7K7V0	Trypanosoma rangeli	60%	89%
A0A3S5H521	Leishmania donovani	97%	100%
A4H3I0	Leishmania braziliensis	92%	88%
D0A214	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	90%
E9AG27	Leishmania infantum	97%	100%
E9AJP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P32784	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	83%
P36148	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	85%
Q9P7P0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	93%
V5B455	Trypanosoma cruzi	62%	90%