D-3-phosphoglycerate dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-3-phosphoglycerate dehydrogenase-like protein

Species:

Leishmania major

UniProt:

E9ACF1_LEIMA

TriTrypDb:

LmjF.03.0030 , LMJLV39_030005200 , LMJSD75_030005200

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ACF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACF1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004617	phosphoglycerate dehydrogenase activity	5	6
GO:0005488	binding	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	8
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	8
GO:0016618	hydroxypyruvate reductase activity	5	2
GO:0030267	glyoxylate reductase (NADP+) activity	6	2
GO:0036094	small molecule binding	2	8
GO:0051287	NAD binding	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:0106345	glyoxylate reductase activity	5	2
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	71	75	PF00656	0.444
CLV_NRD_NRD_1	225	227	PF00675	0.323
CLV_NRD_NRD_1	494	496	PF00675	0.500
CLV_PCSK_KEX2_1	496	498	PF00082	0.504
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.504
CLV_PCSK_SKI1_1	100	104	PF00082	0.631
CLV_PCSK_SKI1_1	126	130	PF00082	0.325
CLV_PCSK_SKI1_1	226	230	PF00082	0.292
CLV_PCSK_SKI1_1	328	332	PF00082	0.285
CLV_PCSK_SKI1_1	415	419	PF00082	0.247
CLV_Separin_Metazoa	430	434	PF03568	0.410
DEG_APCC_DBOX_1	378	386	PF00400	0.447
DOC_CDC14_PxL_1	171	179	PF14671	0.525
DOC_CDC14_PxL_1	281	289	PF14671	0.563
DOC_CKS1_1	389	394	PF01111	0.543
DOC_CYCLIN_RxL_1	123	131	PF00134	0.526
DOC_MAPK_gen_1	151	160	PF00069	0.526
DOC_MAPK_gen_1	21	28	PF00069	0.520
DOC_PP1_RVXF_1	151	158	PF00149	0.525
DOC_PP1_RVXF_1	90	96	PF00149	0.452
DOC_PP4_FxxP_1	203	206	PF00568	0.525
DOC_PP4_FxxP_1	28	31	PF00568	0.439
DOC_USP7_MATH_1	33	37	PF00917	0.448
DOC_WW_Pin1_4	202	207	PF00397	0.525
DOC_WW_Pin1_4	377	382	PF00397	0.525
DOC_WW_Pin1_4	388	393	PF00397	0.525
LIG_14-3-3_CanoR_1	161	170	PF00244	0.549
LIG_14-3-3_CanoR_1	226	235	PF00244	0.525
LIG_14-3-3_CanoR_1	251	256	PF00244	0.557
LIG_14-3-3_CanoR_1	495	505	PF00244	0.487
LIG_14-3-3_CanoR_1	92	96	PF00244	0.453
LIG_Actin_WH2_2	340	357	PF00022	0.563
LIG_Actin_WH2_2	487	504	PF00022	0.579
LIG_APCC_ABBA_1	364	369	PF00400	0.525
LIG_BIR_III_2	172	176	PF00653	0.563
LIG_EH1_1	502	510	PF00400	0.482
LIG_eIF4E_1	503	509	PF01652	0.475
LIG_FHA_1	165	171	PF00498	0.506
LIG_FHA_1	185	191	PF00498	0.500
LIG_FHA_1	195	201	PF00498	0.525
LIG_FHA_1	208	214	PF00498	0.511
LIG_FHA_1	252	258	PF00498	0.525
LIG_FHA_1	284	290	PF00498	0.614
LIG_FHA_1	307	313	PF00498	0.512
LIG_FHA_1	389	395	PF00498	0.525
LIG_FHA_1	416	422	PF00498	0.555
LIG_FHA_1	505	511	PF00498	0.438
LIG_FHA_2	145	151	PF00498	0.447
LIG_FHA_2	301	307	PF00498	0.563
LIG_FHA_2	341	347	PF00498	0.563
LIG_GBD_Chelix_1	460	468	PF00786	0.337
LIG_Integrin_RGD_1	23	25	PF01839	0.447
LIG_LIR_Apic_2	25	31	PF02991	0.436
LIG_LIR_Gen_1	110	121	PF02991	0.465
LIG_LIR_Gen_1	293	302	PF02991	0.538
LIG_LIR_Gen_1	303	312	PF02991	0.517
LIG_LIR_Nem_3	110	116	PF02991	0.446
LIG_LIR_Nem_3	154	160	PF02991	0.525
LIG_LIR_Nem_3	293	298	PF02991	0.538
LIG_LIR_Nem_3	303	307	PF02991	0.517
LIG_LIR_Nem_3	39	43	PF02991	0.488
LIG_LIR_Nem_3	94	98	PF02991	0.645
LIG_Pex14_2	203	207	PF04695	0.525
LIG_PTB_Apo_2	201	208	PF02174	0.525
LIG_PTB_Apo_2	72	79	PF02174	0.453
LIG_PTB_Phospho_1	72	78	PF10480	0.451
LIG_SH2_CRK	113	117	PF00017	0.416
LIG_SH2_CRK	281	285	PF00017	0.563
LIG_SH2_STAT5	138	141	PF00017	0.607
LIG_SH2_STAT5	335	338	PF00017	0.525
LIG_SH2_STAT5	481	484	PF00017	0.427
LIG_SH2_STAT5	66	69	PF00017	0.435
LIG_SH2_STAT5	72	75	PF00017	0.428
LIG_SH2_STAT5	78	81	PF00017	0.421
LIG_SH3_3	365	371	PF00018	0.525
LIG_SH3_3	423	429	PF00018	0.525
LIG_SH3_3	52	58	PF00018	0.499
LIG_SH3_CIN85_PxpxPR_1	140	145	PF14604	0.447
LIG_SUMO_SIM_par_1	220	225	PF11976	0.563
LIG_SUMO_SIM_par_1	30	36	PF11976	0.446
LIG_SUMO_SIM_par_1	343	348	PF11976	0.563
LIG_TYR_ITIM	258	263	PF00017	0.525
LIG_TYR_ITIM	279	284	PF00017	0.563
LIG_UBA3_1	221	227	PF00899	0.508
LIG_UBA3_1	47	54	PF00899	0.432
LIG_Vh1_VBS_1	336	354	PF01044	0.563
LIG_WRC_WIRS_1	301	306	PF05994	0.614
LIG_WRC_WIRS_1	34	39	PF05994	0.439
MOD_CK1_1	340	346	PF00069	0.525
MOD_CK1_1	36	42	PF00069	0.433
MOD_CK1_1	419	425	PF00069	0.573
MOD_CK1_1	504	510	PF00069	0.424
MOD_CK1_1	60	66	PF00069	0.444
MOD_CK2_1	144	150	PF00069	0.447
MOD_CK2_1	209	215	PF00069	0.525
MOD_CK2_1	370	376	PF00069	0.559
MOD_CK2_1	394	400	PF00069	0.525
MOD_CK2_1	43	49	PF00069	0.471
MOD_GlcNHglycan	418	421	PF01048	0.381
MOD_GlcNHglycan	498	501	PF01048	0.492
MOD_GlcNHglycan	55	58	PF01048	0.439
MOD_GlcNHglycan	86	89	PF01048	0.456
MOD_GSK3_1	100	107	PF00069	0.429
MOD_GSK3_1	222	229	PF00069	0.557
MOD_GSK3_1	302	309	PF00069	0.525
MOD_GSK3_1	415	422	PF00069	0.517
MOD_GSK3_1	53	60	PF00069	0.446
MOD_LATS_1	99	105	PF00433	0.448
MOD_N-GLC_1	240	245	PF02516	0.308
MOD_N-GLC_1	290	295	PF02516	0.363
MOD_N-GLC_1	337	342	PF02516	0.325
MOD_NEK2_1	128	133	PF00069	0.540
MOD_NEK2_1	207	212	PF00069	0.525
MOD_NEK2_1	416	421	PF00069	0.611
MOD_NEK2_1	43	48	PF00069	0.419
MOD_NEK2_1	441	446	PF00069	0.502
MOD_NEK2_1	472	477	PF00069	0.523
MOD_NEK2_1	501	506	PF00069	0.444
MOD_NMyristoyl	1	7	PF02799	0.429
MOD_PIKK_1	161	167	PF00454	0.559
MOD_PIKK_1	226	232	PF00454	0.549
MOD_PIKK_1	262	268	PF00454	0.523
MOD_PKA_1	100	106	PF00069	0.439
MOD_PKA_1	226	232	PF00069	0.557
MOD_PKA_1	331	337	PF00069	0.614
MOD_PKA_1	496	502	PF00069	0.495
MOD_PKA_2	144	150	PF00069	0.447
MOD_PKA_2	340	346	PF00069	0.525
MOD_PKA_2	441	447	PF00069	0.446
MOD_PKA_2	496	502	PF00069	0.495
MOD_PKA_2	91	97	PF00069	0.451
MOD_Plk_1	240	246	PF00069	0.528
MOD_Plk_2-3	300	306	PF00069	0.563
MOD_Plk_2-3	68	74	PF00069	0.438
MOD_Plk_4	104	110	PF00069	0.378
MOD_Plk_4	144	150	PF00069	0.447
MOD_Plk_4	331	337	PF00069	0.540
MOD_Plk_4	340	346	PF00069	0.503
MOD_Plk_4	43	49	PF00069	0.420
MOD_ProDKin_1	202	208	PF00069	0.525
MOD_ProDKin_1	377	383	PF00069	0.525
MOD_ProDKin_1	388	394	PF00069	0.525
TRG_DiLeu_BaEn_1	325	330	PF01217	0.563
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.428
TRG_ENDOCYTIC_2	113	116	PF00928	0.415
TRG_ENDOCYTIC_2	260	263	PF00928	0.525
TRG_ENDOCYTIC_2	281	284	PF00928	0.563
TRG_ENDOCYTIC_2	481	484	PF00928	0.417
TRG_ER_diArg_1	494	497	PF00400	0.450
TRG_NES_CRM1_1	300	314	PF08389	0.563
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRG6	Leptomonas seymouri	81%	100%
A0A1X0P8Z4	Trypanosomatidae	65%	100%
A0A2Z4HPZ6	Hormonema carpetanum	29%	100%
A0A3S5H520	Leishmania donovani	93%	100%
A4H3H6	Leishmania braziliensis	85%	100%
B3PK14	Cellvibrio japonicus (strain Ueda107)	27%	100%
E9AG23	Leishmania infantum	93%	100%
E9AJN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O88712	Mus musculus	28%	100%
P0A9T0	Escherichia coli (strain K12)	52%	100%
P0A9T1	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	52%	100%
P0A9T2	Escherichia coli O157:H7	52%	100%
P0A9T3	Shigella flexneri	52%	100%
P40054	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
P40510	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	100%
P43885	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	49%	100%
P87228	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
Q13363	Homo sapiens	28%	100%
Q20595	Caenorhabditis elegans	26%	70%
Q54UH8	Dictyostelium discoideum	55%	100%
Q7N2B2	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	26%	100%
Q9YHU0	Xenopus laevis	27%	100%
Q9Z2F5	Rattus norvegicus	28%	100%