Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ACE4_LEIMA

TriTrypDb:

LmjF.02.0700 , LMJLV39_270033100 , LMJSD75_270033300

Length:

937

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	3
GO:0005930	axoneme	2	2
GO:0043226	organelle	2	4
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ACE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ACE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.526
CLV_NRD_NRD_1	107	109	PF00675	0.538
CLV_NRD_NRD_1	197	199	PF00675	0.657
CLV_NRD_NRD_1	226	228	PF00675	0.525
CLV_NRD_NRD_1	279	281	PF00675	0.511
CLV_NRD_NRD_1	345	347	PF00675	0.460
CLV_NRD_NRD_1	366	368	PF00675	0.512
CLV_NRD_NRD_1	380	382	PF00675	0.446
CLV_NRD_NRD_1	598	600	PF00675	0.518
CLV_NRD_NRD_1	611	613	PF00675	0.453
CLV_NRD_NRD_1	646	648	PF00675	0.517
CLV_NRD_NRD_1	785	787	PF00675	0.512
CLV_NRD_NRD_1	880	882	PF00675	0.608
CLV_PCSK_KEX2_1	170	172	PF00082	0.530
CLV_PCSK_KEX2_1	197	199	PF00082	0.657
CLV_PCSK_KEX2_1	226	228	PF00082	0.506
CLV_PCSK_KEX2_1	279	281	PF00082	0.475
CLV_PCSK_KEX2_1	345	347	PF00082	0.460
CLV_PCSK_KEX2_1	366	368	PF00082	0.485
CLV_PCSK_KEX2_1	380	382	PF00082	0.406
CLV_PCSK_KEX2_1	414	416	PF00082	0.643
CLV_PCSK_KEX2_1	455	457	PF00082	0.658
CLV_PCSK_KEX2_1	580	582	PF00082	0.478
CLV_PCSK_KEX2_1	611	613	PF00082	0.473
CLV_PCSK_KEX2_1	646	648	PF00082	0.519
CLV_PCSK_KEX2_1	785	787	PF00082	0.498
CLV_PCSK_KEX2_1	880	882	PF00082	0.611
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.544
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.642
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.690
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.542
CLV_PCSK_SKI1_1	227	231	PF00082	0.534
CLV_PCSK_SKI1_1	263	267	PF00082	0.574
CLV_PCSK_SKI1_1	367	371	PF00082	0.469
CLV_PCSK_SKI1_1	496	500	PF00082	0.494
CLV_PCSK_SKI1_1	583	587	PF00082	0.513
CLV_PCSK_SKI1_1	631	635	PF00082	0.556
CLV_PCSK_SKI1_1	660	664	PF00082	0.478
CLV_PCSK_SKI1_1	725	729	PF00082	0.539
CLV_PCSK_SKI1_1	802	806	PF00082	0.616
DEG_APCC_DBOX_1	455	463	PF00400	0.649
DEG_APCC_DBOX_1	860	868	PF00400	0.555
DEG_SCF_FBW7_1	39	45	PF00400	0.643
DOC_CKS1_1	39	44	PF01111	0.696
DOC_MAPK_gen_1	528	536	PF00069	0.375
DOC_MAPK_gen_1	580	589	PF00069	0.520
DOC_MAPK_gen_1	774	783	PF00069	0.562
DOC_MAPK_MEF2A_6	580	589	PF00069	0.607
DOC_MAPK_MEF2A_6	720	728	PF00069	0.471
DOC_MAPK_RevD_3	770	786	PF00069	0.587
DOC_PP2B_LxvP_1	929	932	PF13499	0.674
DOC_PP4_FxxP_1	912	915	PF00568	0.632
DOC_USP7_MATH_1	192	196	PF00917	0.621
DOC_USP7_MATH_1	360	364	PF00917	0.535
DOC_USP7_MATH_1	461	465	PF00917	0.588
DOC_USP7_MATH_1	795	799	PF00917	0.597
DOC_USP7_MATH_1	923	927	PF00917	0.677
DOC_WW_Pin1_4	2	7	PF00397	0.732
DOC_WW_Pin1_4	38	43	PF00397	0.675
DOC_WW_Pin1_4	891	896	PF00397	0.749
LIG_14-3-3_CanoR_1	108	117	PF00244	0.556
LIG_14-3-3_CanoR_1	147	155	PF00244	0.627
LIG_14-3-3_CanoR_1	215	220	PF00244	0.615
LIG_14-3-3_CanoR_1	226	232	PF00244	0.606
LIG_14-3-3_CanoR_1	24	29	PF00244	0.684
LIG_14-3-3_CanoR_1	314	322	PF00244	0.434
LIG_14-3-3_CanoR_1	415	425	PF00244	0.628
LIG_14-3-3_CanoR_1	543	553	PF00244	0.505
LIG_14-3-3_CanoR_1	563	567	PF00244	0.249
LIG_14-3-3_CanoR_1	660	669	PF00244	0.529
LIG_14-3-3_CanoR_1	677	683	PF00244	0.463
LIG_14-3-3_CanoR_1	917	921	PF00244	0.702
LIG_Actin_WH2_2	148	165	PF00022	0.596
LIG_APCC_ABBA_1	755	760	PF00400	0.656
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_BIR_III_4	621	625	PF00653	0.471
LIG_CaM_IQ_9	772	788	PF13499	0.585
LIG_Clathr_ClatBox_1	73	77	PF01394	0.471
LIG_FHA_1	209	215	PF00498	0.642
LIG_FHA_1	730	736	PF00498	0.522
LIG_FHA_1	766	772	PF00498	0.541
LIG_FHA_1	923	929	PF00498	0.723
LIG_FHA_2	129	135	PF00498	0.523
LIG_FHA_2	215	221	PF00498	0.604
LIG_FHA_2	43	49	PF00498	0.584
LIG_FHA_2	465	471	PF00498	0.638
LIG_FHA_2	474	480	PF00498	0.554
LIG_FHA_2	521	527	PF00498	0.559
LIG_FHA_2	59	65	PF00498	0.485
LIG_LIR_Gen_1	547	557	PF02991	0.533
LIG_LIR_Gen_1	66	76	PF02991	0.443
LIG_LIR_Gen_1	767	775	PF02991	0.605
LIG_LIR_Nem_3	316	322	PF02991	0.450
LIG_LIR_Nem_3	547	553	PF02991	0.527
LIG_LIR_Nem_3	61	65	PF02991	0.497
LIG_LIR_Nem_3	66	72	PF02991	0.479
LIG_LIR_Nem_3	747	753	PF02991	0.605
LIG_LIR_Nem_3	767	772	PF02991	0.328
LIG_LIR_Nem_3	88	92	PF02991	0.466
LIG_NRBOX	723	729	PF00104	0.584
LIG_OCRL_FandH_1	852	864	PF00620	0.583
LIG_PCNA_yPIPBox_3	288	300	PF02747	0.533
LIG_PCNA_yPIPBox_3	528	540	PF02747	0.475
LIG_REV1ctd_RIR_1	843	851	PF16727	0.573
LIG_SH2_CRK	319	323	PF00017	0.461
LIG_SH2_CRK	550	554	PF00017	0.475
LIG_SH2_CRK	702	706	PF00017	0.556
LIG_SH2_CRK	750	754	PF00017	0.706
LIG_SH2_CRK	769	773	PF00017	0.383
LIG_SH2_NCK_1	348	352	PF00017	0.516
LIG_SH2_SRC	69	72	PF00017	0.585
LIG_SH2_STAP1	348	352	PF00017	0.516
LIG_SH2_STAP1	546	550	PF00017	0.410
LIG_SH2_STAP1	65	69	PF00017	0.505
LIG_SH2_STAT3	284	287	PF00017	0.532
LIG_SH2_STAT3	65	68	PF00017	0.545
LIG_SH2_STAT3	690	693	PF00017	0.556
LIG_SH2_STAT5	284	287	PF00017	0.477
LIG_SH2_STAT5	368	371	PF00017	0.559
LIG_SH2_STAT5	481	484	PF00017	0.577
LIG_SH2_STAT5	546	549	PF00017	0.537
LIG_SH3_3	36	42	PF00018	0.705
LIG_SH3_3	894	900	PF00018	0.755
LIG_SH3_3	910	916	PF00018	0.625
LIG_TRAF2_1	187	190	PF00917	0.632
LIG_TRAF2_1	252	255	PF00917	0.483
LIG_TRAF2_1	332	335	PF00917	0.561
LIG_TRAF2_1	468	471	PF00917	0.545
LIG_TRAF2_1	824	827	PF00917	0.412
LIG_TYR_ITIM	700	705	PF00017	0.563
LIG_UBA3_1	504	511	PF00899	0.400
LIG_Vh1_VBS_1	106	124	PF01044	0.516
LIG_WRC_WIRS_1	466	471	PF05994	0.594
LIG_WW_3	914	918	PF00397	0.612
MOD_CDK_SPK_2	891	896	PF00069	0.771
MOD_CK1_1	19	25	PF00069	0.617
MOD_CK1_1	2	8	PF00069	0.655
MOD_CK1_1	233	239	PF00069	0.584
MOD_CK1_1	464	470	PF00069	0.607
MOD_CK1_1	573	579	PF00069	0.575
MOD_CK2_1	140	146	PF00069	0.564
MOD_CK2_1	249	255	PF00069	0.556
MOD_CK2_1	261	267	PF00069	0.485
MOD_CK2_1	42	48	PF00069	0.643
MOD_CK2_1	464	470	PF00069	0.567
MOD_CK2_1	473	479	PF00069	0.502
MOD_CK2_1	503	509	PF00069	0.515
MOD_CK2_1	518	524	PF00069	0.429
MOD_CK2_1	58	64	PF00069	0.510
MOD_DYRK1A_RPxSP_1	896	900	PF00069	0.639
MOD_GlcNHglycan	19	22	PF01048	0.730
MOD_GlcNHglycan	235	238	PF01048	0.568
MOD_GlcNHglycan	26	29	PF01048	0.723
MOD_GlcNHglycan	762	765	PF01048	0.660
MOD_GlcNHglycan	891	894	PF01048	0.738
MOD_GlcNHglycan	925	928	PF01048	0.640
MOD_GSK3_1	108	115	PF00069	0.490
MOD_GSK3_1	12	19	PF00069	0.723
MOD_GSK3_1	142	149	PF00069	0.590
MOD_GSK3_1	227	234	PF00069	0.609
MOD_GSK3_1	283	290	PF00069	0.496
MOD_GSK3_1	29	36	PF00069	0.645
MOD_GSK3_1	38	45	PF00069	0.623
MOD_GSK3_1	416	423	PF00069	0.641
MOD_GSK3_1	461	468	PF00069	0.625
MOD_GSK3_1	570	577	PF00069	0.504
MOD_GSK3_1	660	667	PF00069	0.530
MOD_GSK3_1	885	892	PF00069	0.757
MOD_GSK3_1	896	903	PF00069	0.638
MOD_GSK3_1	919	926	PF00069	0.640
MOD_GSK3_1	92	99	PF00069	0.477
MOD_N-GLC_1	30	35	PF02516	0.704
MOD_N-GLC_1	729	734	PF02516	0.563
MOD_NEK2_1	1	6	PF00069	0.715
MOD_NEK2_1	162	167	PF00069	0.555
MOD_NEK2_1	199	204	PF00069	0.589
MOD_NEK2_1	214	219	PF00069	0.493
MOD_NEK2_1	221	226	PF00069	0.522
MOD_NEK2_1	231	236	PF00069	0.425
MOD_NEK2_1	535	540	PF00069	0.492
MOD_NEK2_1	574	579	PF00069	0.559
MOD_NEK2_1	845	850	PF00069	0.479
MOD_NEK2_1	867	872	PF00069	0.597
MOD_NEK2_1	92	97	PF00069	0.469
MOD_NEK2_2	192	197	PF00069	0.695
MOD_NEK2_2	360	365	PF00069	0.462
MOD_PIKK_1	208	214	PF00454	0.618
MOD_PIKK_1	221	227	PF00454	0.542
MOD_PIKK_1	283	289	PF00454	0.503
MOD_PIKK_1	481	487	PF00454	0.559
MOD_PIKK_1	675	681	PF00454	0.513
MOD_PIKK_1	845	851	PF00454	0.590
MOD_PKA_1	108	114	PF00069	0.511
MOD_PKA_2	134	140	PF00069	0.637
MOD_PKA_2	146	152	PF00069	0.532
MOD_PKA_2	214	220	PF00069	0.591
MOD_PKA_2	273	279	PF00069	0.482
MOD_PKA_2	313	319	PF00069	0.457
MOD_PKA_2	542	548	PF00069	0.498
MOD_PKA_2	562	568	PF00069	0.247
MOD_PKA_2	574	580	PF00069	0.359
MOD_PKA_2	664	670	PF00069	0.556
MOD_PKA_2	879	885	PF00069	0.667
MOD_PKA_2	916	922	PF00069	0.721
MOD_Plk_1	128	134	PF00069	0.547
MOD_Plk_2-3	112	118	PF00069	0.593
MOD_Plk_2-3	58	64	PF00069	0.548
MOD_Plk_4	12	18	PF00069	0.667
MOD_Plk_4	227	233	PF00069	0.587
MOD_Plk_4	461	467	PF00069	0.678
MOD_Plk_4	535	541	PF00069	0.496
MOD_Plk_4	678	684	PF00069	0.464
MOD_Plk_4	92	98	PF00069	0.477
MOD_ProDKin_1	2	8	PF00069	0.734
MOD_ProDKin_1	38	44	PF00069	0.666
MOD_ProDKin_1	891	897	PF00069	0.742
MOD_SUMO_for_1	141	144	PF00179	0.577
MOD_SUMO_for_1	169	172	PF00179	0.570
MOD_SUMO_for_1	403	406	PF00179	0.681
MOD_SUMO_for_1	585	588	PF00179	0.533
MOD_SUMO_rev_2	506	513	PF00179	0.531
TRG_DiLeu_BaEn_1	723	728	PF01217	0.527
TRG_DiLeu_BaEn_1	767	772	PF01217	0.631
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.462
TRG_ENDOCYTIC_2	319	322	PF00928	0.444
TRG_ENDOCYTIC_2	550	553	PF00928	0.459
TRG_ENDOCYTIC_2	69	72	PF00928	0.573
TRG_ENDOCYTIC_2	702	705	PF00928	0.560
TRG_ENDOCYTIC_2	750	753	PF00928	0.679
TRG_ENDOCYTIC_2	758	761	PF00928	0.683
TRG_ENDOCYTIC_2	769	772	PF00928	0.542
TRG_ENDOCYTIC_2	89	92	PF00928	0.455
TRG_ENDOCYTIC_2	909	912	PF00928	0.637
TRG_ER_diArg_1	196	198	PF00400	0.672
TRG_ER_diArg_1	226	228	PF00400	0.526
TRG_ER_diArg_1	279	281	PF00400	0.545
TRG_ER_diArg_1	345	347	PF00400	0.460
TRG_ER_diArg_1	366	368	PF00400	0.601
TRG_ER_diArg_1	880	883	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	733	738	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	780	784	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ56	Leptomonas seymouri	65%	100%
A0A0N1I2V1	Leptomonas seymouri	26%	91%
A0A0S4JMK5	Bodo saltans	26%	100%
A0A0S4KGN1	Bodo saltans	33%	98%
A0A1X0NJT4	Trypanosomatidae	39%	100%
A0A381MLP4	Leishmania infantum	94%	100%
A0A3Q8IAS8	Leishmania donovani	94%	100%
A0A422NB26	Trypanosoma rangeli	35%	100%
A0A451EJK4	Leishmania donovani	94%	100%
A4H3K2	Leishmania braziliensis	26%	99%
A4HG33	Leishmania braziliensis	77%	100%
A8HUA1	Chlamydomonas reinhardtii	27%	100%
B2RW38	Mus musculus	26%	100%
C9ZJ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	91%
E9ACX3	Leishmania major	100%	100%
E9AJN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q5T655	Homo sapiens	26%	100%
V5D614	Trypanosoma cruzi	38%	100%