LeishMANIAdb
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Alanine--glyoxylate transaminase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Alanine--glyoxylate transaminase
Gene product:
2-aminoethylphosphonate:pyruvateaminotransferas e-like protein
Species:
Leishmania major
UniProt:
E9ACF2_LEIMA
TriTrypDb:
LmjF.03.0040 * , LMJLV39_030005300 * , LMJSD75_030005300 *
Length:
435

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ACF2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACF2

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009987 cellular process 1 12
GO:0019634 organic phosphonate metabolic process 4 12
GO:0019637 organophosphate metabolic process 3 12
GO:0019700 organic phosphonate catabolic process 5 12
GO:0044237 cellular metabolic process 2 12
GO:0046434 organophosphate catabolic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901575 organic substance catabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0008453 alanine-glyoxylate transaminase activity 5 11
GO:0008483 transaminase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016769 transferase activity, transferring nitrogenous groups 3 12
GO:0047304 2-aminoethylphosphonate-pyruvate transaminase activity 5 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 215 217 PF00675 0.237
CLV_NRD_NRD_1 265 267 PF00675 0.239
CLV_NRD_NRD_1 430 432 PF00675 0.387
CLV_PCSK_KEX2_1 157 159 PF00082 0.211
CLV_PCSK_KEX2_1 215 217 PF00082 0.237
CLV_PCSK_KEX2_1 265 267 PF00082 0.237
CLV_PCSK_KEX2_1 316 318 PF00082 0.264
CLV_PCSK_KEX2_1 373 375 PF00082 0.181
CLV_PCSK_PC1ET2_1 157 159 PF00082 0.211
CLV_PCSK_PC1ET2_1 316 318 PF00082 0.264
CLV_PCSK_PC1ET2_1 373 375 PF00082 0.181
CLV_PCSK_PC7_1 369 375 PF00082 0.181
CLV_PCSK_SKI1_1 139 143 PF00082 0.255
CLV_PCSK_SKI1_1 265 269 PF00082 0.248
CLV_PCSK_SKI1_1 277 281 PF00082 0.276
CLV_PCSK_SKI1_1 37 41 PF00082 0.405
CLV_PCSK_SKI1_1 412 416 PF00082 0.361
CLV_PCSK_SKI1_1 418 422 PF00082 0.330
CLV_PCSK_SKI1_1 60 64 PF00082 0.406
CLV_Separin_Metazoa 212 216 PF03568 0.461
DEG_APCC_DBOX_1 97 105 PF00400 0.516
DEG_Nend_UBRbox_1 1 4 PF02207 0.375
DOC_CKS1_1 63 68 PF01111 0.369
DOC_CYCLIN_RxL_1 262 270 PF00134 0.441
DOC_CYCLIN_RxL_1 32 41 PF00134 0.411
DOC_CYCLIN_yCln2_LP_2 159 165 PF00134 0.503
DOC_MAPK_DCC_7 251 261 PF00069 0.516
DOC_MAPK_FxFP_2 43 46 PF00069 0.341
DOC_MAPK_gen_1 86 96 PF00069 0.295
DOC_MAPK_MEF2A_6 157 166 PF00069 0.479
DOC_MAPK_MEF2A_6 277 285 PF00069 0.461
DOC_MAPK_RevD_3 302 317 PF00069 0.503
DOC_PP1_RVXF_1 155 162 PF00149 0.464
DOC_PP1_RVXF_1 58 65 PF00149 0.425
DOC_PP1_RVXF_1 84 91 PF00149 0.457
DOC_PP2B_PxIxI_1 256 262 PF00149 0.516
DOC_PP4_FxxP_1 43 46 PF00568 0.341
DOC_SPAK_OSR1_1 398 402 PF12202 0.372
DOC_USP7_MATH_1 178 182 PF00917 0.510
DOC_USP7_MATH_1 420 424 PF00917 0.364
DOC_USP7_UBL2_3 147 151 PF12436 0.516
DOC_USP7_UBL2_3 33 37 PF12436 0.366
DOC_USP7_UBL2_3 418 422 PF12436 0.359
DOC_WW_Pin1_4 11 16 PF00397 0.401
DOC_WW_Pin1_4 296 301 PF00397 0.413
DOC_WW_Pin1_4 62 67 PF00397 0.426
LIG_14-3-3_CanoR_1 277 282 PF00244 0.454
LIG_14-3-3_CanoR_1 324 329 PF00244 0.432
LIG_14-3-3_CanoR_1 374 379 PF00244 0.417
LIG_Actin_WH2_2 152 169 PF00022 0.508
LIG_APCC_ABBA_1 45 50 PF00400 0.340
LIG_BRCT_BRCA1_1 129 133 PF00533 0.516
LIG_BRCT_BRCA1_1 292 296 PF00533 0.471
LIG_Clathr_ClatBox_1 287 291 PF01394 0.429
LIG_deltaCOP1_diTrp_1 367 375 PF00928 0.480
LIG_EVH1_2 19 23 PF00568 0.380
LIG_FHA_1 199 205 PF00498 0.427
LIG_FHA_1 278 284 PF00498 0.433
LIG_FHA_1 297 303 PF00498 0.418
LIG_FHA_1 343 349 PF00498 0.442
LIG_FHA_2 72 78 PF00498 0.377
LIG_GBD_Chelix_1 304 312 PF00786 0.316
LIG_HP1_1 162 166 PF01393 0.503
LIG_LIR_Apic_2 41 46 PF02991 0.349
LIG_LIR_Gen_1 5 12 PF02991 0.464
LIG_LIR_Nem_3 229 234 PF02991 0.413
LIG_LIR_Nem_3 396 402 PF02991 0.383
LIG_LIR_Nem_3 41 45 PF02991 0.351
LIG_LIR_Nem_3 5 9 PF02991 0.502
LIG_SH2_CRK 376 380 PF00017 0.435
LIG_SH2_GRB2like 378 381 PF00017 0.516
LIG_SH2_STAT5 376 379 PF00017 0.477
LIG_SH3_3 243 249 PF00018 0.516
LIG_SH3_3 295 301 PF00018 0.510
LIG_SH3_3 359 365 PF00018 0.453
LIG_SH3_3 51 57 PF00018 0.470
LIG_SH3_3 9 15 PF00018 0.377
LIG_SUMO_SIM_anti_2 50 56 PF11976 0.323
LIG_SUMO_SIM_par_1 278 284 PF11976 0.456
LIG_WRC_WIRS_1 287 292 PF05994 0.516
LIG_WRC_WIRS_1 3 8 PF05994 0.372
LIG_WRC_WIRS_1 39 44 PF05994 0.355
MOD_CK1_1 28 34 PF00069 0.497
MOD_CK1_1 351 357 PF00069 0.503
MOD_CK2_1 174 180 PF00069 0.496
MOD_CK2_1 389 395 PF00069 0.455
MOD_CK2_1 71 77 PF00069 0.433
MOD_GlcNHglycan 119 122 PF01048 0.214
MOD_GlcNHglycan 144 147 PF01048 0.280
MOD_GlcNHglycan 176 179 PF01048 0.274
MOD_GlcNHglycan 228 231 PF01048 0.275
MOD_GlcNHglycan 277 280 PF01048 0.291
MOD_GlcNHglycan 291 295 PF01048 0.252
MOD_GlcNHglycan 321 324 PF01048 0.316
MOD_GSK3_1 142 149 PF00069 0.503
MOD_GSK3_1 174 181 PF00069 0.450
MOD_GSK3_1 277 284 PF00069 0.443
MOD_GSK3_1 28 35 PF00069 0.430
MOD_GSK3_1 286 293 PF00069 0.466
MOD_GSK3_1 389 396 PF00069 0.413
MOD_GSK3_1 78 85 PF00069 0.431
MOD_N-GLC_2 250 252 PF02516 0.209
MOD_NEK2_1 142 147 PF00069 0.455
MOD_NEK2_1 174 179 PF00069 0.470
MOD_NEK2_1 27 32 PF00069 0.441
MOD_NEK2_1 281 286 PF00069 0.476
MOD_NEK2_1 290 295 PF00069 0.443
MOD_NEK2_1 342 347 PF00069 0.447
MOD_NEK2_1 348 353 PF00069 0.425
MOD_NEK2_1 48 53 PF00069 0.357
MOD_NEK2_2 128 133 PF00069 0.516
MOD_PIKK_1 55 61 PF00454 0.583
MOD_PKA_1 32 38 PF00069 0.369
MOD_Plk_1 187 193 PF00069 0.480
MOD_Plk_1 25 31 PF00069 0.393
MOD_Plk_1 281 287 PF00069 0.533
MOD_Plk_4 128 134 PF00069 0.448
MOD_Plk_4 178 184 PF00069 0.526
MOD_Plk_4 19 25 PF00069 0.466
MOD_Plk_4 374 380 PF00069 0.458
MOD_Plk_4 38 44 PF00069 0.498
MOD_Plk_4 50 56 PF00069 0.332
MOD_ProDKin_1 11 17 PF00069 0.403
MOD_ProDKin_1 296 302 PF00069 0.413
MOD_ProDKin_1 62 68 PF00069 0.436
MOD_SUMO_rev_2 170 177 PF00179 0.526
TRG_DiLeu_BaLyEn_6 263 268 PF01217 0.429
TRG_ENDOCYTIC_2 376 379 PF00928 0.434
TRG_ER_diArg_1 214 216 PF00400 0.437
TRG_ER_diArg_1 265 267 PF00400 0.429
TRG_Pf-PMV_PEXEL_1 265 270 PF00026 0.257
TRG_PTS1 432 435 PF00515 0.602

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IGF3 Leptomonas seymouri 75% 100%
A0A0S4JG24 Bodo saltans 58% 100%
A0A0S4JM51 Bodo saltans 42% 93%
A0A1X0NXQ0 Trypanosomatidae 41% 100%
A0A1X0P8N5 Trypanosomatidae 59% 100%
A0A422NWJ2 Trypanosoma rangeli 42% 100%
A0A451EJL1 Leishmania donovani 94% 100%
A0KJL8 Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049) 35% 100%
A0LMC0 Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) 37% 100%
A0RBE9 Bacillus thuringiensis (strain Al Hakam) 33% 100%
A1B8Z3 Paracoccus denitrificans (strain Pd 1222) 27% 100%
A1SY89 Psychromonas ingrahamii (strain 37) 35% 100%
A1UZE5 Burkholderia mallei (strain SAVP1) 34% 100%
A2S233 Burkholderia mallei (strain NCTC 10229) 34% 100%
A3MCV7 Burkholderia mallei (strain NCTC 10247) 34% 100%
A3NGW6 Burkholderia pseudomallei (strain 668) 34% 100%
A3P2G7 Burkholderia pseudomallei (strain 1106a) 34% 100%
A4H3H7 Leishmania braziliensis 87% 100%
A5F049 Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) 34% 100%
A5W695 Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) 35% 100%
A6L4N0 Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154) 35% 100%
A6TFW2 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) 34% 100%
A7GMM0 Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) 33% 100%
A9MWZ9 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 34% 100%
A9VKQ3 Bacillus mycoides (strain KBAB4) 34% 100%
B0KIG1 Pseudomonas putida (strain GB-1) 36% 100%
B1HPR6 Lysinibacillus sphaericus (strain C3-41) 33% 100%
B1JBM5 Pseudomonas putida (strain W619) 35% 100%
B1Z0T3 Burkholderia ambifaria (strain MC40-6) 37% 100%
B2JLS3 Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815) 36% 100%
B3RBH4 Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1) 36% 100%
B4SWS3 Salmonella newport (strain SL254) 34% 100%
B4T9C6 Salmonella heidelberg (strain SL476) 34% 100%
B4TMB1 Salmonella schwarzengrund (strain CVM19633) 34% 100%
B5BDA1 Salmonella paratyphi A (strain AKU_12601) 34% 100%
B5EXH1 Salmonella agona (strain SL483) 34% 100%
B5FKT6 Salmonella dublin (strain CT_02021853) 34% 100%
B5QTH9 Salmonella enteritidis PT4 (strain P125109) 34% 100%
B5R6T2 Salmonella gallinarum (strain 287/91 / NCTC 13346) 34% 100%
B7HH81 Bacillus cereus (strain B4264) 33% 100%
B7HK48 Bacillus cereus (strain AH187) 33% 100%
B7IN19 Bacillus cereus (strain G9842) 33% 100%
B7JFQ9 Bacillus cereus (strain AH820) 33% 100%
B9IUR6 Bacillus cereus (strain Q1) 34% 100%
C0Q7V5 Salmonella paratyphi C (strain RKS4594) 34% 100%
C1EM34 Bacillus cereus (strain 03BB102) 33% 100%
C3LAM8 Bacillus anthracis (strain CDC 684 / NRRL 3495) 33% 100%
C3LVL9 Vibrio cholerae serotype O1 (strain M66-2) 34% 100%
C3P4E3 Bacillus anthracis (strain A0248) 33% 100%
E9AG24 Leishmania infantum 94% 100%
E9AJP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O08374 Hyphomicrobium methylovorum 24% 100%
O25436 Helicobacter pylori (strain ATCC 700392 / 26695) 23% 100%
O35423 Mus musculus 21% 100%
P09139 Rattus norvegicus 21% 100%
P14776 Synechococcus sp. (strain PCC 6716) 25% 100%
P16421 Anabaena cylindrica 25% 100%
P21549 Homo sapiens 22% 100%
P31029 Callithrix jacchus 23% 100%
P31030 Oryctolagus cuniculus 24% 100%
P43567 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P55819 Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) 26% 100%
P96060 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 34% 100%
Q02JF1 Pseudomonas aeruginosa (strain UCBPP-PA14) 38% 100%
Q0IG34 Aedes aegypti 22% 100%
Q0JZT9 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 36% 100%
Q122G2 Polaromonas sp. (strain JS666 / ATCC BAA-500) 33% 100%
Q128B2 Polaromonas sp. (strain JS666 / ATCC BAA-500) 35% 100%
Q13P97 Paraburkholderia xenovorans (strain LB400) 36% 100%
Q13YI7 Paraburkholderia xenovorans (strain LB400) 34% 100%
Q183T0 Clostridioides difficile (strain 630) 33% 68%
Q1BQZ3 Burkholderia cenocepacia (strain AU 1054) 36% 100%
Q1I7U0 Pseudomonas entomophila (strain L48) 36% 100%
Q2SHM3 Hahella chejuensis (strain KCTC 2396) 39% 100%
Q2T3K6 Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264) 35% 100%
Q39AP8 Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) 37% 100%
Q39BS5 Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) 36% 100%
Q3JH97 Burkholderia pseudomallei (strain 1710b) 34% 100%
Q3K9Y3 Pseudomonas fluorescens (strain Pf0-1) 38% 100%
Q46NS0 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) 37% 100%
Q46UV8 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) 35% 100%
Q4K9L8 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 37% 100%
Q57SD3 Salmonella choleraesuis (strain SC-B67) 34% 100%
Q58369 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 29% 100%
Q5L9Q0 Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) 36% 100%
Q5PFR0 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 34% 100%
Q5RDP0 Pongo abelii 21% 100%
Q62CM5 Burkholderia mallei (strain ATCC 23344) 34% 100%
Q63E45 Bacillus cereus (strain ZK / E33L) 33% 100%
Q63NF6 Burkholderia pseudomallei (strain K96243) 34% 100%
Q64PZ3 Bacteroides fragilis (strain YCH46) 36% 100%
Q6HLM0 Bacillus thuringiensis subsp. konkukian (strain 97-27) 33% 100%
Q73BH8 Bacillus cereus (strain ATCC 10987 / NRS 248) 34% 100%
Q7MF44 Vibrio vulnificus (strain YJ016) 35% 100%
Q7PRG3 Anopheles gambiae 22% 100%
Q81G81 Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) 33% 100%
Q81TE0 Bacillus anthracis 33% 100%
Q87JL4 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 34% 100%
Q88KT0 Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) 36% 100%
Q88YN9 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 33% 100%
Q8D3M4 Vibrio vulnificus (strain CMCP6) 35% 100%
Q8RLU1 Bacillus cereus 33% 100%
Q8RSQ4 Pseudomonas putida 36% 100%
Q8Z8W6 Salmonella typhi 34% 100%
Q92UV9 Rhizobium meliloti (strain 1021) 35% 100%
Q9I434 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 38% 100%
Q9KLY7 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 34% 100%
Q9X1C0 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS