Mediator complex subunit 23

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACF4_LEIMA

TriTrypDb:

LmjF.03.0070 , LMJLV39_030005700 , LMJSD75_030005700

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	667	671	PF00656	0.550
CLV_NRD_NRD_1	421	423	PF00675	0.565
CLV_NRD_NRD_1	435	437	PF00675	0.570
CLV_NRD_NRD_1	490	492	PF00675	0.612
CLV_NRD_NRD_1	544	546	PF00675	0.560
CLV_NRD_NRD_1	56	58	PF00675	0.451
CLV_NRD_NRD_1	765	767	PF00675	0.666
CLV_NRD_NRD_1	828	830	PF00675	0.707
CLV_PCSK_KEX2_1	435	437	PF00082	0.570
CLV_PCSK_KEX2_1	490	492	PF00082	0.612
CLV_PCSK_KEX2_1	543	545	PF00082	0.563
CLV_PCSK_KEX2_1	56	58	PF00082	0.451
CLV_PCSK_KEX2_1	765	767	PF00082	0.666
CLV_PCSK_KEX2_1	830	832	PF00082	0.691
CLV_PCSK_PC1ET2_1	830	832	PF00082	0.691
CLV_PCSK_SKI1_1	236	240	PF00082	0.678
CLV_PCSK_SKI1_1	247	251	PF00082	0.552
CLV_PCSK_SKI1_1	347	351	PF00082	0.438
CLV_PCSK_SKI1_1	375	379	PF00082	0.469
CLV_PCSK_SKI1_1	422	426	PF00082	0.499
CLV_PCSK_SKI1_1	586	590	PF00082	0.447
CLV_PCSK_SKI1_1	605	609	PF00082	0.269
CLV_PCSK_SKI1_1	658	662	PF00082	0.483
CLV_PCSK_SKI1_1	751	755	PF00082	0.393
CLV_PCSK_SKI1_1	774	778	PF00082	0.552
CLV_Separin_Metazoa	487	491	PF03568	0.576
CLV_Separin_Metazoa	540	544	PF03568	0.596
DEG_APCC_DBOX_1	421	429	PF00400	0.552
DEG_APCC_DBOX_1	657	665	PF00400	0.511
DEG_APCC_DBOX_1	74	82	PF00400	0.589
DEG_APCC_DBOX_1	750	758	PF00400	0.427
DEG_Nend_UBRbox_2	1	3	PF02207	0.641
DOC_ANK_TNKS_1	489	496	PF00023	0.594
DOC_CDC14_PxL_1	251	259	PF14671	0.486
DOC_CYCLIN_RxL_1	372	382	PF00134	0.605
DOC_CYCLIN_RxL_1	610	620	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	285	291	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	777	783	PF00134	0.520
DOC_MAPK_gen_1	422	430	PF00069	0.550
DOC_MAPK_gen_1	505	512	PF00069	0.532
DOC_MAPK_gen_1	56	64	PF00069	0.406
DOC_MAPK_gen_1	749	758	PF00069	0.406
DOC_MAPK_MEF2A_6	462	469	PF00069	0.558
DOC_MAPK_MEF2A_6	505	514	PF00069	0.555
DOC_MAPK_MEF2A_6	658	665	PF00069	0.482
DOC_MAPK_MEF2A_6	749	758	PF00069	0.406
DOC_MAPK_NFAT4_5	751	759	PF00069	0.498
DOC_PIKK_1	389	396	PF02985	0.447
DOC_PP1_RVXF_1	345	351	PF00149	0.535
DOC_PP1_RVXF_1	584	590	PF00149	0.502
DOC_PP1_RVXF_1	611	618	PF00149	0.562
DOC_PP1_RVXF_1	728	734	PF00149	0.392
DOC_PP2B_LxvP_1	353	356	PF13499	0.504
DOC_PP2B_LxvP_1	688	691	PF13499	0.586
DOC_PP4_FxxP_1	135	138	PF00568	0.635
DOC_USP7_MATH_1	118	122	PF00917	0.693
DOC_USP7_MATH_1	15	19	PF00917	0.627
DOC_USP7_MATH_1	588	592	PF00917	0.492
DOC_USP7_MATH_1	691	695	PF00917	0.664
DOC_USP7_MATH_1	87	91	PF00917	0.528
DOC_USP7_MATH_2	109	115	PF00917	0.659
DOC_USP7_UBL2_3	797	801	PF12436	0.619
DOC_USP7_UBL2_3	82	86	PF12436	0.581
DOC_USP7_UBL2_3	826	830	PF12436	0.685
DOC_WW_Pin1_4	136	141	PF00397	0.704
DOC_WW_Pin1_4	415	420	PF00397	0.580
DOC_WW_Pin1_4	450	455	PF00397	0.661
DOC_WW_Pin1_4	646	651	PF00397	0.518
LIG_14-3-3_CanoR_1	16	22	PF00244	0.679
LIG_14-3-3_CanoR_1	414	419	PF00244	0.518
LIG_14-3-3_CanoR_1	593	600	PF00244	0.490
LIG_14-3-3_CanoR_1	605	612	PF00244	0.473
LIG_14-3-3_CanoR_1	693	697	PF00244	0.679
LIG_14-3-3_CanoR_1	771	777	PF00244	0.560
LIG_Actin_WH2_2	90	108	PF00022	0.590
LIG_BIR_III_4	36	40	PF00653	0.591
LIG_BRCT_BRCA1_1	465	469	PF00533	0.510
LIG_BRCT_BRCA1_1	636	640	PF00533	0.535
LIG_Clathr_ClatBox_1	191	195	PF01394	0.685
LIG_Clathr_ClatBox_1	464	468	PF01394	0.566
LIG_deltaCOP1_diTrp_1	468	474	PF00928	0.538
LIG_eIF4E_1	781	787	PF01652	0.414
LIG_FAT_LD_1	515	523	PF03623	0.588
LIG_FHA_1	25	31	PF00498	0.598
LIG_FHA_1	294	300	PF00498	0.435
LIG_FHA_1	546	552	PF00498	0.550
LIG_FHA_1	562	568	PF00498	0.424
LIG_FHA_1	606	612	PF00498	0.436
LIG_FHA_2	307	313	PF00498	0.551
LIG_FHA_2	657	663	PF00498	0.510
LIG_FHA_2	698	704	PF00498	0.651
LIG_FHA_2	802	808	PF00498	0.648
LIG_Integrin_RGD_1	668	670	PF01839	0.629
LIG_LIR_Apic_2	134	138	PF02991	0.636
LIG_LIR_Gen_1	127	137	PF02991	0.663
LIG_LIR_Gen_1	174	185	PF02991	0.618
LIG_LIR_Gen_1	262	273	PF02991	0.477
LIG_LIR_Gen_1	302	310	PF02991	0.427
LIG_LIR_Gen_1	364	374	PF02991	0.542
LIG_LIR_Gen_1	395	406	PF02991	0.662
LIG_LIR_Gen_1	507	515	PF02991	0.556
LIG_LIR_Gen_1	686	691	PF02991	0.585
LIG_LIR_LC3C_4	389	393	PF02991	0.678
LIG_LIR_Nem_3	127	132	PF02991	0.733
LIG_LIR_Nem_3	174	180	PF02991	0.596
LIG_LIR_Nem_3	187	192	PF02991	0.597
LIG_LIR_Nem_3	262	268	PF02991	0.471
LIG_LIR_Nem_3	302	308	PF02991	0.423
LIG_LIR_Nem_3	364	369	PF02991	0.552
LIG_LIR_Nem_3	395	401	PF02991	0.609
LIG_LIR_Nem_3	466	472	PF02991	0.560
LIG_LIR_Nem_3	507	511	PF02991	0.576
LIG_LIR_Nem_3	656	660	PF02991	0.423
LIG_LIR_Nem_3	686	690	PF02991	0.575
LIG_LIR_Nem_3	772	776	PF02991	0.445
LIG_LIR_Nem_3	778	784	PF02991	0.437
LIG_LIR_Nem_3	811	816	PF02991	0.601
LIG_LYPXL_yS_3	781	784	PF13949	0.442
LIG_NRBOX	424	430	PF00104	0.544
LIG_NRBOX	553	559	PF00104	0.508
LIG_NRBOX	753	759	PF00104	0.502
LIG_Pex14_1	181	185	PF04695	0.619
LIG_Pex14_1	585	589	PF04695	0.434
LIG_Pex14_1	594	598	PF04695	0.452
LIG_Pex14_2	470	474	PF04695	0.502
LIG_PTB_Apo_2	267	274	PF02174	0.504
LIG_PTB_Apo_2	611	618	PF02174	0.562
LIG_PTB_Phospho_1	267	273	PF10480	0.500
LIG_Rb_LxCxE_1	187	207	PF01857	0.701
LIG_REV1ctd_RIR_1	222	231	PF16727	0.555
LIG_SH2_CRK	273	277	PF00017	0.428
LIG_SH2_PTP2	472	475	PF00017	0.563
LIG_SH2_STAP1	125	129	PF00017	0.696
LIG_SH2_STAP1	172	176	PF00017	0.681
LIG_SH2_STAP1	273	277	PF00017	0.413
LIG_SH2_STAT3	185	188	PF00017	0.577
LIG_SH2_STAT5	185	188	PF00017	0.589
LIG_SH2_STAT5	233	236	PF00017	0.505
LIG_SH2_STAT5	253	256	PF00017	0.461
LIG_SH2_STAT5	265	268	PF00017	0.424
LIG_SH2_STAT5	472	475	PF00017	0.489
LIG_SH2_STAT5	531	534	PF00017	0.535
LIG_SH2_STAT5	598	601	PF00017	0.456
LIG_SH2_STAT5	67	70	PF00017	0.516
LIG_SH2_STAT5	687	690	PF00017	0.568
LIG_SH3_3	177	183	PF00018	0.706
LIG_SH3_3	332	338	PF00018	0.500
LIG_SH3_3	507	513	PF00018	0.561
LIG_SH3_3	777	783	PF00018	0.393
LIG_Sin3_3	426	433	PF02671	0.548
LIG_SUMO_SIM_anti_2	659	665	PF11976	0.519
LIG_SUMO_SIM_par_1	564	570	PF11976	0.553
LIG_TYR_ITIM	175	180	PF00017	0.620
LIG_TYR_ITIM	685	690	PF00017	0.505
LIG_UBA3_1	223	227	PF00899	0.595
LIG_UBA3_1	792	797	PF00899	0.539
LIG_WRC_WIRS_1	205	210	PF05994	0.572
LIG_WW_1	337	340	PF00397	0.572
MOD_CDK_SPxxK_3	415	422	PF00069	0.574
MOD_CDK_SPxxK_3	450	457	PF00069	0.546
MOD_CK1_1	136	142	PF00069	0.668
MOD_CK1_1	203	209	PF00069	0.671
MOD_CK1_1	24	30	PF00069	0.549
MOD_CK1_1	376	382	PF00069	0.615
MOD_CK1_1	404	410	PF00069	0.614
MOD_CK1_1	705	711	PF00069	0.552
MOD_CK2_1	193	199	PF00069	0.575
MOD_CK2_1	306	312	PF00069	0.480
MOD_CK2_1	656	662	PF00069	0.510
MOD_CK2_1	801	807	PF00069	0.694
MOD_Cter_Amidation	54	57	PF01082	0.546
MOD_GlcNHglycan	134	138	PF01048	0.724
MOD_GlcNHglycan	141	144	PF01048	0.719
MOD_GlcNHglycan	150	153	PF01048	0.552
MOD_GlcNHglycan	208	211	PF01048	0.671
MOD_GlcNHglycan	403	406	PF01048	0.618
MOD_GlcNHglycan	443	446	PF01048	0.700
MOD_GlcNHglycan	448	451	PF01048	0.667
MOD_GlcNHglycan	594	597	PF01048	0.483
MOD_GlcNHglycan	706	710	PF01048	0.541
MOD_GlcNHglycan	720	723	PF01048	0.386
MOD_GlcNHglycan	89	92	PF01048	0.593
MOD_GSK3_1	113	120	PF00069	0.717
MOD_GSK3_1	144	151	PF00069	0.713
MOD_GSK3_1	200	207	PF00069	0.659
MOD_GSK3_1	400	407	PF00069	0.654
MOD_GSK3_1	446	453	PF00069	0.654
MOD_GSK3_1	575	582	PF00069	0.630
MOD_GSK3_1	588	595	PF00069	0.372
MOD_GSK3_1	634	641	PF00069	0.524
MOD_GSK3_1	67	74	PF00069	0.487
MOD_GSK3_1	735	742	PF00069	0.516
MOD_GSK3_1	87	94	PF00069	0.297
MOD_LATS_1	245	251	PF00433	0.625
MOD_NEK2_1	113	118	PF00069	0.648
MOD_NEK2_1	159	164	PF00069	0.559
MOD_NEK2_1	219	224	PF00069	0.563
MOD_NEK2_1	306	311	PF00069	0.417
MOD_NEK2_1	373	378	PF00069	0.523
MOD_NEK2_1	401	406	PF00069	0.631
MOD_NEK2_1	480	485	PF00069	0.509
MOD_NEK2_1	501	506	PF00069	0.619
MOD_NEK2_1	592	597	PF00069	0.506
MOD_NEK2_1	634	639	PF00069	0.531
MOD_NEK2_1	645	650	PF00069	0.487
MOD_NEK2_1	739	744	PF00069	0.509
MOD_NEK2_2	588	593	PF00069	0.464
MOD_NEK2_2	77	82	PF00069	0.583
MOD_PIKK_1	15	21	PF00454	0.593
MOD_PIKK_1	529	535	PF00454	0.580
MOD_PIKK_1	739	745	PF00454	0.567
MOD_PIKK_1	91	97	PF00454	0.585
MOD_PK_1	200	206	PF00069	0.531
MOD_PKA_2	118	124	PF00069	0.671
MOD_PKA_2	15	21	PF00069	0.613
MOD_PKA_2	446	452	PF00069	0.639
MOD_PKA_2	592	598	PF00069	0.410
MOD_PKA_2	692	698	PF00069	0.673
MOD_PKB_1	543	551	PF00069	0.507
MOD_Plk_1	194	200	PF00069	0.652
MOD_Plk_1	320	326	PF00069	0.559
MOD_Plk_1	545	551	PF00069	0.514
MOD_Plk_1	705	711	PF00069	0.455
MOD_Plk_1	739	745	PF00069	0.511
MOD_Plk_2-3	463	469	PF00069	0.564
MOD_Plk_4	200	206	PF00069	0.500
MOD_Plk_4	219	225	PF00069	0.536
MOD_Plk_4	408	414	PF00069	0.579
MOD_Plk_4	634	640	PF00069	0.493
MOD_ProDKin_1	136	142	PF00069	0.707
MOD_ProDKin_1	415	421	PF00069	0.577
MOD_ProDKin_1	450	456	PF00069	0.652
MOD_ProDKin_1	646	652	PF00069	0.519
MOD_SUMO_for_1	796	799	PF00179	0.541
MOD_SUMO_rev_2	574	580	PF00179	0.633
MOD_SUMO_rev_2	825	832	PF00179	0.691
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.690
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.548
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.461
TRG_ENDOCYTIC_2	172	175	PF00928	0.601
TRG_ENDOCYTIC_2	177	180	PF00928	0.582
TRG_ENDOCYTIC_2	253	256	PF00928	0.501
TRG_ENDOCYTIC_2	265	268	PF00928	0.392
TRG_ENDOCYTIC_2	273	276	PF00928	0.224
TRG_ENDOCYTIC_2	340	343	PF00928	0.498
TRG_ENDOCYTIC_2	681	684	PF00928	0.414
TRG_ENDOCYTIC_2	687	690	PF00928	0.442
TRG_ENDOCYTIC_2	736	739	PF00928	0.394
TRG_ENDOCYTIC_2	781	784	PF00928	0.442
TRG_ER_diArg_1	489	491	PF00400	0.600
TRG_ER_diArg_1	542	545	PF00400	0.554
TRG_ER_diArg_1	56	59	PF00400	0.427
TRG_ER_diArg_1	628	631	PF00400	0.594
TRG_ER_diArg_1	829	832	PF00400	0.720
TRG_NES_CRM1_1	274	287	PF08389	0.449
TRG_NES_CRM1_1	297	312	PF08389	0.571
TRG_NES_CRM1_1	555	570	PF08389	0.562
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	597	601	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	605	609	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	737	741	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX1	Leptomonas seymouri	65%	93%
A0A0S4JH32	Bodo saltans	26%	96%
A0A1X0PA13	Trypanosomatidae	32%	100%
A0A422N7I6	Trypanosoma rangeli	34%	100%
A0A451EJL3	Leishmania donovani	96%	100%
A4H3H9	Leishmania braziliensis	90%	100%
D0A213	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AG26	Leishmania infantum	96%	100%
E9AJP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%